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					Delivering the Innovation Agenda
                      2006 - 2007
Foreword by Sir Miles Irving
                                     British medical research, resulting       and ways of improving the delivery of
                                     from a programme of increasing            services, but were put off taking them
                                     funding to scientists and clinical        forward because of the complexities
                                     academics, is acknowledged as a           of obtaining funding and exploiting
                                     major international success story that    their ideas.
                                     appears set to continue.
                                                                               It was for them that the Departments
                                     The NHS Plan, recognising the             of Health and Trade and Industry
                                     importance of such activity, has          established NHS Innovations with
                                     declared that the NHS should be           the creation of a network of nine
                                     an organisation with innovation at        Innovation Hubs tasked with the
                                     the heart of its business, and should     development of these bright ideas
                                     ensure that innovations are identified    and exploiting the associated
                                     and developed in the interests of         intellectual property.
   Sir Miles Irving FRCS, FMed Sci   patients and society as a whole.
Chairman, NHS Innovations North                                                The result has been a wave of interest
                                     In the process of encouraging and         by the staff of the NHS, from which
                                     developing this way of thinking, it       many successful developments have
                                     became apparent that a research           arisen. In the financial year 2006-07,
                                     gap existed in that the bright ideas      54 deals were executed, 36 patents
                                     of large numbers of busy individuals      filed and three new companies
                                     working at the sharp end of service       formed. This has confirmed that
                                     delivery were not being exploited.        the previously untapped source of
                                                                               ground-breaking ideas is of financial
                                     Doctors, nurses, therapists, laboratory   benefit, has encouraged an evidence-
                                     scientists, managers, porters and         based approach throughout the NHS
                                     some patients have all been amongst       and has demonstrated to all the staff
                                     those who could see new devices           that their ideas matter.
Introduction by Dr Maire Smith
                                     In spite of an average age of just         Innovation within both Education and
                                     four years, the nine NHS Innovation        Commerce is already being delivered
                                     Hubs are now exposing the culture          by the Hubs through collaborative
                                     of innovation that lies at the heart of    research with universities, licences
                                     the NHS and the creative potential         and new companies. By working
                                     that exists amongst its staff. This        collegiately in marketing, training,
                                     report captures numerous examples          IT, university collaboration and
                                     of that creativity.                        governance, the Hubs are helping
                                                                                build the knowledge economy in the
                                     The Hubs are also realising the            field of Healthcare innovation.
                                     commercial potential within that
                                     creativity and ensuring that the           Working alongside their local
                                     rewards are retained in the NHS for        partners, the Hubs are helping to
                                     the benefit of the service and patients.   bring about transformational change
                   Dr Maire Smith    During the year, the Hubs doubled          in the NHS, attracting recognition
Executive Director, Technology and   their commercial deals and yielded         in the form of national and regional
 Product Innovation, NHS Institute   dividends from innovative technology       awards. They are also building
  for Innovation and Improvement
                                     in the form of improved effectiveness      national links with the devolved
                                     and efficiency for patients, cost          administrations of Wales, Scotland
                                     savings benefits and, in some cases,       and Northern Ireland and, with the
                                     income generation for local Trusts.        National Innovation Centre, starting
                                                                                to share best practice internationally.
                                     The work of the Innovation Hubs
                                     embodies the priorities in the             The Innovation Hubs are well placed
                                     Government’s 10-year Science               on the innovation landscape, with a
                                     and Innovation investment plan.            productive future to help accelerate
                                     Recent Government emphasis on              change at the local level.
NHS Innovation Hubs
  NHS Innovations East
  www.hee.org.uk

  NHS Innovations North
  www.nhsinnovationsnorth.org.uk

  NHS Innovations East Midlands
  www.em-nhs-hub.org

  NHS Innovations South East
  www.nhsinnovations-southeast.com

  NHS Innovations West Midlands
  www.midtech.org.uk

  NHS Innovations North West
  www.trustech.org.uk

  NHS Innovations Yorkshire and Humber
  www.medipex.co.uk

  NHS Innovations London
  www.nhsinnovationslondon.com

  NHS Innovations South West
  www.nisw.co.uk
April 2006 – March 2007
              •   The major categories for innovations are medical diagnostics and laboratory,
                  ICT and software, publications, therapeutics and drug delivery, and medical
                  devices and equipment.
              •   The Hubs filed thirty-six patents during the year.
              •   Fifty-four deals were agreed. These include the first deal from the Hubs’
                  presence at the 38th World Forum for Medicine, MEDICA, the world’s largest
                  medical technologies trade fair.
              •   The technology behind the company spun out by NHS Innovations North,
                  Pulse Diagnostics, won the Technology Innovation category in the Health and
                  Social Care Awards.
              •   Three new companies were formed based on NHS Intellectual Property and
                  services:
                  •   Leeds Reproductive Biosciences Limited
                  •   EPAQ Systems Limited
                  •   NuovoPROBE Limited
              •   During the year the Hubs had approximately 1,000 projects under review.
              •   Over two thirds of the projects under review were technology-related. Of the
                  third of projects that were service-related, most had commercial potential.
              •   NHS Innovations East Midlands won the ‘Service Award’ category, in the
                  Health and Social Care Award, for their Enuresis e-learning package.
              •   The Hubs are building stronger links with the university sector, and have put
                  in place a system of agreements to cover work and jointly owned IP from
                  university hospitals.
              •   Eighty-two people are employed by the nine regional NHS Innovation Hubs.
                  The Hubs cover a population of almost 680,000 clinical staff across England.
              •   The NIC is working with the Hubs to strengthen further their governance
                  systems and metrics to develop even more robust and professional services.
NHS Innovations East
               NHS Innovations East is looking back       Capable of being inserted up to ten
               on another exciting and successful         times faster than current devices,
               twelve months and looks forward            it will be particularly useful when
               to capitalising on its productive first    emergency lung isolation is needed,
               two years.                                 such as in field situations, as well as in
                                                          general and thoracic surgery.
               In that period there have been more
               than 70 innovation disclosures. Among      Potential savings are impressive: for
               the 10 so far commercialised are new       elective procedures treatment costs
               diagnosis and treatment devices,           will be halved, while for trauma
               equipment to increase hospital hygiene,    situations there is nothing comparable
               and fresh approaches to medical            on the market and IP protection is in
               practices. Registrations of Intellectual   place in the UK, US, EU, China, India
               Property and development fund              and Japan. Following Medica, P3-
               expenditure have continued to grow,        Medical signed a nine-month option
               both of which will help mature the         to negotiate an exclusive licence and
               project portfolio to commercialisation,    to help with IP-related costs during
               including four that are expected to        clinical trials at Papworth. CE marking
               reach that stage in Q1 2007-08.            should follow.


