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					SIGMA-ALDRICH MATERIAL SAFETY DATA SHEET Date Printed: 08/03/2004 Date Updated: 04/04/2004 Version 1.5 Section 1 - Product and Company Information Product Name Product Number Brand Company Street Address City, State, Zip, Country Technical Phone: Emergency Phone: Fax: RESERPINE CRYSTALLINE R0875 SIGMA Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 US 314 771 5765 414 273 3850 Ext. 5996 800 325 5052

Section 2 - Composition/Information on Ingredient Substance Name RESERPINE Formula Synonyms CAS # 50-55-5 SARA 313 No

C33H40N2O9 Anquil * Apoplon * Banasil * Bioserpine * Crystoserpine * Deserpine * Diutensen-R * Elserpine * ENT 50146 * Escaspere * Eserpine * Eskaserp * Gilucard * Hiposerpil * Kitine * Klimanosid * Lemiserp * Loweserp * Mayserpine * Methylreserpate 3,4,5-trimethoxybenzoic acid * Naquival * NCI-C50157 * Quiescin * Raucap * Raulen * Raupasil * Raupoid * Raurine * Rausan * Rau-Sed * Rausedan * Rausedil * Rausedyl * Rauserpol * Rausingle * RCRA waste number U200 * Recipin * Resaltex * Resedril * Resedrex * Rese-Lar * Reser-AR * Reserbal * Resercaps * Resercen * Reserfia * Reserjen * Reserlor * Reserp * Reserpal * Reserpamed * Reserpanca * Reserpene * Reserpex * Reserpidefe * Reserpil * Reserpine * Reserpoid * Reserpur * Resersana * Reserutin * Resiatric * Residine * Resocalm * Resomine * Resperin * Resperine * Respital * Restran * Rezerpin * Riserpa * Rivased * Rivasin * Rolserp * Salupres * Salutensin * Sandril * Sedaraupin * Sedserp * Seominal * Serfin * Serfolia * Serp-AFD * Serpaloid * Serpanray * Serpasil * Serpasil premix * Serpasol * Serpate * Serpatone * Serpazil * Serpazol * Serpedin *

Section 3 - Hazards Identification EMERGENCY OVERVIEW Toxic (USA) Harmful (EU). Harmful if swallowed. Target organ(s): Heart. Nerves. Calif. Prop. 65 carcinogen. HMIS RATING HEALTH: 2*

FLAMMABILITY: 0 REACTIVITY: 0 NFPA RATING HEALTH: 2 FLAMMABILITY: 0 REACTIVITY: 0 *additional chronic hazards present. For additional information on toxicity, please refer to Section 11. Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician. INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. DERMAL EXPOSURE In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician. EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. Section 5 - Fire Fighting Measures FLASH POINT N/A AUTOIGNITION TEMP N/A FLAMMABILITY N/A EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Emits toxic fumes under fire conditions. Section 6 - Accidental Release Measures PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area. PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. METHODS FOR CLEANING UP SIGMA - R0875 www.sigma-aldrich.com Page 2

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. Section 7 - Handling and Storage HANDLING User Exposure: Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure. STORAGE Suitable: Keep tightly closed. Section 8 - Exposure Controls / PPE ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Government approved respirator. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. GENERAL HYGIENE MEASURES Wash thoroughly after handling. Section 9 - Physical/Chemical Properties Appearance Physical State: Solid Color: Faintly beige Form: Fine crystals Value At Temperature or Pressure

Property Molecular Weight pH BP/BP Range MP/MP Range Freezing Point Vapor Pressure Vapor Density Saturated Vapor Conc. SG/Density Bulk Density Odor Threshold Volatile% VOC Content Water Content Solvent Content Evaporation Rate Viscosity Surface Tension Partition Coefficient Decomposition Temp. Flash Point Explosion Limits Flammability Autoignition Temp Refractive Index Optical Rotation

608.69 AMU N/A N/A 265 °C N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Degree of Rotation: 10 g/l Solvent: CHCl3 -148 - -122 (+/-2)

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Miscellaneous Data Solubility N/A = not available

N/A Solubility in Water:Soluble.

