The Fall 2012
A Publication of the Department of Pathology and Genomic Medicine
Methodist Laboratories Receive Reaccreditation
he laboratories in The Methodist services for the hospital. “This accreditation
Hospital, Methodist Sugar Land validates that our laboratories consis-
Hospital, Methodist West Hous- tently meet the highest standards of ex-
ton Hospital, and the Kirby ER have cellence. This is essential to all of us in the
again retained their accreditation with Department, as it directly affects the qual-
the College of American Pathologists ity of care we provide our patients here,
(CAP). A 19-member inspection team and at other institutions served by our place September 11th and 12th. The
from the CAP accreditation program con- reference laboratory.” AABB has developed voluntary stan-
ducted its unannounced biennial inspec- The CAP Laboratory Accreditation dards for blood bank blood component
tion on September 12th and 13th. Program is internationally recognized collection, processing, and transfusion
“The inspection team provided a very and approved by the Centers for Medi- and assessed compliance with these stan-
thorough evaluation of all aspects of our care and Medicaid Services as an accred- dards through its accreditation program
laboratories,” said Dr. James Musser, iting organization. The program is in- since 1957. The program strives to im-
chair of the Department of Pathology and tended to improve patient safety by ad- prove the safety of collecting, processing,
Genomic Medicine. “I am extremely vancing the quality of pathology and testing, distributing, and administering
proud of the superb global performance laboratory services through education, blood and blood products.
of our outstanding technical staff and standard setting, and ensuring that labo- For more information on the CAP Labo-
faculty. Our patients and medical staff ratories meet or exceed regulatory re- ratory Accreditation Program, visit
colleagues can be assured that the quality quirements. cap.org. For more information on AABB
of our pathology services is second to The Blood Bank at The Methodist Hos- standards and accreditation, visit
none nationally.” pital also received reaccreditation from aabb.org.
“These are very important inspections,” the American Association of Blood Banks
said Manuel Hinojosa, director of laboratory (AABB) following an inspection that took
102nd Annual Meeting Table of Contents
Baltimore, Maryland 2 Dr. Dina Mody to Receive
March 2-8, 2013
Drs. Jian Chen and Christopher
Leveque Receive Fenwal Award
To register or submit an abstract, visit uscap.org. Abstract submission deadline is
October 7th. 3 Dr. Alberto Ayala Receives Award
for Professional Excellence
New Diagnostic Test Offerings
4 In Focus: The Neuropathology
To register or submit an abstract, visit texpath.org. Abstract submission deadline is 5 Lab Stats: San Jacinto Methodist
LABORATORY REPORT 2
Dr. Dina Mody to Receive Papanicolaou Award
r. Dina Mody, medical director in 1958 and is the highest award given by
of cytopathology for the De- the ASC. The bronze medal is presented
partment, will receive the pres- annually to a member of the society in
tigious Papanicolaou Award from the recognition of meritorious contributions
American Society of Cytopathology in the field of cytopathology. Past recipi-
(ASC) at the society’s annual meeting on ents of the award include Drs. Ibrahim
November 3rd in Las Vegas, Nevada. Ramzy, Leopold Koss, and George Pa-
“This is a humbling experience,” said panicolaou himself (posthumously).
Dr. Mody. “The recognition that this Dr. Mody received her medical degree
award represents is immense, and I am from the Seth G.S. Medical School at
grateful that my peers have bestowed Bombay University in India and com-
this honor upon me.” pleted her pathology residency training
“Receipt of the Papanicolaou Award is at Baylor College of Medicine. She was
the pinnacle of achievement in cytopa- the recipient of the Lifetime Achieve-
thology,” said Dr. James Musser, chair of ment Award from the College of Ameri-
the Department of Pathology and Ge- can Pathologists in 2009.
nomic Medicine for the System. “We are For more information on the ASC, visit Dina R. Mody, M.D.
extremely proud that the society has rec- cytopathology.org. For more information
ognized the many contributions that Dr. on Dr. Mody, visit methodisthealth.com/
Mody has made to the field.” Mody.
