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					Brochure
More information from http://www.researchandmarkets.com/reports/2213824/




2011 Emerging Medical Technologies Spotlight: A Report of
Investment & Partnering Opportunities

Description:    This report includes details on 408 emerging medical technology companies that: have presented at
                a 2011 LSI Emerging Medical Technologies Spotlight meeting or have been identified by LSI's in-
                house research team in 2011.

                This report is included in LSI's Emerging Medical Technologies Spotlight Library.

                All companies include technology, market(s), key executive, and contact information.

                Two- to three-page executive summaries are provided on some of the companies. Executive
                summaries typically include:
                - Company Contact Information
                - Company Overview (structure, size, year founded, etc.)
                - Competitive Landscape
                - Technological Advantage
                - Stage of Development
                - Target Markets
                - Financial Summary and Sales Forecasts
                - Financing & Partnering Needs
                - IP Position & Status
                - Management Team
                - Exit Strategy
                - More

                Coverage includes innovations in a broad spectrum of medical technology areas including:
                - 20 Aesthetics/Dermatology Companies
                - 83 Biomaterials Companies
                - 52 Biotechnology/Cell Therapy Companies
                - 81 Cardiovascular Companies
                - 14 Dental Companies
                - 86 Diagnostics Companies
                - 49 Drug Delivery Companies
                - 43 Endocrine Companies
                - 40 Gastroenterology Companies
                - 30 Gynecology/Women's Health Companies
                - 46 Imaging Companies
                - 58 Neurology Companies
                - 57 Oncology Companies
                - 26 Ophthalmology Companies
                - 49 Orthopedics Companies
                - 21 Pain Management Companies
                - 67 Patient Monitoring/Management Companies
                - 30 Pharmaceutical Companies
                - 29 Respiratory Companies
                - 33 Spine Companies
                - 50 Surgery Companies
                - 35 Urology Companies
                - 58 Vascular Companies
                - 24 Wound Management Companies

                *Coverage of all 408 companies in 2011 is included. This report is segmented by calendar quarter.



Contents:       BRIEF TECHNOLOGY DESCRIPTIONS FOR COMPANIES COVERED
- ZeroFold, the lowest profile balloon available for improving deliverability and effectiveness of
balloon angioplasty catheters
- X-ray light valve device for use in conjunction with mammography screening and future imaging
modalities
- Wrist-band glucose monitoring for the detection of hypoglycemia
- World's smallest leg compression device for the prevention of deep vein thrombosis (DVT) in
surgical patients, as a safe and effective alternative to Lovenox, for a significantly reduced price
- Wireless, non-invasive, and portable brainwave recording device for convenient at-home sleep
monitoring and analysis to: 1-offer insight into the diagnosis and treatment of conditions such as
Alzheimer's, autism, cancer, epilepsy, depression, and schizophrenia and 2-reveal how drugs affect
the brain
- Wireless, implantable heart device that allows Congestive Heart Failure (CHF) patients to monitor
data using a handheld instrument
- Wireless 3G cellular-enabled blood glucose meter that instantly transmits glucose values to a care
-management server and provides instant feedback and coaching to patients with diabetes
- Whole-body imaging technology for orthopedic applications
- Vital signs monitoring device for use as an early congestive heart failure (CHF) crisis indicator at
home, to avoid acute/expensive hospitalizations
- Versatile, easy-to-use, accurate, and cost effective aorto-ostial stent positioning system to
facilitate precise stent implantation in coronary and renal arteries
- Venous stenting device and ablation technology for the treatment of chronic venous disease
- Unit-dose, prefilled, room-temperature stable vaccine reconstitution and delivery device
- Unique, patented, activated collagen, CellerateRX(R) for the expanding diabetes and greater
wound care markets
- Ultrasound-based molecular imaging agents that can be used to: 1-diagnose and stage disease, 2
-monitor response to therapy in the pharmaceutical research setting, and 3-elucidate the biology of
disease processes in the basic science setting
- Two clinically proven lumbar, motion-preservation spinal implants that offer surgeons: 1-a lumbar
joint replacement that has provided superior treatment over fusion and disc replacement, for
patients with degenerative lumbar joint disease and 2-a posterior dynamic stabilization system
used to restabilize the spine after surgery for spinal stenosis, as an alternative to lumbar fusion
- Turnkey SaaS software solution that dramatically reduces errors, turnaround times, and costs of
MRI, CT, and PET-CT diagnostic reports
- Transcutaneous vagus nerve stimulation to treat patients suffering from drug-resistant epilepsy or
other difficult-to-treat neurological and psychiatric disorders
- Tissue expander technology that allows both diagnostic and therapeutic capabilities never before
available during tissue expansion
- Thrombectomy catheters for patients with peripheral artery disease (PAD)
- Thermal pulsation system for effective, in-office treatment of evaporative dry eye
- Thermal infusion fluid warmer device that enables surgeons to manage and warm up to five fluids
at once
- Therapies for the treatment of acute wounds, chronic wounds, scarring, abnormal scarring,
inflammation and pain, fibrosis, surgical adhesions, and orthopedic procedures
- The world's first homozygous parthenogenetic stem cell lines that can provide therapeutic cells
with the potential to be transplanted into hundreds of millions of individuals of differing ages and
racial backgrounds with minimal risk of immune rejection
- The Vortex ZDS(TM) catheter reduces Catheter Associated Urinary Tract Infections (CAUTIs) by at
least 50% to replace Foley catheter as the indwelling urinary catheter of choice
- The TOPS(TM) System is an implantable device that allows axial rotation, lateral bending,
extension, and flexion. The implant facilitates bending, straightening and twisting movements at
the affected segment of the spine while blocking excessive posterior and anterior sagittal
translation.
