Discover Rush Spring 2013

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					         it’s how medicine should be
                                                 ®
                                                     |   spring 2013




                                                                                     THE InsPIr aTIon IssUE




                   In our last issue, we
                asked our readers, “What
               says ‘inspiration’ to you?”
              Out of numerous submissions,
             our jury selected Community by
               Day by Sandra Holubow as
                 the cover image for the
                     Inspiration Issue.
inside




           2 Parkinson disease:                      4 Inspired by you:
              How attentive listening inspired           When physicians at Rush
              a potential breakthrough                   learn from their patients             www.rush.edu
    IS THERE A CONNECTION?

    INSPIRING DISCOVERY: GI PROBLEMS
    MAY BE LINKED TO PARKINSON DISEASE
    How did Ali Keshavarzian, MD, a gastroenterologist at Rush University Medical Center, get involved in Parkinson disease
    research? He became inspired to learn more when his sister was diagnosed with the condition in the late 1990s.

    Keshavarzian already knew                               (or gut leakiness), can also                                was still at the seminar, saying that his sister might
    of the research showing                                 cause brain damage simi-                                    be right, that Parkinson disease actually starts in
    that Parkinson patients                                 lar to Parkinson disease. If                                the gut with toxin leaks,” Shannon says. “This
    often have gastrointestinal                             lipopolysaccharide (LPS), a                                 email inspired a series of meetings to brainstorm
    (GI) problems and emotion-                              toxin produced by bacteria                                  how we might look into the idea.”
    al stress along with the                                that is usually contained in                                  Shannon recruited Jeffrey Kordower, PhD,
    disease. It was his sister,                             the intestines, was intro-                                  a neurology researcher at Rush, to help with
    however, who insisted                                   duced into other parts of                                   the project. Building on previous findings in
    these issues had actu-                                  the body, damage to the                                     the fields of neurology and gastroenterology,
    ally caused her Parkinson       Ali Keshavarzian,       brain lasted longer.            Kathleen Shannon,           Keshavarzian created a hypothesis, and the
    disease, rather than just       MD, has spent his          “It suddenly dawned on       MD, is currently            team began testing it through a clinical trial.
    being part of it. Although      career studying the     me that maybe my sister         involved in clinical        In the end, the trial (results published in May
                                    connections be-                                         testing of creatine
    Keshavarzian assured his                                was right,” Keshavarzian                                    2012) showed promising results that link LPS
                                    tween stress, the GI                                    (a supplement) as
    sister this was not the case,   tract and disease —     says. He began to theorize:     a treatment for             that leaks out of the intestine with a chain of
    he kept the idea in mind.       specifically the ef-     “We know that stress, like      Parkinson disease           nerve-cell changes that move to the brain and
                                    fect of gut leakiness   alcohol, can cause the gut      and agents to slow          become Parkinson disease. If further research
    THE aHa! MoMEnT                 on diseases such as     to leak. What if stress causes disease progres-             confirms this connection, it may transform the
    Keshavarzian went with his      Crohn’s and ulcer-      leaks that let LPS into the     sion in Hunting-            way investigators approach the disease (see
                                    ative colitis.                                          ton’s disease.
    sister to the Rush Parkinson                            body? A person would                                        “From the lab to the clinic”).
    Disease and Movement Disorders Center for               have to have a genetic susceptibility for the dis-            It doesn’t surprise Shannon that such a discov-
    her treatment. There, they met with Kathleen            ease, but the LPS leakage might be the trigger for          ery grew from a spark lit by Keshavarzian’s sister.
    Shannon, MD, a movement disorders special-              Parkinson.” He turned immediately to Shannon.               “Almost all of our ideas are inspired by listening to
    ist, who, along with treating patients, conducts           “I got an email from Dr. Keshavarzian while he           patients,” she says.
    Parkinson research. Keshavarzian and Shannon
    began a series of conversations about their respec-
    tive research.
       In late 2006, Keshavarzian attended a seem-                    From the lab to the clinic
    ingly unrelated GI seminar. There, he heard                       Translational research aims to facilitate the conversion of scientific discoveries — like those above —
    how laboratory research showed that alcohol,                      to practical applications. This process relies on volunteers who participate in clinical trials. “If more
    which can cause gastrointestinal permeability                     people participate in trials, we could have new medications and new treatments available much
                                                                      more quickly,” Shannon says. To see a list of clinical trials currently taking place at Rush, visit
                                                                      www.rush.edu/studies.