               With income from commercialisation         Simon Talbot, the company’s managing
               increasing, and being returned to the      director, said: “The opportunity
               NHS, NHS Innovations East plans its        to deal directly with professionals
               continuing evolution by promoting          experienced in technology transfer is
               licensing opportunities to the wider       a great example of how the NHS and
               business sectors in the UK and overseas.   the private sector can co-operate to
                                                          facilitate innovation in patient care.”
               In 2006-07 considerable worldwide
               interest was shown in a novel              The unsightly effects of scarring
               endotracheal tube designed by Dr           following surgery, trauma and burns
               Sunit Ghosh, a consultant anaesthetist     could be reduced significantly by a
               at Papworth Hospital NHS Foundation        new technique involving a single,
               Trust. When NHS Innovations East           precisely-timed insulin injection. In a
               featured it at Medica 2006, the            research breakthrough which could
               world’s largest medical and healthcare     benefit millions of people annually,
               trade fair, it made a big impression       the use of insulin to reduce levels of
               on P3-Medical Limited, a UK-based          scar tissue is being developed by Dr
               devices manufacturer.                      Claire Linge, Group Leader in Cell
Biology at the Research Institute,           further development of the software
Northwood, Middlesex. Preliminary            tool to build strategic alliances with
clinical trials have produced promising      other software solutions and increase
results and the technique, for which a       the number of care pathways.
patent is pending, will be progressing
into full-scale clinical trials during the   The Innovations Hub is an honorary
coming year.                                 member of i10, an organisation
                                             that provides businesses with easy
NHS Innovations East is assisting Dr         access to the academic expertise and
Linge with the patent application            facilities within universities and higher
and negotiating with pharmaceutical          education institutions in the East of
companies to progress the research           England.
into large-scale trials.


The Hub has also supported inventors
at the East of England SHA in the
development of ‘scenario modelling’
software that determines the level
of healthcare provision required as
the population size, demographic




                                                                                “
and mechanism of service provision
change.


NHS Innovations East established
ownership of the intellectual property,                                                  The opportunity
as this was dispersed between a                                                          to deal directly
number of NHS stakeholders, and
                                                                                         with professionals
negotiated the development of the
scenario generator software with                                                         experienced in
Simul8 Corporation on behalf of the                                                      technology transfer is
SHA. This included joint ownership                                                       a great example of how
of the software, 200 free licences
                                                                                         the NHS and the private
to Simul8’s platform technology (to
be used by the NHS) and a royalty                                                        sector can co-operate to
on commercial sales of the software                                                      facilitate innovation in
outside the NHS in England.                                                              patient care.
The NHS Institute for Innovation
                                                                                         Simon Talbot, MD P-3 Medical
and Improvement (NHSIII) is funding
NHS Innovations North
               Hub Director Dr Richard Hoare has          2005 with his tracheosophageal valve
               a clear message for NHS innovators         cleaner (more colloquially, the ‘flush
               in the North East: “IP is an asset that    brush’), a device that raises the quality
               must be looked after, so don’t be          of life of post-laryngectomy patients
               suspicious of us - use us”.                by improving the cleaning of voice
                                                          prostheses.
               There is plenty of evidence that
               his words are heard. Since NHS             NHS Innovations North patented the
               Innovations North was established in       device and licensed it to manufacturer
               2002, 10 products have been brought        Novagen, which is now seeking
               to market, including most recently a       distribution opportunities through
               blood tag label reader, a paediatric       market leaders in the ENT arena.
               imaging chair, a hand splint and a
               urine flow meter.                          HDA medium, a test for antibiotic-
                                                          resistant strains of MRSA and other
               So far the Hub has favoured licensing      micro-organisms, won the regional
               as the route for exploiting technology     NHS Bright Ideas in Health Awards
               transfer, although it expects to see       2006 for its inventor, Dr Michael Ford,
               spin-outs and joint ventures increase      Operational Services Manager at
               in number.                                 Newcastle’s Freeman Hospital. Halving
                                                          the standard diagnosis time, the HDA
               Pulse Diagnostics was its first spin-      medium is now patent pending in the
               out, which it set up in April 2006         UK and internationally. Six overseas
               with Newcastle-upon-Tyne Hospitals         diagnostics companies are interested in
               NHS Foundation and venture capital         manufacturing it and a deal is awaited.
               partner Exomedica, to commercialise
               a low-cost, non-invasive arterial          In the last six years, Occupational
               disease detection system. With             Therapist Philip Renforth has made
               potentially significant cost savings for   and used well over 3,000 neoprene
               the NHS and promising overseas sales       splints at Wansbeck General Hospital,
               opportunities, the Hub is now seeking      Ashington. Now his guide to making
               additional funding for clinical testing    simple, cost-effective and user-friendly
               and evaluation.                            splints is being sold on ennovations.
                                                          co.uk, the e-commerce website that
               Peter Samuel, Consultant ENT               NHS Innovations North runs jointly
               Surgeon at Sunderland Royal Hospital,      with the North West and Yorkshire
               approached Innovations North in            and Humber Hubs.
An Occupational Health Officer, Lynn
Pattinson at the County Durham
and Darlington Acute NHS Trust, has
come up with a novel stool designed
to eliminate muscle pain experienced
by professionals, such as midwives,
who work at a low level. NHS
Innovations North has protected the
stool through a registered design, and
it has now been successfully licensed
to MDTi - a leading UK medical
goods manufacturer. The Hub is
supporting preliminary trials and, on
launch, the product will be available
to other UK Trusts as well as the wider
healthcare market, with the potential
of improving occupational back care
for clinicians in a broad range of
healthcare environments.




