Documents
Resources
Learning Center
Upload
Plans & pricing Sign in
Sign Out

SAP-10075157.20061222.7019

VIEWS: 5 PAGES: 6

									Safety Data Sheet

CRA-cis-salt

1. Product and Company Identification
Product name Product code Company information CRA-cis-salt SAP-10075157 Enquiries: F. Hoffmann-La Roche AG Postfach CH-4070 Basel Switzerland Phone Fax +41-61/688 54 80 +41-61/681 72 76 Local representation:

2. Composition/Information on ingredients
Chemical name Synonyms - cis-3-Methyl-5-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4pentadienyl-triphenylphosphonium chloride C15-Phosphonium chloride C15-Wittig salt β-Ionylidenethyl-triphenyl-phosphonium chloride cis-Vinyl salt 66939-98-8 3077 Ro4370820-001 C33H37P HCl
q

CAS number UN number Roche number Empirical formula Molecular mass

501.09 g/mol

ClP+

Date: 22.12.06/CSE (SEISMO)

Replacing edition of:

5.9.06

Page: 1/6

CRA-cis-salt

3. Hazards identification
Most important hazards - Harmful if swallowed. - Irritating to eyes, respiratory system and skin. - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

4. First-aid measures
Eye contact Skin contact Inhalation Note to physician - rinse immediately with tap water for 10 minutes - open eyelids forcibly - remove contaminated clothes, wash affected skin with water and soap - do not use any solvents - remove the casualty to fresh air and keep him/her calm - get medical treatment - treat symptomatically

5. Fire-fighting measures
Suitable extinguishing media Specific hazards - water spray jet, dry powder, foam, carbon dioxide - formation of toxic and corrosive combustion gases (phosphorus oxides (eg, phosphorus pentoxide)) possible - substance is hazardous for water: contain fire-fighting wastewater - consider dust explosion hazard - precipitate gases/vapours/mists with water spray - collect contaminated fire-fighting water separately, must not be discharged into the drains

Protection of fire-fighters Special method of fire-fighting

6. Accidental release measures
Personal precautions Environmental protection Methods for cleaning up - ensure adequate ventilation - do not allow to enter drains or waterways - collect solids (avoid dust formation) and hand over to waste removal

Date: 22.12.06/CSE (SEISMO)

Replacing edition of:

5.9.06

Page: 2/6

CRA-cis-salt

7. Handling and storage

Handling Technical measures - processing in closed systems, if possible superposed by inert gas (e.g. nitrogen) - avoid dust formation; high dust explosion hazard - take precautionary measures against electrostatic charging - provide exhaust ventilation - enamel, glass, aluminium, stainless steel, PTFE
*1

Suitable materials Storage Storage conditions

-

dry and ventilated place protected from heat, light and humidity under argon < -15 °C

Validity Packaging materials

- 2 years, see expiry date on the label - tightly closing; material: aluminium, PTFE - lined with polyethylene bag trans-Vinyl salt
*1

*1

referring to:

8. Exposure controls/Personal protection

Engineering Measures Personal protective equipment Respiratory protection Hand protection Eye protection

- see 7.

- in case of open handling or accidental release: particle mask or respirator with independent air supply - protective gloves (eg made of neoprene, nitrile or butyl rubber) - safety glasses

9. Physical and chemical properties
Colour Form Odour Bulk density Solubility white to yellowish powder or powder with lumps slightly acidic ~ 0.5 g/ml ~ 2 weight %, water (20 °C) completely soluble, ethanol completely soluble, methanol completely soluble, isopropanol completely soluble, dichloromethane
Replacing edition of: 5.9.06 *1 *1 *1 *1 *1 *1 *1

Date: 22.12.06/CSE (SEISMO)

Page: 3/6

CRA-cis-salt

Melting temperature *1 referring to:

173 to 176 °C trans-Vinyl salt

10. Stability and reactivity
Stability Conditions to avoid - stable under the conditions mentioned in chapter 7 - humidity - light - air - bases, oxidizing agents, water, atmospheric oxygen, humidity trans-Vinyl salt
*1

Materials to avoid *1 referring to:

11. Toxicological information
Acute toxicity - LD50 - LD50 - LD50 710 23 19 mg/kg mg/kg mg/kg (oral, mouse) (i.p., mouse) (i.p., rat)
*1 *1 *1 *1 *1 *1

Local effects

- eye: irritant - skin: irritant - respiratory tract: irritant - not mutagenic (Ames test, without and with metabolic activation; OECD No. 471 (Salmonella typhimurium, Escherichia coli)) trans-Vinyl salt

Mutagenicity

*1

referring to:

12. Ecological information
Inherent biodegradability - not inherently biodegradable 0 %, 28 d (MITI Test II, OECD No. 302 C) - not inherently biodegradable 0 %, 28 d (Zahn-Wellens test, OECD No. 302 B) - highly toxic for fish (rainbow trout) LC50 1 mg/l LC0 0.5 mg/l LC100 2 mg/l (OECD No. 202) - observe local/national regulations trans-Vinyl salt

*1

*1

Ecotoxicity

*1

Air pollution *1 referring to:

Date: 22.12.06/CSE (SEISMO)

Replacing edition of:

5.9.06

Page: 4/6

CRA-cis-salt

13. Disposal considerations
Waste from residues - observe local/national regulations regarding waste disposal

14. Transport information

IATA

Class 9

UN/ID 3077

PG III

PI 911/911

Label 9

IMDG

Class 9

UN 3077

PG III

EmS F-A S-F

PI P002/IBC08

Label 9

Mark marine pollutant

RID/ADR

Class 9

UN 3077

PG III

Haz.no 90

PI P002/IBC08

Label 9

Classif.code M7

Proper shipping name

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

Technical name

cis-3-Methyl-5-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4pentadienyl-triphenylphosphonium chloride

15. Regulatory information
Classification and labelling according to EU directives

Xn R22 R36/37/38 R50/53 S22 S26 S37 S61 Note Water hazard class (Germany)

N

Harmful if swallowed. Irritating to eyes, respiratory system and skin. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable gloves. Avoid release to the environment. Refer to special instructions/Safety data sheets. - EU classification and labelling are based on data of a substance of similar structure 3: strongly hazardous for water (own classification according to directive VwVwS of 17.05.1999)
Replacing edition of: 5.9.06 Page: 5/6

Date: 22.12.06/CSE (SEISMO)

CRA-cis-salt

16. Other information
Use Safety-lab number - intermediate BS-7531 BS-6327 BS-6328 BS-7530

Edition documentation

- changes from previous version in sections 11

The information in this safety data sheet is based on current scientific knowledge. It should not be taken as expressing or implying any warranty concerning product characteristics.
Date: 22.12.06/CSE (SEISMO) Replacing edition of: 5.9.06 Page: 6/6


								
To top