PHARMACOLOGY TOPICS
KEY: COURSES: GEN = Human Genetics, CELL BIO = Cell Biology & Histology, ANAT = Human Anatomy & Development, NEUROBIO = Neurobiology, PHYSIOL = Physiology, BBB = Biological Basis of Behavior, MICRO = Medical Microbiology, EPH = Epidemiology & Public Health, IMM = Immunobiology, PATHOL = Pathological Basis of Human Disease, BIOCHEM = Biochemistry MODULES: OPHTHO = Ophthalmology, RESP = Respiratory, NEUR = Clinical Neuroscience, GI = Digestive Diseases, CV = Cardiovascular, PSYCH = Clinical Psychiatry, REPRO = Reproductive Medicine, MS = Musculo-Skeletal System, RENAL = Renal/Urology Systems, HEME = Hematology, ONC = Oncology, ENDO = Endocrine Systems, DERM = Dermatology LEC = Lecture, WS = Workshop, C = Conference, PC = Physiology Conference, CC = Clinical Correlation, CBCC = Cell Biology Clinical Correlation, GR CPC = Grand Rounds Clinico-Pathologic Correlation, BC = Biochemistry Conference
TOPIC Introduction & Principles of Pharmacology Pharmacokinetics and Pharmacodynamics; absorption, distribution, action and elimination
PHARMACOLOGY COURSE -LEC Introduction and Pharmacokinetics (Howe) -LEC Clinical Correlations (Hodsdon) -LEC Common Mechanisms of Drug Action (Howe)
OTHER COURSE
MODULE
Drug metabolism & interactions
-LEC Drug Metabolism and Drug Interactions (Hodsdon) -LEC Clinical Correlations (Hodsdon)
Pharmacogenetics
GEN -LEC Genetics in Medicine
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Science of drug therapy
CELL BIO -LEC Signaling I and II (receptors and slgnaling) -LEC Growth Factors & Oncogenes -LEC Cellular Endocrinology (how hydrophilic and hydrophobic ligands work) -CBCC Lysosomal Storage Disease (Man-6-P tagged agents)
ONC -LEC Novel strategies to treat cancer
Introduction to autonomic nervous system
-LEC Introduction to Autonomics (Howe)
ANAT -C Nervous system (neurotransmitter pharmacology) NEUROBIO -LEC Myelinated Nerve (4aminopyridine) PHYSIOL -LEC Autonomic Nervous System, (wide variety of ANS drugs)
Cholinergic System -Muscarinic and Nicotinic agonists & antagonists -Parasympathomimetics, parasympathetic blocking agents and anti-cholinesterases
-LEC The Cholinergic Synapse (Howe) -LEC Neuromuscular Blockers (Howe) -LEC Parasympathomimetics and Muscarinic Antagonists (Howe)
PHYSIOL -PC Cystic Fibrosis (pilocarpine) -PC Malignant hyperthermia (succinyl choline, dantrolene) -PC Myasthenia Gravis (edrophonium, pyridostigmine)
OPHTHO -LEC Basic Eye Exam (dilating drops) RESP -LEC Pulmonary Pharmacology
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-Agents acting at the neuromuscular junction and autonomic ganglia
-LEC Clinical Correlations (Howe)
-LEC Na/K Channels (Nicotinic acetylcholine receptor, neurotoxins) -LEC Electrochemical properties of skeletal muscle -PC Myasthenia Gravis (curare)
-LEC Asthma & COPD (anticholinergics) -LEC Smoking cessation (nicotine patch and gum, varenicline/chantix) NEUR
-LEC Microcirculation (ACh) ANAT -C Micturition WS (muscle relaxant, urinary) CELL BIO -LEC The Neuron (botox) -LEC Muscle & NMJ (ACh & NMJ) Adrenergic System -Adrenergic agonists & antagonists -Epinephrine & NorEpinephrine, sympathomimetics -LEC The Noradrenergic Synapse & Catecholamines (Howe) -LEC Sympathomimetics (Howe) -LEC Adrenergic Blockers (Howe) -LEC Clinical Correlations (Akhtar) -LEC Nacrolepsy (amphetamines) PHYSIOL -PC ßAR Desensitization -LEC Microcirculation -LEC Renal blood flow & glomerular filtration (dopamine) -LEC Renal transport salt water 1 (dopamine)