The Papanicolaou Award was established
Drs. Jian Chen and Christopher Leveque Receive Fenwal Award
r. Christopher The AABB is an international
Leveque, medical association representing indi-
director of the Blood viduals and institutions involved
Bank, and Dr. Jian Chen, PGY4 in the field of transfusion medi-
resident, were the recipients of cine and cellular therapies. The
the Fenwal Scholarship from association is committed to im-
the American Association of proving health by developing
Blood Banks (AABB) for their and delivering standards, ac-
abstract entitled: “Body Mass creditation, and educational pro-
Index Affects Stem Cell Yield.” grams that focus on optimizing
The award will be formally patient and donor care and
presented during the AABB safety.
annual meeting in October. For more information on Dr.
The Fenwal Awards are pre- Drs. Chen (left) and Leveque (right) with a stem cell donor in the Blood Bank. Leveque, visit method-
sented annually by the AABB isthealth.com/Leveque. For more
as distinguished candidates are identi- national recognition for exceptional aca- information on the AABB, visit aabb.org.
fied. demic work.” In addition to his medical
“Advances in patient care are a result of director responsibilities in the Blood
superior academic inquiry,” said Dr. Bank, Dr. Leveque is also the director of
Leveque. “Scholarships such as this one the Blood Banking/Transfusion Medicine
greatly assist our trainees by providing Fellowship Program.
LABORATORY REPORT 3
Dr. Alberto Ayala Receives Award for Professional Excellence
r. Alberto Ayala, elected dep- accomplishments.
uty chief of pathology, re- Dr. Ayala received his medical degree
ceived the Award for Profes- from the School of Medicine at Universi-
sional Excellence from his alma mater, dad Autonoma de Nuevo Leon in 1960.
Universidad Autonoma de Nuevo The university is the third largest in
Leon, in Monterrey, Mexico. He was Mexico and the oldest institution of
presented with the award in a ceremony higher education in that country.
at the university on September 20th. For more information on Dr. Ayala,
“This is a great honor,” said Dr. visit methodisthealth.com/Ayala. For more
Ayala. “The university has always been information on Universidad Autonoma
important to me, and I am grateful to de Nuevo Leon, visit uanl.mx/universidad.
receive such an award from it.”
The Award of Excellence was estab-
lished in 2004 to recognize alumni with
distinguished academic and professional Alberto G. Ayala, M.D.
Irene Shu, Ph.D.
Clinical Chemistry Fellow
r. Irene Shu, clinical chemistry fellow, is one of three recipients of the Depart-
ment’s Trainee Leadership and Innovation Award for the third quarter of 2012.
She received the award with residents, Dr. Gabriela Quiroga-Garza (PGY4) and
Dr. Sergio Pina-Oviedo (PGY3), for developing and validating a vitamin D assay. The test
was previously done as a send-out to a reference laboratory.
Dr. Shu received her Ph.D. in chemistry from the University of Washington in Seattle in
2011. She began the Clinical Chemistry Fellowship under the direction of Dr. Ping Wang
last year. Irene Shu, Ph.D.
New Diagnostic Test Offerings:
Thyroid Gene Mutation Panel
Thyroid cancer is the most common studies have demonstrated that the ma-
endocrine malignancy, with an incidence lignant potential of these indeterminate
that has steadily grown in the United thyroid lesions can be predicted by mo-
States over the past 10 years. Most thy- lecular testing. That is, if gene mutations
roid lesions are readily diagnosed by characteristic of malignant tumors are
cytopathological examination of fine identified, then surgical excision may be
needle aspirate (FNA) material. How- recommended over conservative ap-
ever, in a small proportion of cases, the proaches. Diff-Quik stain of thyroid FNA
cytomorphology reveals indeterminate Dr. Dina Mody has been an advocate for aspirate with ACUS diagnosis.