2   Fast fact:     Benjamin Franklin devised a catheter with a flexible tube. His inspiration? Older brother John,
                   who suffered from kidney stones and required daily catheterization.
                                                                                                                                                     www.rush.edu



                                                                                                                     Easy as 1, 2, 3 ...
INSPIRATION                                                                                                      Making the most
AND THE                                                                                                          out of every breath

LUNGS
                                                                                                                 More than half a billion. That’s the number
                                                                                                                 of times the average person will inspire
                                                                                                                 (draw air into the lungs) in a lifetime. And
Your hardworking lungs are                               of the lungs adequately,” says Brian Stein, MD, a       though most of us rarely give breathing a
on the job every day. Their                              pulmonologist at Rush University Medical Center.        second thought, this constant exchange of
two basic tasks: to inspire,                             And when you can’t fully empty your lungs,              carbon dioxide for fresh oxygen fuels every
or bring in a supply of oxy-                             you’ll also have trouble getting enough air in, he      cell in the body. Jennifer Ryan, PT, DPT, a car-
gen that allows the body to                              explains. “With asthma, inflamed airways narrow         diovascular and pulmonary physical therapist
survive and function, and                                in response to triggers that range from pet dander      at Rush University Medical Center, shares
to expire, or remove carbon                              to mold. COPD, which includes chronic bronchi-          recommendations she gives patients:                Jennifer Ryan, PT,
dioxide (waste).                                         tis and emphysema, can also result in inflamed                                                             DPT, specializes in
                                                                                                                                                                    physical therapy for
                                                                                                                  1
   But breathing might not                               airways, as well as destruction of air sacs in the              When you’re out of breath or
                                                                                                                                                                    critically ill patients.
come easily if your lungs        Brian Stein, MD,        lungs, where oxygen enters the blood.”                          stressed, try belly breathing.
                                                                                                                                                                    She also conducts
aren’t working properly — for    is co-director of the      At the Rush Comprehensive Allergy, Asthma            “Whether you’re trying to catch a breath           continuing educa-
example, when disease pre-       Rush Comprehen-         and Sinus Center, treatment focuses on disease          during intense exercise or feeling stressed        tion seminars and
                                 sive Allergy, Asthma
vents air from flowing prop-                             management, including medication and lifestyle          by traffic, belly breathing helps,” says            serves as a mentor
                                 and Sinus Center.
erly into or out of the lungs.                           changes. Clinic experts also provide asthma educa-      Ryan. “It allows you to draw in a higher           on clinical reason-
                                 His research focuses
                                                         tion that includes avoiding triggers and treatment      volume of air, and it’s calming.” Here’s           ing and decision
                                 on the quality of
                                                                                                                                                                    making in acute
BrEaTHInG In Some lung           care provided when      for aggravating conditions, such as acid reflux, that   how she suggests newbies begin: With
                                                                                                                                                                    care situations.
conditions, such as pulmo-       people with asthma      often accompany the condition. For COPD, smok-          one hand on your belly so you’ll feel what
nary fibrosis, limit how much    and COPD come to        ing cessation, medications and specially designed       happens, do a quick sniff, sniff — like a dog. “Sniffing wakes
                                 emergency rooms.
air the lungs take in. With                              exercise programs can help people stay active.          up your diaphragm, the muscle that separates your lungs from
this disease, scarring and                                                                                       the organs in your abdomen,” Ryan says. Continue breathing so
stiffening of the lungs make it difficult to take a      ProTECTIon If your lungs are healthy, do what           your belly moves up and down, but more slowly. It also elicits
deep breath. While there can be many reasons for         you can to keep them that way. Lung function            the body’s relaxation response, helping relieve muscle tension.
scarring, including breathing in workplace dust,         naturally declines with age, Stein says. “Avoid any-
often the cause isn’t known.
   Treatment can include oxygen therapy and exer-
                                                         thing that may accelerate that.” Smoking tops the
                                                         list. Exposure to dust, fibers (such as asbestos) or      2      Listen to mom: straighten up. If the muscles in your
                                                                                                                          rib cage and thorax aren’t properly aligned, they can’t
cise programs (available at Rush Oak Park Hospital)      hazardous chemicals can also damage the lungs. If       pull in the volume of air needed to keep cells oxygenated. “When
to help people stay active despite the disease.          you work around these substances, use the recom-        you’re slumped at your computer, your lungs don’t have room to
And because pulmonary fibrosis has been known            mended protective equipment and procedures.             expand,” says Ryan. So, if you sit for long periods, try this simple tip
to worsen quickly, clinical trials at Rush are focus-        Finally, when it comes to maintaining healthy       for correcting your posture: Roll a hand towel to a diameter of two
ing on new medications designed to slow lung             breathing, diet and exercise play more of a role        inches and position it on your chair so it’s right in front of the bones
function decline.                                        than you might think. Excess pounds can squeeze         that hurt when you’re sitting on a bicycle seat. The towel helps
                                                         the chest wall and restrict the lungs, impeding easy    keep your pelvis and spine aligned so that your rib cage can expand.
BrEaTHInG oUT Asthma and chronic obstruc-                breathing. And aerobic exercise conditions your heart

