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Publications Nov 2012

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Publications Nov 2012 Powered By Docstoc
					                                James A Fraser
                                   Publications

1. Zhang Y, Wu J, Jeevaratnam K, King JH, Guzadhur L, Ren X, Grace AA, Lei M,
   Huang CL-H & Fraser JA (2012). Conduction Slowing Contributes to Spontaneous
   Ventricular Arrhythmias in Intrinsically Active Murine RyR2-P2328S Hearts. Journal
   of cardiovascular electrophysiology; in press, DOI: 10.1111/jce.12015.
2. King JH, Zhang Y, Lei M, Grace AA, Huang CL-H & Fraser JA (2012). Atrial
   arrhythmia, triggering events and conduction abnormalities in isolated murine RyR2-
   P2328S hearts. Acta physiologica (Oxford, England); in press, DOI:
   10.1111/apha.12006.
3. Wu J, Zhang Y, Zhang X, Cheng L, Lammers WJ, Grace AA, Fraser JA, Zhang H,
   Huang CL-H & Lei M (2012). Altered sinoatrial node function and intra-atrial
   conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap
   syndrome. American journal of physiology Heart and circulatory physiology 302,
   H1510–23.
4. Zhang Y, Fraser JA, Jeevaratnam K, Hao X, Hothi SS, Grace AA, Lei M & Huang
   CL-H (2011). Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in
   murine RyR2-P2328S hearts. Cardiovascular research 89, 794–804.
5. Pedersen TH, L-H Huang C & Fraser JA (2011). An analysis of the relationships
   between subthreshold electrical properties and excitability in skeletal muscle. The
   Journal of general physiology 138, 73–93.
6. Huang CL-H, Pedersen TH & Fraser JA (2011). Reciprocal dihydropyridine and
   ryanodine receptor interactions in skeletal muscle activation. Journal of muscle
   research and cell motility 32, 171–202.
7. Fraser JA, Huang CL-H & Pedersen TH (2011). Relationships between resting
   conductances, excitability, and t-system ionic homeostasis in skeletal muscle. The
   Journal of general physiology 138, 95–116.
8. Fraser JA (2011). Dimethyl sulphoxide addition or withdrawal causes biphasic
   volume changes and its withdrawal causes t-system vacuolation in skeletal muscle..
   The Journal of physiology, letter 589, 5555–6.
9. Zhang Y, Fraser JA, Schwiening C, Killeen MJ, Grace AA & Huang CL-H (2010).
   Acute atrial arrhythmogenesis in murine hearts following enhanced extracellular
   Ca(2+) entry depends on intracellular Ca(2+) stores. Acta physiologica (Oxford,
   England) 198, 143–158.
10. Usher-Smith JA, Huang CL-H & Fraser JA (2009). Control of cell volume in
    skeletal muscle. Biological reviews of the Cambridge Philosophical Society 84, 143–
    159.
11. Smith JM, James MF, Fraser JA & Huang CL-H (2008). Translational imaging
    studies of cortical spreading depression in experimental models for migraine aura.
    Expert review of neurotherapeutics 8, 759–768.
12. Mehta AR, Huang CL-H, Skepper JN & Fraser JA (2008). Extracellular charge
    adsorption influences intracellular electrochemical homeostasis in amphibian skeletal
    muscle. Biophysical journal 94, 4549–4560.

