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0 Nutritional Innovations in DSM DSM Innovation Day, 28 September 2006 Krijn Rietveld DSM Nutrition Cluster Vision 2010: Building on Strengths 1 Building on Strengths Market-driven growth and innovation Increased Presence Emerging Economies Operational Excellence Value Creation DSM Nutrition Cluster DSM Activities - Clusters 2 Managing Board Corporate Staff Innovation Center Shared Competence & Services Nutrition DSM Nutritional Products Life Science Fine Chemicals Pharmaceutical Products Anti-Infectives Performance Materials Engineering Plastics (incl. Dyneema) Resins Elastomers Industrial Chemicals Fibre Intermediates Melamine Agro Energy Animal Nutrition & Health Human Nutrition & Health New Business Development Food Specialties DSM Nutrition Cluster Innovation will drive the Market growth in Nutrition 3 We innovate beyond the product! New Business Development will grow the young products, will launch the pipeline products and will acquire products and start-up companies to further enrich the portfolio. Branding as umbrella for: Recognizable DSM Brand Safety on our own products Efficacy on our own products Quality of our products Traceability for each raw material IP to protect DSM and DSM’s customers Partnerships with our customers: Co-marketing for product launches Joint clinical trials Product Awareness creation DSM Nutrition Cluster The Innovation engine 4 External sourcing Enhanced Launch & Product Management NBD Business management (NBD) Key functions driving development of new products Idea Idea Identificati- evaluat Feasibility Development ion on Scale up Launch NBD product mgmt Handover R&D DSM Nutrition Cluster Innovation matters to us … DSM is the pioneer in identifying and developing innovative ingredients for food, feed and personal care … …and, our integrated research approach is key to maintain leadership in this competitive environment DSM Nutrition Cluster DSM’s full set of competences Present in all fields !!! 6 Discovery Synthesis Formulation Safety Efficacy Marketing Genomics Proteomics Biochemistry Photochemistry Extraction Chemical Synthesis Fermentation BioTransformation Emulsification Milling Micronisation Spray drying Extrusion Granulation Metabolism Mutagenicity Reproduction Toxicity Carcinogencity Nutrigenomics In vitro proof Animal Studies Human Studies Global Organization Branded Products Technical Service Application Development Regulatory Support IP Protection DSM Nutrition Cluster Discovery of new Bioactive Ingredients 7 Health Segment Molecular target Screening Assays Hit evaluation and selection Natural Products Library Natural Biosources extract collection Candidate Multidimensional Dereplication / Efficacy / Safety We screen thousands of compounds to identify the best candidate. DSM Nutrition Cluster DFS Platform: Enzymes and Protein Hydrolysates 8 ….. Casein CV D B app eer lica tion s Soy fa In nt C on su m Sp er be or ne t Protein Pro Gln fit s Leu Pro Pro Pro Val Val Val Asn Pro Phe Met Gly Val Fish Ob es ity DSM Nutrition Cluster c lia Ce Glu Lys Arg Lys Protease toolbox y GM P Wh e Diabetes Consumer benefits ize Ma Gly Leu Ile Ser Ala Glu Arg Bioactive peptides Pro Pro Met Leu New Business Development Offering new business opportunities 9 DSM Nutrition Cluster DSM Nutrition has ambitious Goals 10 400 million Growth of Sales in 2010 • Market development of recently (2005, 2006) introduced products • Developing new applications of young products • New introductions from the Pipeline • Acquisition / licensing of products • Acquisition of Start-Ups We are and will be the leading Nutritional Company bringing major Innovation to the Industry DSM Nutrition Cluster Clear Benefits, Transparent Results - with Brewers Clarex™ • Brewers Clarex™proline-specific endoprotease derived from A. niger • Hydrolyze specifically proline rich peptides* • Guarantee beer colloidal stability > 13 months shelf life • Cost effective (low CAPEX & OPEX) • Easy to use (liquid form, addition beginning fermentation) • Improve beer quality and flavor stability • Simplify brewery layout • Reduce energy consumption • Sustainable ‘ Green’ over all production chain • Compatible with “particle free” concept • Awarded “Best product offered to brewing industry” in October 2005, Poland * Colloidal haze formation is mediated by cross-linking of one proline rich peptide to several polyphenols and of one polyphenol to several proline rich peptides resulting in a large aggregate. 