                                                                                                                   3
tive pulmonary disease (COPD), are both known            and lungs and helps your body use oxygen efficiently,            Find your best breathing pattern for exercising —
as obstructive lung diseases that can cause short-       increasing your endurance for everyday tasks. “It                and stay hydrated. As you do your 20 minutes (or
ness of breath. “But the primary problem with            turns your body from a gas-guzzling pickup into a       more!) of daily exercise, find the breathing pattern that feels
obstructive disease is that you can’t get air out        Prius,” Stein says.                                     right for you. “It’s a myth that you have to breathe through your
                                                                                                                 nose and not your mouth,” Ryan says. “Listen to your body and
         let’s talk allergies and sinus problems — from your own computer. Join experts                          breathe in the way that’s most comfortable.” If you do breathe
 MorE
         at rush for an online chat session thursday, April 25, from noon to 1 p.m. at                           through your mouth, you’ll lose more moisture, so staying hy-
www.facebook.com/rushuniversitymedicalcenter.                                                                    drated is especially important. Hydration keeps the mucus lining
                                                                                                                 of the airways working to clear out germs, pollen and dust.



Fast fact:        The average person inspires — that is, breathes in — 12 to 20 times a minute.                                                                                       3
    Between working nine- to 10-hour days and caring for her mother in a                                                             Annabelle Volgman, MD, is
                                                                                                                                     the medical director of the
    nursing home, Pat Negrette had little energy or inspiration to focus on her                                                      Rush Heart Center for Women,
    own well-being. And it showed. She was overweight, and her cholesterol,                                                          where she addresses the needs
                                                                                                                                     of women with heart disease
    triglycerides, blood pressure and blood glucose levels were all rising. Her                                                      and works to prevent it. She is a
                                                                                                                                     prominent leader of the Ameri-
    cardiologist, Annabelle Volgman, MD, warned Pat that she was headed
                                                                                                                                     can Heart Association’s Go Red
    down a dangerous path.                                                                                                           for Women movement.