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-LEC NMJ & ALS (Tensilon/AChE inhibitors)
BBB -LEC Post-Traumatic Stress Disorder (ßblocker) -LEC Prefrontal Cortex/Mental Illness (adrenergic drugs)
GI -LEC ßblocker for portal HTN ENDO -LEC Pharmacology of Thyroid & Adrenal (treatment of pheo pre-surgery) OPHTHO -LEC Optic nerve & Glaucoma (topcial ßblocker, alpha agonists)
RESP -LEC Pulmonary Pharmacology
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-LEC Asthma & COPD (ßagonists) -LEC Smoking cessation (bupropion, clonidine) CV -LEC HTN (adrenergic antagonists/agonists) 5HT/serotonin agonists and antagonists NEUROBIO -LEC Imaging the Human Brain (serotonin transporters) PSYCH -LEC Mood disorders & antidepressants (SSRIs, SNRIs) -LEC Somatic Treatment of Mood & Anxiety Disorders (SSRIs, SNRIs) REPRO -LEC Maternal & Perinatal Mortality (ergotamine for primary postpartum hemorrhage) Drugs affecting neurotransmission in the Central Nervous System BBB -LEC Learning/Memory -LEC Obsessive Compulsive Disorder (NMDA) -LEC Nacrolepsy (amphetamines, oxybate) -LEC Eating disorders (CRF) PSYCH -LEC Somatic Treatment of Mood & Anxiety Disorders (SSRIs, SNRIs, TCAs, MAO-Is, Li, valproic acid, lamotrigine, carbamazepine)
NEUROBIO
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-LEC Synaptic Mechanisms (glutamate agonists) -LEC Excitabiity of Central Neurons (tetrodotoxin) -LEC Imaging the Human Brain (dopamine transporters, nicotinic acetylcholine, serotonin transporters, GABA/benzo receptors) General anesthetics PHYSIOL -PC Malignant hyperthermia (thiopental, halothane) Local anesthetics ANAT -C Nervous system (nerve blocks) -C Child birth (spinal block) -LAB Foregut cholangiocarcinoma (celiac block) -LAB Hip -LAB Knee Ankle -LAB Shoulder (nerve blocks) Hypnotics/Sedatives NEUROBIO -LEC Sleep & Arousal (sleeping pills, treatment of nacrolepsy) PSYCH -LEC Sleep (benzodiazepines, non-benzo hypnotics, melatonin, melatonin agonists) -LEC Red Eye disorders (anesthetics) NEUR -LEC General Anesthetics
OPHTHO -LEC Basic Eye Exam (topical anesthetics)
Antidepressants and Antianxiety
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BBB
PSYCH
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drugs -LEC Stress -LEC Narcolepsy -LEC Eating disorders -LEC Post-Traumatic Stress Disorder -LEC Arousal/Sleep (benzodiazepines, antidepressants, ßblockers) -LEC Depression (antidepressants, mood stabilizers) -LEC Obsessive Compulsive Disorder (antidepressants) NEUROBIO -LEC Neurotransmitters & Receptors (antidepressants) Psychosis, Mania and Antipsychotic drugs BBB -LEC Schizophrenia (antipsychotics) Epilepsies and Anticonvulsants NEUROBIO -LEC Neural basis of epilepsy (anti-eptilectics) -CC Epilepsy (anticonvulsants) -WS Obstetrics (Mg for seizure prophylaxis in preecclampsia) PSYCH -LEC Antipsychotic drugs -LEC Somatic Treatment of Mood & Anxiety Disorders (SSRIs, SNRIs, TCAs, MAO-Is, Li, valproic acid, lamotrigine, carbamazepine) -LEC Anxiety disorders -WS Eating disorders -WS Suicide & mood disorders -WS Psychopharmacology RESP -LEC Smoking cessation (nortriptyline) -LEC Mood disorders & antidepressants
NEUR -LEC Anticonvulsants REPRO
Treatment of CNS degenerative
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NEUROBIO
NEUR
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disorders (e.g. Parkinson’s, Alzhemier’s..)
