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									KELISEMA S.r.l.
Active Ingredients for the Cosmetic Industry

Kelisema in the world
Our major partners
UK - Aston Chemicals Ltd NL/B - Keyser & McKay F - Warwick Adriss SA CH – Prochem A.G. E - Delta Tecnica SA D - ICM Barrier Handels GmbH GR - Cellco Chemicals Ltd TW - Fairlink Trading Co. Ltd BRA - Chemy Union Quimica Ltda

KELISEMA

PH - Eunice Ltd

Our products

Vegetable Protein Derivatives
        Glusol Kelyamin Gluplex series Glusol 10K Orysol Oryplex Maysol Kelisoy Hydrolyzed Wheat Gluten Hydrolyzed Wheat Protein Native Wheat Protein - Surfactant Complexes High Molecular Weight Hydrolyzed Wheat Protein Hydrolyzed Rice Protein Native Rice Protein - Surfactant Complexes Hydrolyzed Corn Protein Hydrolyzed Soy Protein Hydrolyzed Nettle Protein Hydrolyzed Mallow Protein

 KeliPro Urtica  KeliPro Malva

Our products

Animal Protein Derivatives
 Kelimilk  Keliwool         Hydrolyzed Collagen Native Collagen 1% Desacol Collagen-Hyal Collagen Collagen Collagen Collagen LSS IMZ CTC CCK Hydrolyzed Milk Protein Hydrolyzed Keratin

Soluble Collagen Desamidocollagen Soluble Collagen and Sodium Hyaluronate Soluble Soluble Soluble Soluble Collagen Collagen Collagen Collagen and and and and Sodium Lauryl Sulfate Sodium Cocoamphoacetate Cetrimonium Chloride Potassium Cocoate

Our products

Specialties
     Thermal Heilmoor Shea Butter Cegaba Sodium Hyaluronate Kelifluo series Heilmoor Clay Butyrospermum Parkii Carboxyethyl-g-aminobutyric acid Sodium Hyaluronate Polyperfluoroethers-in-glycerin emulsions

Vegetable Extracts
     Glycolic Extracts Hydroglycolic extracts Liposoluble extracts Propolis Aloe Gel

Protein Derivatives
Effective wheat, soy, rice, corn and leaf protein derivatives for skin and hair care. Mild processing preserves amino acid integrity Traditional and innovative animal protein derivatives from safe and healthy sources

Glusol • Hydrolyzed Wheat Gluten
General Information

Description  High purity wheat protein hydrolysate obtained by gentle enzymatic digestion process. Optimum molecular weight and strategically placed amino acids for outstanding functional and technological benefits Available types  Liquid 15% active matter, light colour and odour  Liquid 35% active matter, light colour and odour  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Improves skin/eye tolerability of surfactants  Has hair conditioning and repairing effects  Helps retaining moisture on hair and skin  Thickens and stabilises foam in detergent formulation

Glusol • Hydrolyzed Wheat Gluten
General Information

Technical Information Available  Technical Data Sheet  Safety Data Sheet       Primary Skin Irritation Test Ocular Irritation Test Hair Substantivity Evaluation Surfactant Tolerability Improvement Evaluation Scavenging Activity Evaluation Foaming Properties Evaluation

Glusol • Hydrolyzed Wheat Gluten
Effectiveness highlights

Surfactant Tolerability Improvement Evaluation  Glusol reduces the transepidermal water loss caused by repeated use of irritant skin detergents
350 300
TEWL % Change

250 200 150 100
SLS 1%

50 0 1st Week 2nd Week

SLS 1% + GLUSOL 1%

3rd Week

4th Week

Forearm Washing Test 2 daily washings of 5 minutes for 4 weeks with aqueous Sodium Lauryl Sulfate (SLS) 1% and SLS 1% + GLUSOL 1%. Evaluation of the Transepidermal Water Loss (TEWL).

Glusol • Hydrolyzed Wheat Gluten
Effectiveness highlights

Scavenging Activity Evaluation  The free radicals scavenging activity of Glusol is much higher than that of a common wheat protein hydrolysate
35
Scavenging activity %
34.71%

30 25 20 15

GLUSOL WPH

13.32%

10 5 0 GLUSOL WPH

Scavenging Activity Evaluation In vitro test based on the drop of viscosity of hyaluronic acid solutions caused by free radicals. Glusol is compared with a commercial wheat protein hydrolysate (WPH) with similar molecular weight and isoelectric point. Special hydrolysis process used in the preparation of Glusol makes it more hydrophobic in the terminal positions of the peptide chains, exposing aromatic groups to the action of free radicals.