    “Dr. Volgman kept telling me to diet and exer-        read nutrition labels; and, in general, live a       huge life changes inspires me
    cise, but it went in one ear and out the other,”      healthy life.                                        to keep motivating them,”
    says Pat. “I just thought it would be too difficult      Rather than grabbing take-out for a quick din-    she says. “When people
    to change my habits.”                                 ner fix, Pat now prepares nutritious meals with      are determined, like Pat,
       Then two years ago, Volgman diagnosed Pat          fresh, seasonal vegetables and lean proteins. She    they succeed.”
    with metabolic syndrome, a condition in which         avoids processed foods and reads every label
    a combination of risk factors occur concurrently      to check for sodium, fat, fiber and protein. She
    and increase a person’s risk for type 2 diabetes      exercises regularly and logs 10,000 steps a day      Want to find out
    and heart disease. Learning diabetes was immi-        on her pedometer.                                    more about your
    nent was a wake-up call that inspired Pat to             The results from her efforts have further         personal heart
    focus on herself.                                     inspired her to stay committed to healthy living.    health? Join our Take
       “I was taking care of everyone except myself; it   She has shed 15 pounds and reversed her meta-        Care of Your Heart
    was time to take care of me,” she says.               bolic syndrome. Her cholesterol, triglycerides,      event on Feb. 23. Find out
                                                          blood pressure and blood glucose levels are all      more on page 7.
    MaKInG a CHanGE Volgman directed Pat                  down, and her risk for developing diabetes has
    to the “Eat Well, Love Better, Move More (ELM)”       been significantly lowered.
    study, a program through the Rush University             “This was something I did for myself, and I’m
    Prevention Center that’s designed to reverse          happy I did,” says Pat. “Once I got started, it
    metabolic syndrome through lifestyle modifica-        wasn’t even that hard. I feel good and I have
    tion. Each week, Pat and other study participants     more energy.”
    learned how to cook healthier foods; exercise;           Volgman is also thrilled. “Seeing patients make




                   Want to get to know these doctors better?
         CLICK
                   Visit www.rush.edu/discover to watch videos
       of them discussing their philosophies of care.




4   Fast fact:         Diagnostic equipment that analyzes blood in 30 seconds, significantly smaller heart pacemakers and implanted defibrillators,
                       and infrared ear thermometers that read body temperature in two seconds: All were inspired by nasa technologies.
                                                                                                                                                 www.rush.edu


HOW DO YoUr PaTIEnTs INSPIRE YOU?
Every day, physicians at Rush University Medical Center strive to provide the care patients need to get back to
their lives. But they learn plenty from their patients as well. Seeing their strength and courage often inspires
physicians to be more empathetic and work harder to deliver advanced, high-quality care. Here, three physicians
at Rush share how their patients have touched them.


“I see many families who truly give me pause. They spend weeks, some-
times months, at the bedside of a critically ill infant. And despite their     Debra Selip, MD, is the pediatric medicine director of
pain and grief, they say thank you. If it were me in that situation, I’m not   the Rush Fetal and Neonatal Medicine Center and has ex-
sure I’d even be able to look up from underneath a blanket, but these          tensive expertise in fetal and neonatal congenital anoma-
families find a way to do it and to show their appreciation. It has humbled    lies and in the care of high-risk and acutely ill newborns.
me and has helped me stay positive even in the face of something hor-
rific. And I now stop to say thank you no matter what.”



“When a 28-year-old woman with lupus came to my clinic, I could tell           room, I saw determination on her face. She said she
she was very ill. But I certainly did not expect the year-long ordeal that     wanted to beat this disease.
followed. She went into a coma after I admitted her to the hospital.             “She worked tirelessly through intensive physical
After a bone marrow biopsy, she was diagnosed with a rare, poten-              therapies and underwent year-long chemotherapy.
tially lethal disease called hemophagocytic lymphohistiocytosis (HLH),         Getting her back on her feet involved an incredible
which also involved her central nervous system. HLH treatment typically        collaboration among multiple specialists and services
includes chemotherapy, massive doses of steroids and immunosuppres-            at Rush, including hematology, infectious disease,
sive agents.                                                                   rheumatology, neurology, intensive care, pulmonol-
   “She was comatose for about three weeks and a meaningful recov-             ogy, physical therapy and rehabilitation.
ery looked doubtful. But a few days after we started chemotherapy,               “Today she has her life back. She is working as an architect; she is in
her mental status began to improve. Still, at the same time, the steroids      excellent physical shape; and she is enjoying leading a normal life. Every
caused severe muscle weakness.                                                 time I talk about her, I am inspired. This is why I do what I do.”
   “I will never forget the day she regained consciousness and became
aware of what had happened to her. Imagine waking up basically crip-           Jamile Shammo, MD, is a hematologist who specializes in bone marrow disor-
pled, dependent on a breathing machine and feeding tube, and learning          ders. Her research interests include myelodysplastic syndromes, myeloproliferative
you have a potentially lethal condition. But one day as I walked into her      disorders and aplastic anemia.