- The technology, based on growth factor extract from reindeer bones, improves bone formation in
bone healing problems
- The SENSIMED Triggerfish(R) "eye-Holter" is a paradigm-changing technology consisting of a
disposable contact lens telemetric sensor, which for the first time provides ophthalmologists with
the full ambulatory 24-hour IOP profile, conveniently and during uninterrupted daily activities and
sleep
- The only minimally invasive cure for spinal stenosis that maintains the natural dynamics of the
spine
- The only device-based therapy, offering low-cost and non-invasive treatment for a wide range of
antenatal conditions; thereby promising to prevent preterm birth
- The only device enabling simultaneous, non-invasive, and continuous measurement of blood flow
and oxygen saturation
- The NuLens(TM) Dynacurve IOL is an implantable, flexible lens that changes it curvature in
response with the movements of the eyes accommodative muscle system
- The next-generation brain monitor for safer anesthesia and sedation and improved patient
outcomes in Operating Rooms (ORs) and Intensive Care Units (ICUs)
- The next major step in the treatment of early breast cancer: replacing lumpectomy with a
percutaneous, minimally invasive outpatient procedure under local anesthesia that not only
eradicates the cancer, but is not disfiguring and leaves no scar
- The most advanced Infrared Light Therapy technology available that is clinically proven to reduce
sports injury healing time by >60%, with additional applications for oral tissue and migraines
- The first robotic system capable of offering full force-reflection to laparoscopic surgeons in any
surgical practice
- The first passive fetal movement monitor (detector, analyzer, and data logger) for expectant
mothers to use at home
- The first non-invasive, prep-free imaging test for colon cancer
- The first miniature and highly accurate guide for brain surgery that is fully MRI-compatible and
gives the possibility to perform simultaneous bilateral procedures, in addition to being easy-to-use
and cost-effective
- The first and only wire-independent embolic protection that uses any single guide wire of choice
for the entire procedure and seamlessly integrates with standard workflow
- The company's testing services include cytogenetics, fluorescence in-situ hybridization (FISH),
flow cytometry, morphology studies, anatomic pathology, and molecular genetic testing
- Teraherz-based, real-time, video-rate imaging system
- Tendon repair device that utilizes a simple and familiar technique to ingeniously join tissue
together, with broad applications across a range of surgical sub-specialties
- Temporary implantable ventricular assist device (VAD) that wraps around the heart and squeezes
it to help pump blood
- Technology to preserve the normal, healthy tissue of patients that today is damaged as a by-
product of current treatments
- Technology to embed Nitric Oxide (NO), part of the innate immune system, into polymer medical
devices to make them antimicrobial without the issues of antibiotic resistance
- Technology that manages the exit sites of central venous catheters by promoting the formation of
a biological seal around the catheter that blocks the route for bacteria
- Technology that enables and facilitates seamless stenting of all coronary bifurcation disease
scenarios
- Technology that combines diagnostic imaging and therapeutic laser into one device enabling
image-guided navigation when performing retina laser procedures, with the potential to reduce:
treatment time, retreatment rates, and risk of complications
- Technology platforms that improve surgical efficiency in complex orthopedic procedures such as
total joint replacement, spinal fusion, and trauma fixation: 1-For medical device manufacturers,
RepAssist(TM) reduces training costs, dramatically compresses the time it takes for new reps to
provide value in the OR, and enhances rep efficiency with existing accounts. 2-For
hospitals/surgery centers, Virtual Backtable(TM) significantly enhances OR team proficiency in
organizing and utilizing instrumentation, independent of the team's experience level with the
implant system or surgeon, resulting in improved surgical efficiency and higher surgeon
satisfaction.
- Technology for nurses/pharmacy technicians/emergency responders to more safely and effectively
vaccinate the public in the event of a biological or viral pandemic
- Technologies that: 1-Temporarily plug body passageways with a thermo-transitioning gel that is
delivered as a cold liquid, solidifies at body temperature, and is later flushed away and 2-Keep body
passageways open with gentle passively dilating devices, as well with more rigid construction of an
open design, to prevent eventual long-term blockage
- System that is capable of simultaneous quantitative and independent determination of up to 100
biomarkers in individual cells, not possible with existing technologies, for early disease diagnosis
and monitoring of treatment efficacy
- System that cools cerebral spinal fluid to reduce injuries associated with spinal and cerebral
ischemia
- System for the diagnosis and location of stroke, vasospasm, AVMs, aneurysms, and other brain
disorders within minutes, including differentiation of ischemic and hemorrhagic stroke
- Synthetic cartilage technology for joint repair
- Synthetic 3D extracellular matrices to support tissue growth for use in a wide range of
regenerative medicine
- Sutureless, anastomotic connectors to provide a controlled method of joining vessels
- Surgical instruments, medical lasers, and other medical devices
- Superior nasal drug delivery that can increase therapeutic drug concentrations in the brain and
lower drug concentrations in the blood
- Subcutaneously implanted drug delivery device for slow and consistent release of therapeutic
agents over a period of weeks or months, as an alternative to current treatments with a long
regimen of injections and/or clinical visits
- StimBrace addresses osteoarthritic knee pain by intelligently strengthening leg muscles to
stabilize and brace the knee during real-world use
- Sternal closure system that maintains rigid fixation of the sternum in multiple directions of force
and eliminates the common causes of sternal dehiscence
- Spine implant system that stabilizes and restores the spinal anatomy of persons that have
suffered a vertebral compression facture (VCF)
- Spinal probe that uses radiofrequency (RF) ablation on nerves thought to be the cause of chronic
back pain
- Software that can read and analyze the image stack of a CT scan and draft a report that includes
major pathological findings, identification of key images, and quantitative measurements - provided
to the radiologist at the customers site
- Software for efficiently coordinating the delivery of patient care outside of hospitals; it optimizes
home care operations and can turn a medical practice into an ACO
- Soft, flexible devices with tissue-like characteristics that can be used for health and wellness,
cardiology, and neurology to make surgical diagnosis and treatment easier - based on a new
generation of thin, conformal electronics technology that endures bending, twisting, and stretching
without sacrificing performance
- Smart-phone based ultrasound imaging system
- Small, discrete, and disposable device to reduce food intake
- Small molecule plasma kallikrein inhibitors for the treatment of diabetic macular edema (DME)
- Single-use needle-free injection system for liquid medications
- Single-use devices that will address epicardial access, protection, and treatment facilitating the
electrophysiologist's ability to perform cardiac ablations more efficiently and with a higher degree of
safety and effectiveness
