Michigan Department of Education
Technology-Enhanced Lesson Plan 2007
Created by: Christine G. Harris
Lesson Abstract: -Students will Research the Human Genome project and understand the
importance of mapping the human genome. Students will interpret pedigree, electrophoresis gel plates
and DNA fingerprints. Students will construct a recombinant DNA model. Students will
debate/discuss bioethical issues and current topics in genetics.
Subject Area: Biology
Grade Level: 10th
Unit Title: Recombinant DNA Technology
Michigan Educational Technology Standards Connections:
Michigan Educational Technology Standards (METS) - 9th to 12th Checklist
1. Basic Operations and Concepts
a. Students demonstrate a sound understanding of the nature and operation of
1. Students discuss emerging technology resources (e.g., podcasting, webcasting, compressed
video delivery, online file sharing, graphing calculators, global positioning software).
3. Students understand the importance of both the predictable and unpredictable impacts of
6. Students understand that access to online learning increases educational and workplace
Michigan High School Content Expectations Connections:
B4.2 DNA, RNA, and Protein Synthesis
B4.2h – Recognize that genetic engineering techniques provide great potential and
B4.r2i – Explain how recombinant DNA technology allows scientists to analyze the
structure and function of genes. (recommended)
B4.r5x Recombinant DNA
Recombinant DNA technology allows scientist in the laboratory to combine the genes
from different sources, sometimes different species, into a single DNA molecule. This
manipulation of genes using bacterial plasmids has been used for many practical
purposes including the mass production of chemicals and drugs. (recommended)
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B4.r5a – Explain how recombinant DNA technology allows scientists to analyze the structure and
function of genes. (recommended)
B4.r5b – Evaluate the advantages and disadvantages of human manipulation of DNA.
Estimated time required to complete lesson:
Estimated total time: 225 minutes
Daily estimate: 45 minutes
Number of days: 5
Note: the lesson should take a minimum of 200 minutes.
www.encarta.msn.com keyword: plasmids
www.infoplease.com keyword: plasmids
Prior required technology skills:
-Students need to be familiar with the use of their assigned laptops
-Students will be given websites to visit
-Students will need to be able to use the following programs:
Sequence of Activities:
Day One and Day Two:
1. Introduction to biotechnology Notes/lecture using PowerPoint
2. Class discussion on the Human Genome Project
3. Human Genome Activity
a. Lap tops and or a computer lab will be necessary
b. This is to be done individually
c. What is not completed in class must be completed as homework
1. Turn in Human Genome Activity
2. Classroom Discussion about the Human Genome Project:
a. Advantages to this project
b. Future advancements
c. Technology involved
4. Notes/Lecture: Biotechnology and restriction enzymes
1. Lab: Paper Plasmids
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1. Review HGP and Lab
2. Quiz: Restriction Enzymes and Plasmids
3. Begin Lecture Notes on Gel Electrophoresis
Human Genome Project – understanding the meaning
Lab: Paper Plasmids and Restriction Enzymes
1. What is the Human Genome project?
2. What is biotechnology?
3. What is the purpose of biotechnology?
4. Are the moral and ethical issues surrounding biotechnology?
5. What is a restriction enzyme?
6. What is a plasmid?
7. What role do plasmids and restriction enzymes play in biotechnology?
Scoring Criteria: Briefly explain how the pre-assessment would be scored (actual
test? teacher observation?) Include an answer key, if necessary.
Topic Quiz: Restriction Enzymes and Plasmids
Unit Test: This would be given at the end of the unit (includes answer key)
Unit Test Answer Sheet
Scoring Criteria: Test answer key include in the document.
-Computer (lap top, desk Mac or PC)
Media (agar growth plates)
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Application Beyond School:
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-Notes and lecture will be presented via the following:
All presentations will be presented using a LCD projector which allows large
print and color to be displayed. This allows all students to see the material
*Power point presentation
-including pictures and animations
*Elmo: modified overhead projector which allows for teacher
to write as material is presented.
-The material can be displayed using different colors.
-Material can be presented in a very large font this way
*Human Genome Project:
-web site information can be set up in the text reader
*The Paper Plasmid Lab:
-can be set up in the text reader. This will assist
students in the directions of the lab
Teacher Reflection and Notes:
This lesson takes a relatively difficult concept to grasp and provides a number of useful ways for
students to get their hands on it. The use of computers for both information disseminating and
gathering is used. A paper, scissor lab is used to allow students the time to cut, paste, think and see
what is happening.
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