“We’ve come a long way in developing effective treatments and improv-          and, therefore, far less toxic.
ing survival rates for kids with bone cancer. But there are significant —         “In cancer biology labs at Rush, we’re trying to iden-
sometimes devastating — side effects to these treatments.                      tify which patients will respond to which chemotherapy
   “About seven years ago, a boy was referred to me with osteosarcoma in       drugs. If we know up front that certain patients won’t
his hip. We treated him with chemotherapy — the standard treatment at          respond to certain drugs, we can try alternatives. We
the time — and I performed a limb-sparing operation, implanting a metal-       won’t expose them to toxicity that isn’t going to be
lic hip. However, the chemo that saved his life did extensive damage to his    effective. It’s an approach that will help patients both
heart, and he suffered heart failure. Fortunately, he was able to have a       survive cancer and be healthier down the road.”
heart transplant, and today he’s doing very well.
   “Seeing this boy beat his cancer and then have to endure a heart            Steven Gitelis, MD, is an orthopedic oncologist and director of the Rush Limb
transplant was devastating. It inspired me to start looking for new            Preservation Program. He focuses on limb salvage using bone substitutes, grafts
ways to treat patients that are equally effective but more targeted            and prosthetics.



    more online                        Visit www.rush.edu/discover for another doctor’s story of inspiration.
At www.rush.edu

Fast fact:         The new hospital at Rush University Medical Center has been listed in Infrastructure 100: World Cities Edition,
                   a report that showcases 100 of the most innovative and inspiring urban infrastructure projects around the world.                                 5
    RUSH IN THE NEWS



                                                                                                                                                        CLInICaL TrIaLs aT rUsH

                                                                                                                                                    ASPIRE STUDY
                                                                                                                                                    The Department of Pulmonary and Critical Care

       Treatment for fragile X syndrome, autism                                                                                                     Medicine is conducting a study of patients’ pulmo-
                                                                                                                                                    nary arterial hypertension symptoms and how they
       There are plenty of questions and uncertainty                          The study found that the drug compound                                are being treated. This study does not require any
       when it comes to treatment options for fragile X                    STX 209 by Seaside Therapeutics improved symp-                           additional treatments, test procedures or drugs and
       syndrome and autism. But a recent study provides                    toms in study participants with fragile X and sig-                       does not replace the patients’ regular medical care.
       new possibilities.                                                  nificant social deficits or autism. Additional studies                     Participants must meet the following criteria:
          Researchers at Rush University Medical Center                    suggest that STX 209 may be helpful for autism                           • Have a diagnosis of pulmonary arterial hypertension
       and the University of California, Davis MIND                        without fragile X syndrome, as well. This treat-                         • Currently taking the drug treprostinil or other
       Institute found that an investigational compound                    ment is the first such discovery for fragile X syn-                        FDA-approved treatment(s) for pulmonary arte-
       that targets the underlying brain mechanisms in                     drome and, potentially, the first for autism.                              rial hypertension
       fragile X effectively helps with social avoidance —                    “This study will help to signal the beginning of a                      This is a partial list of inclusion and exclusion
       one of the core deficits in both fragile X and                      new era of targeted treatments for genetic disor-                                      criteria. For more information, call
                                                                                                                                                       CaLL
       autism spectrum disorders. Fragile X syndrome is                    ders that have historically been regarded as beyond                                    Joyce Brown at (312) 942-6771.
       the most common known cause of inherited intel-                     the reach of treatment with medications,” says
       lectual impairment. It is also the leading known                    Elizabeth Berry-Kravis, MD, PhD, the lead author of                      LUMBAR SPONDYLOSIS STUDY
       single-gene cause of autism.                                        the study and a pediatric neurologist at Rush.                           The Department of Orthopedic Surgery is conduct-
                                                                                                                                                    ing a study to determine how spinal osteoarthritis