                                           “
With more innovations under
development, venture capital
partner, Exomedica, has offered
NHS Innovations North £1 million to
invest in further spin-outs. Alternative   A test for antibiotic-
sources of venture capital are also        resistant strains of MRSA
being considered for other potential
                                           and other micro-organisms
projects, including a method of
                                           is halving the standard
automating the haemodialysis
of premature babies (in which              diagnosis time. The HDA
a Malaysian company is already             medium is now patent
interested), a diagnostic blood test,      pending in both the UK
an eye diagnostic and an IT-based          and internationally. Six
training and communications system
                                           overseas diagnostics
for NHS staff.
                                           companies are interested
                                           in manufacturing it and a
                                           deal is awaited.
NHS Innovations East Midlands
               Patients of all ages are now                When Derby Hospitals occupational
               benefiting from the medical devices,        therapist Jan Nicholson wanted
               therapeutics, diagnostics, software         to develop her idea of a low-cost
               and service delivery improvements           book page-turner for children
               that NHS Innovations East Midlands          with disabilities, local Rolls Royce
               has helped develop during the past          apprentices agreed to take it on, but
               four years.                                 were unable to make a prototype.
                                                           The project was then transferred
               Some innovations, however, are              to NHS Innovations East Midlands,
               specifically designed for children.         which brought in REMAP, a charity
               ‘All About Nocturnal Enuresis’,             whose retired engineers and
               for instance, is a novel e-learning         craftsmen make working prototypes
               package that won a Care of Children         of equipment for the disabled free
               Award in 2006.                              of charge. After resolving a number
                                                           of deficiencies, they produced a
               Originally a Nottingham University          successful version and Nottingham
               Hospitals Children’s Clinic-based           Rehab Supplies is now selling the
               support project, NHS Innovations            product through its catalogue.
               East Midlands took it over and
               helped develop it into a ‘must-have’        In 2006 the Hub identified an
               facility for paediatricians, GPs, health    international company with a
               visitors, child psychologists, nursery      significant problem sourcing human
               school teachers and parents. Enuresis       tissue to support its research.
               nurses in particular have praised the       Leicester Bone Bank is the largest
               packs highly.                               hospital-based repository of bone
                                                           for transplant in the UK and has a
               With all IP rights protected, packs are     robust and well regulated system for
               now being made available through the        harvesting and processing surplus
               charity ERIC (Education and Resources       bone. The East Midlands Hub
               for Improving Childhood Continence),        facilitated the relationship between
               and Nottingham Rehab Supplies is            the two parties and provided advice
               taking a licence and will feature it in     on how to allow the legal transfer
               its 2008 catalogue for international        of samples to the company. This has
               sale. A spoken option is available for      helped support the not-for-profit work
               children with poor reading skills, and it   at the bone bank as well as move
               has even been translated into Gujerati      forward the company’s research into
               for use in India.                           regenerative medicine.
Anyone can benefit from a Derby
hand surgeon’s idea of a plastic sleeve
that allows a patient’s arm to be
sterilised before he or she goes into
the operating theatre. NHS Innovations
East Midlands obtained patent
protection and then asked Medex
(part of Smiths Medical) to produce
a prototype. Medex is now licensed
to market the sleeve to the NHS.
Meanwhile, discussions are taking
place about a similar sleeve for legs.


RaDOS (Research and Development
Operating System), a professional
and accurate way of managing
the requirements of the Research
Governance Framework for Health and
Social Care and R&D support funding,
is the result of two years’ work by a




                                          “
team at Broxtowe & Hucknall PCT.
Other NHS Trusts are now buying a
generic version for local adaptation.


