Docstoc

THE BLOOD SEROTONIN LEVELS IN ASCITIC AND NON ASCITIC .pdf

Document Sample
THE BLOOD SEROTONIN LEVELS IN ASCITIC AND NON ASCITIC .pdf Powered By Docstoc
					Archive of SID
                                                                                                                                 71-75 ,1 ûoBíy,65 ûoôk ,1389 ,þßyrLìAk RBÛýÛdO |úéXì

                Qýu@úG çPHìpýÒ ô çPHì þPyõâÿBø|úWõW ok óõg òýðõOôpu fõÇu þuopG
                                                                 úPuAo@okBùG 2þ×ýËð lýÏu | *1Èýdì pýykoA
                                                             3

                                                      .óApüA–óçýâ ,óçýâ ûBãzðAk ÿqoôBzÞ ûlßzðAk þìAk ïõéÎ ûôpâ )|1
                                                             .óApüA–qApýy ,qApýy ûBãzðAk þßyrLìAk ûlßzðAk )2
                                       .óApüA–óçýâ ,óçýâ ûBãzðAk ÿqoôBzÞ ûlßzðAk ïAk ÿsõèõürýÖ {üApâ lyoA þuBñyoBÞ úPgõì@ {ðAk )3
                                                      |)1388 ûBì ÿk | 14 :þüBùð }pünK | , 1388 ûBì kAkpg| | 9 :úèBÛì QÖBüok|(|

                                                                                                                                                                          ûlýß^|
               lyo BG þPyõâÿBø|úWõWok IéÒA úÂoBÎ òüAqA þyBð RB×éO .lñPvø xBvc þHéÚ þüBuoBð úG QHvð ÿkBüqoAlÛì úG þPyõâÿBø|úWõW lülW ÿBø|úüõu
               úuok, îèBuô þPýu@ÿBø|úWõW ok óõg (5-HT|(òýðõOôpu óArýì úvüBÛì ,{üBìq@òüA qA Ùlø .lüBíð|þì qôpG Qýu@ÿoBíýG Roõ¾ úG ô ÐüpuoBývG
                                                   |
                                           «
               àüpøok.lyûkB×PuA þÖkB¿O çìBÞf pÆok êüoõPÞBÖ {üBìq@àüqAoõËñì òýíø úG .QuA ûkõG þPyõâÿBø|úWõWqA )JBÞô xçKqpÞ@oõGo@,xAo(úüõu
               îývÛO QívÚ ôk úG Bø|úðõíð òüA, óõg ÿpýâúðõíðô ÿoAnâûoBíyqA wK ô lyAlW Qýu@úG çPHì úWõW úÏÇÚ 12ô îèBuúWõW úÏÇÚ 12 oõGrì úüõuúuqA
               okïpuòýðõOôpuóArýìòýýÏOoõËñìúGpãük{hGôlükpâÿoô@ÐíWþðõgÿBø|úXñuApÖþgpGþuopGÿApGEDTA| ÿôBc ÿBø|úèõèok QívÚ àü.lðly
                                                                                                            |
               QulGYüBPðqA.lükpâòýýÏOBø|RôB×OÜýÚkêdìòßðAk}ôoBGôlðlyúvüBÛìwðBüoAôúürXO}ôoqAûkB×PuABGBøoBíýOlyúPhüoEDTA|óôlGÿBø|úèõè
                                                                                                                             |
               qApO òýüBK ÿoAk þñÏìoõÇG þPýu@ÿBø|úWõWok óõg òýðõOôpu.(p<0/05)| lñPvøoAk|þñÏì ÙçPgA ÿAoAk óõg òýðõOôpupËðqA úüõuúu:lyïõéÏì ûlì@
               ú^pâA úÞ QÖpâúXýPð óAõOþì Anè.(p<0/05)|koAk kõWôoAk|þñÏì êGBÛPìpýSBO óõg òýðõOôpupËðqA ÿoBíýGô úüõuòýG.(p<0/05)|QuA îèBuÿBø|úWõW
                                        |                                                                             |
               Qýu@úG çPGAqA lÏG ,Bø|úWõW óõgok ó@óArýì þèô kõy|þì Qýu@ÿoBíýGqôpGô ÿõüo óõgoBzÖ {üArÖA UÎBGô ûkõG ÝôpÎ ûlññÞäñO êìBÎ àü òýðõOôpu
                                                                                                                                   | .lGBü|þì {øBÞ
                                                                                                                         .Qýu@,þPyõâÿBø|úWõW ,óõg òýðõOôpu:ÿlýéÞÿBø|ûsAô