-LEC Basal Ganglia (dopamine D1/D2 receptor mechanisms) -CC Movement disorders (DA system, cholinergic, glutamate, GABAergic) -LEC Aging Brain (DA transporters) -LEC Alzheimer’s (cholinesterase inhibitors, NMDA, anti-oxidants, anti-inflammatory drugs, estrogen, amyloid-directed therapy)
-LEC Movement disorders (AntiParkinson’s therapy)
Opioid (narcotic) analgesics
BBB -LEC Pain (opiates, antidepressants, analgesics)
NEUR -LEC Opioids -LEC Pain Management
Alcohol/Ethanol
BBB -LEC Addiction (alcohol) ANAT -LAB Abdominal trauma
PSYCH -LEC Substance abuse
Drug addiction/abuse/dependence, and Pyschomimetics
BBB -LEC Learning/Memory (NMDA) -LEC Addiction (stimulants, opiates, marijuana, nicotine)
PSYCH -WS Drugs to treat substance abuse -LEC Substance abuse
NEUROBIO
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-LEC Neurotransmitters & Receptors (drugs of abuse, psychoactive drugs) Histamine, bradykinin & antihistamines Lipid autocoids, eicosanoids & platelet activating factors: Prostaglandins, thromboxane & leucotrienes -LEC Aspirin, NSAIDS & AntiHistamines (Sessa) -LEC Aspirin, NSAIDS & AntiHistamines (Sessa) ANAT -LEC Circulatory System (PG’s & patent ductus) PHYSIOL -LEC Microcirculation (prostacyclin) -LEC Renal blood flow & glomerular filtration (leukotrienes, prostaglandins) -LEC Maternal & Perinatal Mortality (prostaglandins for primary postpartum hemorrhage) -WS Obstetrics (Misoprostol induction) -WS Early Pregnancy (Misoprostol, incomplete abortion) RESP -LEC Pulmonary Pharmacology -LEC Asthma & COPD (leukotriene modifiers) -LEC Pulmonary hypertension & Cor pulmonale (prostacyclines) Analgesic-antipyretic and antiinflammatory agents; gout; Nonnarcotic analgesics -LEC Aspirin, NSAIDS & AntiHistamines (Sessa) MS -LEC Osteoarthritis (NSAIDs & acetaminophen/Tylenol) -LEC Rheumatoid Arthritis
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NEUR -LEC Stroke (aspirin) REPRO
-LEC Spondylosis (DMARDS, biologics, TNF) -LEC Acute arthritis (cochicine, allopurinol) NEUR -LEC Headache & vertigo (analgesic rebound) -LEC Pain Management Asthma therapy CELL BIO -LEC Respiratory System (smooth muscle relaxants and asthma) -CBCC Pulmonary/asthma (asthma treatment) RESP -LEC Pulmonary Pharmacology -LEC Asthma & COPD (anticholinergics, ßagonists, corticosteroids, leukotriene modifiers, mast cell stabilizers, theophylline, antiIgE therapy e.g. omalizumab) -WS Asthma, sleep, breathing & neuromuscular disease (anticholinergics, ßagonists, corticosteroids, leukotriene modifiers, mast cell stabilizers, theophylline, antiIgE therapy e.g. omalizumab) -WS Pediatrics case Surfactant replacement therapy RESP -WS Pediatric case infant respiratory distress syndrome RESP -WS Pediatric case cystic fibrosis
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DNase
Diuretics
ANAT -LAB Heart (diuretics for CHF) PHYSIOL -LEC Membrane Transport & intracellular composition (diuretics) -PC Cystic Fibrosis (amiloride) -PC Hyperkalemic periodic parasysis (acetazolamide) -LEC Renal transport salt water 1, (furosemide, bumetanide, ethacrynic acid, thiazides, metolazone, amiloride, triamterene) -PC Liddle’s disease (amiloride, triamterene, aldosterone, spironolactone) -LEC Renal excretion of calcium, phosphorus, magnesium (furosemide, bumetanide) -LEC Renal excretion of potassium (aldosterone)
RENAL -LEC Diuretics CV -LEC HTN (diuretics)
Vasopressin and other agents affecting renal conservation of water