                                          Anyone can benefit
                                          from a Derby hand
                                          surgeon’s idea of a
                                          plastic sleeve that
                                          allows a patient’s
                                          arm to be sterilised
                                          before he or she
                                          goes into the
                                          operating theatre.
NHS Innovations South East
               “It can seem a long and daunting task     rheumatoid arthritis treatments,
               getting new technologies adopted          EvaluLogix is expected to save the NHS
               by the NHS.” For delegates attending      hundreds of thousands of pounds.
               the Hub’s Practical Partnerships in
               Healthcare symposium in December          Former Health Minister, Lord Hunt of
               2006, this might have sounded             Kings Heath, was clearly impressed,
               rather a discouraging theme. They         calling it “A wonderful example of
               soon discovered, however, that the        innovation from within the NHS being
               intention was to firmly demolish such     developed in partnership with the
               a perception.                             private sector for the benefit of all.
                                                         The role of NHS Innovations South
               They heard that, although an              East in this process has been crucial.
               innovation could take several years to    Their work shows that staff within the
               reach the market, no-one in the NHS       NHS are often best placed to identify
               with a good idea should be dissuaded      needs and come up with creative
               from approaching their Hub as the first   solutions”. Development partner EPS
               step towards turning it into reality.     Research is now marketing EvaluLogix
                                                         in the UK.
               Indeed, as Chief Executive, John
               Stedman, felt confident enough to         Another novel service developed
               say soon after taking up his role in      during the year uses state-of-the-art
               early 2007: “We have developed            credit card-sized tracking devices for
               a significant pipeline of projects        dementia patients. Not only does
               and established good working              it allow them to live in their homes
               relationships with NHS innovators and     longer, but can quickly locate them if
               management that provide a good            they do wander off.
               foundation for 2007-08”.
                                                         Dr. Rupert McShane, Consultant
               One of several completed licensing        and Honorary Senior Lecturer in Old
               deals was that with Roche, the global     Age Psychiatry with Oxfordshire and
               pharmaceutical giant, for EvaluLogix,     Buckinghamshire Mental Health
               pioneering anti-TNF (tumour necrosis      Partnership NHS Trust, brought this
               factor) software invented by Dr Raashid   idea to NHS Innovations South East,
               Luqmani, Consultant Rheumatologist        which then brokered a partnership
               at Oxford’s Nuffield Orthopaedic          between the NHS and GPS technology
               Centre. By radically simplifying          experts, FollowUs Ltd. After
               the complex process of assessing          refinement, the product is now being
               a patient’s suitability for advanced      marketed throughout the UK.
Recent licence agreements included
one on behalf of Portsmouth Hospitals
NHS Trust for ALERT® (Acute Life-
threatening Events - Recognition and
Treatment), a one-day training course
now being used globally.


Also from Portsmouth came Vitalpac,
a handheld software system enabling
clinical staff to monitor and track in
real time the progress of acutely ill
patients in hospital. The benefits are
improved patient care and better use
of hospital resources.




                                         “
                                         By radically simplifying
                                         the complex process
                                         of assessing a patient’s
                                         suitability for advanced
                                         rheumatoid arthritis
                                         treatments, EvaluLogix
                                         is expected to save
                                         the NHS hundreds of
                                         thousands of pounds.
NHS Innovations West Midlands
              David Gleaves, Chief Executive of          the help of Professor Serguei Semenov
              NHS Innovations West Midlands,             of Keele University. Potential investors
              summarises his Hub’s role as: “The         were identified and the Hub then
              interface between the NHS and the          worked closely with the inventors,
              commercial world. Our insight is           the investors, the Trust and Keele
              unique. Whether your idea is complex       in the formation of NuovoPROBE
              or simple, we are interested - it could    Ltd, dedicated to the technology’s
              well make a difference. And when           commercialisation. NuovoPROBE is
              we think an idea can be developed,         now actively seeking funding from the
              we always pass the baton to the best       EU and other sources.
              runner”. Proof is not hard to find.
                                                         Professor Spiteri said: “The Hub has
              Some of the innovations licensed           supported and assisted both the Trust
              during the year were brought to the        and myself continuously through what
              Hub’s attention through its annual         has proved to be a long and complex
              innovation awards. One example was         process towards commercialisation.
              a novel application of a safe in-situ      This is new and unfamiliar territory
              imaging technique called Optical           for us, and I have no hesitation in
              Coherence Tomography (OCT) for             stating that, without their specialist
              the screening and diagnosis of lung        expertise and involvement, it would
              and other cancers, pioneered by a          not have been possible to progress
              team of clinicians and scientists led by   the innovation to this stage”.
              Professor Monica Spiteri at University
              Hospital of North Staffordshire.           If such an innovation represents the
                                                         complex end of the scale, then few
              Using a database of OCT images and         could be much simpler than the
              the corresponding histology images,        ‘dressing loop’ from Catherine Sykes,
              surgeons will be able to determine         deputy head of the occupational
              exactly which tissue needs to be           therapy service at University Hospital
              removed, thus reducing the number          Birmingham NHS Foundation Trust.
              of cases where cancerous tissue            In the screw-top container is a large
              remains and therefore the amount of        elastic band which, under guidance
              post-operative treatment required.         from an occupational therapist, a
                                                         patient must be able to remove,
              Initially, NHS Innovations West            put both feet through, and bring
              Midlands filed a patent to protect         up the body and over the head.
              not just the original IP, but also         Success means that he or she can be
              subsequent improvements made with          discharged.
For around a fifth of patients needing
to be assessed before discharge, this
reduces the length of time the pre-
discharge assessment takes, meaning
they can go home more quickly and
free up beds for others - evidence that
simplicity is no barrier to ideas that
save time and give value for money.


This innovation has been licensed to
Nottingham Rehab Supplies, which
plans to market it with a CD for use
by occupational therapists.


Catherine said: “I never thought I’d
be classed as an inventor. I’m thrilled
that this invention is now about to
become a commercial product that
could help occupational therapists and
patients around the country, or even




                                          “
the world”.