- Shape memory implants that restore motion and eliminate pain for patients requiring soft tissue
repair, fracture fixation, or joint fusion
- Self-expanding, fully removable, temporary inferior vena cava (IVC) filter used in conjunction with
the placement of a central line for the prevention of pulmonary embolism
- Robotic and manual endoscopy devices for increased ergonomics during laparoscopic surgery
- Revolutionary raman-spectroscopy based platform technology licensed from the BC Cancer
Agency to aid in the early detection of cancer
- Revolutionary portable device to provide easy and efficient screening methods for early detection
of age-related macular degeneration, diabetic maculopathy, and other types of retinal disease in
the human eye
- Revolutionary HyperQ technology based on advanced signal processing of the high frequency ECG
signal, enabling more accurate results in the initial diagnosis of coronary artery disease
- Repair and regeneration technology platforms designed to mend and regrow hard tissue (such as
bone) and soft tissue (such as cartilage)
- Removable adhesion barriers for spinal, tendon, and nerve-related surgery to reduce post-
operative scarring, pain, numbness, muscles weakness or limited motion
- Remotely controlled percutaneous catheter system for use in a wide range of interventional
applications
- Remote (wireless) continuous EEG (cEEG) brain monitoring of critical care patients that
significantly reduces mortality rates, improves patient outcomes, and saves millions of dollars in
patient care expense
- Regenerative stem cell therapy to treat heart failure (HF), acute myocardial infarction (MI),
angina, peripheral artery disease (PAD), and hard-to-heal wounds including burns, diabetic foot
ulcers, venous stasis ulcers, and pressure ulcers
- Regenerative medicine company developing novel treatments from hair growth to cancer
therapies based on the products of cells grown under simulated embryonic conditions
- Real-time vital signs monitoring with data collected from earbuds and streamed wirelessly to
mobile devices or the web for viewing
- Real-time pathology solution for cancer surgical guide, with microchip-based in vivo imaging
systems
- Real-time orthopedic surgery imaging system that will save valuable time for surgeons and
hospitals, while improving surgery accuracy and patient safety
- Radiofrequency balloon catheter technology
- Radiofrequency (RF)-based device for the treatment of congestive heart failure (CHF)
- Radiofrequency (RF)-based detection systems to reduce the risk of retained surgical sponges
- Proven patented technology platform that rapidly and accurately measures oxidative stress and
oxidizability in blood and other biologic fluids, with multiple diagnostic applications
- Proprietary medical devices and patient interfaces for the enhancement of patient safety through
capnography monitoring
- Professional and home use devices for automated bladder assessment incorporating a novel,
extremely compact, 3D ultrasound scan head and embedded image processing technology
- Products for surgical RF ablation, valve replacement or repair, and coronary artery bypass (CABG)
grafting
- Pressure-controlled Intermittent Coronary Sinus Occlusion (PICSO) device for acute coronary
syndrome (ACS) and heart failure patients
- Prefilled, easy-to-carry epinephrine auto-injection device for people with severe allergies
- Portable/mobile nuclear cardiology imaging system
- Portable, self-contained system for the precise minimally invasive removal of diseased tissue, to
restore natural tendon and soft tissue function in the elbow, knee, ankle, foot, and shoulder
- Portable, patch-based device that delivers "slow release" ultrasound to treat localized pain and
induce soft tissue healing
- Portable, non-invasive device designed to offer transcutaneous pulsed electro-magnetic field
stimulation therapy for treating post-operative pain and inflammation in superficial soft tissue
- Portable, disposable, non-powered suction device for negative pressure wound therapy (NPWT)
- Portable pediatric vision-screening device for early diagnosis of serious vision abnormalities
- Portable and advanced point-of-care diagnostics equipment
- Point-of-care diagnostic tests for infectious diseases capable of detecting virulence markers
produced only during ACTIVE infections
- Physical and chemical resurfacing of orthopedic implants and stents which allows for drug elution
without the use of a binding polymer
- Permeable, micro-porous, flexible, and user-friendly implants in tubular or patch shape for bone
reconstruction and fracture repair in surgical procedures
- Permanent, catheter-based implant that reduces mitral regurgitaiton by reshaping the mitral
valve
- Percutaneously-inserted interspinous process fusion cages that provide for stabilization of the
spine
- Percutaneous vertebral augmentation (PVA) system for controlling bone cement delivery and
leakage during spinal surgery
- Patient monitoring system providing real-time continuous information via four physiological
parameters - sensed at the tissue level, reflecting the patient's systemic metabolic state
- Patent-protected, FDA-approved, gentler power-assisted liposuction devices offering more
controlled and faster fat removal, with less trauma to the doctor and patient
- Pancreatic islet cell transplantation as a potential cure for Type I diabetes
- P.L.E.A.S.E.(R) (Precise Laser Epidermal System) - a novel transdermal delivery device for high
molecular weight drugs, that can be used by medical personnel or the patient
- Ozone injection system for multiple spinal applications, including herniated disc, to eliminate the
need for multiple steroid injections and/or a surgical discectomy
- Orthopedic implants for limb lengthening/correction/reconstruction
- Optical Ultrasound Tomography(R) (OUT) is a patented technology that identifies brain injuries,
brain hematomas, malignant breast cancers, and Inflammatory Breast Cancer safely and quickly
and displays 3D images in "real time" and can transmit the images to waiting hospitals and
surgeons. The cameras are lightweight and portable, and can be mounted on a bedside providing
continuous monitoring of hemorrhages and the flow of blood. They can be used in an ambulance,
on the battlefield, on the Little League field, and in the ER.
- Off-the-shelf implantable allograft tissue to support peripheral nerve repair and regeneration
- Novel, implantable cardiovascular device
- Novel solutions for wound closure
- Novel implantable ultrasound flow-measuring devices with flow data wirelessly transmitted from
within the body
- Novel bioresorbable regenerative scaffolds that provide 3D architecture for enhanced tissue repair
- Novel and clinically-validated percutaneous approach for the treatment of functional mitral
regurgitation in the heart failure population
- Novel 3D cell culture devices for stem cell, tissue engineering, cancer, and drug discovery
applications
- Non-systemically absorbed compounds for the treatment of diabetes and obesity, as an
alternative to gastric bypass surgery
- Non-surgical, removable hearing device that transmits sound through the teeth for the treatment
of single-sided deafness
- Non-invasive, rapid assessment of dP/dt in Cardiac Resynchronization Therapy (CRT) for lead
placement, lead optimization, and monitoring
- Non-invasive, fully automated system for the accurate assessment of: cardiovascular/diabetic
autonomic neuropathy, effectiveness of beta-blocker therapy, and risk stratification of sudden
cardiac death
- Non-invasive, controlled, and sustained release back-of-the-eye therapeutics for sight-threatening
diseases such as: severe uveitis, diabetic macular edema, and age-related macular degeneration
(AMD)
- Non-invasive ultrasound device for the treatment of glaucoma