11 DSM Nutrition Cluster The cheese ripening accelerator 12 • Accelerzyme CPG speeds up flavor development in cheese • Benefits for cheese manufacturers • • • • Reduced ripening time, higher cash flow More cheeses can be produced in ripening warehouse More tasteful cheese in same ripening time -> higher Sales value cheeses Shortening bitter phase during ripening process • Suitable for various cheese applications • Purified enzyme, therefore very reliable • Unique properties • Only active in cheese, not in milk or whey • Inactivated during whey processing • Allergen-free DSM Nutrition Cluster MAXAPAL® A2: A new product for improved egg yolk emulsifier properties • Egg yolk is an emulsifying ingredient for oil-in-water emulsions, such as mayonnaise and dressings; the lecithin in egg yolk is the responsible ingredient. • Maxapal A2 (a purified non animal Phospholipase A2) is used as a processing aid to convert lecithin into lysolecithin which has improved oil/ water emulsifier properties • Usage of Maxapal A2 results in emulsions with high physical stability, exceptional heat stability and cost-in-use advantage for the mayonnaise manufacturer. Egg yolk 1 Fatty acid Fatty acid 1 Maxapal A2 2 3 Fatty acid OH 2 Fatty acid Choline Maxapal A2 treated egg yolk 3 Phosphoric acid Choline Phosphoric acid Lecithin Lysolecithin two samples based on the same mayonnaise recipe heated at 120° C for 20 minutes DSM Nutrition Cluster Unlimited Natural Taste Enhancement 14 • Maxarome® Select is produced from primary grown bakers yeast • 14% natural nucleotides • Natural taste enhancement function • Due to its unique neutral taste, Maxarome® Select can be used in a wide range of culinary applications • Natural impact ! No taste compromise while reducing salt or fat are replacing monosodiumglutamate (E621) DSM Nutrition Cluster The natural way to eat less 15 • Fabuless™: unique ingredient targeting weight management • Efficacy substantiated by several published clinical trials: • reduction in calorie intake at subsequent meals • effect on weight maintenance after dieting • effective for normal, overweight and obese users • Enabling dairy customers to innovate, with successful product launches in Italy and Portugal this year • Dietary supplement launches in US, France, Spain, and more planned with LTP • 100% Natural, No Novel Food www. Nutrition Cluster DSM ResistTemptation.com Muscle energy for active people 16 • PeptoPro® is a natural bioactive peptide derived from milk • functional ingredient for fast muscle refueling and faster energy recovery • Commercially available in Europe and US • Improved taste • Efficacy substantiated in 3 clinical trials: • Improved performance in trained athletes significantly by 1.5 to 3 % DSM Nutrition Cluster Shape up your system 17 • The LAFTI® range of probiotics comprises three strains: • Lactobacillus acidophilus • Lactobacillus casei • Bifidobacterium animalis • LAFTI probiotics are live micro-organisms that are naturally present in the microflora and may contribute to: • Strengthen your natural defense • Promote healthy digestion • Suitable for application in: • Dietary supplements • Dairy and other food products DSM Nutrition Cluster The essence of green tea 18 • Old Asian health tradition supported by solid science • Natural and pure • Easy access to all the excellent benefits from green tea • Naturally derived from green tea leaves • Caffeine- and pesticide free • Can be easily added to beverages, foods or OTC products • Fits into a modern and fast-paced lifestyle • “Mind and body in balance” DSM Nutrition Cluster The Natural Goodness from Olives 19 • HIDROX® is produced from fresh, organically grown olives • 6% olive