                                          I never thought I’d be
                                          classed as an inventor. I’m
                                          thrilled that this invention
                                          is now about to become a
                                          commercial product that
                                          could help occupational
                                          therapists and patients
                                          around the country, or
                                          even the world.
                                          Catherine Sykes, innovator
NHS Innovations North West
              NHS Innovations North West               into the skull and spine for
              (TrusTECH ) has developed a wealth
                         ®
                                                       administering pain relief.
              of experience in the management of IP
              from the NHS to improve healthcare.      In response to the growing number
                                                       of companies and universities seeking
              Using its specialised knowledge, it      appraisal of new medical devices and
              continues to provide a service to        medicinal products, NHS Innovations
              regional NHS Trusts to maximise          North West has been developing
              the potential of their innovations       a web-based clinical expertise and
              and ideas and develop them into          trial database.
              successful products and services. As a
              result, patient care improves and the    The database, known as ACTNoW®,
              Trusts and innovators benefit from the   holds information on clinical staff in
              revenue generated.                       the region with a proven capacity to
                                                       undertake clinical trials. Information
              During the year under review, for        includes the expertise from NHS Trust
              example, a consultant ENT surgeon        and Clinical Trial Units, Research
              at Salford Royal NHS Foundation          Networks, university and local
              Trust, motivated by the lack of an       Research Ethics Committees and PCTs
              appropriate training aid, came to        from across the region.
              NHS Innovations North West with a
              plaster of Paris prototype of a human    ACTNoW® has 900 registered
              head with a realistic replaceable nose   individuals or organisations interested
              structure. The model allows doctors      in taking part in clinical trials, and
              and students to practise rhinoplasty,    the Hub continues to collect data
              the common yet complex procedure         through on-line registration. In 2006,
              popularly known as a ‘nose job’.         TrusTECH® began to work with two
                                                       other Innovation Hubs to develop one
              Having first protected the IP, NHS       resource for the North of England.
              Innovations North West identified a
              Kent-based company, Adam,Rouilly         Key users of ACTNoW® are
              Ltd, as a potential manufacturer, and    universities, Strategic Health
              agreed licence terms.                    Authorities, and the pharma and
                                                       medical device industries to gain
              In a similar development, Adam,          direct access to clinical expertise.
              Rouilly also made a manikin that
              allows doctors and students to           Thanks to ACTNoW®, a greater
              practise accurate needle placement       number of clinical trials are now
taking place across the North West,        December 2006, the gown has been
resulting in better patient outcomes.      extensively promoted, generating
The database has increased revenue         orders from Trusts nationwide and
for the Trusts, fostered a closer          hospitals overseas.
working relationship with industry and
is helping build NHS research capacity     With backing from North West
and capability.                            Development Agency, NHS
                                           Innovations North West acquired the
NHS Innovations North West, jointly        franchise for, and has taken over the
with the University of Manchester,         management of, Medilink North West
also negotiated and signed an              in order to develop a viable business
options licence for a novel pelvic floor   support network for the North West
stimulation device undergoing clinical     medical technology community.
trials in Autumn 2007.


The Hub is also looking at the use of
essential oils as an active ingredient
in body washes for use by immuno-
compromised patients, and as a
preservative in other general cosmetic




                                                                             “
products. License negotiations are
now taking place.


Of course, innovations do not
necessarily have to be medical devices,                                            Thanks to ACTNoW®, a
as demonstrated by the modesty-                                                    greater number of clinical
protecting hospital gown designed by                                               trials are now taking place
Karen Jacob, Linen Services Manager
                                                                                   across the North West,
at Lancashire Teaching Hospitals NHS
Foundation Trust.
                                                                                   resulting in better patient
                                                                                   outcomes. The database has
Following initial market research,                                                 increased revenue for the
NHS Innovations North West                                                         Trusts, has fostered a closer
managed the IP issues, selected West
                                                                                   working relationship with
Yorkshire-based Interweave Textiles
                                                                                   industry and is helping build
Ltd to make the gown, and handled
negotiations and legal agreements                                                  NHS research capacity and
between it and the Trust. Launched in                                              capability.
NHS Innovations Yorkshire and Humber
               Richard Clark, CEO of NHS                 In November 2006 the Hub formed
               Innovations Yorkshire and Humber,         EPAQ Systems Ltd to commercialise
               (Medipex) believes that success breeds    software for an interactive personal
               success. Indeed, ideas for commercial     assessment questionnaire for women
               activity, on which the Hub focuses,       with pelvic floor problems. Developed
               continue to be plentiful, with nearly     by Dr Stephen Radley, also from
               20 deals, including three spin-outs, so   Sheffield Teaching Hospitals Trust, and
               far completed, and a fourth pending.      systems designers Illuminaries Ltd, it
                                                         enables patients - even those with no
               The first spin-out was Aperio             pc experience - to answer questions
               Diagnostic Ltd in March 2006,             on screen and print a diagnostic
               which the Hub set up with fellow          report. Forty UK hospitals intend to
               shareholders Exomedica (an early-         order it and it has been acclaimed
               stage innovation developer), Sheffield    internationally, particularly in the US.
               Teaching Hospital and Biofusion.
               The device in question is a cervical      A new spin-out company, Imagel
               cancer probe that gives an immediate      Ltd, is to be formed to market a true
               answer with 90 per cent accuracy,         3-D dosimeter developed by the
               developed by Dr John Tidy, Consultant     Hull and East Yorkshire NHS Trust,
               Gynaecologist at Sheffield Teaching       and York and Hull universities. The
               Hospitals NHS Foundation Trust, and       device is now being trialled at leading
               Emeritus Professor Brian Brown, from      radiotherapy centres and is expected
               the University of Sheffield’s Medical     to be available commercially soon.
               Physics department.
                                                         The Hub has also co-invested in
               Multi-centre clinical trials and the      Leeds Reproductive Bioscience Ltd to
               regulatory processes required for         develop a novel diagnostic tool for
               UK and overseas marketing are             improving success rates of in-vitro
               now taking place, while a simpler         fertilisation procedures.
               version is being considered for
               developing countries.                     The fact that some hospital staff
                                                         find lifting heavy drip bags quite
               Dr Mark Fisher, Exomedica’s               challenging could soon change
               Technology Director, said: “This          following the development of an
               development demonstrates how              ergonomically superior, motorised
               collaboration between the academic        drip-stand. Based on an original
               sector and the NHS can generate a         design by the Medical Engineering
               truly disruptive technology”.             section of Sheffield Teaching Hospitals
NHS Foundation Trust, it has been
licensed to manufacturer Pavillion
Medical Ltd, UK.