- Non-invasive tumor ablation and incisionless surgery using high-intensity ultrasound
- Non-invasive system for the treatment of acute ischemic stroke and other vascular disorders
using externally applied ultrasound that can be rapidly and easily deployed by virtually any
emergency room staff
- Non-invasive real-time diagnostic tools for early detection, prevention, and management of Acute
Kidney Injury (AKI) in critical care environments
- Non-invasive nitric oxide gas (gNO) technology and iontophoresis drug delivery for treating
diseases of the skin and nails
- Non-invasive neuromodulation device that exposes the brain to an oscillating magnetic field, for
the treatment of psychiatric and neurological disorders such as major depressive disorder and
bipolar depression
- Non-invasive method for detecting the presence of a right-to-left cardiac shunt (i.e., PFO) to
enable medical treatment and/or closure before the occurrence of a debilitating or life-threatening
stroke or heart attack
- Non-invasive imaging system for the early detection of pre-cancerous tissue and to guide early
treatment intervention
- Non-invasive imaging capsule for colon cancer screening
- Non-invasive hand-held device that detects abnormal heart sounds and uses a smart-phone
interface for the diagnosis of coronary artery disease (CAD)
- Non-invasive disposable device to automatically deliver a new therapy called *Remote Ischemic
Preconditioning*, an adjunct to traditional treatments for heart attack and stroke that mitigates
ischemia-reperfusion injury and has been clinically shown to reduce infarct size by 50%, without
side effects
- Non-invasive devices for continuous real-time evaluation of hemodynamic changes
- Non-invasive device using muscular counter pulsation (MCP) technology for the treatment of
acute and chronic heart failure (CHF) in a clinical, ambulatory, or at-home setting
- Non-invasive device to alleviate the symptoms of subjective tinnitus that synchronously presents
sound using headphones and tactile representations to an intra-oral array on the tongue
- Non-invasive Auto-Targeting Neurostimulation (ATN) device for high-stimulation pinpoint
treatment of lower back pain
- Non-compressible hemostatic fibrin sealant for high-volume bleeding in intraoperative surgery
and trauma
- Nicotinic receptor agonist compounds for the treatment of asthma and other inflammatory
respiratory and non-respiratory diseases
- Next-generation, cost-effective ophthalmic implants made from STAR(R) biomaterial that will help
patients suffering from glaucoma and corneal blindness
- Next-generation vaccines based on patented LAMP Technology that induce a strong and complete
immune response, with applications in allergy, cancer, and infectious disease
- Next-generation quantitative angiography
- Next-generation PCR system that can provide absolute quantification of nucleic acid molecules, at
higher resolution and lower target levels than the current standard, thereby identifying diseases
earlier in progression
- Next-generation medical devices with anti-fouling surface modifications that reduce the risk of
complications over long durations
- Next-generation insulin analogs for both the rapid-acting and long-acting insulin markets
- Next-generation extracellular matrix (ECM) products for advanced wound healing and tissue
regeneration, with improved handling, strength, resorbability, and infection control over existing
products
- Next generation X-ray scintillator device that provides high resolution imaging
- New embolotherapy catheter that minimizes reflux when administering medication
- Neurocatheter for the removal of blood clots in the brain
- Needle-free silicone patch for vaccine delivery
- Molecular testing that analyzes gene expression in airway epithelial cells to detect early signs of
lung cancer
- Modular, powered, proprietary articulating technology for endoscopes and laparoscopes, enabling
surgical safety, flexibility, and procedural innovations
- Minimially invasive percutaneous implantable cardioverter defibrillator (PICD) for the treatment of
cardiac arrhythmias
- Minimally invasive, joint preserving treatment option for chronic knee osteoarthritis (OA) pain; an
alternative to total knee replacement (TKR)
- Minimally invasive system for decompressing pinched nerves in the spine, based on highly
maneuverable tools and a precise tissue-removal mechanism
- Minimally invasive spinal disc regeneration technologies (SRTs) with a goal of biologically
regenerating the tissues of the disc to restore the natural visco-elastic, biomechanical, and fluid
characteristics of the inner core and outer tensil ring
- Minimally invasive protostatic reshaping device for the treatment of lower urinary tract symptoms
due to benign prostatic hyperplasia (BPH)
- Minimally invasive orthopedic device for the treatment of hip pain
- Minimally invasive memory polymer devices for use in peripheral vascular, non-vascular, and
neurovascular applications
- Minimally invasive interstitial laser therapy (ILT) as an alternative to lumpectomy
- Minimally invasive devices using radiofrequency (RF) energy for the treatment of
gastroesophageal reflux disease (GERD) and fecal incontinence (FI)
- Minimally invasive catheter-based system that safely, rapidly, and effectively removes thrombus
and restores blood flow in the peripheral vasculature utilizing ultrasound energy to destroy clots,
without harming adjacent healthy tissue or generating dangerous emboli
- Miniaturized, hand-held, instrument-mounted optical measurement and navigation systems for
surgical applications
- Miniaturized, continuously adaptable, left ventricular assist device (LVAD) for the treatment of
heart failure
- Miniature infrared thermal imaging cameras combined with a spectroscopic infrared real-time in
vivo analysis device for the early detection/accurate identification of internal lesions and tumors, as
an add-on to existing endoscopes
- Microwave-based soft tissue ablation
- Micro-needle skin patch for delivery of the influenza vaccine
- Microcatheters for treating and preventing acute ischemic stroke
- MGI Medical's "Pulse Flowmeter" provides sensitive, early detection of hemodynamic instability
through continuous, non-invasive assessment of peripheral blood flow. This permits early detection
and management of blood loss and/or heart failure when there have been no changes in vital signs.
- Medipacs first-ever, solid-state polymer pump platform is the "end-game" for low cost, high
precision drug delivery solutions and it will spawn electronic syringe products that reformulate
markets
- Medical records application on a simple USB flash drive for patients, providers, and insurers
- Medical image viewing solution that enables physicians to access/view critical patient
images/information from anywhere, without compromising the security/privacy of the data
- Medical devices for the treatment of neurovascular conditions
- MedApps' solutions utilize cloud computing to connect patients and professional care providers,
enabling proactive healthcare delivery
- Mammary Aspirate Specimen Cytology Test (MASCT System(TM)) that collects a small amount of
nipple aspirate fluid (NAF) in 10 minutes, using no radiation and is painless
- Low-cost mobile device and software that adapts smartphones into ECG machines
- Liver dialysis system that removes protein-bound toxins plus water-soluble toxins from blood and
is more effective and cost-efficient than currently available therapies
- Less invasive technologies and a more effective option for Primary Open Angle Glaucoma patients
- KeyHole Cup(R) is designed to provide a safer and efficient entry into the abdominal cavity during
laparoscopic surgery. It allows for a more rapid insufflation than standard techniques, mitigating
associated risks.
