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Leishmaniasis

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Leishmaniasis Powered By Docstoc
					Brittany Lilos
A parasitic disease found in
parts of the tropics, subtropics,
and southern Europe
It is caused by Leishmania, a
  protozoan parasite.
It is caused by Leishmania, a
  protozoan parasite.




     Zoonotic disease
   By bites of female
    Phlebotomine
    Sandfly
   By bites of female
    Phlebotomine
    Sandfly

   Blood transfusions,
    contaminated needles
   By bites of female
    Phlebotomine
    Sandfly

   Blood transfusions,
    contaminated needles

   Congential
    transmission (rare)
Contagious through physical
 contact?
Contagious through physical
 contact?



  No!

 Only through ways
 mentioned..
 SMALL
 Noiseless
 Bites   may not hurt!
 SMALL
 Noiseless
 Bites   may not hurt!
1.5 million new
cases cutaneous
   every year
 500,000 new
 cases visceral
   per year

12 million people
    infected

 350 million at
      risk
“Black fever”
    “Black fever”



Most dangerous
form!
    “Black fever”


Most dangerous
form!

Nearly always
fatal if left
untreated
Skin   sores
 Skin   sores

 Canspread to
 nose/mouth
 and cause
 Mucocutaneous
 Leishmaniasis
 producesdisfiguring lesions which destroy
 the mucous membranes of the nose, mouth,
 and throat
a. Cutaneous
b. Mucocutaneous
c. Visceral
 All   ages
 All   ages

 Depends      on LOCATION
 All   ages

 Depends      on LOCATION

 Highest      risk time: dawn to dusk
 Missionaries   Anyone who is active/does
                research
                at night




Travelers
                Soldiers
1.   Looking for symptoms

2.   Examining tissue samples for Leishmania
     parasite

3.   Doing blood tests
     that detect antibody
     (immune response)
There is an effective set of FIRST
LINE DRUGS used for treatment.


 Pentostam
There is an effective set of FIRST
LINE DRUGS used for treatment.


 Glucantime
If those do not work, there are also
SECOND LINE DRUGS.



          Lomidine



          Fungizone
…Experimental Treatments

      Allopurinol




      Ambisome




     Ketaconazole
Vaccine?
 Science News
 Visceral Leishmaniasis:
 Successful Vaccine Trial In
 Dogs
 ScienceDaily (Aug. 16, 2005) — Visceral leishmaniasis,
 which is the most severe form of that group of diseases,

 affects 500 000 people in the world each year. …
 Paromomycin
 Intramuscular (IM)
 Injection
 for visceral leishmaniasis
 Paromomycin
 Intramuscular (IM)
 Injection
 for visceral leishmaniasis
   1. Spray living, sleeping areas with insecticide
   1. Spray living, sleeping areas with insecticide
   2. If needed, use a bed net
Pictures:


http://news.bbc.co.uk/2/shared/spl/hi/health/03/travel_health/diseases/html/leishmaniasis.stm
http://www.susanamendez.com/LeishmaniaFacts/WhatIsLeishmaniasis.html
http://www.nlm.nih.gov/medlineplus/ency/imagepages/2652.htm
http://www.who.int/entity/leishmaniasis/disease_epidemiology/en/index.html
http://commons.wikimedia.org/wiki/Image:Globe.svg
(map) http://www.wehi.edu.au/research/divisions/inf/labs/handman/leishmaniasis.html
http://www.keele.ac.uk/depts/aep/staff/rdcmres.htm
http://www.sciencedaily.com/releases/2008/08/080814154331.htm
http://www.fic.nih.gov/news/publications/global_health_matters/GHM_leishmaniasis_10-07.htm
http://www.stanford.edu/group/parasites/ParaSites2006/Leishmaniasis/LandR.htm
http://en.wikipedia.org/wiki/Leishmaniasis
http://www.nature.com/nrmicro/journal/v5/n11_supp/fig_tab/nrmicro1748_F2.html
(first chart) http://www.infektionsforschung.uni-wuerzburg.de/research/agmoll/research/
(bio chart) http://www.wehi.edu.au/research/overview/inf.html
http://edoc.hu-berlin.de/dissertationen/al-jawabreh-amer-2005-11-25/HTML/chapter1.html
http://freepages.genealogy.rootsweb.ancestry.com/~leveritt/2610.htm
http://www.ccr.ust.hk/research%20area.htm
http://helpithinkimarockstar.blogspot.com/2008/08/on-road-warfare-gray-hair-and-rainy.html
http://www.state.gov/r/pa/ei/pix/b/nea/iraq/19134.htm
http://www.miyazaki-med.ac.jp/parasitology/orphan/HTML/med/4sodium.html
http://www.speciation.net/Public/Objects/Glossary/?we_objectID=854
http://en.wikipedia.org/wiki/Glucantime
http://www.sciencedaily.com/releases/2005/08/050814165616.htm
http://www.oneworldhealth.org/leishmaniasis
http://www.global-b2b-network.com/b2b/26/844/pest_control.html
http://www.jvibe.com/node/1672
http://www.outdoorlife.com/article/Survival/Survival-Tip-of-the-Day-1000063128
http://teaching.path.cam.ac.uk/partIB_pract/P14/
http://www.bullwrinkle.com/ShoppingPages/allopurinol_dogs.htm
http://www.drug3k.com/drug/Ambisome-12207.htm

				
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posted:1/25/2013
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