Section 10 - Stability and Reactivity STABILITY Stable: Stable. Materials to Avoid: Oxidizing agents, Reducing agents. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides. HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract. Ingestion: Harmful if swallowed. TARGET ORGAN(S) OR SYSTEM(S) Heart. Central nervous system. SIGNS AND SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. TOXICITY DATA Oral Rat 420 mg/kg LD50 Remarks: Behavioral:Antipsychotic. Intraperitoneal Rat 44 MG/KG LD50 Remarks: Brain and Coverings:Recordings from specific areas of CNS. Subcutaneous Rat 25 MG/KG LD50 Intravenous Rat 15 MG/KG LD50 Oral Mouse SIGMA - R0875 www.sigma-aldrich.com Page 4

> 50 mg/kg LD50 Intraperitoneal Mouse 5 MG/KG LD50 Subcutaneous Mouse 5610 UG/KG LD50 Intravenous Mouse 21 MG/KG LD50 Remarks: Behavioral:Altered sleep time (including change in righting reflex). Behavioral:Change in motor activity (specific assay). Gastrointestinal:Hypermotility, diarrhea. Intravenous Dog 500 UG/KG LD50 Intraperitoneal Rabbit 7 MG/KG LD50 Remarks: Nutritional and Gross Metabolic:Changes in:Body temperature decrease. Intravenous Rabbit 15 MG/KG LD50 Subcutaneous Guinea pig 65 MG/KG LD50 Oral Bird (wild) 100 mg/kg LD50 CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. Species: Woman Route of Application: Oral Dose: 456 UG/KG Exposure Time: Y Frequency: C Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and Appendages: Other: Tumors. Species: Rat SIGMA - R0875 www.sigma-aldrich.com Page 5

Route of Application: Oral Dose: 54 MG/KG Exposure Time: 77W Frequency: C Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors. Blood:Lymphomas including Hodgkin's disease. Species: Rat Route of Application: Subcutaneous Dose: 132 MG/KG Exposure Time: 2.5Y Frequency: I Result: Tumorigenic:Neoplastic by RTECS criteria. Gastrointestinal:Tumors. Skin and Appendages: Other: Tumors. Species: Mouse Route of Application: Oral Dose: 433 MG/KG Exposure Time: 2Y Frequency: C Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and Appendages: Other: Tumors. Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Species: Mouse Route of Application: Subcutaneous Dose: 200 MG/KG Exposure Time: 2Y Frequency: I Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax, or Respiration:Tumors. Skin and Appendages: Other: Tumors. Species: Rat Route of Application: Oral Dose: 216 MG/KG Exposure Time: 2Y Frequency: C Result: Tumorigenic:Carcinogenic by RTECS criteria. Endocrine:Adrenal cortex tumors. Skin and Appendages: Other: Tumors. Species: Woman Route of Application: Oral Dose: 73 MG/KG Exposure Time: 2Y Frequency: C Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and Appendages: Other: Tumors. Species: Woman Route of Application: Oral Dose: 24 MG/KG Exposure Time: 13Y Frequency: C Result: Tumorigenic:Neoplastic by RTECS criteria. Brain and Coverings:Tumors. Species: Woman Route of Application: Oral Dose: 16 MG/KG Exposure Time: 3Y Frequency: C SIGMA - R0875 www.sigma-aldrich.com Page 6

Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and Appendages: Other: Tumors. Species: Rat Route of Application: Oral Dose: 340 MG/KG Exposure Time: 3Y Frequency: I Result: Tumorigenic:Neoplastic by RTECS criteria. Gastrointestinal:Tumors. Endocrine:Thyroid tumors. Species: Mouse Route of Application: Oral Dose: 1120 MG/KG Exposure Time: 2Y Frequency: I Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Tumors. Skin and Appendages: Other: Tumors. IARC CARCINOGEN LIST Rating: Group 3 NTP CARCINOGEN LIST Rating: Clear evidence. Species: Mouse/rat Route: Feed CHRONIC EXPOSURE - TERATOGEN Result: Laboratory experiments have shown teratogenic effects. Species: Rat Dose: 2500 UG/KG Route of Application: Intraperitoneal Exposure Time: (19D PREG) Result: Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord). Effects on Embryo or Fetus: Fetal death. Species: Rat Dose: 3 MG/KG Route of Application: Subcutaneous Exposure Time: (12-15D PREG) Result: Specific Developmental Abnormalities: Cardiovascular (circulatory) system. Effects on Newborn: Physical. Species: Rat Dose: 4 MG/KG Route of Application: Subcutaneous Exposure Time: (16-19D PREG) Result: Specific Developmental Abnormalities: Cardiovascular (circulatory) system. Effects on Newborn: Biochemical and metabolic. Species: Rat Dose: 800 UG/KG Route of Application: Intramuscular Exposure Time: (9D PREG) Result: Specific Developmental Abnormalities: Eye, ear. Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on SIGMA - R0875 www.sigma-aldrich.com Page 7

Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Species: Rat Dose: 800 UG/KG Route of Application: Intramuscular Exposure Time: (9D PREG) Result: Specific Developmental Abnormalities: Craniofacial (including nose and tongue). Maternal Effects: Other effects. Nutritional and Gross Metabolic:Weight loss or decreased weight gain. Species: Rat Dose: 1 MG/KG Route of Application: Intramuscular Exposure Time: (9D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. Species: Rat Dose: 1500 UG/KG Route of Application: Intramuscular Exposure Time: (10D PREG) Result: Specific Developmental Abnormalities: Central nervous system. Species: Rat Dose: 50 MG/KG Route of Application: Unreported Exposure Time: (8D PREG) Result: Effects on Embryo or Fetus: Fetal death. Species: Mouse Dose: 600 UG/KG Route of Application: Oral Exposure Time: (7-12D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. CHRONIC EXPOSURE - MUTAGEN Result: Laboratory experiments have shown mutagenic effects. Species: Rat Dose: 2200 NG/PLATE Cell Type: Embryo Mutation test: Morphological transformation. Species: Mouse Route: Intraperitoneal Dose: 2 MG/KG Mutation test: Micronucleus test Species: Mouse Route: Intraperitoneal Dose: 30 MG/KG Exposure Time: 48H Mutation test: Cytogenetic analysis Species: Mouse Route: Intraperitoneal Dose: 200 UG/KG Mutation test: Dominant lethal test SIGMA - R0875 www.sigma-aldrich.com Page 8

Species: Hamster Dose: 4 MG/L Cell Type: Embryo Mutation test: Morphological transformation. Species: Hamster Dose: 2 MG/L Cell Type: ovary Mutation test: Sister chromatid exchange Species: Hamster Route: Intraperitoneal Dose: 4 NG/KG Mutation test: SLN CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Species: Woman Dose: 200 UG/KG Route of Application: Intravenous Exposure Time: (39W PREG) Result: Effects on Newborn: Viability index (e.g., # alive at day 4 per # born alive). Effects on Newborn: Other neonatal measures or effects. Species: Woman Dose: 4800 UG/KG Route of Application: Unreported Exposure Time: (32-39W PREG) Result: Effects on Newborn: Stillbirth. Species: Rat Dose: 11130 UG/KG Route of Application: Oral Exposure Time: (21D MALE) Result: Effects on Fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles). Species: Rat Dose: 17500 MG/KG Route of Application: Oral Exposure Time: (3-9D PREG) Result: Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea). Species: Rat Dose: 6 MG/KG Route of Application: Oral Exposure Time: (60D PRE) Result: Maternal Effects: Menstrual cycle changes or disorders. Species: Rat Dose: 21217 UG/KG Route of Application: Oral Exposure Time: (30W PRE) Result: Effects on Fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated ).

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Species: Rat Dose: 2 MG/KG Route of Application: Intraperitoneal Exposure Time: (2D PRE) Result: Maternal Effects: Ovaries, fallopian tubes. Species: Rat Dose: 700 UG/KG Route of Application: Intraperitoneal Exposure Time: (8-14D PREG) Result: Effects on Newborn: Stillbirth. Effects on Newborn: Growth statistics (e.g., reduced weight gain). Effects on Newborn: Behavioral. Species: Rat Dose: 1 MG/KG Route of Application: Subcutaneous Exposure Time: (1D PRE) Result: Maternal Effects: Menstrual cycle changes or disorders. Species: Rat Dose: 1250 UG/KG Route of Application: Subcutaneous Exposure Time: (5D MALE) Result: Paternal Effects: Testes, epididymis, sperm duct. Paternal Effects: Prostate, seminal vessicle, Cowper's gland, accessory glands. Species: Rat Dose: 400 UG/KG Route of Application: Subcutaneous Exposure Time: (11-14D PREG) Result: Effects on Newborn: Behavioral. Species: Rat Dose: 1500 UG/KG Route of Application: Subcutaneous Exposure Time: (12-15D PREG) Result: Effects on Newborn: Growth statistics (e.g., reduced weight gain). Effects on Newborn: Biochemical and metabolic. Effects on Newborn: Physical. Species: Rat Dose: 2 MG/KG Route of Application: Subcutaneous Exposure Time: (12-17D PREG) Result: Maternal Effects: Ovaries, fallopian tubes. Species: Rat Dose: 400 UG/KG Route of Application: Subcutaneous Exposure Time: (1D PRE) Result: Effects on Fertility: Other measures of fertility Species: Rat Dose: 9 MG/KG Route of Application: Parenteral Exposure Time: (1-9D PREG) Result: Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea).