       Emotional neglect increases risk of stroke                                                                                                   is related to the segmental rotational motion of the
                                                                                                                                                    lumbar spine and the degeneration of the inter-
       The experiences of your childhood often shape                       they were made to feel afraid or intimidated, and                        vertebral discs over time. The study, called Lumbar
       who you are emotionally and mentally. Now                           whether they were punished physically.                                   Spondylosis: Aging vs. Symptomatic Degeneration
       research shows that how you were treated as a                         The study, published in an online issue of                             Biomechanics, will use computed tomography (CT)
       child can affect your physical health as well.                      Neurology, found the risk of stroke was nearly                           and magnetic resonance imaging (MRI) to assess
         A study by researchers at the Rush Alzheimer’s                    three times higher in people who reported a mod-                         the health of participants’ vertebral discs.
       Disease Center suggests that people who were                        erately high level of childhood emotional neglect                          Participants must meet the following criteria:
       emotionally neglected as children may have a high-                  than those who reported a moderately low level.                          • Be between 60 and 80 years old
       er risk of stroke later in adulthood. In the study,                   “The results add to a growing body of evidence                         • Not have a history of chronic low-back pain
       participants in the Memory and Aging Project                        suggesting that early-life factors, such as traumatic                      (i.e., steady pain that has lasted more than
       (who did not have dementia and were 55 years of                     childhood experiences, influence the development                           three months)
       age or older) took a survey measuring physical and                  of physical illness and common chronic conditions                        • Not have metal implants or pacemakers
       emotional abuse before age 18. Questions focused                    of old age,” says David Bennett, MD, director                            This is a partial list of inclusion and exclusion crite-
       on whether participants felt loved by their parents                 of the Rush Alzheimer’s Disease Center and co-                                         ria. For more information, call Jennifer
                                                                                                                                                       CaLL
       or caregivers when they were younger, whether                       author of the study.                                                                   Baumgartner at (312) 942-7272.


    DISCOVER RUSH is published as a service         Chief Executive Officer                          information in DISCOVER RUSH comes
    for the rush community.                         larry J. goodman, md                            from a wide range of medical experts.
                                                                                                    models may be used in photos and
    rush uniVersitY medicAl center                  For information about DISCOVER RUSH,            illustrations. if you have any questions         rush is a not-for-profit
    1700 w. Van buren st., suite 456                contact erin thorne at erin_thorne@rush.edu     about your health, please contact your           health care education
    chicago, il 60612-3244                          or (312) 942-3215. For general information      health care provider.                            and research enterprise
    www.rush.edu                                    about rush or for help finding a physician,      ©rush university medical center                  comprising rush university
                                                    call (888) 352-RUSH (7874).                     cum28634                                         medical center, rush
                                                                                                                                                     university, rush oak park
    pleAse note: All physicians featured in this publication are on the medical faculty of rush university medical center. some of the physicians    hospital and rush health.
6   featured are in private practice and, as independent practitioners, are not agents or employees of rush university medical center.
| s At u r d AY
                                                                                                                                                         www.rush.edu



                                   rUsH UPCOMING EVENTS
                                                                         |
F r i d AY




                     Free clAsses For Your heAlth                            spring 2013
                              For a complete and up-to-date list of community wellness events
                     CLICK
                              at Rush and online health chats, visit www.rush.edu/calendar,
                   where you can also find presentations from previous talks.