features that result in a diagnosis of applying molecular tests to better inform
atypical cells of undetermined signifi- the management of patients with indeter- predict the metastatic behavior of overtly
cance (ACUS) or follicular lesion of un- minate thyroid FNA diagnoses. To sup- malignant thyroid carcinomas. The gene
certain significance (FLUS). port this strategy, the Molecular Diagnos- mutation test is available now and can be
Although the rate of ACUS/ FLUS diag- tics Laboratory has validated a gene mu- performed on fresh tissue, FNA speci-
noses at TMH are much lower than the tation panel to identify alterations com- mens preserved in fixative or RPMI, and
national average (2.1% compared to monly encountered in malignant thyroid formalin-fixed, paraffin-embedded tissue.
9.9%, Bethesda recommendation under tumors, including mutations in the genes For more information, please contact
7%), these cases remain an unsolved di- encoding BRAF, HRAS, KRAS, and Dr. Randall Olsen at email@example.com or
agnostic dilemma. Recently published NRAS. These gene mutations may also Dr. Dina Mody at firstname.lastname@example.org.
LABORATORY REPORT 4
In Focus: The Neuropathology Team
europathology is the subspe- Methodist Neuro-
cialty of anatomic pathology logical Institute,
that focuses specifically on the and excellent
study of diseases of nervous system tis- training experi-
sue. These studies are usually conducted ences to the resi-
through the examination of small surgi- dents and fellows
cal biopsies or whole brains obtained in the Department
from autopsies. of Pathology and
The Department of Pathology and Ge- Genomic Medi-
nomic Medicine has a team of three cine.
board-certified neuropathologists. This
The neuropathology team: from left, Drs. Andreana Rivera, Suzanne Powell,
team provides vital support to the busy
and Hidehiro Takei.
patient care activities conducted at the
Suzanne Z. Powell, M.D. Hidehiro Takei, M.D. Andreana L. Rivera, M.D.
Chief, Neuropathology Associate Medical Director, Neuropathology Staff Pathologist, Neuropathology
Dr. Powell received her M.D. degree Dr. Takei received his medical degree Dr. Rivera received her M.D. degree
from the West Virginia University Col- from the National Defense Medical Col- from the Baylor College of Medicine in
lege of Medicine in Morgantown, West lege in Saitama, Japan in 1990. He holds Houston, Texas in 2004. She completed
Virginia in 1988. She completed her resi- subspecialty certification in cytopathol- her pathology residency at Baylor and
dency training at the University of Flor- ogy, neuropathology, and molecular ge- fellowships in neuropathology and mo-
ida Health Science Center in Jacksonville, netic pathology. Dr. Takei is also the lecular neuropathology at The University
and a fellowship in neuropathology at medical director of autopsy pathology for of Texas MD Anderson Cancer Center.
the University of Florida College of Medi- the Department. Dr. Rivera is also the director of the Re-
cine in Gainesville. For more information on Dr. Takei, visit search Pathology Core for The Methodist
In addition to providing excellent clini- methodisthealth.com/Takei. Hospital Research Institute.
cal services, Dr. Powell is especially in- For more information on Dr. Rivera,
volved with the mentoring of trainees visit methodisthealth.com/Rivera.
and holds numerous education leader-
ship positions, both in the Department
and at the national level in several socie- For more information on the neuropa-
ties. She has chaired both the Residency thology service at Methodist, please con-
Program Directors of Pathology Council tact Dr. Suzanne Powell at email@example.com.
and the Residency Review Committee for
Pathology of the Accreditation Council
for Graduate Medical Education.
For more information on Dr. Powell,
Dr. Powell in conference with Dr. Takei (right) mentors resident, Dr. Rivera (right) mentors resident,
Department trainees. Dr. Miguelina De la Garza. Dr. Nathan Lee.