    Roõ¾ úG úÞ kõy|þì eypO ÿõüo þñüpÞôlðA ôoõð ÿBø|ëõéu qA þÏÂõì oõÇG
    I¿Î åAô I¿Î ÈuõOô lñPvø þèBýéPýKA ôoõð ÿBø|úÚBu ïBð úG þüBø|oBPgBu                                                                 úìlÛì
    ô)13(lñyBG|þì òýð õOôpu | ÿôBc ÿBø|ëõðApâqA þñÒ Bø|ëõéu òüA lðA|ûly þøk                                                  ö
                                                                                               úÞlyBG|þìÿõüoÝôpÎÿõÚôpSõìûlññÞäñOàüôþHéÚápdìàüòýð õOôpu
    ok ótývÞA {øBÞ úG iuBK okBø|ëõéu òüA qA òýð õOôpu ÿkBüq pükBÛì eypO                        úÂoBÎ qôpG ô ÿõüo óõg oBzÖ {üArÖA IHu Bø|úWõW| | åo óôok úG ó@ ÜüorO
    ok òýð õOôpu þíÞ pükBÛì þÏýHÆ QèBc ok )21(lPÖA|þì ÝB×OA þüAõø ÿoBXì                        ólGþìõíÎÿBø|åo| ólykBzâIHuþvÞAõLýøÈüApy.)28(kõy|þìQýu@
    ÝôpÎqA Bø|QÞçK úÞ þìAkBì luo|þì pËð úG lyBG|þì ÿpýâ|ûqAlðA êGBÚ BíuçK                      ÜüpÆ qA êíÎ òüA lñÞ|þì ÅBHÛðA úGoAkAô Ao ÿõüo ÿBø|åo îPvýu BìA,kõy|þì
    qA þÞBc þÞolì aýø ô lðpýâ|þì Ao kõg òýð õOôpu lññÞ|þìoõHÎ }oAõâûBãPuk                      Roõ¾ àüspðok@ ÿBø|óõìoõøô òýð õOôpu ,òýéO ôlðA þâo ÿBø|ûlññÞ| |äñO
    kõW ô lñyBG òýð õO ôpu lýè õO úGokBÚ lyo êcApì qA àüpøok Bø|QÞçK úÞ|òüA                    kõHíÞ lð õy|þì eypO JB¿ÎA ÿBùPðA Büô ëBýéOôlðA ÿBø|ëõéu qA úÞ kpýâ|þì
    ÐíXOïBãñøokôûlyûpýgmBø|QýuõHìôpOokóBâlðpKokòýð õOôpu.)16(koAlð                             ok Ao þíýuBPK ÿBø|ëBðBÞ sBPèô úG úPvGAô ÿBø|ú`üok kpßéíÎ lüly órLývÞA
    ÿBø|úWõW ok þüõñ¿ìoõÇG Qýu@ úÞ þüBø|{üBìq@ok.)5(kkpâ|þì kAq@ Bø|ó@                         óly ûrüoçKk úGpXñì úÞ lñÞ|þìoBùì ÝôpÎoAlW ÙB¾ ÿA|ú`ýøBì ÿBø|ëõéu
    ô þüBüpPÞBG lüoBÞBu þéK õLýè lñðBì þÞpdì kAõì ÜüorO qA ûkB×PuA BG ô ,þPyõâ                 kõy|þì åo ÅBHÛðA úXýPðok ô þíuçK õPýu îývéÞ QËéÒok {üArÖA BG BzÒ
    UÎBGkAõìÜüorOúÞlükpâûløBzìlykBXüABø|ó@ëBGlüoôúGÿrèõéurüoRAom                               x õð õOokpünKQzâpGRApýýÓOUÎBG,RlìûBOõÞôlülyótývÞA|kõHíÞ.)26(
    àüpdO qA þyBð ÑõÂõì òüA êýèk kõy|þì BíuçK òýð õOôpu {üArÖA                                                 |
                                                                                               pýTßOBGÿoBPgBupýýÓOIHuRlìþðæõÆótývÞAkõHíÞúßýèBcokQuAþâo
    ÿkBÎ QèBc ok )1,|2,|3,4(lyBG|þì kAõì òüA ÜüorO pSA ok Bø|QýuõHìôpO                         äñO pSA .)8(kõy|þì Bø|åo oAlW ok ÙB¾ ÿA|ú`ýøBì ÿBø|ëõéu RpWBùìô
    úG QHvð ÿpPzýG þâpgpu óõg oBzÖ Qýu@ úG xBvc þPyõâ ÿBø|úWõW                                 óAõñÎ QdO àüspðok@ÿBø|ûlðpýâÈuõO úüo | ÝôpÎ ÿôopG òýð õOôpu þâlññÞ
    kAõì ÿlüoô | ÜüorO BG Qýu@ ÿBÛèA ÈüApyokô lðoAk Qýu@ úG ïôBÛì ÿBø|úWõW                     pPzýG .)22( kõy|þì ïBXðA)|5-HTT|( òýð õOôpu êÚBð ô |5-HT2A| ô|5-HT1B|
    xBvc ÿBø|úWõW qA pPzýG ïôBÛì ÿBø|úWõW ok óõg oBzÖ pýýÓO ápdì                               lýèõO ûkôo òýÖBìôpÞôpPðA ÿBø|ëõéu ÈuõO óõg }kpâok kõWõì òýð õOôpu
    þPyõâ ÿBø|úWõWok þèBG lüoô úG òýð õOôpu îýÛPvì ÜüorO.)10,20(lyBG|þì                        ok ûpýgm Roõ¾ úG Bø|QÞçK óôokok óõg }kpâok òýð õO ôpu ô )21(kkpâ|þì
    50 óõgoBzÖ {üArÖA ô QuA ûly ÿõüo óõg oBzÖ ok þÏüpu {üArÖA UÎBG                             ÐíXO ,ûBãzüBìq@ ÈüApy ok ,oõýÆ ok .)16(koAk oApÚ BPèk ÿBø|ëõðApâ
    ïôBÛìÿBø|ÿBø|úüõuJBhPðA)5(QuAûkõGÜüorOqAêHÚó@oAlÛìqApPzýGl¾ok                              òýð õOôpu.)6(QuAûlyûløBzìòýð õOôpuoõÃcúGiuBKokBø|QýuõHìôpO