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Species: Rat Dose: 3750 UG/KG Route of Application: Unreported Exposure Time: (15D MALE) Result: Paternal Effects: Testes, epididymis, sperm duct. Effects on Fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles). Species: Mouse Dose: 10 MG/KG Route of Application: Intraperitoneal Exposure Time: (1D PREG) Result: Effects on Fertility: Other measures of fertility Species: Mouse Dose: 120 UG/KG Route of Application: Subcutaneous Exposure Time: (1D PRE) Result: Effects on Fertility: Other measures of fertility Species: Mouse Dose: 400 UG/KG Route of Application: Parenteral Exposure Time: (1D PRE) Result: Effects on Fertility: Other measures of fertility Species: Mouse Dose: 3200 UG/KG Route of Application: Parenteral Exposure Time: (1D PRE) Result: Maternal Effects: Uterus, cervix, vagina. Species: Mouse Dose: 1600 UG/KG Route of Application: Unreported Exposure Time: (1D PRE) Result: Effects on Fertility: Other measures of fertility Species: Dog Dose: 32 UG/KG Route of Application: Oral Exposure Time: (1D MALE) Result: Paternal Effects: Other effects on male. Species: Monkey Dose: 100 MG/KG Route of Application: Subcutaneous Exposure Time: (14W PRE) Result: Maternal Effects: Menstrual cycle changes or disorders. Species: Guinea pig Dose: 170 UG/KG Route of Application: Subcutaneous Exposure Time: (35-68D PREG) Result: Effects on Newborn: Stillbirth. Effects on Newborn: Viability index (e.g., # alive at day 4 per # born alive). Species: Guinea pig Dose: 340 UG/KG Route of Application: Subcutaneous Exposure Time: (35-68D PREG) Result: Effects on Newborn: Other neonatal measures or effects. SIGMA - R0875 www.sigma-aldrich.com Page 11

Effects on Newborn: Biochemical and metabolic. Section 12 - Ecological Information No data available. Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Section 14 - Transport Information DOT Proper Shipping Name: Environmentally hazardous substances, solid, n.o.s. UN#: 3077 Class: 9 Packing Group: Packing Group III Hazard Label: Class 9 PIH: Not PIH IATA Non-Hazardous for Air Transport: Non-hazardous for air transport. Section 15 - Regulatory Information EU ADDITIONAL CLASSIFICATION Symbol of Danger: Xn Indication of Danger: Harmful. R: 22 Risk Statements: Harmful if swallowed. S: 22 36/37/39 Safety Statements: Do not breathe dust. Wear suitable protective clothing, gloves, and eye/face protection. US CLASSIFICATION AND LABEL TEXT Indication of Danger: Toxic (USA) Harmful (EU). Risk Statements: Harmful if swallowed. Safety Statements: Do not breathe dust. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Wear suitable protective clothing, gloves, and eye/face protection. US Statements: Target organ(s): Heart. Nerves. Calif. Prop. 65 carcinogen. UNITED STATES REGULATORY INFORMATION SARA LISTED: No TSCA INVENTORY ITEM: Yes UNITED STATES - STATE REGULATORY INFORMATION CALIFORNIA PROP - 65 California Prop - 65: This product is or contains chemical(s) known to the state of California to cause cancer. CANADA REGULATORY INFORMATION SIGMA - R0875 www.sigma-aldrich.com Page 12

WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. DSL: No NDSL: Yes Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses. WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.

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