- Irrigation devices for improved visualization during upper and lower gastrointestinal (GI)
procedures
- Intra-articular ion channel modulators for the treatment of osteoarthritis (OA) in all synovial joints
- Interwoven biopolymer 3D-oriented matrices that more accurately mimic natural extra cellular
matrix (ECM) for use in cell and tissue engineering applications
- Intelligent continuous glucose monitoring device utilizing recent innovations in microneedle and
bluetooth technology, to provide a more accurate and pain-free method than what current devices
offer
- Integrated molecular diagnostic system that is easy to use and requires little or no training
- Innovative, compact, non-invasive systems for the early detection of skin, lung, colon, and
cervical cancers
- Innovative single-use surgical retractors designed to manage all MIS exposure needs in
gynecological, digestive, visceral, and vascular surgery
- Innovative hydrogel technology for tissue repair including cartilage, bone, and dermal of the knee,
wrist, elbow, shoulder, and ankle
- Injectable, synthetic bone subsitutes
- Infection control technology that does something no other product can - protect and disinfect
BOTH the needleless injection site and the end of the IV tubing male luer
- Incubator with over 100 highly novel medical technology inventions spanning most medical
markets
- Incubator with 12 fully owned portfolio companies and 20+ fully owned pipeline technologies,
driven by unmet market need
- In vivo optical imaging devices for real-time diagnosis in a broad range of applications
- ImplantLock, a device that enables a safe alternative to vertical bone augmentation or sinus lifting
as well as immediate functional loading even after tooth extraction
- Implantable, wireless, intracranial pressure monitor for use in patients with tumors, prior strokes,
and traumatic brain injuries (TBI)
- Implantable pacing and defibrillation device that detects the early onset of atrial fibrillation and
chronic heart failure and delivers targeted medications
- Implantable neurostimulation system for the treatment of obstructive sleep apnea (OSA)
- Implantable neurostimulation device for the treatment of obstructive sleep apnea (OSA)
- Implantable hearing device that provides extraordinary acoustic performance in a completely
invisible device
- Implantable electronic gastric stimulation device for the treatment of obesity
- Implantable devices that allow surgeons to reduce the morbidity of spinal deformity surgery with
a procedure that is quicker, safer, and more cost-effective than existing techniques
- Implantable device to treat epilepsy by anticipating seizures and delivering intracranial drugs
- Implantable device consisting of a series of miniature magnetic beads, linked together to form a
"bracelet" around the Lower Esophageal Sphincter (LES) for the treatment of gastroesophageal
reflux disease (GERD)
- Implantable artificial pancreas for the treatment of patients with Type I & Type II diabetes
- Immunomagnetic cell capture system which isolates and removes pathogens directly from the
blood in under 30 minutes
- Immediate detection and identification of bacteria in bodily fluids through optical spectroscopy
with low quantities of material without bacteria culturing
- Immediate and permanent contraception implant for women to use as an alternative to surgical
tubal ligation
- ImagistxProstate(R), a breakthrough prostate imaging technology providing a diagnostic tool to
identify prostate cancer via its 21 MhZ center frequency, 512 element array, and 3D ultrasound
capabilities
- Imaging systems for the non-invasive, in vivo detection of cancerous and pre-cancerous lesions
- Imaging systems enabling the examination of epithelial tissues in the bladder, cervix, colon,
esophagus, lung, oral cavity, and stomach
- Image-guided interventional endoscopy products
- HistoScanning(TM) is an innovative imaging-based modality available in the Tissue
Characterization market; the only one offering accurate 3D detection and localization of cancer
lesions
- High-stability, short-length expandable implants that eliminate the need for complex bone
augmentation - shortening overall time to implantation and significantly lowering treatment costs
- High-quality, cost-efficient, single-room proton beam radiotherapy (PBRT) system as an
alternative to conventional high-energy x-rays
- Highly multiplexed real-time PCR-based assays for the accurate detection of hospital-acquired
antibiotic resistant bacteria such as MRSA, MSSA, and pathogens causing Sepsis and
gastrointestinal infections
- High-intensity ultrasound energy for non-invasive reduction of arterial plaque
- High-durability tissue heart valves for transcatheter and surgical implantation with percutaneously
-exchangeable leaflets for lifetime service without anti-coagulation therapy
- Headset that detects and records brainwaves for the diagnosis of Alzheimer's disease and other
neurological disorders
- Hand-held, non-contact vein illumination device for imaging veins just below the surface of the
skin
- Hand-held, disposable device that transdermally removes spider and reticular veins without a
sclerotherapy agent
- Hand-held ultrasound tool that displays a see-through image in the medical practitioner's line of
sight, at the patient's skin surface
- Hand-held smart drill with robotic technology that provides: safe depth control, accurate depth
measurement, bone density measurement, and performance feedback for orthopedic and spine
applications
- Hand-held device that sublingually monitors changes in carbon dioxide (CO2) levels for the
prevention of septic shock
- Handheld device for monitoring chronic disease home-care patients using a single drop of blood
- Growth factor, stem cell, scaffold, and bioadhesive technologies that improve the body's ability to
regenerate healthy cartilage, improve joint function, and prevent degenerative disease
- Grafts for small diameter (less than 5mm) artificial blood vessels in both peripheral and coronary
applications
- Genomics-based diagnostic tests for obstructive coronary artery disease (CAD), cardiac
arrhythmias, and heart failure (HF)
- Genetic test for expectant mothers that detects spina bifida
- Functional optical imaging technology for the early diagnosis and guided treatment of blinding
retinal diseases and diseases of other organs of the body; it is the only optical imaging approach
that allows visualization of the capillaries, non-invasively (without any contrast agent)
- Full Sense(TM) Bariatric Device which is implanted and extracted via endoscopy and causes
satiety leading to weight loss
- Fluorescent markers/optical sensors that provide an accurate and rapid determination of kidney
function
- Flexible patch applied over the neck that uses light wavelengths to produce and control the
production of nitric oxide (NO) in vascular tissue leading to the brain, for the treatment of
Alzheimer's and other neurological disorders
- Flexible endoscopy and endoluminal surgery device
- Fish-skin-derived tissue regeneration technology for chronic wounds and hernia repair that
improves upon current human and porcine technologies through improved economics & clinical
performance, reduced disease transfer risk, and absence of cultural constraints on usage
- Fine-needle aspiration system for use in interventional endoscopic procedures
- Femoral vascular access catheter that uses a longer and shallower angle arteriotomy, providing
better site closure WITHOUT vascular closure implants
- Fast-track development of novel drugs for an unmet medical need - Alzheimer's disease - with
rapid payback on investment
- Eye-tracking device for earlier diagnosis of Parkinson's disease and other neurological diseases
- EPIFLO utilizes cutting-edge oxygen concentration technology to create tissue regenerative
processes driving closure of delayed-healing acute or chronic wounds
- Energy-based thermal surgery device that provides better soft tissue cutting and coagulation
- Endovascular device targeting the treatment of abdominal aortic aneurysms (AAAs)
- Endoluminal device for incisionless treatment of obesity
- EMMA (Electronic Medication Management Assistant) - a remote medication administration unit
that is placed in a patient's residence to enable a healthcare professional (i.e., pharmacist or nurse)
to remotely administer their oral medications
- Ellanse, the first dermal filler family offering a complete customized solution in medical aesthetics
- Electrophysiological mapping device for the treatment of complex cardiac arrhythmias
- Electro-grafting coating technology for implantable biomedical applications; used for the fast
healing post drug-eluting-stent (DES) implantation (avoiding late stage thrombosis)