Kelyamin • Hydrolyzed Wheat Protein
General Information

Description  High purity wheat protein hydrolysate obtained by the action of a special enzyme pool, which yields a high level of free amino acids and small peptides  Specifically featured for hair care and hair hygiene products Available types  Liquid 20% active matter, light colour and odour  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Repairs damaged hair keratin  Imparts body and volume to the hair strand  Helps retaining moisture on the hair surface  Prevents hair damage in waving/colouring treatments

Kelyamin • Hydrolyzed Wheat Protein
General Information

Technical Information Available  Technical Data Sheet  Safety Data Sheet     Primary Skin Irritation Test Hair Substantivity Evaluation Hair Hydrating Evaluation Hair Protection Evaluation

Kelyamin • Hydrolyzed Wheat Protein
Effectiveness highlights

Hair Substantivity Evaluation  Hair substantivity from shampoo application. Comparison of Kelyamin with two commercial wheat protein hydrolysates
0,8

mg Peptides/g Hair

0,7 0,6 0,5 0,4 0,3 0,2 0,1 0 KELYAMIN WPH 5KD Damaged Hair Virgin Hair WPH 100KD

Hair substantivity from shampoo application Hair tresses are treated with a simple shampoo formulation containing 5% of the test products. Kelyamin is better adsorbed on both virgin and damaged hair than protein derivatives that do not contain a significant amount of free amino acids.

Kelyamin • Hydrolyzed Wheat Protein
Effectiveness highlights

Hair Moisturisation Evaluation  Kelyamin helps hair to absorb and retain moisture, contributing to the hair health and beauty
12

% Variation of Hair Weight

10 8 6 4 2 0 Moisture Uptake Moisture Release KELYAMIN Control

Evaluation of moisture uptake and release Hair tresses pre-treated with Kelyamin and untreated tresses (Control) are incubated at 76% RH. % variation of hair weight is measured after 72 hours: this measures the moisture uptake. Tresses are then incubated at 50% RH and weighted again after 72 hours: this measures the moisture release.

Gluplex Series • Native Wheat Protein - Surfactant Complexes
Background

Native Wheat Proteins. Why use them in cosmetics ?      They are cheap and easily available from renewable sources No hydrolysis process: their amino acids are not subject to degradation They have very high molecular weight They have very high hydrophobicity For these features, they display excellent skin protecting properties

Problems  They have very low water solubility  They form a rubber-like matter in aqueous environment  They are easily attacked by microorganisms

Gluplex Series • Native Wheat Protein - Surfactant Complexes
Mechanism and Aim of Protein-Surfactant Complexation

Protein-Surfactant complexation…  The chemical bonds generated between protein and surfactant molecules are weak but numerous. Main contributes are due to hydrophobic and ionic bonds  The protein chains are unfolded without hydrolysys  Primary and secondary structure of the proteins are unaffected  The unfolding is reversible and there is no irreversible denaturation  Proteins solubilisation is achieved  Hydrophobicity of proteins is increased  Native Wheat Proteins can be used in cosmetic formulations

Gluplex Series • Native Wheat Protein - Surfactant Complexes
General Information

Basic features  Clear, low-coloured solutions  Protein content 5% minimum  Surfactant content 5-8%  Ash 1-2%  Full water miscibility  Compatibility with surfactant solutions Major performances  Surfactant irritancy reduction  Improvement of foam properties of detergents  Improvement of plasticity of syndets  Substantivity to hair and skin  Easy recovery in finished products

Gluplex LES • Native Wheat Protein - Laureth Sulfate Complex
General Information

Description  Aqueous solution of Native Wheat Proteins complexed with Sodium Laureth Sulfate. Available types  Liquid 6% protein content Cosmetic Properties And Uses  High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available  Technical Data Sheet Ocular Irritation Test  Safety Data Sheet Surfactant Tolerability Evaluation  Primary Skin Irritation Test Foaming Properties Evaluation

Gluplex LES • Native Wheat Protein - Laureth Sulfate Complex
Effectiveness highlights

Foaming Properties Evaluation  Small amounts of Native Wheat Proteins improve foaming and foam stability of Sodium Laureth Sulfate
200 190

Foam Height in mm

180 170 160 150 140 130 120 50/50 60/40 70/30 80/20 90/10 Time 0 After 10 min LES

LES/Protein ratio

Foam height for solutions with different LES/Native Wheat Protein ratio Foam height values at time 0 (foam expansion) and after 10 minutes (foam stability). Replacing part of the surfactant with native wheat proteins produces a moderate increase of foam stability.