                   Take Care of Your Heart                  discuss joint replacement options for
|




                   saturday, Feb. 23                        hips, knees and shoulders.
t h u r s d AY




                   8:30 a.m. to noon
                   searle conference center                   Join Us From Your
                   1725 w. harrison st., Fifth Floor          Computer — Ask the
                   Learn about risk factors for               Expert: How to Better
                   heart disease, such as diabetes,           Manage Severe Allergies
                   hypertension and cholesterol;              thursday, April 25
                   conditions, including arrhythmias,         noon to 1 p.m.
                   heart failure and vascular disease;        www.facebook.com/
|




                   and the latest treatment options           rushuniversitymedicalcenter
                   available.                                 Millions of adults and children
w e d n e s d AY




                                                              in the U.S. struggle with allergy
                   Lung Cancer: Diagnosis,                    symptoms, such as sneezing and
                   Treatment and Research                     congestion. In this online chat
                   thursday, march 21                         conducted via Facebook, send in       rush Generations presents:
                   6 to 8 p.m.                                your questions from the conve-
                   Armour Academic center                     nience of your home or work to
                                                                                                    older adult and caregiver programs
                   600 s. paulina st., room 976               experts at Rush. They will answer     Unless otherwise stated, the Rush Generations programs below are held
                   At The Coleman Foundation                  your questions about severe           at Rush University Medical Center, Searle Conference Center, Fifth Floor
                   Comprehensive Lung Cancer Clinic           allergies, including diagnosis,       (Elevator II, Professional Building), 1725 W. Harrison St.
|




                   at Rush, physicians use the most           treatment and management. If          Your Pelvic Health                     Take Charge of
                   advanced methods of imaging,               you’d like to submit questions in     wednesday, Feb. 20                     Your Diabetes
t u e s d AY




                   biopsy and analysis to determine           advance, post them via Twitter        1 to 3 p.m.                            monday, march 25
                   each patient’s stage and treatment.        using #rushhealthchat or send an      Changes in pelvic health frequently    1 to 3 p.m.
                   Join experts at Rush to learn the lat-     email to health_chat@rush.edu.        occur as we age, but experienc-        Older adults have the highest risk
                   est advances in the diagnosis, treat-                                            ing frequent urinary urges, pain       of developing diabetes. Come hear
                   ment and research of lung cancer at      Women’s Health:                         and incontinence should not be         experts from Rush discuss the risk
                   this free event.                         Menopause, Osteoporosis                 ignored. Participate in a discussion   factors for diabetes, and learn what
                                                            and Incontinence                        with experts from Rush about pel-      you can do to better manage and
|




                   Joint Replacement Options                thursday, may 23                        vic health for women, including        prevent complications associated
                   for Hips, Knees and Shoulders            6 to 8 p.m.                             common physical changes that           with it. Interested participants can
m o n d AY




                   wednesday, April 10                      Armour Academic center                  occur with aging, and learn            sign up for a free, six-week self-
                   6 to 8 p.m.                              600 s. paulina st., room 976            about the latest treatment             management workshop for people
                   Armour Academic center                   A woman’s risk of osteoporosis and      options available.                     with prediabetes and diabetes.
                   600 s. paulina st., room 976             urinary incontinence increases as she
                   Rush’s orthopedic program is ranked      enters perimenopause and meno-
                   among the best in the country by         pause. At this free event, experts
|




                   U.S.News & World Report. At this         from Rush will discuss prevention,
                   free event, orthopedic surgeons will     symptoms and treatment options.             Because space is limited, please call to reserve
s u n d AY




                               You can get helpful health information in your
                                                                                                            your seat. For more details and to register,
                    CLICK
                               email inbox each month with our e-newsletter,                           call (888) 352-rUsH (7874). Free parking in the
                   Discover Rush Online. sign up today at www.rush.edu/discover.                              Rush garage is available with validation.7
                                                                                                     1700 w. Van buren st., suite 456                                        nonprofit org.
e-newsletter: DISCOVER RUSH ONLINE                                                                   chicago, il 60612-3244
                                                                                                                                                                              u.s. postage
                                                                                                                                                                                PAID
                                                                                                                                                                             rush university
Was YoUr MoTHEr rIGHT?                                                                                                                                                       medical center

Does sugar really make you hyper? Does reading in dim light actually ruin your
eyes? Learn whether mom gave you sound advice or whether medical science
says otherwise in the February issue of Discover Rush Online. Sign up for the
newsletter at www.rush.edu/discover.