- Effective antimicrobial coatings and compounds that are broad-spectrum and fast-acting against
clinically relevant pathogens, including multi-drug resistant strains such as MRSA
- Effective and convenient phototherapy system available for in-home treatment of scalp/small-
area psoriasis and other photo-responsive skin diseases
- Easy, safe, and convenient injection of drugs and vaccines in a solid dosage form using the Glide
SDI(R) (Solid Dose Injector)
- Dynamic and intelligent optics for use in spectacle lenses for the correction of presbyopia
- Drugs to treat dry Age Related Macular Degeneration (dAMD) and other vascular diseases of the
eye, including Glaucoma, DME, and Diabetic Retinopathy
- Drugs to treat breast and other cancers by targeting cancer stem cells
- Drug therapy focusing on the carotid body for the treatment of sleep-related breathing disorders
- Drug therapy by way of modulating the N-methyl-D-aspartic acid receptor for the treatment of
depression and other central nervous system disorders
- Drug delivery platform that releases a cocktail of therapeutic proteins in response to a variety of
local and systemic inflammatory and ischemic diseases
- DNA-testing platform that enables results from a wide variety of gene signatures to be delivered
quickly, simply, and cost-effectively at the point-of-care (POC) within an hour
- Disposable device for the prevention of catheter-related infections from hemodialysis
- Diagnostic tests that leverage the ability to extract clinically relevant information from maternal
blood, including a non-invasive prenatal test to diagnose specific genetic and other inherited
disorders
- Devices that facilitate minimally invasive access to a beating human heart and the delivery of
therapeutic options intended to treat complex cardiovascular diseases
- Devices for arthroscopy, hip, knee, and spine surgery, in addition to radiofrequency identification
(RFID) tracking technology
- Device-based technology with an anti-inflammatory therapeutic platform to appreciably widen the
present window of treatment for ischemic stroke to 12-18 hours
- Device used to safely deliver epidural anesthesia during childbirth and other procedures
- Device that uses localized vibrations to reduce pain during injections
- Device that prepares 10 million micro-droplets per hour for use in drug discovery, genomics,
molecular epidemiology, and proteomics
- Device that increases the size of skin grafts without the use of chemicals, biologics, or enzymes
- Device that delivers iron transdermally for patients with iron-deficiency anemia
- Device providing sustained intravesical drug delivery for the treatment of Overactive Bladder
(OAB), Interstitial Cystitis (IC), and other bladder conditions
- Device for the intraocular delivery of photoactive nanoparticles for the treatment of retinitis
pigmentosa, macular degeneration, and diabetic retinopathy
- Device for the early detection, assessment, and monitoring of mild perceptual impairment (MPI),
an early indicator of mild cognitive impairment
- Device for dry powder pulmonary delivery to treat patients with Parkinson's disease
- Developing healthier drugs from whole-plants. MAHDL, developed to elevate HDL-C, has
undergone tests in man with positive results and has an IND from the FDA. Other whole-plant
therapeutics are under development for dementia.
- Developing a whole-plant therapeutic, AMZ0026, that exhibits immunomodulator properties for
the treatment of HIV/AIDS. Preliminary clinical studies in patients that are seropositive for HIV-1
have demonstrated a positive effect on CD4 and CD4/CD8 blood serum levels.
- Developer of easy-to-use genetic tests (clinically validated DNA SNP patterns) that empower
individuals to prevent certain chronic conditions and manage their existing health and wellness
through actionable guidance
- Customized Sound Therapy (CST) system for tinnitus therapy
- Cost-effective lab-on-a-chip system that anyone can use to get laboratory quality results in any
location, within minutes, and with minimal training
- Continuous glucose monitoring system using an intravascular, optical fluorescence-based sensor
to support clinical implementation of tight glycemic control (TGC) in the intensive care unit (ICU)
- Compounds for oncology indications, including: 1-the prevention of A) chemotherapy-induced
nausea and vomiting (CINV), B) post-operative nausea and vomiting (PONV), and C) chronic cough
and 2-treatment for patients with non-small cell lung cancer (NSCLC) whose tumors express an
Anaplastic Lymphoma Kinase (ALK) fusion protein
- Compact, home-based device for male fertility assessment
- Cloud/web-based medical imaging data management software and infrastructure as services - to
replace picture archiving communication system (PACS) at a significantly reduced cost
- ClearSolution represents the next wave in integrated, intra and interoperative physiologic
monitoring. ClearSolution enables a non-invasive, wireless solution for continuous, multi-modal
patient monitoring for image-facilitated minimally invasive surgery, improved CAD detection, and
remote patient monitoring.
- Catheter-based technologies aimed at restoring blood flow for patients with obstructed vessels
- Catheter-based drug delivery system for the treatment of vascular disease and restenosis
- Cartilage repair using cell therapy - true, 100% hyaline cartilage tissue, in a single procedure,
using an off-the-shelf product
- Cardiac mapping catheters to analyze electrical heart activity for the diagnosis of cardiac
arrhythmias
- Capsule-based hydrogels to reduce food intake in obese patients
- Bone anchorage technology for use in spine, trauma, and general orthopedics
- Blood tests for the early detection of breast cancer, ovarian cancer, lung cancer, Alzheimer's, and
other serious diseases where significant unmet clinical needs exist
- Bioseparation technology, for use outside of the research lab, with broad applications from
molecular diagnostics to transplant therapies
- Bioluminescent (light producing) proteins and related substrates that can: 1-be used as an
adjunct to surgery, including laparoscopy, 2-track the progression of disease and evaluate the
effectiveness of therapy, and 3-diagnosis a disease process before there are symptoms or
anatomical features such as tumors
- Biologically-active plastic surgical patch for rotator cuff and tendon injuries, designed to promote
healing and formation of new bone
- Biologically compatible polymers that provide non-surgical regenerative therapies for treating
chronic and acute episodes of pain
- Biodegradable, inflatable balloon device which separates healthy organs from adjacent tumors
receiving radiation therapy
- Biocompatible surgical mesh with high tensile stiffness and strength, similar to native tendon, that
is sutured over torn or degenerative tissue as a reinforcement to surgical repair to allow for rapid
tissue in-growth
- Biocompatible and biodegradable synthetic scaffold to aid soft tissue regeneration of the anterior
cruciate ligament (ACL) of the knee
- Biocellulose technology that eliminates the risks/complications/limitations inherent in animal,
human, and synthetic biomaterials
- Best-in-class platform to optimize genes and proteins in human therapeutics
- Balloon dilatation catheters capable of completing an angioplasty, fluid delivery, and
thrombectomy without changing catheters
- Atherosclerotic plaque dissolution through chemical means for treating occlusive and non-
occlusive atherosclerotic disease that may reduce the need for permanent implants like drug-
eluting stents (DES), while also potentially addressing plaque instability
- Artificial sphincter device for use in ostomy and stoma care
- Anti-infectives for the treatment of severe infectious diseases
- Anti-infective compounds designed to mimic host defense proteins, but with completely
synthetic/non-peptide backbones, for serious, life-threatening, acute disorders
- Anatomically appropriate orthopedic implants, unique instrumentation, and biologics for pediatric
and small stature patients
- An ultrasensitive hand-held probe that is capable of detecting specialized, subcutaneously injected
magnetic materials and is used to locate lymph nodes to support the diagnosis and treatment of
cancer
- An ophthalmic device company delivering Navigated Retinal Laser Therapy to address the unmet
need for durable and cost-effective outcomes in the treatment of major vision-threatening retina
diseases, primarily caused by a complication of diabetes
- An interactive, computer-assisted system utilizing image-guided robotics to enhance the quality of
hair follicle harvesting during hair restoration surgery