Gluplex LS • Native Wheat Protein - Lauryl Sulfate Complex
General Information

Description  Aqueous solution of Native Wheat Proteins complexed with Sodium Lauryl Sulfate. Available types  Liquid 5% protein content Cosmetic Properties And Uses  High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available  Technical Data Sheet Ocular Irritation Test  Safety Data Sheet Surfactant Tolerability Evaluation  Primary Skin Irritation Test Foaming Properties Evaluation

Gluplex LS • Native Wheat Protein - Lauryl Sulfate Complex
Effectiveness highlights

Surfactant Tolerability Improvement Evaluation  Small amounts of Native Wheat Proteins improve the skin tolerability of detergent formulations
7

g Water/g Collagen film

6,5 6 5,5 5 0.0% 0.1% 0.2% 0.3% Formulation A Formulation B 0.4%

Wheat protein %

Collagen membrane test The amount of water absorbed by an insoluble collagen membrane immersed in a tenside solution is predictive of its in vivo irritancy. Two simile detergent formulation (A and B) were tested. Increasing amounts of native wheat proteins (Gluplex LS) reduce the water uptake of the collagen film. The protein protection is more effective on formulation A, less mild than formulation B.

Gluplex OS • Native Wheat Protein - Olefin Sulfonate Complex
General Information

Description  Aqueous solution of Native Wheat Proteins complexed with Sodium C14-16 Olefin Sulfonate. Available types  Liquid 6% protein content Cosmetic Properties And Uses  High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available  Technical Data Sheet Cytotoxicity Evaluation  Safety Data Sheet  Primary Skin Irritation Test

Gluplex AC • Native Wheat Protein - Cocoate Complex
General Information

Description  Aqueous solution of Native Wheat Proteins complexed with Potassium Cocoate. To be used in soap-based detergents. Available types  Liquid 6% protein content Cosmetic Properties And Uses  High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available  Technical Data Sheet Cytotoxicity Evaluation  Safety Data Sheet  Primary Skin Irritation Test

Orysol • Hydrolyzed Rice Protein
General Information

Description  High purity rice protein hydrolysate obtained by mild enzymatic hydrolysis of rice seed protein. Optimum average molecular weight of 3000 Daltons provides high hair/skin substantivity and product stability Available types  Liquid 15% active matter, light colour and odour  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Imparts body and volume to the hair strand  Helps retaining moisture on the hair surface  Improves skin/eye tolerability of surfactants  Thickens and stabilises foam in detergent formulation

Orysol • Hydrolyzed Rice Protein
General Information

Technical Information Available  Technical Data Sheet  Safety Data Sheet  Primary Skin Irritation Test  Hair Substantivity Evaluation  Foaming Properties Evaluation

Orysol • Hydrolyzed Rice Protein
Effectiveness Highlights

Hair Substantivity Evaluation  Orysol peptides are very well adsorbed on normal and damaged hair from aqueous solutions at mild exposition conditions (30°C, 15 minutes)
8

mg Peptides/g Hair

7 6 5 4 3 2 1 0 1% 2% 3% 4% Damaged Hair Virgin Hair 5%

Protein concentration

Hair substantivity from aqueous solutions Up to a 5% protein concentration, an increasing amount of Orysol peptides is adsorbed onto hair.

Maysol • Hydrolyzed Corn Protein
General Information

Description  High purity corn protein hydrolysate obtained by the action of a special enzyme pool, which yields a high level of free amino acids (especially leucine, proline and sulphur-containing AA) and small peptides Available types  Liquid 20% active matter, light colour and odour  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Imparts body and volume to the hair strand  Helps retaining moisture on the hair surface  Thickens and stabilises foam in detergent formulation

Maysol • Hydrolyzed Corn Protein
General Information

Technical Information Available  Technical Data Sheet  Safety Data Sheet  Primary Skin Irritation Test  Hair Substantivity Evaluation  Foaming Properties Evaluation

Maysol • Hydrolyzed Corn Protein
Effectiveness Highlights

Hair Substantivity Evaluation  Maysol peptides are very well adsorbed on normal and damaged hair from aqueous solutions at mild exposition conditions (30°C, 15 minutes)

6

mg Peptides/g Hair

5 4 3 2 1 0 1% 2.5% 5% Damaged Hair Virgin Hair

Hair substantivity from aqueous solutions Up to a 5% protein concentration, an increasing amount of Maysol peptides is adsorbed onto hair.