The acronym IRPS will undoubtedly
become increasingly familiar. Standing
for Interactive Radiotherapy Planning
for Students, this on-line system
fills an important training gap and
makes expensive support systems
unnecessary. First it shows users how
isodose distributions are produced,
then tests their newly acquired
knowledge.


The idea was developed by Drs John
Conway and Stephen Tozer-Loft and
a team from the Radiotherapy Physics
Department at Sheffield’s Weston Park
Hospital. IRPS is being sold worldwide




                                         “
on line through the e-commerce
website www.ennovations.co.uk.


In an interesting departure from
mainstream activity, an MBA student
                                         This development
is currently assessing the commercial
potential of this website for his        demonstrates how
MBA dissertation. The website was
                                         collaboration between
designed by the Innovation Hub for
products emerging from the NHS, and      the academic sector
is shared with the other two Northern
                                         and the NHS can
England Hubs.
                                         generate a truly
                                         disruptive technology.
                                         Dr Mark Fisher, Technology
                                         Director, Exomedica
NHS Innovations London
              NHS Innovations London (NHSIL) has         products to the ATAG™ device at the
              made good progress in its first year,      moment and the Hub believes that
              following the merger of the four           it could help address a significant
              London hubs into one. It assembled         market, save thousands of lives each
              a strong team, devised and launched        year and generate valuable income for
              its Xpedite IP management system,
                         ™                               the Trust.
              and built a full portfolio of invention
              disclosures, even receiving as many        The market for devices used in hole-
              as15 on one extraordinary day.             in-the-heart surgery has been valued
                                                         at many millions, but there are many
              Fourteen products are in development       issues surrounding the function of
              with four products already                 current products. NHSIL is project
              undergoing preliminary clinical trials,    managing a design programme for
              and, of 19 in business development,        a new foramen ovale device from an
              licences for nine are being negotiated.    interventional cardiologist’s idea. The
              Five potential company start-ups are       Hub is gradually building a significant
              under review, of which two are at the      portfolio of cardiac devices.
              business planning stage.
                                                         Sepsis remains one of medicine’s most
              One of the start-ups is PerQtech  ™        difficult and devastating conditions,
              based on an ascending thoracic aorta       accounting for 27 per cent of the UK’s
              graft (ATAG ) system, developed by
                          ™                              intensive care admissions. Of these,
              Professor Martin Rothman of Barts          more than 20 per cent die. AGL1 is
              and the London NHS Trust. NHS              a potential revolutionary therapeutic
              Innovations London is now working          for inflammatory disease developed
              with third parties to develop and trial    by Dr Gareth Ackland and Alexander
              a prototype, ahead of clinical trials in   Gourine of University College London
              2008/09.                                   Hospitals NHS Foundation Trust and
                                                         University College London.
              Chief Executive, David Chilvers, said:
              “We took Professor Rothman’s idea          Working closely with the inventors,
              and, with partners, designed and           NHS Innovations London has
              developed the product from scratch         protected AGL1’s IP in the UK and
              in nine months. We have proved             internationally and it is currently
              that NHSIL can accelerate the pace         undergoing pre-clinical evaluation.
              of development of such innovations,        First-stage venture financing and
              which means that they reach patients       contract manufacture for Phase 1
              sooner”. There are no alternative          clinical trials will follow. AGL1 has
an estimated annual market value           taking place for the first six products,
of £700 million. If successful in          including a Patient Public Involvement
clinical trials, AGL1 offers the Trust a   (PPI) Toolkit for Practice Based
significant potential income.              Commissioning and an Electronic
                                           Team Tool for speeding up audits using
In 2006 the Hub assisted in setting up     Health Commission standards. Both
a test centre for the remote monitoring    are from Wandsworth PCT. There is
of childhood epilepsy. The condition       also a Client Data Collection System
is difficult to diagnose and the side      (CDCS) for Psychological Services from
effects of the wrong treatment are         Newham PCT, and LetterMaker, which
significant. The wireless web-browser      is an add-on to i-Soft ICM from Kings
was developed by the Great Ormond          College Hospital NHS Foundation
Street Hospital for Children NHS           Trust.
Trust, and enables consultants to
remotely monitor epileptic children        Three London PCTs are currently
in their home. Its benefits include        using new web-based Procurement
an improvement in patient life             Management Analysis Software
quality, greater accuracy of results,      (PUMA) for seamless reporting of data
faster clinical decision-making and a      for Practice Based Commissioning
reduction in Trust costs, with sales and   of healthcare services, developed by