PHYSIOL -LEC Renal blood flow & glomerular filtration (atrial natriuretic peptide) -LEC Renal transport salt water 1 (vasopressin, atrial natriuretic peptide)
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-LEC Renal excretion of potassium (vasopressin) -LEC Renal excretion of water (vasopressin) Drugs affecting the renin, angiotensin and aldosterone system -LEC ACE Inhibitors & Vasodilators (Sessa) PHYSIOL -LEC Renal blood flow and glomerular filtration (angiotensin II) CV -LEC HTN (ACE-inhibitors, ARBs)
-LEC Renal transport salt water 1 (angiotensin, aldosterone, spironolactone) -LEC Integration of salt and water balance (renin, angiotensin & aldosterone) Treatment of myocardial ischemia; Xanthines & coronary vasodilators -LEC ACE Inhibitors & Vasodilators (Sessa) CV -LEC Acute Coronary Syndromes (thrombolytics, aspirin, Gp IIb/IIIa inhibitors, ßblockers, heparin, ACE-inhibitors) Drugs to treat hypertension -LEC ACE Inhibitors & Vasodilators (Sessa) -LEC Clinical Correlations (Asch) PHYSIOL -LEC Smooth muscle (Calcium channel blockers) -LEC Microcirculation (NO, endothelin) -LEC Short term neural control of arterial pressure (variety of
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ANAT -LAB Thoracic aneurysm
CV -WS Preventive cardiology (Treatmtent of HTN, lipids) -LEC HTN (diuretics, Ca channel blockers, adrenergic antagonists/agonists, vasodilators, ACE-I, ARBs) REPRO -LEC Maternal & Perinatal Mortality (anti-HTN for pre10/29/2009
drugs) -LEC Renal blood flow & glomerular filtration (endothelin, NO)
ecclampsia) -WS Obstetrics (pre-ecclampsia Rx HTN) RESP -LEC Pulmonary Pharmacology -LEC Pulmonary HTN & Cor pulmonale (endothelin-1 antagonist bosentan, nitric oxide, Ca channel blockers, PDE5-inhibitors) -LEC Pathology of pulmonary vascular disease (endothelin1 antagonist bosentan, nitric oxide, Ca channel blockers, PDE5-inhibitors) CV -WS Heart failure
Drugs for treating Congestive Heart Failure
-LEC ACE Inhibitors & Vasodilators (Sessa) -LEC Drugs Affecting Cardiac Contractility (TBA)
ANAT -LAB Heart (diuretics & inotropics for CHF) PHYSIOL -LEC Membrane transport & intracellular composition (ouabain) -LEC Heart as a Pump (+ and – inotropic agents) -LEC Regulation of cardiac output/venous return (adenosine)
Antiarrhythmics
-LEC Anti-Arrhythmics (Ehrlich) -LEC Clinical Correlations (TBA)
PHYSIOL -LEC Cardiac action potentials & conduction (tetrodotoxin, procainamide, diltiazem,
CV -LEC ECG III (Treatment of tachycardias)
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dihydropyridines, phenylalkylamines) -LEC Control of heart rhythm & contractility (ACh, Epi, NorEpi, glycosides) ANAT -LAB Thoracic aneurysm PHYSIOL -LEC Nutrition 1 (HMG CoAreductase inhibitors) Treatment of gastric acidity, ulcers and GERD ANAT -C Nervous system, (H2 blockers, PPI) PHYSIOL -LEC Gastric & Pancreatic Secretion (ACh, gastrin, histamine, VIP, CCK, carbachol, PG, VIP, GRP, somatostatin, cimetidine, ranididine, GIP) -PC ZE Syndrome (ACh, gastrin, histamine, PG, VIP, somatostatin, cimetidine, ranitidine, omeprazole) Drug therapy of bowel motility and water flux; antiemetics; drug therapy of pancreatic and biliary disorders PHYSIOL -LEC GI Motility (ACh, gastrin, NorEpi, VIP, CCK) -LEC Intestinal fluid and electrolyte transport (aldosterone, amiloride, 5HT)
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-WS EKG (anti-arrythmics)
Treatment of hypercholesterolemia, dyslipidemias
-LEC Statins & Lipid Lowering Agents (Sessa)