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13. Killeen MJ, Thomas G, Gurung IS, Goddard CA, Fraser JA, Mahaut-Smith MP,
    Colledge WH, Grace AA & Huang CL-H (2007). Arrhythmogenic mechanisms in the
    isolated perfused hypokalaemic murine heart. Acta physiologica (Oxford, England)
    189, 33–46.
14. Usher-Smith JA, Fraser JA, Huang CL-H & Skepper JN (2007). Alterations in triad
    ultrastructure following repetitive stimulation and intracellular changes associated
    with exercise in amphibian skeletal muscle. Journal of muscle research and cell
    motility 28, 19–28.
15. Sabir IN, Fraser JA, Killeen MJ, Grace AA & Huang CL-H (2007). The contribution
    of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine
    hearts. Pflügers Archiv : European journal of physiology 454, 209–222.
16. Sabir IN, Fraser JA, Cass TR, Grace AA & Huang CL-H (2007). A quantitative
    analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic
    Langendorff-perfused murine hearts. Pflügers Archiv : European journal of
    physiology 454, 925–936.
17. Huang CL-H, Sun L, Fraser JA, Grace AA & Zaidi M (2007). Similarities and
    contrasts in ryanodine receptor localization and function in osteoclasts and striated
    muscle cells. Annals of the New York Academy of Sciences 1116, 255–270.
18. Fraser JA & Huang CL-H (2007). Quantitative techniques for steady-state
    calculation and dynamic integrated modelling of membrane potential and intracellular
    ion concentrations. Progress in biophysics and molecular biology 94, 336–372.
19. Fraser JA, Usher-Smith JA & Huang CL (2007). The influence of intracellular
    lactate accumulation upon cell volume and pH in muscle. The Journal of physiology
    582, 467–470.
20. Usher-Smith JA, Xu W, Fraser JA & Huang CL-H (2006). Alterations in calcium
    homeostasis reduce membrane excitability in amphibian skeletal muscle. Pflügers
    Archiv : European journal of physiology 453, 211–221.
21. Usher-Smith JA, Skepper JN, Fraser JA & Huang CL-H (2006). Effect of repetitive
    stimulation on cell volume and its relationship to membrane potential in amphibian
    skeletal muscle. Pflügers Archiv : European journal of physiology 452, 231–239.
22. Usher-Smith JA, Fraser JA, Bailey PSJ, Griffin JL & Huang CL-H (2006). The
    influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle.
    The Journal of physiology 573, 799–818.
23. Fraser JA, Usher-Smith JA & Huang CL-H (2006). Charge-difference modeling of
    the influence of intracellular lactate and H+ on cell volume in skeletal muscle. The
    Journal of physiology 573, 812–818.
24. Fraser JA, Wong KY, Usher-Smith JA & Huang CL-H (2006). Membrane potentials
    in Rana temporaria muscle fibres in strongly hypertonic solutions. Journal of muscle
    research and cell motility 27, 591–606.
25. Fraser JA, Rang CEJ, Usher-Smith JA & Huang CL-H (2005). Slow volume
    transients in amphibian skeletal muscle fibres studied in hypotonic solutions. The
    Journal of physiology 564, 51–63.
26. Fraser JA, Middlebrook CE, Usher-Smith JA, Schwiening CJ & Huang CL-H
    (2005). The effect of intracellular acidification on the relationship between cell


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     volume and membrane potential in amphibian skeletal muscle. The Journal of
     physiology 563, 745–764.
27. Yee Chin J, Matthews HR, Fraser JA, Skepper JN, Chawla S & Huang CL-H (2004).
    Detubulation experiments localise delayed rectifier currents to the surface membrane
    of amphibian skeletal muscle fibres. Journal of muscle research and cell motility 25,
    389–395.
28. Fraser JA & Huang CL-H (2004). A quantitative analysis of cell volume and resting
    potential determination and regulation in excitable cells. The Journal of physiology
    559, 459–478.
29. Ferenczi EA, Fraser JA, Chawla S, Skepper JN, Schwiening CJ & Huang CL-H
    (2004). Membrane potential stabilization in amphibian skeletal muscle fibres in
    hypertonic solutions. The Journal of physiology 555, 423–438.
30. Chin DX-L, Fraser JA, Usher-Smith JA, Skepper JN & Huang CL-H (2004).
    Detubulation abolishes membrane potential stabilization in amphibian skeletal
    muscle. Journal of muscle research and cell motility 25, 379–387.
31. Martin CA, Petousi N, Chawla S, Hockaday AR, Burgess AJ, Fraser JA, Huang
    CLH & Skepper JN (2003). The effect of extracellular tonicity on the anatomy of
    triad complexes in amphibian skeletal muscle. Journal of muscle research and cell
    motility 24, 407–415.
32. Cooper SJ, Chawla S, Fraser JA, Skepper JN & Huang CLH (2002). Separation of
    detubulation and vacuolation phenomena in amphibian skeletal muscle. Journal of
    muscle research and cell motility 23, 327–333.
33. Chawla S, Skepper JN, Fraser JA & Huang CL-H (2002). Osmotic processes in
    vacuolation and detubulation of skeletal muscle. Cell biology international 26, 905–
    910.
34. Fraser JA, Skepper JN, Hockaday AR & Huang CL (1998). The tubular vacuolation
    process in amphibian skeletal muscle. Journal of muscle research and cell motility 19,
    613–629.
                        Work currently under review:
35. Skov M, Riisager A, Fraser JA, Nielsen OB & Pedersen TH (2012) Extracellular
    Mg2+ and Ca2+ suppress myotonia in ClC-1 inhibited rat muscle. Neuromuscular
    Disorders, under review.
36. Zhang Y, Matthews GDK, Guzadhur L, Jeevaratnam K, Lei M, Huang CL-H &
    Fraser, JA (2012) Both slowed propagation and increased dispersion of conduction
    direction produce arrhythmic substrate in right ventricular outflow tracts of murine
    Scn5a+/- hearts. Cardiovascular Research, under review.