- An implantable, bionic retina for patients with degenerative retinal diseases
- An expandable, funnel-shaped cannula for the removal of intravascular material during
extracorporeal circulation
- An elegant, user-friendly alternative to traditional eye dropper bottles that will allow multi-dose of
preservative-free ophthalmic formulations
- An easy-to-use, low-cost, point-of-care (POC) ELISA-based adjunctive screening kit, specifically
for oral cancer
- An automated, continuous glucose monitor for bedside use in intensive and critical care
- An artificial silicone microchip, which stimulates retinal cones and rods to restore retinal function
- An affordable drug delivery pump/patch that is cost-competitive with pre-filled pen injectors and
offers a superior end-user experience
- An accurate, low-cost home healthcare device for use by patients to self-measure Intraocular
Pressure (IOP)
- ALIVIOS Intelligent Eyewear enables people challenged with low vision to do more, including the
ability to zoom in and out, improve brightness and contrast of whatever they are looking at, and
even quickly store visual information for a closer look later
- Aerosol-based inhaled insulin delivery device
- Aerosol technology which efficiently delivers therapeutics into the abdominal cavity of patients
during surgery to combat post-surgical complications such as pain and adhesions
- Aerolase cosmetic lasers have user-validated superiority on key attributes: efficacy and safety,
particularly on hard to treat darker complexions; unique multi-purpose function and portability; yet
industry-low cost
- Advanced surgical devices for ear, nose, and throat (ENT) surgery
- Advanced medical technology that combines CO2 laser capabilities with autologous stem cells to
significantly improve cardiac output in patients with heart disease or heart failure
- Advanced long-term hemodialysis and peritoneal dialysis catheters
- AdaptDx - A novel diagnostic instrument that can detect and track age-related macular
degeneration (AMD) from its beginning stages, allowing for early intervention
- Accurate, ultra-low-cost whole genome sequencing by way of a simple, single-molecule detection
process
- A wireless, touch-screen insulin pump featuring a blood glucose meter, food library, and an
activity monitor
- A wireless, remote-controlled unit targeting tissue expansion for breast reconstruction
- A web-enabled, low level electromagnetic therapy system, that provides HealthCare providers in
the Complementary and Alternative Medicine (CAM) marketplace with a device that improves both
their Patients' Health and their Business
- A wearable product that uses Touch Activated Phlebotomy (TAP) technology to reduce the
inconvenience of blood sampling and facilitate simpler diagnoses
- A vertebral restoration system that uses spine-specific osteogenic biomaterials to restore
vertebral stability
- A unique, non-invasive tool for the analysis of muscle function to assist in the evaluation and
treatment of neck and back injuries and illnesses
- A unique, high-resolution, and MRI-compatible deep brain stimulation (DBS) system comprising
implants with navigation and steering software to treat Parkinson's disease (PD)
- A unique Sharklet-patterned urinary catheter that will reduce catheter-associated urinary tract
infections (CAUTIs)
- A unique permanent injectable bulking agent for the endoscopic treatment of GERD (chronic
heartburn)
- A unique lipid-soluble anti-oxidant heavy metal chelator that is safe and effective, for which the
company is pursuing orphan drug approval
- A thrombectomy catheter for peripheral artery disease (PAD) that features a rotating, extending
tip
- A therapeutic for HIV that is divergent from current approaches, in that rather than fight against
HIV's greatest strengths - mutation frequency & rate of replication - the drug exploits these
"strengths" to cause viral population collapse
- A take-home conception aid system that is designed to address the growing unmet need of
delayed/unsuccessful natural fertility that historically has had similar results to intrauterine
insemination (IUI), yet can now be done in the privacy of the home
- A small, injectable ophthalmic implant containing multiple, laser-activated reservoirs designed for
the on-demand, physician-controlled release of ocular drug therapies to the back of the eye
- A simplified, ultra-sensitive, and dynamic platform for point-of-care (POC) diagnostics that is
capable of direct sample-signal amplification diagnostics in low-cost, rapid lateral flow, and hand-
held cartridges in both single and multiple test formats
- A self-contained, leadless electrode and an independent miniature pacemaker for the left side of
the heart, based on a novel micro-generator that harvests energy from the movement of the heart
- A scalable molecular diagnostic chip platform that will allow for the diagnosis of diseases in five
minutes as well as in-home monitoring of conditions such as: profound venous thrombosis,
embolisms, and myocardial infarctions (MI)
- A safe, simple, and cost-effective solution that will revolutionize the vascular anastomosis
procedure
- A revolutionary technology to sterilize proteins in dehydrated formulations by irradiation (beta,
gamma) or Ethylene Oxide
- A revolutionary device that will facilitate broad implementation of extracorporeal CO2 removal and
oxygen supplementation resulting in the avoidance of airway intubation, sedation, and invasive
mechanical ventilation
- A removable surgical implant to improve vision loss resulting from presbyopia
- A rapid, monthly test that uses glycated albumin to monitor gestational and type 2 diabetes more
effectively
- A point-of-care diagnostic system for rapid, sensitive, quantitative biomarker panels that delivers
laboratory-quality results in a clinic or doctor's office, within minutes
- A Peripheral Nerve Stimulation (PNS) system for patients suffering from severe, intractable pain
- A percutaneous, catheter based system for the temporary isolation of the liver from the systemic
blood circulation and local administration of chemotherapy drugs at high concentrations, directly
into the liver without systemic side effects - under optimal drug conditions
- A Percutaneous Tracheostomy (PT) system that simplifies the traditional PT technique to be used
by more physicians OUTSIDE of the Operating Room (OR) and in faster times than current devices
- A percutaneous implant for mitral valve repair
- A patented ultrasound miniaturization technology which has enabled the creation of iPod sized
ultrasound pain therapy systems with unprecedented operation times of up to 6 hours on a single
cell phone battery
- A novel suite of workflow tools that automate the viewing, analysis, and interpretation of x-rays
for musculoskeletal disease
- A non-invasive, safe cardiac diagnostic system that in a 10-minute test reliably detects existence
or absence of ischemia and monitors treatment efficacy
- A non-invasive, portable device that treats glioblastomas with electrical fields
- A non-invasive, optical brain monitor for monitoring hypnosis (depth of anesthesia) and level of
sedation via direct non-invasive measurement of changes in deoxyhemoglobin (deoxy Hb)
- A non-invasive, automatic analyzer that uses measurements of sweat gland activity to determine
whether a patient is at risk for diabetes
- A non-invasive, accurate, and easy-to-use female fertility monitor
- A non-invasive optical brain monitor for monitoring depth of anesthesia and level of sedation via
direct measurement of deoxyhemoglobin and hemodynamic response
- A non-invasive hand-held system for accurately measuring circulating blood volume in real-time,
to quickly identify and treat shock
- A neurostimulation technology to improve function and independence after stroke
- A minimally invasive, green, laser-based technology for the treatment of benign prostatic
hyperplasia (BPH), as an alternative to traditional TURP surgery
- A minimally invasive stent platform that offers safe, simple, and accelerated healing for the
treatment of endoluminal diseases
- A minimally invasive implantable pulse generator (IPG) to treat obese and type II diabetics by
applying electrical stimulation to the duodenum
- A medical implant surface technology company focused on the design and manufacturing of
proprietary and cellular-friendly interbody fusion devices for the spine
- A mechanical thrombectomy kit that will help restore blood flow and reduce hemorrhagic
complications associated with acute ischemic stroke therapy
- A market leading non-invasive hypoglycemic symptom detection device that protects diabetics
from emergency low-blood sugar events. Hypoglycemia healthcare costs average $7,000 per
episode and can result in death to the patient.