NEUR -LEC Stroke (Statins) CV -LEC Cholesterol (resins, fibrates, niacin, statins, ezetimibe) GI -LEC Pharmacology of upper GI tract (antacids, PPI, H2 blockers, sulcrafate, bismuth, antimuscarinics, prostaglandins)
GI -LEC Pharmacology of upper GI tract (Prokinetics, Reglan, Cisapride, somatostatin) -LEC Lower GI tract Pharmacology (anti-diarrheals)
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-LEC Irritable Bowel Syndrome (Serotonin regulation) -LEC Pancreatitis (steatorrhea/pancreatic enzymes) -LEC Gallbladder disease -LEC Cholestasis and cholestatic syndromes (bile acid binders, rifampicin) GI -LEC Lower GI tract Pharmacology (5ASA, steroids, immunosuppressive agents, anti-TNF antibodies) REPRO -WS GYN Infections diseases RESP -LEC Pneumonia -WS Pneumonia DERM -WS Intro (topical steroids, oral antibiotics) -WS Inflammation (topical steroids, oral abx, topical & oral retinoids) -WS Infections (topical & oral abx, antiparasitics) -WS Pigment/Acne (abx, retinoids)
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Treatment of Inflammatory Bowel Disease (IBD)
CELL BIO -CBCC GI/IBD (infliximab)
Antibiotics (PCNs, cephalosporins, other ßlactam Abx; antimetabolites, sulfonamides, TMP/SMZ; DNA synthesis inhibitors, quinolones; aminoglycosides; protein synthesis inhibitors; miscellaneous antibiotics)
-LECs Antimicrobials I, II and III (Turk) -LEC Clinical Correlations (Dembry)
MICRO -LEC Antibiotic Resistance (also all LECS/LABS on microbes include discussion of treatment) BIOCHEM -LEC Gene expression III: Translation (antibiotic mechanism)
Treatment of TB, MAI, leprosy
-LEC The Therapy of Tuberculosis (Anderson)
RESP -WS Pneumonia, TB & Lung Cancer (treatment of TB)
Treatment of malaria Antifungal agents
-LEC Antimalarials (Ha) -LEC Antifungal Therapy (Anderson) -LEC Clinical Correlations (Dembry)
Antiviral therapy
-LEC Antiviral Therapy (Paintsil)
MICRO -LECs HIV Colloquium BIOCHEM -BC HIV (HIV inhibitors)
GI -LEC Viral hepatitis therapy -LEC Pharmacotherapy of hepatitis REPRO -LEC GYN neoplasia (HPV vaccine) OPHTHO -LEC Red Eye disorders (topical antivirals for herpes simplex keratitis, zoster uveitis)
Cancer therapy
CELL BIO -LEC Blood vessels & angiogenesis (VEGF) BIOCHEM -BC Molecular Therapeutics: Methotrexate
ONC -LECs Cancer Chemotherapy I, II, III -LEC Novel strategies to treat cancer -LEC Breast cancer (antiestrogens, anti-HER2 therapy)
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-LEC Tumor Immunology (Immunologic treatment for cancer) HEME -LEC Hgb synthesis (hydroxyurea) -LEC Myeloproliferative disorders (hydroxyurea) -LEC Acute Leukemia -LEC Chronic Leukemia -LEC Hodgkin’s Disease -LEC Non-Hodgkin’s Lymphoma -LEC Plasma cell disorders (novel myeloma therapies) -LEC Aplastic anemia and bone marrow failure sydromes REPRO -LEC GYN neoplasia -WS Early Pregnancy (methotrexate for ectopic pregnancy) DERM -WS Neoplasms (chemotherapeutics, e.g. imiquimod) GI
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L18 Colon Cancer (chemotherapy) Immunosupressants, toleragens, immunostimulants, vaccines and antibodies IMM -LEC Immune response to self, non-self (Cyclosporin A) NEUR -LEC NMJ & ALS -LEC Diseases of Muscle (Steroids for immunosuppression) MS -LEC Immunosuppressive Agents (Lolis) -LEC Connective Tissue Diseases (cyclophosphamide) -LEC Myopathies (azathioprine, steroids) ONC -LEC Tumor Immunology (Immunologic treatment for cancer) REPRO -LEC GYN neoplasia (HPV vaccine) RESP -LEC Pulmonary Pharmacology -LEC Interstitial Lung Disease -WS Interstitial Lung Disease DERM