polyphenols, 2.5% hydroxytyrosol • Powerful antioxidant • May help reduce inflammation and support joint health • Evidence of cardiovascular benefits • Exciting potential for sports beverages • Suitable for application in various food types and beverages • Mediterranean diet • GRAS affirmed DSM Nutrition Cluster Rosehips: Unique natural relief for Osteoarthritis Patients • Rosehip powder is produced from the seeds and husks of fruit from rosehip plant Rosa canina L. • 100% natural product, no side effects, no chemical and biological preparation • Proven in clinical trials to reduce symptoms of osteoarthritis • Enhanced quality of life (better mood, mobility and energy) • Safe and long-term treatment of OA • Can cut expenses on regular OA medicine up to 50% • Patent protection for production process and use of rosehips in arthritis DSM Nutrition Cluster 20 21 For a better frame of body Pure genistein supported by an extensive safety program A nature-identical isoflavone primarily for the prevention of osteoporosis Can substitute for estrogen in post-menopausal women BONISTEIN™ taken with calcium & vitamin D will ensure healthy bones Healthy bones as we age means independence and full enjoyment of life For healthy bones calcium is only part of the story DSM Nutrition Cluster ALL-Q® (Coenzyme Q10) 22 • CoQ10 is a vitamin-like compound, essential for the production of energy in the body • It is a powerful antioxidant and benefits cardiovascular health, aging, skin health and brain diseases such Alzheimer's and Parkinson’s • ALL-Q® bead-let technology allows CoQ10 to be utilized in food & beverages and supplements such as tablets and capsules • ALL-Q® CoQ10 is produced by fermentation and is readily absorbed by the body (bioavailable) DSM Nutrition Cluster All-Q™ plus 23 • Combination of two essential skin antioxidants Coenzyme Q10 and vitamin E • Protects against damage from UV radiation • Anti-wrinkle effects, skin soothing and moisturizing effects • Ideal ingredient for skin protection formulations, regenerating products or energizing applications for maintaining healthy and beautiful skin DSM Nutrition Cluster Parsol® SLX in Personal Care 24 UV protection in hair care Exposing your hair to sun light can cause the color of your hair to fade and the hair structure to be destroyed. Using UV-filters in hair care formulations will keep your hair shiny and colorful! DSM Nutrition Cluster The advanced source of Vitamin D3 25 Improve skeletal development to support maximum performance Enhance bird health and welfare by minimizing leg disorders Improves lay persistence and hatchability Reduce wastage and down-grades at processing Increases carcass yield DSM Nutrition Cluster Acquisition of CRINA 26 • Pioneer in the development of plant extracts for use as feed additives • CRINA products stabilize intestinal micro-flora, thus promoting health and stimulating growth and performance of the animal • Perfect fit with DSM’s ambitions and strategy for growth in Animal Nutrition Cluster • Part of DSM since June 2006 • Example of innovative growth via acquisition DSM Nutrition Cluster Science defines a new role for nutrition for well-being 27 and healthy aging Modifiable Lifestyle Nutrition Non-Modifiable Genome Nutrigenomics explains the interaction of nutrients at genome level and informs on risks as well as on impact of lifestyle and nutrition For the first time ever the function of nutrition and its components can be studied at the molecular level and the finding can be used for innovative solutions to unmet costumer needs. DSM Nutrition Cluster Personal Nutrition …. since we are all different …. 28 …inside as well as outside DSM Nutrition Cluster DSM Nutrition, the Innovator in the Industry 29 • 400 million sales growth in 2010 • Focus on innovative growing segments of Health & Nutrition • Broadest set of competences in the industry • Branding to support our products • Many new products introduced during the last years • Well filled internal Pipeline • Attractive (Alliance) partner for other companies (external innovation) DSM Nutrition Cluster