                                                                            |Email: |ar_mohit@guilan.ac.ir| | 0131-6690274 :pGBíð 0131-6690274 :ò×éO :ëôõvì ûlñvüõð)∗
                                                                                                                                                        ö
                                                                                                                                                                www.SID.ir
ArchiveBíof6SID,þßyrLìAk RBÛýÛdO úéXì
  |1389 ,1 ûo y , 5ûoôk                                                                                                                                     72
  | ïpu òýðõOôpu pËð qA Bø|ó@ êGBÛPì pýSBOô ØéPhì êìAõÎ úvüBÛì qA ê¾Bc YüBPð –1 ëôlW   úüo ÝôpÎ QýÖpÊ þPýèBÏÖ ô ÿoBPgBu kõHùG úG qBýð ÿõüo óõgoBzÖ {üArÖA úG
                           .QuA ûly û kAk óBzð ápPzì pýÒ Ùôpc BGoAk|þñÏì ÿBø|RôB×O*
                                                                                       úG þÏýHÆ |oõÇG úÞ þPyõâ ÿBø|úWõW óõg òýð õOôpu ÿôo óõñÞ BO )27(koAk
   |(ng/ml(|ïpu òýð õOôpupükBÛì*       êìBÎpø f õÇu                   êìBÎ             ÿBø|úWõW óõg BG ó@úvüBÛìô Bø|ó@ok ÿoBíýGqôpGqA lÏG ô lðA|ûly çPHì Qýu@
         |2234/66±136 /5a                 JBÞ                                          òýð õOôpu eÇu þuopG {øôtK òüA Ùlø | ô QuA ûlzð ïBXðA þÛýÛdO îèBu
           |2161/92± 183/2|a             xAo                         úü õu| |
        |1995/74± 154/55b              xçKqpÞ @o õGo@                                  | îèBu ÿBø|úWõW òýG RôB×Oô þPyõâ ÿBø|úWõW ØéPhì ÿBø|úüõu ok óõg
        |2298/64± 105/53a                  îè Bu                    ÿoBíýG| |                                                                 .QuA ûkõG çPHìô
          |1962/91± 210/6b                 þPýu@
         | |2333/66± 118/4a              îèBu JBÞ
        |2136/33± 154/6|bc
           | |2318/75±106/3a
                                        þPýu@JBÞ
                                         îèBu xAo
                                                                                                                   oBÞ}ôoôkAõì
                | |2005/08± 260c        þPýu@xAo                   êGBÛPìpSA | |       ô JBÞ ,xAo úüõu úu úÞ ,þPyõâ ÿBø|úWõW }oôpK úÎorì úu qA
            | |2244/16± 91/9ab      îèBu xçKqpÞ @o õGo@
          |1747/33±217/2d           þPýu@xçKqpÞ @o õGo@                                óBvßü þÇýdì ÈüApypüBu ô òupËð qAô lðkAk|þì }oôpK Ao xçK qpÞ @oõGo@
                                                                                       úP×ø ok QyAlð kõW ô Bø|ó@ok Bø|ÿoBíýG püBu úG çPGA úÛGBu òýñ`íø ô lðkõG
   ÿpPíÞóõgòýð õOôpuÿAoAkxçKqpÞ @oõGo@úüõuô|(p<0/05)|lðkõGoAk|þñÏì                     pø qA( Qýu@ úG çPHì úWõW úÏÇÚ 12ô îèBu úWõW úÏÇÚ 12,}oôpK îP×ø
   ÿoAk|þñÏì RôB×O JBÞô xAo òýG.(p<0/05)|kõG JBÞô xAo ÿBø|úüõu úG QHvð                 ïBXðAkõGpPzýGQýu@ÑõýyúÞóBPvìqê¿Öokÿpýâ|úð õíð.lükpâAlW)úüõu
   oõÇG þPýu@ ÿBø|úWõW óõg ïpu òýð õOôpu .(p<0/05)|lzð| ûløBzì                         ,þñýèBG RBý¾õ¿g ÿôoqA AlPGA ,Qýu@úG çPHì ÿBø|úWõW ÿqBu|AlW ÿApG .ly
   ô úüõu òýG êGBÛPì pýSBO .(p<0/05)|kõG îèBu ÿBø|úWõW qA pPíÞ ÿoAk|þñÏì               ,QuõK óly ûqõðBýu ô þâkpvÖA,{üoô ZBO þßzgô þâkoõg òý^ lñðBì
   ÿoAk|þñÏì RôB×O þPýu@ xAo ô þPýu@ JBÞ.(p<0/05)|lükpâoAk|þñÏì ÿoBíýG                 qA wK ô lðly AlW Qýu@ úG áõßzì ÿBø|úWõW ÿpPzýG kAlÏO
   þPýu@ xAo ô îèBu JBÞ ok óõg ïpu òýð õOôpu .(p<0/05)|lñPyAlð                         þÏÇÚ òýýÏO ÿApG.ly úPÖpâ Bø|ó@ úíø qA óõg úð õíð,ÿoAnâ|QìçÎ