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-WS Systemic disease (steroid & steroid-sparing immunosuppresives) GI -LEC LGI Pharmacology (IBD tx with biological immunosuppressive medications) HEME -LEC Hematopoiesis (hematopoietic colony stimulating factors) -LEC Anemia, Fe deficiency (Fe) -LEC Protein & carbohydrate digestion & absorption (cobalamin) BIOCHEM -BC Erythropoietin Hematology: coagulation and anticoagulants, thrombolytics, antiplatelet drugs, Vitamin K -LEC Drugs Affecting Platelet Function (Calderwood) PHYSIOL -LEC Hemostasis (procouagulants, anticoagulants) HEME -LEC Platelets -LEC Coagulation -LEC Pharmacologic agents in hematology -LEC Microangiopathic disorders (drugs that cause TTP) -LEC Thrombotic disorders NEUR -LEC Stroke (TPA, aspirin,
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Hematology: Nutritional anemias (Fe, B12, folate), vitamins, minerals, hematopoietic growth factors
PHYSIOL -LEC Composition of Blood (Fe, erythropoietin, G-CSF) -LEC Erythrocytes (erythropoietin)
-LEC Folate & B12
Aggrenox) RESP -LEC Thromboembolic disease (heparins, warfarin, thrombolytics) -WS Acid/Base, ARDS, DVT/PE, URI (heparins, warfarin, thrombolytics) CV -LEC Acute Coronary Syndromes (thrombolytics, aspirin, Gp IIb/IIIa inhibitors, heparin) Hematology: Blood Component Therapy HEME -LEC Blood Component Therapy -LEC Platelets Pituitary hormones and their hypothalamic releasing hormones PHYSIOL -LEC Hypothalamic pituitary axis (PRL, GH, FSH, LH, ACTH, ADH, arg vasopressin, IGF-I, CRH, GnRH, GHRH, TRH, DA, somatostatin, POMC) Thyroid and anti-thyroid therapy CELL BIO -LEC Cellular Endocrinology (e.g. TSH, T3, TRH...) PHYSIOL -LEC Thyroid Function (T4, T3, thyroglobulin, TSH, TRH) ENDO -LEC Pharmacology of Thyroid & Adrenal
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-PC Hyperthyroid (T4, T3, thryroglobulin, TSH, TRH, PTU) Sex hormones (Estrogens, progesterones, androgens, oral contraceptive pills, hormone replacement therapy, menopause, reproduction, menstruation, sexual dysfunction) CELL BIO -LEC Intro to male/female reproduction (male/female steroids) PHYSIOL -LEC Hypothalamic pituitary axis (OCP’s) -LEC Female reproductive physiology (GnRH, FSH, LH, inhibins, activins, estrogen, progesterone) -LEC Physiololgy of pregnancy (hCG, LH, hPL, PGH, CRH, POM-C, ACTH, progesterone, estrogen, DHEA-S, MSH) -PC McCune-Albright Syndrome (estrogen, FSH, LH, testolactone) -LEC Male reproductive physiology (GnRH, FSH, inhibin, LH, testosterone) REPRO -LEC Abnormal puberty (GnRH agonists, testosterone, HRT, PRL) -LEC Amenorrhea (HRT, dopamine agonists for PRL) -LEC Menopause/aging (HRT) -WS Reproductive Endocrinology/Infertility (OCP’s, HRT) -WS Obstetrics/Maternal-Fetal Medicine (GnRH agonists, OCP’s, clomiphene) -LEC Maternal & Perinatal Mortality (Pitocin) -WS Obstetrics (Pitocin induction)
-LEC Abnormal vaginal bleeding (estrogen, progesterone) -LEC Adnexal masses (OCP’s for ovarian cysts) -LEC Male Reproduction (PDE5inhibitors) -LEC Sexual Dysfunction (PDE5inhibitors) ONC -LEC Breast cancer (anti-
