Intensive Insulin Therapy

							                       Medical Intensive Care Unit Readings and Resources




Surviving Sepsis Campaign
Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, et al. Surviving sepsis campaign
guidelines for management of severe sepsis and septic shock. Crit Care Med 2004;32:858-73.



Early Goal-Directed Therapy
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in
the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.



Fluid Resuscitation: SAFE Study
Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, et al. A comparison of albumin and
saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004;350:2247-56.



Sepsis: Vasopressor Use
Dellinger RP. Cardiovascular management of septic shock. Crit Care Med 2003;31:946-55.

Dünser MW, Mayr AJ, Ulmer H, Knotzer H, Sumann G, Pajk W, et al. Arginine vasopressin in
advance vasodilatory shock: A prospective, randomized, controlled study. Circulation
2003:107:2313-9.



Sepsis: Relative Adrenal Insufficiency
Annane D, Sébille V, Troché G, Raphaël JC, Gajdos P, Bellissant E. A 3-level prognostic classification
in septic shock based on cortisol levels and cortisol response to corticoptropin. JAMA
2000;283:1038-45.

Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, et al. Effect of treatment
with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.
JAMA 2002;288:862-71.



Intensive Insulin Therapy
Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive
insulin therapy in critically ill patients. N Engl J Med 2001;345:1359-67.

Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, et al. Intensive
insulin therapy in the Medical ICU. N Engl J Med 2006;354:449-61.
Activated Protein C
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. Efficacy and
safety of recombinant human activated protein c for severe sepsis. N Engl J Med 2001;344:699-
709.



Hospital-Acquired, Ventilator-Associated, Healthcare-associated Pneumonia
American Thoracic Society and Infectious Diseases Society of America. Guideline for the
management of adults with hospital-acquired, ventilator-associated, and healthcare-associated
pneumonia. Am J Resp Crit Care Med 2005;171:388-416.



Ventilator-Associated Pneumonia
Chastre J, Wolff M, Fagon JY, Chevret S, Thomas F, Wermert D, et al. Comparison of 8 vs 15 days
of antibiotic therapy for ventilator-associated pneumonia in adults. JAMA 2003;290:2588-98.



Sedation and Analgesia
Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, et al. Clinical practice
guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med
2002;30:119-41.

Ely EW, Truman B, Shintani A, Thomason JWW, Wheeler AP, Gordon S, et al. Monitoring sedation
status over time in ICU patients: Reliability and validity of the Richmond Agitation-Sedation Scale
(RASS). JAMA 2003;289:2983-91.

Kress JP, Pohlman AS, O’Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill
patients undergoing mechanical ventilation. N Engl Med 2000;342:1471-7.

Schweickert WD, Gehlbach BK, Pohlman AS, Hall JB, Kress JP. Daily interruption of sedative
infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med
2004;32:1272-6.



Neuromuscular Blockade
Murray MJ, Cowen J, DeBlock H, Erstad B, Gray AW, Tescher AN, et al. Clinical practice guidelines
for sustained neuromuscular blockade in the adult critically ill patient. Crit Care Med 2002;30:142-
56.



Anemia in Critical Illness
Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ, et al. Efficacy of recombinant
human erythropoietin in critical ill patients. JAMA 2002;288:2827-35.