                                                                               “
consulting fees capable of generating      Enfield PCT.
valuable potential revenues.
                                           Other significant reductions in
After receiving £19k Proof of Concept      administrative workload come
funding, the Trust’s Dr Stewart Boyd       from CABI (Computer Assisted               The Hub believes
said: “NHS Innovations London is also      Brief Intervention), a web-based
giving invaluable support helping us       system for Quit-Smoking Services           that a device, such
to find and negotiate with possible        healthcare professionals, and E-HR,
                                                                                      as ATAG™, could
commercial partners”.                      a web-based HR Administration
                                           tool from the Barts and the                help address a
With the support of its Steering           London NHS Trust.
                                                                                      significant market,
Group of London Trust Chief
Executives, NHSIL is acting as a                                                      save thousands of
conduit to disseminate new software
                                                                                      lives each year and
developments. The resulting
prevention of replication will lead to                                                generate valuable
considerable savings and efficiencies
for the NHS. Currently installations are
                                                                                      income for the Trust.
NHS Innovations South West
              Since April 2006, NHS Innovations        their agreement is crucial to an
              South West (NISW) has worked             initiative worth progressing.”
              on over 120 projects, some of
              which are being progressed to            Catherine Boyce, a TIL in
              licence opportunity and some to          Gloucestershire, agrees: “One of the
              commercialisation with partners          key benefits of the South Western
              via alternative routes to market.        model is that, as well as developing
              The projects range widely, from          our own skills and knowledge in the
              sophisticated medical devices and        field of innovation, we have well-
              NHS-focused software products to         established contacts within the Trusts,
              novel training materials.                and many of the innovators we come
                                                       across are also our colleagues”.
              Working closely with Pera, an
              international innovation consultancy,    One innovation, now with MDTi for
              NISW is driving innovation in the        commercialisation, is the IV ‘Sty’,
              region through a network of nine Trust   invented by Sam McDonald, a nurse
              Innovation Leaders (TILs), based in      with Cornwall and Isles of Scilly PCT.
              leading hospitals. NISW’s eight-month    Her device overcomes the problems
              training programme, delivered by Pera    caused when, in some traditional intra-
              and tailored for the NHS, educates       venous sets, the second, or ‘piggy-
              TILs in how to promote, develop          back’, drip line becomes detached
              and manage innovation and cultural       from the other. Sam’s ‘sty’ keeps the
              change within their own Trust.           ‘piggy-back’ in place.


              The TILs are supported by a full-time    Gloucestershire Royal Hospital is
              innovation ‘coach’. NISW staff have      pioneering Raman spectroscopy, a
              extensive experience in intellectual     novel technique for real-time early
              property evaluation and commercial       diagnosis of cancer.
              exploitation. Its two business
              development managers both come           Dr Nicholas Stone, the hospital’s
              from the private sector and understand   Consultant Clinical Scientist/Head of
              markets and how to reach them.           Biophotonics Research, comments:
                                                       “The Hub’s support, through the
              Hub Chief Executive Maria Hassard        TILs, has been invaluable in enabling
              says: “An appropriately skilled NHS      us to develop stronger commercial
              workforce is better able to spot the     partnerships and negotiate agreements
              right projects for development. We       and patents Their positive approach
              work closely with the Trusts because     made us feel our work is useful to the
NHS, giving us greater vigour to move
forward with taking these ideas closer
to reality in the clinic”.


The Be-Smart cart, conceived by
Kathryn Smith, Lead Occupational
Therapist with Cornwall Partnerships
Trust, is a mobile, fully self-contained
sensory room offering a personalised
environment of lights, colours, sounds,
smells and items to touch.


With the assistance of NHS Innovations
South West and the backing of
Cornwall Partnerships Trust, Kathryn
has now established a ‘spin-out’
business to exploit commercially this,
and other IP, to the benefit of the NHS.


Her work has been recognised by the




                                           “
Medical Futures Innovation Awards
and by Stannah Stairlifts, who made
her Occupational Therapist of the Year.


                                           The Hub’s support, through
                                           the TILs, has been invaluable
                                           in enabling us to develop
                                           stronger commercial
                                           partnerships and negotiate
                                           agreements and patents.
                                           Their positive approach made
                                           us feel our work is useful to
                                           the NHS, giving us greater
                                           vigour to move forward with
                                           taking these ideas closer to
                                           reality in the clinic.
                                           Dr Nicholas Stone, Consultant
                                           Clinical Scientist
Case Study: Odstock Medical Ltd