                         www.rush.edu




       BODY, HEAL THYSELF
                                                                                                                                                   clinical trials, but the hope is
                                                                                                                                                   that it will be added to the
                                                                                                                                                   list of treatment options for
        The body has an amazing secret weapon: the              tumor. In particular, Aiken is studying a vaccine                                  patients with brain tumors,
        immune system. Because of its power to protect          for glioblastoma multiforme that, while it won’t                                   alongside current standards
        and restore the body, it has inspired a whole field     prevent cancer, is intended to kick-start the body’s                               of care.
        of treatment — immunotherapy — that harnesses           immune system to help it slow the growth of the
        the body’s own immune system to fend off, and           cancer cells that form a glioblastoma.                                            EnCoUraGInG nEW
        recover from, disease.                                                                                              Robert Aiken, MD, aLTErnaTIVEs Surgery,
                                                                oUTsIDE MoTIVaTIon How does the vaccine                     is director of The    chemotherapy, radiation
        THE sYsTEM aT WorK The immune system                    inspire the body to heal itself? Cells that help antibod-   Coleman Founda-       therapy and biologic thera-
                                                                                                                            tion Comprehensive
        goes to work when the body detects an invader,          ies recognize antigens, which are known as dendritic                              pies are among the treat-
                                                                                                                            Brain Tumor Clinic
        such as unfriendly bacteria or foreign matter,          cells, and cancer tumor cells are extracted from a          at Rush and focuses ments currently available at
        known as an antigen. The presence of the antigen        patient. The two are combined so that dendritic cells       his research on       The Coleman Foundation
        triggers cell and chemical activity that produces       are able to identify the cancer cells. Then the cancer      creating novel treat- Comprehensive Brain Tumor
        antibodies, varieties of white blood cells that         cells are removed from the mix and the dendritic cells,     ments for malignant Clinic at Rush. The clinic also
        destroy the invaders. This process usually takes        now trained to set the immune system in motion              brain tumors.         offers patients the opportunity
        place seamlessly. However, when the intruders are       against the tumor, are injected into the patient.                                 to enroll in clinical trials —
        complex cancer cells, the immune system often           Simply put, the vaccine, known as the DCVax vaccine,        such as the ones Aiken continues to run — to test
        needs a little extra push.                              is designed to help the body mount a response that          the DCVax vaccine. He’s also embarking on another
           The field of immunotherapy, or the use of stem       kills cancer cells, slowing the growth of the tumor.        study to look at an antibody that might aid patients
        cell therapies and vaccines, gives the body that           The vaccine must be given repeatedly in order            with recurrent brain tumors. Will it inspire a next
        push. Robert Aiken, MD, a neuro-oncologist, is          to continue to boost the patient’s natural immune           step in the attack on these life-altering intruders?
        researching ways to inspire the immune system to        responsiveness, which may work to keep the cancer           Follow the progress of research at Rush to find out.
        go after glioblastoma, a kind of malignant brain        in check and prolong life. The vaccine is still in          Visit www.rush.edu/follow-research.

                    the coleman Foundation comprehensive brain tumor clinic at rush brings together a multidisciplinary team to create individualized
          CaLL
                    treatment plans for patients. For more information or to schedule an appointment, call (888) 352-RUSH (7874).




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Description: Spring 2013 issue of Discover Rush, the quarterly community newsletter published by Rush University Medical Center in Chicago.