Kelisoy • Hydrolyzed Soy Protein
General Information

Description  High purity soy protein hydrolysate obtained by mild enzymatic hydrolysis of soy bean protein. Optimum average molecular weight of 2000 Daltons provides high hair/skin substantivity and product stability Available types  Liquid 20% active matter, light colour and odour  Liquid 40% active matter, light colour and odour  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Helps retaining moisture on the hair surface  Improves skin/eye tolerability of surfactants  Thickens and stabilises foam in detergent formulation

Kelisoy • Hydrolyzed Soy Protein
General Information

Technical Information Available  Technical Data Sheet  Safety Data Sheet  Primary Skin Irritation Test  Foaming Properties Evaluation

Kelisoy • Hydrolyzed Soy Protein
Effectiveness Highlights

Foaming Properties Evaluation  Small amounts of Kelisoy improve foaming and foam stability of common anionic and amphoteric surfactants
200 180 160 140 120 100 80 60 0.0% 0.1% 0.5% 1.0% Time 0 After 5 min 2.0%

Foam Height in mm

Protein concentration

Kelisoy at different protein concentration + Cocamidopropyl Betaine at 0.01% Foam height values at time 0 (foam expansion) and after 5 minutes (foam stability). The foaming performances of Kelisoy can be used to improve the foaming efficacy of detergents, and allow to reduce the amount of surfactants in formulations.

KeliPro URTICA • Hydrolyzed Nettle Protein
General Information

Description  An innovative selective extract from the leaves of Urtica dioica (common nettle). Contains the concentrated protein fraction, enzymatically hydrolyzed, with free amino acids.  Dedicated to hair care cosmetics, where hair and scalp proteinisation is requested Available types  Liquid 10% active matter  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Repairs damaged hair keratin  Imparts body and volume to the hair strand  Helps retaining moisture on the hair surface

KeliPro MALVA • Hydrolyzed Mallow Protein
General Information

Description  An innovative selective extract from the leaves of Malva sylvestris (mallow). Contains the concentrated protein fraction, enzymatically hydrolyzed, with free amino acids.  Dedicated to skin care cosmetics and cleansing products, where proteinisation and moisturisation is requested Available types  Liquid 10% active matter  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Skin conditioner and film-forming agent with moisturising, soothening and protecting effects  Improves skin tolerability of surfactants

Kelimilk • Hydrolyzed Milk Protein
General Information

Description  Partial protein hydrolysate obtained by mild enzymatic hydrolysis of foodgrade milk casein. About 20% of protein content is made of free amino acids  Specifically featured for skin care and skin hygiene products Available types  Liquid 15% active matter, light colour and odour  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Helps retaining moisture on the skin surface  Reduces the transepidermal water loss  Improves skin/eye tolerability of surfactants  Thickens and stabilises foam in detergent formulation  Has a significant scavenging activity on free radicals

Kelimilk • Hydrolyzed Milk Protein
General Information

Technical Information Available  Technical Data Sheet  Safety Data Sheet  Primary Skin Irritation Test  Skin Hydration Evaluation  Scavenging Activity Evaluation

Kelimilk • Hydrolyzed Milk Protein
Effectiveness Highlights

Short Term Effects on the Hydration Parameters of the Skin  Kelimilk produces a small increase of hydration, and a significant short-term reduction of the transepidermal water loss

Evaluation of skin hydration (EC) and transepidermal water loss (TEWL) Kelimilk was applied at 2% protein concentration on the skin of 20 subjects. The short-term reduction of the TEWL reveals a reinforcement of the skin barrier function. This can be a valid performance in protecting and hydrating skin care cosmetics.

Kelimilk • Hydrolyzed Milk Protein
Effectiveness Highlights

Scavenging Activity Evaluation  The free radicals scavenging activity of Kelimilk is much higher than that of a common milk protein hydrolysate
50 45
Scavenging activity %
47.9%

40 35 30 25 20 15 10 5 0 KELIMILK

KELIMILK MPH

26,5%

MPH

Scavenging Activity Evaluation In vitro test based on the drop of viscosity of hyaluronic acid solutions caused by free radicals. Kelimilk is compared with a commercial milk protein hydrolysate (MPH) with similar molecular weight and isoelectric point. Special hydrolysis process used in the preparation of Kelimilk makes it more hydrophobic in the terminal positions of the peptide chains, exposing aromatic groups to the action of free radicals.