   .(p<0/05)QyAk ÿoAk|þñÏì RôB×O îèBu JBÞ BG þPýu@ xçKqpÞ @oõGo@rýð ô                  ÿBø|úWõW qA þüBzâ lHèBÞok .QÖpâ Roõ¾ þüBzâ lHèBÞ,þPýu@ ÿBø|úWõW
   ûløBzì ÿoAk|þñÏì RôB×O îèBu xçK qpÞ @oõGo@ ô îèBu xAo ô îèBu JBÞ òýG                óôok ok äðo koq ÐüBì ÿkBüq pükBÛì ÐíXO êìBy þüBø|úðBzð Qýu@ úG çPHì
   ô îèBu ÿBø|úWõW òýG RôB×O ,þð õg ÿBø|úXñuApÖpüBupËðqA.(p<0/05)|lzð                  Bø|úüo þð õgpK ,þPéßu ÿBø|ú`ýøBì óly ûpýO ,koBßüpK úvýÞ ô þíßy ûp×c
   }oBíy koõìok ÿoBíýG ô úüõu òýG êGBÛPìpýSBO .(p<0/05)|lyoAk|þñÏì çPHì                oõËñì úG .kõG kpâ ó@ úHèô ïAõÚoB^k lHÞ òýñ`íø.ly ûløBzì Bø|úýéÞ ïoõOô
   òÇG ô k ÑõíXì úG QuAo òÇG QHvð ô QüpÞõOBíø ,rìpÚ ÿBø|ëõHéâ                          ô lðA|ûkõG çPHì Qýu~ BùG ÐÇÚoõÆ úG ûly JBhPðA ÿBø|úWõW úÞ|òüAqA óBñýíÆA
   ÿoBíýG ô úüõu êGBÛPì pýSBO ,òýGõéâõíøkoõì ok þèô (p<0/05)|lyoAk|þñÏì                QuAo òÇG QHvð QuA ûlzð ÝõÖ îDçÎqôpG IWõì þv×ñO ÿBø|ÿoBíýGpüBu
                                                   .(p<0/05)|lzðoAk|þñÏì               òüA úÞ þüBø|úWõW ok ô lükpâ òýýÏO Bø|ó@ ok| )RV/TV(|òÇG ô k ÑõíXì úG
                                                                                                       .)11,15(lðly úPgBñy þPýu@óAõñÎ úG kõGpO æBG 0/229qA QHvð
                                       UdG                                             îývÛO{hGô kúGîèBuôþPýu@ÿBø|úWõWqAûlyúPÖpâÿBø|óõgúð õíð
   oõÆ úG þPýu@ ÿBø|úWõW ok ïpu òýð õOôpu eÇu {üBìq@ òüA ok                            þuopG ÿApG |EDTA |kBÛÏðA l ûkBì ÿôBc ÿBø|úèõè ok QívÚ àü.ly
   kõWõì òýð õOôpu .)1 ëôlW(QuA ûkõG îèBu ÿBø|úWõW qApPñýüBK ÿoAk|þñÏì                 êßy ô Bø|ëõHéâ }oBíy,QüpÞõOBíø l¾ ok lñðBì óõg ØéPhì RBý¾õ¿g
    òýð õOôpuôl¾ok98 BO95 óArýì úG þPÞçK òýð õOôpu êìBy óõg }kpâ ok                    ûkBìóôlGÿBø|úèõèêgAkokpãük{hG ôQÖpâoApÚûkB×PuAkoõìBø|ó@ÿpøBÊ
   òüAok òýñ`íø |)17,18,19,21( lyBG|þì l¾ok5BO2 óArýì úG BíuçKok kõWõì                 ÿpýâ|ûqAlðA ÿApG.QÖooBßG òýð õOôpu ÿpýâ|ûqAlðA ÿApG úÞ ly úPhüo kBÛÏðA lÂ
   oBíy pËð qA þPýu@ô îèBu ÿBø|úWõW| òýG þ¿hzì RôB×O {üBìq@                            óBíè@| Labor Diagnostika NordQÞpyúGÉõGpìArüæAQýÞqAïpuòýð õOôpu
   |kõW ô QÖpâ oApÚ úWõO koõì úÞ ÿrý^ þèôlzð ûløBzì Bø|QýuõHìôpO                       àüok êüoõPÞBÖ {üBìq@ àü qA ûkB×PuA BG ûlì@ QulG ÿBø|ûkAk.ly ûkB×PuA
   ,Qyok ÿBø|êD õÞAô ÿôBc ô pPâorG QHvð úG ô pßýK ëõÒ ÿBø|QýuõHìôpO|                   ó@ok úÞQÖpâoApÚ êýédO ô úürXO koõìoApßO 12 BG |(CRD)| þÖkB¿O"çìBÞf pÆ
   okrýðþÏýHÆpýÒÿBø|QýuõHìôpOúÞkõGþPýu@ÿBø|úWõWþð õg}pPvâok                            îèBu ÿBø|úWõW ô ëôA êìBÎ óAõñÎ úG xçKqpÞ @oõGo@ô JBÞ,xAo úüõu úu
    ÿpøBÊ êßy ÿôo | pG Qýu@ luo|þì pËð úG YüBPð òüA qA.ly ûlük Bø|ó@ òýG               òýãðBýì òßðAk } ôoqA ûkB×PuA BG ô ly úPÖpâpËðok ïô k êìBÎ óAõñÎ úGoBíýG ô
   úG qBýð ó@ ûlðoô@ kõWõG oBÞ ôqBu BìA QuA úPyAk ÿkBüqpýSBO Bø|QýuõHìôpO                 .ly ïBXðA| SAS|oArÖA ïpðqA ûkB×PuA BG úÆõGpì RBHuBdì .ly úvüBÛì BøoBíýO
                                                 .koAk ÿpO|ÜýÚk ÿBø|{üBìq@
   IHu ÝôpÎ êgAk ok îø oô k úG Bø|QýuõHìôpO ókpÞ ÐíW BG òýð õOôpu                                                       YüBPð
   úGBø|QýuõHìôpOÐíXO.)6,15(kõy|þìBø|åoóôokà^õÞÿBø|úPhèêýßzO                           òüA .QuA ûly ûkAk {üBíð ,2ô1 ëôAlW ok Bø|ûkAk úürXO qA ê¾Bc YüBPð
   ïBXðA QuA òýð õOôpu ÿBø|ûlðpýâ qA þßü úÞ |5HT2| Ñõð ûlðpýâ úÇuAô                    ÙçPgA ÿAoAk óõg òýð õOôpu pËð qA úüõu úu :lñyBG|þì püq fpy úG YüBPð