LABORATORY REPORT 5
Lab Stats: San Jacinto Methodist Hospital
Medical Director: Joyce Maldonado, M.D. “We all work hard to support our
Dr. Maldonado received her M.D. medical staff in providing the best possible
degree from the University of Oklahoma
care to our patients, and it shows: our
College of Medicine in 1983, and com-
pleted pathology residency at the Baylor
hospital is ranked higher than any other
College of Medicine. Dr. Maldonado in Houston outside of the Texas Medical
became the medical director of the labo- Center.”
ratories at San Jacinto Methodist Hospi- Joyce Maldonado, M.D.
tal in 2008, where she also currently
chairs the Patient Safety Council and
“I enjoy serving the people of Baytown
serves on other hospital committees.
and Pasadena every day. This is a won-
Faculty: Claudia P. Molina, M.D.
derful and diverse community.”
Dr. Molina received her M.D. degree Claudia P. Molina, M.D.
from the Francisco Marroquin University
School of Medicine in 1994. She com-
pleted pathology residency and a medi-
cal microbiology and infectious disease
pathology fellowship at The University
of Texas Medical Branch in Galveston,
Texas, and a surgical pathology fellow-
ship at The Methodist Hospital.
Faculty: Enrique M. Gomez, M.D. “We have strong leadership, quality
Dr. Gomez received his medical degree facilities, and a supportive staff; it is a
from the Ponce School of Medicine in great environment for a pathologist.”
2003. He completed pathology residency Enrique M. Gomez, M.D.
at The University of Texas Medical
School in Houston, and a surgical pathol-
ogy fellowship at The University of
Texas MD Anderson Cancer Center.
Director: Gail Lumus, BS, MT
Ms. Lumus received her Bachelor of
Science in 1970 from Baylor University in
Waco, Texas. She has been the laboratory “Our laboratory is exceptional, and we
director at the San Jacinto Methodist are very proud to be part of such a highly-
Hospital since 1987. ranked hospital.”
Manager: Karen Simon, BS, MT Gail Lumus, BS, MT
Ms. Simon received her Bachelor of Sci-
ence in Medical Technology from the
University of Louisiana at Lafayette. In
addition to managing the staff, she also
oversees the Quality Improvement (QI)
program for the laboratory.
Staff: “A good team is built on mutual re-
The laboratory currently employs 78
spect and open communication, and we
staff members that include technical su-
pervisors, medical technologists, phle-
have a great team here.”
Karen Simon, BS, MT
botomists, histology assistants, proces-
sors, and technicians. A successful labo-
ratory requires a group effort, and these
“Teamwork is the key.”
Terry Gibson, MT
employees work as a unified group to
ensure the highest quality of care at San
Jacinto Methodist Hospital.
Pictures from top: Dr. Maldonado at the autostainer; Dr. Molina at the chemistry analyzer; Dr. Gomez in the Histology Laboratory; Ms. Lumus in her office; and
Ms. Simon (left) with Medical Technologist Terry Gibson in the Core Laboratory.
LABORATORY REPORT 6
Cagle PT, Zhai QJ, Murphy L, Low PS. Folate Receptor in Adenocarcinoma and Squamous Cell Carcinoma of the Lung: Potential Tar-
get for Folate-Linked Therapeutic Agents. Arch Pathol Lab Med. 2012 Sep 14. [Epub ahead of print]
Chen WC, Rodriguez-Waitkus PM, Barroso A, Balsaver A, McKechnie JC. A Rare Case of Gastric Fundic Gland Adenocarcinoma
(Chief Cell Predominant Type). J Gastrointest Cancer. 2012 Jul 12. [Epub ahead of print]
Cunningham MT, Olson JD, Chandler WL, Van Cott EM, Eby CS, Teruya J, Hollensead SC, Adcock DM, Allison PM, Kottke-
Marchant KK, Smith MD. External quality assurance of fibrinogen assays using normal plasma: results of the 2008 College of Ameri-
can Pathologists proficiency testing program in coagulation. Arch Pathol Lab Med. 2012 Jul;136(7):789-95.