          Recognition for publications (by publication number).
1:   Subject of editorial: Napolitano C (2012). Bridging the dimensions of research on
     cardiac ryanodine receptor mutations. Journal of Cardiovascular Electrophysiology ,
     in press DOI: 10.1111/jce.12028
2: Subject of editorial: Heijman J, Wehrens XHT & Dobrev, D. (2012). Atrial
   arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia – is there

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    a mechanistic link between sarcoplasmic reticulum Ca2+ leak and reentry? Acta
    Physiologica, in press. DOI: 10.1111/apha.12038
12: ARM shortlisted for Science, Engineering and Technology (SET) Student of the Year
    award, 2008, for this project.
13: Highlighted as key article 2006/2007 by Acta Physiologica, and top 20 most read
    article in this journal, 2007.
22: Work winning Faculty Poster Prize, Faculty of Biology, University of Cambridge
    prize, for JAU.
22: Prompted invitation to write article for Physiology News.
26: Subject of editorial: Lindinger MI (2005). Intracellular [H+]: a determinant of cell
    volume in skeletal muscle. Journal of Physiology 563, 643.
28: Prompted invitation to write article for Physiology News.
29: EAF awarded Science, Engineering and Technology (SET) award for best Biology
    student, 2003 for this project.
31: CAM awarded Science, Engineering and Technology (SET) award for best Biology
    student, 2002 for this project.


               Conference presentations and invited articles:
A. Sim, J & Fraser JA (2012). The determinants of t-system volume in resting skeletal
   muscle. Physiology 2012, Edinburgh. Proc Physiol Soc. 27, PC314.
B. Orsman LD & Fraser JA (2012) An analysis of the functional consequences of ion
   permeability distributions between the t-system and surface membrane during skeletal
   muscle excitation. Gordon Research Conference “Excitation-contraction coupling”,
   Les Diablerets.
C. Zhang Y, Wu J, Huang CL, Fraser JA (2012). Measurement and interpretation of
   electrocardiographic QT intervals in murine hearts. Physiology 2012, Edinburgh. Proc
   Physiol Soc 27, PC15.
D. Zhang Y, Matthews GD, Black LA, Huang CL, Lei M, Fraser JA (2012) Assessment
   of magnitude and dispersion of epicardial conduction velocity in Langendorff
   perfused murine hearts. Cardiovascular Physiology themed meeting, Manchester
   2012. Proc Physiol Soc 28.
E. King JH, Zhang Y, Huang CL-H & Fraser JA (2011). The relationship between
   conduction velocity and atrial arrhythmogenicity under conditions of altered Ca2+
   homeostasis in RyR2-p2328s murine hearts. 56th Annual Meeting of the Biophysical
   Society, San Diego.
F. Zhang Y, Wu J, Jeevaratnam K, King JH, Guzadhur L, Ren Z, Lei M, Grace AA,
   Huang CL, Fraser JA (2011) Conduction velocity changes contribute to
   arrhythmogenicity in a murine model of catecholaminergic polymorphic ventricular
   tachycardia, RyR2-P2328S. Physiology 2011, Oxford. Proc Physiol Soc 23, PC159.
G. Fraser JA, Usher-Smith JA & Huang CL-H (2006). A quantitative analysis of
   electrochemical equilibria in the sarcoplasmic reticulum of striated muscle. Proc
   Physiol Soc 4, 2P-3P.

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H. Usher-Smith JA, Fraser JA & Huang CL-H (2006). Acidification protects skeletal
   muscle cell volume during anaerobic exercise. Physiology News. 65, 15-16.
I. Fraser JA & Huang CL (2004b). The interdependence of cell volume and resting
   membrane potential. (Invited article). Physiology News 58, 21-22.




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