                                                                                                                                                  www.SID.ir
Archive of SID
    73                                                                                                      ...çPHì þPyõâ ÿBø|úWõW ok óõg òýðõOôpu fõÇu þuopG

                             .QuA ûly û kAk óBzð ápPzì pýÒ Ùôpc BGoAk|þñÏì ÿBø|RôB×O¥þðõg ÿBø|úXñuApÖ püBupËð qA Bø|ó@ êGBÛPì pýSBO ô ØéPhì êìAõÎ úvüBÛì qA ê¾Bc YüBPð–2ëôlW
      êÞ úG QuAo òÇG QHvð¥        |(g/dl( òýGõéâõíø¥               % QüpÞõOBíø¥
               Bø|òÇG                                                                            )|×10|6|/ml|(rìpÚ ëõHéâ|¥|          êìBÎpø f õÇu                êìBÎ
           0/27±0/033 |a|          | 11/675±1/525 |a|                    32/4±4/448 |b|                   |2/844±0/411a                   JBÞ
          0/265±0/045a               12/315±1/484a                  | 35/06±4/493|a|                    2/704±0/442a                     xAo                     úü õu
          0/274±0/028a                11/52±0/892 |a                  32/64±2/683|b                    |2/667±0/213a |              xçKqpÞ @o õGo@
          0/172±0/021 |b|              | 10/63±1/12 |b|                 |29/51±3/905 |b|               2/438±0/292 |b|                   îè Bu                  ÿoBíýG
          0/373±0/051a|              13/047±1/48a                       37/23±4/63a                     3/039±0/419a |                  þPýu@
           0/187±0/021|b|             10/30±1/298|a|              | 27/64±3/569|d|                   | 2/475±0/362|c|                  îèBu JBÞ
          0/368±0/046|a|              13/05±1/752|a|                37/16±5/33|ab                       | 3/214±0/461|a               þPýu@JBÞ
          0/165±0/019|bc|             10/96±1/257|a|                 | 30/96±3/588|c|               | 2/362±0/372|c                    îèBu xAo                êGBÛPìpSA
          0/365±0/072|a|             13/67±1/712|a|                   | 39/16±5/398|a               3/046±0/513|ab                    þPýu@xAo
          0/164±0/023|c|              10/62±0/792|a|                     29/92±2/139|c                  2/477±0/142|c|            îèBu xçKqpÞ @o õGo@
          0/385±0/034|a|              12/42±0/992|a|                35/36±3/174|b|                      2/858±0/284|b|            þPýu@xçKqpÞ @o õGo@