Keliwool • Hydrolyzed Keratin
General Information

Description  Partial protein hydrolysate obtained by mild enzymatic hydrolysis of virgin Merino wool, with food-grade proteases at low temperature and neutral pH. Optimum average molecular weight of 3000 Daltons provides high hair substantivity  Specifically featured for hair care and hair hygiene products Available types  Liquid 20% active matter, light colour and odour  Powder 95% active matter, preservative free Cosmetic Properties And Uses  Repairs damaged hair keratin  Imparts body and volume to the hair strand  Helps retaining moisture on the hair surface  Prevents hair damage in waving/colouring treatments

Keliwool • Hydrolyzed Keratin
General Information

Technical Information Available  Technical Data Sheet  Safety Data Sheet  Primary Skin Irritation Test  Hair Substantivity Evaluation  Foaming Properties Evaluation

Keliwool • Hydrolyzed Keratin
Effectiveness highlights

Hair Substantivity Evaluation  Keliwool peptides are very well adsorbed on normal and damaged hair from aqueous solutions at mild exposition conditions (30°C, 15 minutes)

3
mg Peptides/g Hair

2

2,64

1

1,35

0 Treated Hair Virgin Hair

Hair substantivity from aqueous solutions In spite of the relatively high average molecular size of Keliwool peptides (3 KD), with a low presence of free amino acids, a good adsorption on virgin and treated hair is observed. The high content of Cysteine residues (abt. 7% on total amino acids) can explain this behaviour.

Specialties
Natural and synthesised functional substances for safe and effective cosmetics

Thermal Heilmoor Clay • Thermal Heilmoor
General Information

Description  Natural peloid found in millennial deposits located at 800-1000 m above sea level in Lower Austria, formed by decomposition and slow biological maturation of plants. It is manually extracted and prepared in place without addition of chemical substances Available types  The fibrous and gelatinous dark-brown paste as found in nature Cosmetic Properties And Uses  The Thermal Helimoor Clay contains a variety of useful cosmetic substances: humic acids, phytosterols, tritrepenes, phospholipids, amino acids and a rich mineral fraction  It can be used in face and body masks, bath products and creams for its revitalising, soothening and refreshing properties

Shea Butter • Butyrospermum Parkii
General Information

Description  Natural fat obtained by cold pressing the shea nuts and refined without the use of solvents, according to the best Italian olive oil tradition  The chemical-physical and organoleptic characteristics of Shea Butter reflect the 100% natural standard quality. Tests have demonstrated its major activity releasing active substances in comparison with official ointments

Available types  The natural white to yellowish fatty fraction of shea nuts
Cosmetic Properties And Uses  For all skin-protecting products, sun products and for the treatment of skin dryness an ageing

Sodium Hyaluronate Bio
General Information

Description  It is produced by controlled fermentation of selected bacterial strains. Its molecular weight is close to the analogous product obtained by extraction from cockscomb (mean value of 1.600.000 Daltons) Available types  Liquid 1% active matter  Powder 95% active matter Cosmetic Properties And Uses  Hyaluronic acid (and its sodium salt) is known for its ability to reversibly bind a large amount of water molecules. On the skin surface it forms a highly hydrated, protecting layer that can maintain moisture for long, since the polymer is not absorbed into the skin  The visco-elastic properties of the hydrated film confer a characteristic smoothness and reduce skin dryness and roughness

Cegaba • Carboxyethyl-g-aminobutyric acid
General Information

Description  Cegaba is a synthesised amino acid, naturally found in the cerebral tissue of mammalians, especially in the cerebrospinal liquid. This molecule is involved in the biosynthetic pathways that promote cell growth and cells proliferation Available types  Liquid 2% active matter  Liquid 10% active matter  Powder 99% active matter Cosmetic Properties And Uses  In vivo application of Cegaba has showed a significant increase of the proliferation rate of fibroblasts and the production of collagen fibres in the skin.  A reduction of the hair loss rate has also been observed

Kelifluo Series • Predispersed Polyperfluoroethers Emulsions
General Information

Description  A range of anhydrous emulsions of cosmetic grade polyperfluoroethers in glycerine. An advantageous and practical tool for incorporating polyperfluoroethers in aqueous and anhydrous cosmetic formulation Available types  Kelifluo 1500 10% and 25%  Kelifluo 3200 10% and 25%  Kelifluo 6250 10% and 25% Cosmetic Properties And Uses  Emulsions, oils, gels, detergents, powders and a variety of cosmetic formulations can take advantage of the unique skin and hair protecting/hydrating properties of the Polyperfluoroethers contained in Kelifluo  The Kelifluo predispersions can be used for the formulation of aqueous and anhydrous cosmetic systems

KELISEMA S.r.l.
Via Urago, 13/B I-22038 Tavernerio – Como Tel. +39 031 427746 Fax +39 031 427745 www.kelisema.it office@kelisema.it

Thanks you for your kind attention !


								
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