                 The company                                   the Trust on a part-time basis.
                 Odstock Medical Ltd (OML) is one of
                 the first NHS commercial companies            The Foundation Trust owns the patents
                 in England. Owned by Salisbury NHS            for the FES products, although they are
                 Foundation Trust, it is based at Salisbury    licensed to OML. The Trust has invested
                 District Hospital near Odstock, Wiltshire.    in personnel, new product development
                 The company was launched in June 2007.        and refurbishment of a headquarters
                                                               building on the hospital site, but leaves
                 OML produces functional electronic            the company to run itself on a day-to-day
                 stimulation (FES) devices, including          basis.
                 the successful Odstock Dropped Foot
                 Stimulator (ODFS), invented in the 1980s      All OML staff who have worked in the
                 by Prof Ian Swain and Dr Paul Taylor of the   Trust’s Medical Physics Department for
                 Trust’s Medical Physics Department.           two years or more are stakeholders in the
                                                               company. The majority shareholding lies
                 The device can help people who have           with the Trust. The hospital’s charitable
                 suffered stroke, cerebral palsy and MS,       trustees own 18 percent and the staff 12
                 walk more easily. It has helped to change     percent.
                 the lives of approximately 6,000 people
                 to date and OML believes there are about      Chairman Barry Bull commented: “There is
                 200,000 people in the UK and hundreds of      no expectation for anyone to get rich, just
                 thousands globally who could benefit from     to plough revenue back into patient care.
                 the device.                                   Indeed, we do not expect there will be a
                                                               dividend for some time; all surpluses will
                 Salisbury NHS Foundation Trust Finance        go into research and marketing.”
                 Director Malcolm Cassells said: “Over the
                 years we recognised the massive potential     Marketing
                 of the FES as a therapeutic treatment, but    Perceived restrictions on ‘advertising’ by
                 knew that it needed to be able to stand       NHS trusts initially made marketing the
                 alone, independent from the Trust, so         products difficult, but the formation of a
                 that it did not have to compete with other    company specifically to market and further
                 departments for Trust resources.”             develop FES technology overcame many of
                                                               these problems.
                 The 25 strong OML team is being built
                 around Prof Swain, a director of the          The company marketing strategy has
                 company, and Dr Taylor, both of whom          been to target patients and primary care
                 continue to treat patients. CEO, Jon Lewis,   trusts. A magazine advertising campaign
                 was formerly MD of a medical products         targeted MS and stroke sufferers. People
                 company. The Trust has appointed two          responding to the ads received an
                 directors, Malcolm Cassells and non-          information pack and two booklets, one
                 executive director, Barry Bull, a former      for patients and one for doctors. Patients
                 senior executive of Unilever. Most of the     cannot access FES without a referral from
                 team are seconded to the company from         their GP or consultant for a suitability
assessment to ensure that FES is an
appropriate treatment for their condition.


OML notes the areas in which interest
among patients is high and contacts the
relevant PCTs to inform them of their
patients’ enquiries and advise them about
FES if it is new to them.


After five weeks OML had received 1,000
enquiries from patients, trusts and PCTs.


Barry Bull, said: “Many trusts at NHS
Confederation were very interested to
see what can be done within the NHS.
We were able to explain that we are
working to the same disciplines that we
always have in the NHS; that nothing
has changed except the opening up of
opportunities to share the benefits of FES
with many more people.”


Chief Executive, Jon Lewis, said: “It is an
opportunity to take a fresh look at the
Trust’s income streams. While DH funding
will continue to be the main income for
any FT, it is important for them to consider
ways of opening up new income streams
such as commercialising innovations from       The Dropped Foot Stimulator enables patients with a dropped
staff. OML has a close relationship with the   foot to walk further, faster, safer and more easily. By applying
innovation hub, NHS Innovations South
                                               small electrical pulses to nerves which supply a paralysed muscle,
West, in pursuing this goal”.
                                               FES can cause the muscle to contract. It has helped patients with
He added: “There’s a big difference
                                               conditions such as stroke, multiple sclerosis, cerebral palsy,
between privatising and commercialising.
We are commercialising a product that will     Parkinson’s Disease and some spinal cord injuries.
help thousands of patients. Profits are not
going to some London bank but back into
patient care and the development of more       The stimulation is applied using skin surface electrodes or an
new products.”                                 implanted device and is controlled by a footswitch placed under
                                               the heel, which detects when the patient begins to lift the foot
                                               off the ground and when the heel returns to the ground.
Case Study: Sheffield Knight Table
                  The SKT is an operating table               the SKT has an upper and lower
                  accessory from Sheffield Teaching           frame with adjustable knee rest that
                  Hospital NHS Foundation Trust that          allows powered manoeuvrability in
                  addresses spinal access.                    a controlled fashion by means of a
                                                              hand controller and battery powered
                  The Problem                                 actuator.
                  A leading orthopaedic surgeon had
                  identified a need for a specialist          The Hub provided a project
                  piece of equipment to attach to the         management service to ensure all
                  operating table to assist with minimal      parties were kept informed of design
                  invasive spinal surgery techniques.         issues and progress. it also made
                  During this form of spinal surgery the      sure that the creative input of the
                  patient is semi-aware and lies face         Clinical Engineering Department
                  down in a prone position to provide         (Intellectual Property) was reflected in
                  the surgeon with access to the surgical     the subsequent agreement reached
                  site. It is usually necessary to raise,     with the surgeon over royalties on
                  lower or tilt the patient to provide easy   future sales of SKT. Because this is
                  access to the spine. The surgeon had        a specialised market the quantity
                  an existing design for this specialised     of units sold is unlikely to be large,
                  accessory, not found on a standard          although each unit is of relatively
                  table. This proved the equipment’s          high value. In consultation with
                  potential but was still not satisfactory,   the Innovation Hub, the Clinical
                  so he approached Sheffield Teaching         Engineering Department acted as
                  Hospitals Clinical Engineering              the manufacturer and CE marked
                  Department and NHS Innovations              the product with appropriate
                  Yorkshire & Humber to see if an             product liability insurance in place.
                  improved table could be developed.          The Hub also produced a brochure
                                                              and undertook marketing support.
                  The result is the Sheffield Knight Table    The result is an innovative product,
                  (SKT). The SKT is fully portable, can       designed and developed within a
                  be easily stored when not required          clinical environment incorporating
                  and is designed as an accessory             input from theatre staff, infection
                  for any operating table equipped            control nurses and many other
                  with Medirails. When assembled              skilled staff.
                  and connected to the theatre table
NHS Innovations Yorkshire & Humber provided
a project management service to ensure all
parties were kept informed of design issues
and progress. The Innovation Hub also made
sure that the creative input of the Trust’s
Clinical Engineering Department (Intellectual
Property) was reflected in the agreement. In
addition, the Hub produced a brochure for the
product and provided marketing support.
images: wellcome collection




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