    RAløBzì BG ô kkpâ|þì þPýu@ÿBø|úWõWok Bø|ó@óly åorG ô Bø|QýuõHìôpO                       oBzÖpPzýG {üArÖA UÎBG ÿõüo ÿBø|åpgpuok Bø|úPhè òüA êýßzO Anè|kõy|þì
                                                .koAk QÛGBÇì ÜýÛdO òüA YüBPð ô              kõgêíÎúÞ|òüAqAwKóõgóBüpWúGûlykAq@òýð õOôpuôkkpâ|þìÿõüoóõg
    ûlñølðBzð Qýu@ÿoBíýG ô úüõu êìBÎ ô k òýGoAk|þñÏì êGBÛPìpýSBO kõW ô                      þvÞôolýø–5 úG ô ûly úürXO qAlývÞA òýì@õð õì îürð@ úéýuô úG kAk ïBXðA Ao
    ô úPyAk ÿpPzýG QìôBÛì ÿoBíýG| |úG çPGA êGBÛìok Bø|úüõu þÃÏG úÞ QuA òüA                  ÈuõO Büô kõy|þì ÐÖk oAokA ÜüpÆ qAô ûly êülHO lýuA àýPuæ ôlñüA
    ok|pãük ÙpÆqA QuA úPyAk Ao ÿpPzýG RApýýÓO Bø|ó@ok óõg òýð õOôpu f õÇu                   ô k òüA kõy|þì JnW ûoBG ô k ëBÏÖ JnW qBG ÜüpÆ qAô Bø|QýuõHìôpO
    qA pPzýG ÿoAk|þñÏìoõÆ úG xAo ÿBø|úWõW ok QüpÞõOBíø óArýì {üBìq@ òüA                     RApýýÓO óArýì ûlññÞ òýýÏO òýð õOôpu óly úürXOô Bø|úPhè qôpG þñÏükAlüôo
    koAk kõW ô ÿA|úýÂpÖ úÇGAo òüAokô )2 ëôlW|)|QuA ûkõG xçKqpÞ @oõGo@ô JBÞ                  ô óõýuçývÞôolýø ÜüpÆ qA ólG ok òýð õOôpu .lyBG|þì óõg òýð õOôpu ok
    þSôoõì QýøBì þPyõâ ÿBø|úWõW QüpÞõOBíø þHvð }qoA úÞ|òüA pG þñHì                                              .)9(kõy|þì lýèõO óBÖõPLüpO úñýì@lýuA óõýuçývÞõGpÞk
    ûkB×PuA koõì Bø|úWõW QìôBÛì òýýÏOok þ¿gBy óAõñÎ úG lðAõO|þì ô úPyAk                     QgBu lð ôo ok qBýð koõì êìAõÎ pãükô óBÖõPLüpO úñýì@lýuA òýìBO Anè
    úG ÿpPzýG QýuBvc kpu ÿAõøokpOæBG QüpÞõOBíø BG ÿBø|úWõW ô kpýâoApÚ                       BñG )23,24(QuA þùülG ÿpìA úPÖo Quk qA óArýì| |òýìBOoõËñì úG,òýð õOôpu
    BG þè ô koAk ÄÚBñO óBÛÛdìqA þÃÏG YüBPð BG úýÂpÖ òüA lñ^pø)25(lðoAk Qýu@                 qBÒ@ok Bø|úWõW ok ïpuô BíuçK òýð õOôpu óArýì koAk ëBíPcA ú^ pâA òüApG
    JBhPðA Bø|úüõu þÃÏG úÞ QÖpâ úXýPð óAõO|þì {üBìq@ òüA YüBPð úG úWõO                      óBìq Qynâ BG þèô lyBG úPÖBü þð ôrÖ ÿõüo óõg oBzÖ {üArÖA úG óly oB^k
    lðoAk oApÚ kpu ÿAõøô J@ BG Ð×Opì ÉBÛð ok úÞ þyoôpK ÑoArì ÿApG þHuBñì                    ûApíø úG Ao Bø|úWõW þðAõOBð ô þPvu úÞ ÿoBíýG ïôAlO ô RBßüpdO úìAkAô
                          ö
    úÂoBÎòüAëpPñÞokpSõìÿBø|ûAoqAþßüïôBÛìÿBø|úüõuJBhPðAAnè.lñyBG|þíð                         ûBãPuk ÀÚBð kpßéíÎ òýñ`íøô ûly áAoõg úG þupPuk ïlÎ UÎBGkoAk
                                                                  | | .lyBG|þì                                                                         «
                                                                                            óArýì úXýPð okô xpPuk ok óBÖõPLüpO úñýì@ lýuA óArýì qAæBíPcA }oAõâ
                                                                                            ÿôo ûly ïBXðA ÿBø|þuopG pãük ÙpÆ qA .)7(løBÞ|þì óõg òýð õOôpu
                                                                                            ÿBø|úWõWok úÞ QuA ûkAk óBzð IéÚ RçÃÎ àüspðok@ BPG ÿBø|ûlðpýâ
                               References                                                   BPG ÿBø|ûlðpýâ îÞApO lñPvø çPHì Qýu@ô QuAo òÇG þüBuoBð úG úÞ þPyõâ
    1. Bowen, O. T., Erf, G. F., Anthony, N. B., Wideman, R.
        F. (2008) Pulmonary hypertension triggered by
                                                                                            qA þßüô)12(QuA ûkõG îèBu ÿBø|úWõW qA pPíÞ ÿoAk|þñÏì oõÆ úG àüspðok@
        lipopolysaccharid in ascites-susceptible and -resistant                             ëB¿OA lðAõO|þì Qýu@ úG çPHì ÿBø|úWõW ok óõg òýð õOôpu {øBÞ êüæk
        broiler in not amplified by aminoguanidine,a specific                               úG qBýð ûlñü@ok úÞ lyBG Bø|ó@ ÈuõO óly úÞõéG ôoõGrì ÿBø|ûlðpýâ úG ó@pPzýG
        inhibitor of inducible nitric oxide synthase. Poult. Sci.                           Ì×c ÿApG úÞ þüBøoBÞôqBu òýñ`íø.koAk kõW ô úñýìq òüAok ÿpPzýG úÏèBÇì
        87:125-132.                                                                         ÿõüoóõgoBzÖþÏýHÆûkôldìÌ×cokþÏulðoAkkõW ôólGokëkBÏOQèBc
    2. Bowen, O. T., Erf, G. F., Chapman, M. E., Wideman,                                   êìBy ÝôpÎ ûlññÞ kBzâ êìAõÎ óly ëBÏÖ úG óAõO|þì Bø|ó@ úéíW qA úÞ lðoAk
        R. F. (2008) Plasma nitric oxide concentrations in                                  eypO ÝôpÎ ïõýéO ôlðA qA úÞkõíð ûoByA òýéßüBuBPuôpKô àüpPýð lývÞA
        broiler        after       intravenous            injections               of
                                                                                            úéGBÛíüõüoóõgoBzÖ{üArÖAápdìêìAõÎBGúÞQuAþùülGAnè)14(lð õy|þì
        lipopolysaccharide or microparticles. Poult. Sci.
                                                                                            qApO òýüBK çPHì ÿBø|úWõWok Ao óõg òýð õOôpu f õÇu BPuAo òýíøokô lññÞ
        87:636-644.
                                                                                            qA ÿpýâõéW ÜüpÆqAAooBÞòüAôlñðBupG êÚAlc úG Apð@pSA BO úPyAk ûBãð þÏýHÆ lc
    3. Chapman, M. E., Wideman, R. F. (2006) Evaluation of
        the serotonin receptor blocker methiothephin in broiler
                                                                                            ok kõWõì òýð õOôpu JnW ô Bø|QýuõHìôpO ÈuõO òýð õOôpu óly kAq@
        injected intravenously with lipopolysaccharide and                                  óôokÿBø|êD õÞAôîXc{üArÖAúGpXñìúÞlñøk|þìïBXðABø|ó@úéýuõGBíuçK