Dhingra S, Ayala A, Chai H, Moreno V, Zhao B. Renal myopericytoma: case report and review of literature. Arch Pathol Lab Med. 2012
Duan X, Sneige N, Gullett AE, Prieto VG, Resetkova E, Andino LM, Wu Y, Gilcrease MZ, Bedrosian I, Dawood S, Arun B, Albarracin
CT. Invasive paget disease of the breast: clinicopathologic study of an underrecognized entity in the breast. Am J Surg Pathol. 2012
Gao L, Hammoudi AA, Li F, Thrall MJ, Cagle PT, Chen Y, Yang J, Xia X, Fan Y, Massoud Y, Wang Z, Wong ST. Differential diagnosis
of lung carcinoma with three-dimensional quantitative molecular vibrational imaging. J Biomed Opt. 2012 Jun;17(6):066017.
Ghodsizad A, Fahy BN, Waclawczyk S, Liedtke S, Gonzalez Berjon JM, Barrios R, Mehrabi A, Karck M, Ruhparwar A, Kögler G. Por-
tal application of human unrestricted somatic stem cells to support hepatic regeneration after portal embolization and tumor surgery.
ASAIO J. 2012 May-Jun;58(3):255-61.
Grilley-Olson JE, Hayes DN, Moore DT, Leslie KO, Wilkerson MD, Qaqish BF, Hayward MC, Cabanski CR, Yin X, Socinski MA,
Stinchcombe TE, Thorne LB, Allen TC, Banks PM, Beasley MB, Borczuk AC, Cagle PT, Christensen R, Colby TV, Deblois GG, Elmber-
ger G, Graziano P, Hart CF, Jones KD, Maia DM, Miller CR, Nance KV, Travis WD, Funkhouser WK. Validation of Interobserver
Agreement in Lung Cancer Assessment Hematoxylin-Eosin Diagnostic Reproducibility for Non-Small Cell Lung Cancer-The 2004
World Health Organization Classification and Therapeutically Relevant Subsets. Arch Pathol Lab Med. 2012 May 14. [Epub ahead of
Gupta A, Pacha O, Skaria R, Huynh T, Truong L, Abdellatif A. Retroperitoneal sarcoma presenting as acute renal failure, secondary to
bilateral renal artery invasion. Clin Nephrol. 2012 Aug;78(2):164-8.
Hammadah M, Gaber L, Raghavan R. Renal cortical necrosis following a colonoscopy. Clin Nephrol. 2011 Dec 16. [Epub ahead of
Harvey AM, Truong LD, Mody DR. Diagnostic Pitfalls of Hashimoto's/Lymphocytic Thyroiditis on Fine-Needle Aspirations and
Strategies to Avoid Overdiagnosis. Acta Cytol. 2012;56(4):352-60.
Husain AN, Colby T, Ordonez N, Krausz T, Attanoos R, Beasley MB, Borczuk AC, Butnor K, Cagle PT, Chirieac LR, Churg A, Dacic S,
Fraire A, Galateau-Salle F, Gibbs A, Gown A, Hammar S, Litzky L, Marchevsky AM, Nicholson A, Roggli V, Travis WD, Wick M.
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2012 Update of the Consensus Statement from the International
Mesothelioma Interest Group. Arch Pathol Lab Med. 2012 Aug 28. [Epub ahead of print]
Kim K, Ihm H, Ro JY, Cho YM. High-level expression of stem cell marker CD133 in clear cell renal cell carcinoma with favorable prog-
nosis. Oncol Lett. 2011 Nov;2(6):1095-1100.
Kim K, Ro JY, Kim S, Cho YM. Expression of stem-cell markers OCT-4 and CD133: important prognostic factors in papillary renal cell
carcinoma. Hum Pathol. 2012 Aug 31. [Epub ahead of print]
Kwon BS, Ha CM, Yu S, Lee BC, Ro JY, Hwang S. Microscopic nodes and ducts inside lymphatics and on the surface of internal or-
gans are rich in granulocytes and secretory granules. Cytokine. 2012 Aug 9. [Epub ahead of print]
Kobayashi SD, Musser JM, DeLeo FR. Genomic analysis of the emergence of vancomycin-resistant Staphylococcus aureus. MBio. 2012
Lee EW, Kim JH, Ahn YH, Seo J, Ko A, Jeong M, Kim SJ, Ro JY, Park KM, Lee HW, Park EJ, Chun KH, Song J. Ubiquitination and deg-
radation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis. Nat Commun. 2012 Jul 31;3:978.