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estrogens) Adrenal corticosteroids and analogs, ACTH, inhibitors of synthesis and actions of adrenocortical hormones CELL BIO -CBCC Endocrine/Adrenal (adrenal steroids) PHYSIOL -LEC Adrenal hormone secretion & action (steroids, CRH, ACTH, cosyntropin, aldosterone, spironolactone, epinephrine angiotensin, DA, NorEpi, DHEA, androstenedione) ENDO -LEC Pharmacology of Thyroid & Adrenal Steroids NEUR -LEC NMJ & ALS -LEC Diseases of Muscle (Steroids for immunosuppression) OPHTHO -LEC Red Eye, (topical steroids) RESP -LEC Pulmonary Pharmacology -LEC Asthma & COPD (corticosteroids) -WS Interstitial Lung Disease (steroids for ILD’s) DERM -WS Intro (topical steroids, oral antibiotics) -WS Inflammation (topical steroids, oral abx, topical & oral retinoids) -WS Systemic disease (steroid & steroid-sparing immunosuppresives) Diabetes
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CELL BIO
ENDO
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Insulin, oral hypoglycemic agents, pharmacology of endocrine pancreas
-CBCC Energy/Type II Diabetes (Insulin, oral hypoglycemic agents) PHYSIOL -LEC Nutrition 1 (insulin) -LEC Renal excretion of potassium (insulin) -LEC Endocrine Pancreas: Insulin and Glucagon (insulin, glucagon, somatostatin, sulfonyl ureas) -PC Diabetic Ketoacidosis (insulin, glucagon, epinephrine)
-LEC Treatment of Diabetes
Bone turnover, mineral ion homeostasis
CELL BIO -LEC Bone (drugs & antibodies for osteoporosis) PHYSIOL -LEC Renal excretion of calcium, phosphate, magnesium (PTH, calcitonin, VitD) -LEC Mineral metabolism (PTH, VitD) -PC Hyperparathyroidism (PTH, VitD, catechols, VMA)
Dermatologic pharmacology
DERM -WS Intro (topical steroids, oral antibiotics)
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-WS Inflammation (topical steroids, oral abx, topical & oral retinoids) -WS Infections (topical & oral abx, antiparasitics) -WS Pigment/Acne (abx, retinoids) -WS Neoplasms (chemotherapeutics, e.g. imiquimod) -WS Systemic disease (steroid & steroid-sparing immunosuppresives) OPHTHO -LEC Basic Eye Exam (topical anesthetics, dilating drops) -LEC Red Eye disorders (topical antibiotics, steroids, anesthetics) -LEC Retinal Vascular Diseases (anti-VEGF) -LEC Optic nerve & glaucoma (ßblockers, prostaglandin analogs, alpha agonists) BIOCHEM -BC Molecular sleuthing: conjunctivitis (treatment of conjunctivitis)
Ocular pharmacology
Toxicology, treatment of poisoning
EPH -WS Cases in Environmental
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Health -WS Cases in Occupational Health BIOCHEM -LEC Gene expression I: Transcription (alpha amanitin) -LEC Oxidative Phosphorylation (uncouplers) Heavy metals & heavy metal antagonissts EPH -WS Cases in Environmental Health -WS Cases in Occupational Health PHYSIO -LEC Water transport (Hg) Complementary and Alternative Medicine, Herbal therapies PRE-CLINICAL CLERKSHIP COMPLEMENTARY & ALTERNATIVE MEDICINE (Yr 2)
Intravenous Fluid Therapy
CELL BIO -CBCC Cholera (fluid replacement Na, glucose)
RENAL -LEC IV Fluids
Food/Nutrition
PHYSIOL -LEC Nutrition 1 (xylitol, Dtagatose) -LEC Nutrition 2 (vitamins)
CV -LEC Obesity (fats, cholesterol, anti-oxidants, vitamins, micronutrients, fiber, alcohol)
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BIOCHEM -BC McArdle’s Disease (treatment with sucrose) PHYSIOL -LEC Nutrition 2 (vitamins) BIOCHEM -BC Vitamins & nutrition: Folate (Vit B, D, thiamine, homocysteine)
Mucronutrient supplementation
ONC -LEC Cancer Epidemiology & Prevention (micronutrient supplementation in cancer prevention) REPRO -LEC Maternal & Perinatal Mortality (Mg for seizures in preeclampsia) -LEC Teratology (Folate for neural tube defects) CV -LEC Obesity (micronutrients)
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