                                                                                                                                                        www.SID.ir
ArchiveBíof6SID,þßyrLìAk RBÛýÛdO úéXì
  |1389 ,1 ûo y , 5ûoôk                                                                                                      74
      microparticles. Poult. Sci. 85:2222-2230.                       the drinking water on right ventricular failure and
   4. Chapman, M. E., Taylor, R. L., Wideman, R. F. (2006)            ascites in broiler chickens. Avian Phthol. 16:61-71.
      Analysis of plasma serotonin levels homodynamic              16. Keele, C. A., Neil, E., Joels, N. (1982) Samson
      responses following chronic serotonin infusion in               Wrights Applied Physiology. (30thed.) Oxford
      broilers challenged with bacterial lipopolysaccharide           Medical Publications. London,UK. pp.558-559.
      and microparticles. Poult. Sci. 85:528-536.                  17. Kereveur, A. Callebert, J., Humbert, M., Herve, P.,
   5. Chapman,      M.    E., Wideman,        R.    F.   (2002)       Simonneau, G. Launay, J. M., Drouet, L. (2000) High
      Homodynamic responses of broiler pulmonary                      plasma serotonin levels in primary pulmonary
      vasculature to intravenously infused serotonin. Poult.          hypertension: effect of long-term epoprostenol theapy.
      Sci. 81:231-238.                                                Arterioscler. Thromb. Vasc. Biol. 20:2233-2239.
   6. Currie, R. (1999) ascites in poultry: recent                 18. Lachin, F., Dijs, B. V., Lachin, A. E. (2002) Pulmonary
      investigation. Avian Pathol. 28:313-326.                        hypertension, left ventricular dysfunction and plasma
   7. Elizabeth Liner, A., Diaz, J., Ni, W., Szasz, T, Burnett,       serotonin. Br. J. Pharmacol. 137:937-938.
      R., Watts, S. W. (2008) Vascular reactivity 5-HT             19. Lee, S. L., Wang, W. W., Lanzillo, J. J., Fanburg, B. L.
      uptake and blood pressure in the serotonin transporter          (1994) Serotonin produces both hyperplasia and
      knockout rat. Am. J. Physiol. (Heart and Circulatory            hypertrophy of bovine pulmonary hypertension. Am.
      Physiology). 294:1745-1752.                                     J. Physiol. 266:46-52.
   8. Farber, H. W., Loscalzo, J. (2004) Pulmonary arterial        20. Lorenzoni, A. G., Anthony, N. B., Wideman, R. F.
      hypertension. The Eng. J. Med. 351:1655-1665.                   (2008) Transpulmonary pressure gradient verifies
   9. Ganong, W. F. (2003) Review of medical physiology.              pulmonary hypertension is increased arterial
          th
      (21 ed.) McGraw Hill Companies. SanFrancisco,                   resistance in broiler. Poult. Sci. 87:138-145.
      USA. Inc. pp. 181-257.                                       21. Maclean, M. R., Herve, P. Eddahibi, S., Adnot, S.
   10. Hamal, K. R., Wideman, R. F., Anthony, N., Erf, G. F.          (2000) 5-hydroxytryptomin and the pulmonary
      (2007) Expression of inducible nitric oxide synthase in         circulation:receptors,transporters and relevance to
      lung of broiler chickens following intravenous                  pulmonary arterial hypertension. Br. J. Pharmacol.
      cellulose microparticle injection. Poult. Sci. 86:984-          131:161-168.
      998.                                                         22. Marcos, E., Adnot, S., Pham, M. H., Nosjean, A.,
   11. Hassanzadeh, M., Bozorgmeifard, M. H., Akbari, A.              Raffestin, B., Hamon, M., Eddahibi, S. (2003)
      R., Buyse, J., Decuypere, E. (2000) Effect of                   Serotonin transporter inhibitors protect against
      intermittent lighting sehedules during the natural              hypoxic pulmonary hypertension. Am. J. Respira.
      scotoperiod on T3-Induced ascites in broiler chicken.           Crit. Care Med.168:487-493.
      Avian Pathol. 29:433-439.                                    23. Sainio, E. L., Pulkki, K., Young, S. N. (1996) L-
   12. Hassanzadeh, M., Buyse, J., Decuypere, E. (2001)               tryptophan:       biochemical,      nutritional        and
      Relationship between myocardial β-adrenergic                    pharmacological aspects. Amino Acids.10:21-47.
      receptor characteristics and the incidence of ascites in     24. Schaechter, J. D., Wurtman, R. J. (1990) Serotonin
      broiler chickens. Avian Pathol. 30:169-174.                     release varies with brain tryptophan levels. Brain Res.
   13. Ito, S., Ohta, T., Nakazato, Y. (1999) Characteristics of      532:203-210.
      5-HTcontaining chemoreceptor cells of the chicken            25. Shosberg, A., Bellaiche, M., Zeitlin, G., Ya`acobi, M.,
      aortic body. J. Physiol.16:61-67.                               Cahaner, A. (1996) Hematocrit values and mortality
   14. Jane, A., Ali, M. F., Baily, L., Moreno, L., Harrington,       from ascites in cold-stressed broilers from parents
      L. S. (2008) Role of nitric-oxide and prostacyclin as           selected by ematocrit. Poult. Sci. 75:1-5.
      vasoactive hormones released by the endothelium.             26. Sweeney, M., Yuan, J. X. (2000) Hypoxic pulmonary
      Exp. Physiol. 93:141-147.                                       vasoconstriction: role of voltage gated potassium
   15. Julian, R. J. (1987) The effect of increased sodium in         channels. Respir. Res. 1:40-48.