Lee H, Choi SK, Ro JY. Overexpression of DJ-1 and HSP90α, and loss of PTEN associated with invasive urothelial carcinoma of uri-
nary bladder: Possible prognostic markers. Oncol Lett. 2012 Mar;3(3):507-512.
Continued page 7
LABORATORY REPORT 7
RECENT PUBLICATIONS continued
Li JY, Lopez JI, Powell SZ, Coons SW, Fuller GN. Giant cell ependymoma-report of three cases and review of the literature. Int J Clin
Exp Pathol. 2012;5(5):458-62.
Liu Z, Treviño J, Ramirez-Peña E, Sumby P. The small regulatory RNA FasX controls pilus expression and adherence in the human
bacterial pathogen group A Streptococcus. Mol Microbiol. 2012 Aug 6. [Epub ahead of print]
Marquez L, Feske ML, Teeter LD, Musser JM, Graviss EA. Pediatric Tuberculosis: The Litmus Test for Tuberculosis Control. Pediatr
Infect Dis J. 2012 Jul 3. [Epub ahead of print]
Mehta S, Singh C, Plata KB, Chanda PK, Paul A, Riosa S, Rosato RR, Rosato AE. β-lactams increase the antibacterial activity of dapto-
mycin against clinical MRSA strains and prevent selection of DAP-resistant derivatives. Antimicrob Agents Chemother. 2012 Sep 17.
[Epub ahead of print]
Ordóñez NG, Shen SS, Zenali M, Deavers MT. Melan A (A103) is not a Marker of Mesothelioma. Appl Immunohistochem Mol Morphol.
2012 Jul 19. [Epub ahead of print]
Oviedo SP, Cagle PT. Diffuse malignant mesothelioma. Arch Pathol Lab Med. 2012 Aug;136(8):882-8.
Raparia K, Lin JW, Donovan D, Vrabec JT, Zhai QJ, Ayala AA, Ro JY. Chondroblastoma-like chondroma of soft tissue: report of the
first case in the base of skull. Ann Diagn Pathol. 2012 Jun 26. [Epub ahead of print]
Shen SS, Truong LD, Ro JY, Ayala AG. Use of frozen section in genitourinary pathology. Pathology. 2012 Aug;44(5):427-33.
Sneige N, Thomison JB, Malpica A, Gong Y, Ensor J, Silva EG. Peritoneal washing cytologic analysis of ovarian serous tumors of low
malignant potential to detect peritoneal implants and predict clinical outcome. Cancer Cytopathol. 2012 Aug 25;120(4):238-44.
Wright AM, Smith D, Dhurandhar B, Fairley T, Scheiber-Pacht M, Chakraborty S, Gorman BK, Mody D, Coffey DM.
Digital Slide Imaging in Cervicovaginal Cytology: A Pilot Study. Arch Pathol Lab Med. 2012 Sep 12. [Epub ahead of print]
Editor-in-Chief Claudia P. Molina, M.D. Ping Wang, Ph.D.
The Laboratory Report The Methodist Hospital
April A. Ewton, M.D. Seema Mullick, M.D. Editorial Coordinator Clare Rose, M.B.A.
The Laboratory Report is a publication Editorial Committee Thu Ngo, M.D. Philip Randall Manuel Hinojosa, M.H.A.
of The Methodist Hospital System Hazel L. Awalt, M.D. Steven Shen, M.D., Ph.D.
Department of Pathology and Department Chair
Christopher Leveque, M.D. Paul Sumby, Ph.D. James M. Musser, M.D., Ph.D.