- A low-cost, clip-on eye-piece for mobile phones that mimics and replaces the expensive laser-
based Shack-Hartmann wavefront aberrometers to diagnose the most common refractive eye
disorders: myopia (nearsightedness), hypermetropia (farsightedness), astigmatism, and presbyopia
(age-related visual impairment)
- A low-cost incision guide that is applied with an adhesive sticker before a medical scan and leaves
behind an ink imprint of locational markings (such as a grid or ruler) on the patient's skin so that
the surgeon can accurately correlate target locations with the medical image
- A Leptin product as a novel hormone replacement therapy for Alzheimer's disease (AD) and/or as
a preventative for those who are at risk
- A hand-held device with a touch-screen interface that identifies a patient's preferred language
and then collects his/her information, medical history, symptoms, and complaints, which are then
summarized into the caregiver's language and can be accessed on the device/through a facility's
electronic health records (EHR) system
- A handheld device for the as-needed treatment of allergic rhinitis
- A handheld breath analyzer for the measurement of fat metabolism
- A genomics diagnostic tool company, with a transformative technology that integrates sample
preparation and sequencing on a chip, delivering actionable data in the doctor's office; supported
by a $30 million large grant project with access to 15 million samples associated with cradle to
grave electronic medical records established a decade ago
- A family of single-use devices that provide quantitative pressure measurements, while alleviating
doubt and uncertainty during common medical procedures such as central line insertions, spinal
taps, and epidurals
- A disruptive, non-invasive, and long-term neuro-monitoring technology with the potential to
reduce stroke and damage from aneurysms, tumors, and other neurologic trauma
- A disruptive next-generation low profile (14 French), pre-mounted and pre-packaged "package-to
-patient" percutaneous Transcatheter Heart Valve (THV)
- A disposable, flexible conduit that provides a protective channel through which an endoscope is
inserted for sinus surgery, to keep the introduction site open throughout the course of the
procedure, thereby minimizing trauma along the nasal passageway
- A disposable skin patch that provides diabetics with a painless, BLOODLESS, easy-to-use, and
rapid method for monitoring glucose levels
- A device that uses non-invasive ultrasound to disrupt the blood-brain barrier, for delivery of large
molecule therapeutics to treat primary and metastatic brain tumors
- A business and technology research & development platform, dedicated to delivering innovative
            solutions for the musculoskeletal disorders industry
            - A broad platform of minimally invasive intramedullary devices to improve fracture fixation, reduce
            soft tissue trauma, and speed the patient's return to normal daily activities
            - A breakthrough platform technology that provides highly porous (>65%), load-bearing orthopedic
            implants in both surface active (metal, ceramic) and resorbable materials
            - A biopharmaceutical company with an extensive library of structurally diverse bioactive peptides
            with broad applications in the health, beauty, and pharmaceutical industries
            - A "smart shirt" that can count a patient's heartbeats through its sensors, record a medical quality
            electrocardiogram (ECG), and detect the respiration rate, body temperature, and position of the
            patient (standing, walking, lying, asleep, or fallen)
            - 510(k) cleared device using acoustic reflectometry to continuously monitor breathing tubes for
            placement, movement, and obstruction, enabling adverse event prevention
            - 3-D full-breast ultrasound imaging device for the detection of benign or malignant masses
            - 24-hour intraocular pressure monitoring of glaucoma patients by a telemetric, implantable micro
            sensor
            - 1-Trans-nasal catheter for real-time imaging of atrial fibrillation (AF) ablation procedures; 2-Intra-
            cardiac catheter for real-time image guidance of percutaneous valve and other structural heart
            repair procedures; 3-High-definition intravascular ultrasound (IVUS) system, with near-OCT image
            resolution; and 4-Image-guided, endoventricular injection catheter for stem cell and/or biological
            agent therapy for congestive heart failure (CHF)
            - 1-Novel 510(k)-cleared XCOIL(TM) mechanical thrombectomy device initially targeting DVT and
            stroke patients and 2-Novel 510(k)-cleared EViTAR(TM) double-lumen, coaxial neurocatheters for
            intracranial delivery of small molecules, biologics, stem cells/gene-based therapies, and smart
            sensor enhancements
            - 1-Non-invasive in vitro diagnostic (IVD) blood test for the detection and/or monitoring of 14
            different types of cancer, 2-Combination Immunogene Therapy (CIT) technology that could lead to
            a vaccine or possibly treat those already diagnosed with cancer
            - 1-Effective cryosurgical tool that is simple and safe to use without cryogenic gasses or liquids for
            all medical office skin lesion removal needs, 2-Cervical freeze attachment for gynecology use, 3-
            Third-generation technology to accommodate cryosurgical treatments for prostate, liver & renal
            cancers and cardiac aberrant foci ablation
            - 1-Deep brain stimulator (DBS) to treat movement disorders, 2-A hybrid auditory implant (HAI) to
            treat severe hearing loss
            - 1-Biopsy needles with enhanced ultrasound visualization, 2-Microencapsulated tissue markers, 3-
            Devices for the local, accurately positioned, chemoablative treatment of soft tissue cancers
            - 1-Biochemical sensing technologies for continuous glucose monitoring and 2-Drug-delivery
            devices for osteoporosis management
            - 1-Adult stem cell collection and storage, 2-VSEL(TM) (very small embryonic-like) stem cells for
            tissue regeneration, 3-Contract cell manufacturing for clients around the world, Progenitor Cell
            Therapy, 4-Therapeutics such as a T-cell regulatory technology to treat disorders of the immune
            system, 5-A wound healing technology that uses autologous bone marrow-derived stem cells, 6-An
            autologous bone marrow-derived cell line selected to treat damaged heart muscle following AMI
            - 1-A spray drying technology to enable the storage of plasma in diverse environments by methods
            that are far simpler/less costly than those used currently and 2-A product to enable platelets to be
            stored in refrigerators rather than at room temperature to: (i) improve safety, (ii) extend shelf life,
            and (iii) significantly reduce costs
            - 1-A long-term cardiac rhythm monitor and 2-A disposable electrocardiography (ECG) monitor for
            use for up to 30 days



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