                                                                                                                   www.SID.ir
Archive of SID
    75                                                           ...çPHì þPyõâ ÿBø|úWõW ok óõg òýðõOôpu fõÇu þuopG

    27. Wideman, R. F., Chapman, M. R., Hamal, K. R.,
        Bowen, O. T. Lorenzoni, A. C., Erf, G. F., Anthony, N.
       B. (2008) An inadequate pulmonary vascular capacity
       and susceptibility to pulmonary arterial hypertension
       in broiler. Poult. Sci. 87:146-154.
    28. Wideman, R. F., Chapman, M. E., Wang, W., Erf, G. F.
        (2004) Immune modulation of pulmonary
       hypertension response to bacterial lipopolysaccharide
       (endotoxin) in broiler. Poult. Sci. 83:624-637.




                                                                                                  www.SID.ir
Archive of SID
    89                                                                                         J. Vet. Res. 65, 1:71-75, 2010


    THE BLOOD SEROTONIN LEVELS IN ASCITIC AND NON
                  ASCITIC BROILERS
                                                 Mohit, A.1*, Nazifi, S.2, Arasteh, B.3
                    1
                        Department of Animal Sciences, Faculty of Agriculture, University od Guilan, Rasht-Iran.
                2
                    Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz-Iran.
                                          3
                                          Graduated from the Guilan University, Rasht-Iran.
                                         (Received 30 May 2009 , Accepted 4 January 2010)


       Abstract:
              Modern strains of broiler are highly susceptible to heart failure. Heart related mortalities are
          observed predominantly in fast growing broiler chickens. The aim of this study was to investigate
          serotonin levels in ascitic and non ascitic broilers of three strains (Ross, Arbor Acres plus and Cobb).
          In this respect, a factorial test in CRD method applied for the statistical analyses. In each of these three
          strains, 12 ascitic and 12 non-ascitic broilers were selected. After tagging and blood sampling, blood
          were collected and divided in two parts. One part was applied for some blood hematological
          assessment and other part was used for determining serum serotonin levels. The results showed
          significant differences among the strains (p<0.05). The blood serotonin levels of ascitic chickens were
          significantly lower than the non ascitic ones (p<0.05).There was a significant interaction between
          strain and disease in blood serotonin levels(p<0.05).
       Keywords: blood serotonin, broiler, ascites.

    *Corresponding author’s email: ar_mohit@guilan.ac.ir, Tel: 0131-6690274, Fax: 0131-6690274




                                                                                                                   www.SID.ir

				
DOCUMENT INFO
Shared By:
Categories:
Tags:
Stats:
views:0
posted:1/17/2013
language:Slovak
pages:6