The Toxicology Forum 2006 ANNUAL EUROPEAN MEETING November 14-16, 2006 Hilton Brussels Hotel PROGRAM
Tuesday, November 14 9:00 Opening Remarks David Longfellow, President, The Toxicology Forum Arpad Somogyi, Vice President of European Affairs, The Toxicology Forum Endocrine Modulators: General Aspects and Special Questions Chair: Ursula Gundert-Remy, Federal Institute of Risk Assessment, Germany
SESSION I
9:10
Introduction Chair Scientific Background: Mechanisms of Endocrine Modulation Receptor–Related Effects Sari Mäkelä, University of Turku, Finland Nongenomic Actions of Estradiol and Bisphenol A: Mechanism and Physiological Relevance István Ábrahám, Eötvös Loránd University, Budapest
9:15
9:55 10:05
Discussion Test Methods Human Health Endpoints Walter Lichtensteiger, University of Zürich, Switzerland Combination Testing Andreas Kortenkamp, University of London, UK The View of Industry Gernot Klotz, Bayer AG, Germany
10:50 11:00 11:30
Discussion Break Endocrine Modulating Effects of Bisphenol A Gisela Degen, University of Dortmund, Germany Bisphenol A: Different Effect Profiles at Low and High Doses? Lorenz Rhomberg, University of Cambridge, USA Metabolism of Bisphenol A: Species Differences Wolfgang Dekant, University of Würzburg, Germany Discussion Lunch
11:45
12:00
12:15 12:30
13:45
Research Strategies for Endocrine Modulators Tuomo Karjalainen, DG Research, European Commission, Brussels Discussion General Discussion Helmut Greim, Technical University of Munich, Germany All Speakers Updates Chair: Richard Adamson, American Beverage Association, USA
14:05 14:15
SESSION II
14:30
Evaluation of Chemical Substances by the Scientific Committee on Health and Environmental Risks of the European Commission Helmut Greim, Technical University of Munich, Germany Discussion Harmonization of Risk Assessment of Genotoxic Carcinogens in Food in the EU Sue Barlow, Independent Consultant in Toxicology, UK Discussion Are the Dose-Response Curves of Genotoxic Carcinogens Linear? James Swenberg, University of North Carolina, USA Discussion Break Risk Assessment in the Era of REACH Thomas Hartung, Joint Research Centre, ECVAM, Italy Discussion Report on the International Conference “Toxicology and Ecotoxicology in Central and Eastern Europe” Mykola Prodanchuk, L.I. Medved Institute of Ecohygiene and Toxicology, Ukraine Discussion Recent Food Scares in Europe Herman Koëter, European Food Safety Authority (EFSA), Italy Discussion Reception
14:45 14:50
15:05 15:10
15:25 15:30 16:00
16:15 16:20
16:35 16:40
16:55 18:00
Wednesday, November 15 SESSION III Nanomaterials: Life Sciences and Regulatory Aspects Chair: David Warheit, DuPont De Nemour, Haskell Laboratory, USA
8:30
Introduction Chair Physico-chemical Characteristics of Nanomaterials: Overview of Applications and Relevance to Health Effects Vicki Colvin, Rice University, USA Discussion Exposure Assessment of Nanomaterials in the Workplace: Technical Issues and Measuring of Nanomaterials Thomas Kuhlbusch, IUTA, University Duisburg-Essen, Germany Discussion Health Effects of Nanomaterials – Gaps in Current Knowledge: Research on Implications, Inhalation and Dermal Exposure Harald Krug, Forschungszentrum Karlsruhe, Germany Discussion Break Nanomedicine: Diagnostic Imaging and Therapeutic Applications Paul Borm, Hoogeschool Zuyd, Netherlands Discussion Risk Assessment of Nanomaterials in the EU and Its Regulatory Implications Philippe Martin, DG SANCO Discussion Ethics and Nanotechnology Michael Rogers, Risk, Ethics and Law, Belgium Discussion Panel Discussion Chair Michael Mehta, University of Saskatchewan, Canada Lunch Biomarkers for Liver and Kidney Toxicity: Clinical and Drug Development Perspectives Chair: Jack Reynolds, Independent Consultant in Toxicology
8:40
9:00 9:10
9:30 9:40
10:00 10:10 10:40
11:00 11:10
11:30 11:40
12:00 12:10
12:30
SESSION IV
14:00
Introduction Chair Industry Perspective: Biomarkers and Drug Toxicity Philippe Vanparys, Janssen Pharmaceutica, Belgium
14:10
14:30 14:40
Discussion Industry Perspective: New Biomarkers and Risk Assessment Michael Lawton, Pfizer Inc, USA Discussion Academic Perspective Jürgen Borlak, Fraunhofer Institute of Toxicology and Experimental Medicine, Germany Discussion Break Regulatory Perspective EU: Status of Regulatory Acceptance in Europe Connie Brouwer, RIVM, The Netherlands Discussion Regulatory Perspective USA: FDA Approach to Regulatory Acceptance Yvonne Dragan, National Center for Toxicological Research, FDA, USA Discussion Panel Discussion Chair, All Speakers
15:00 15:10
15:30 15:40 16:10
16:30 16:40
17:00 17:10
Thursday, November 16 SESSION V Herbal Products in Therapeutic, Nutritional and Cosmetic Uses Chair: TBA
8:30
Introduction Chair Herbal Medicinal Products: Legislation and Regulatory Aspects in the EU Werner Knöss, Federal Institute for Drugs and Medical Devises, Germany Discussion The Viewpoint of Scientific Institutions in the EU Fritz Kemper, University of Münster, Germany Discussion Safety Assessment of Botanicals and Botanical Preparations in Food and Food Supplements: The Role of EFSA and Perspectives Djien Liem, European Food Safety Authority (EFSA), Italy Discussion Herbal Constituents in Cosmetic Products and Uses Joachim Blank, Cosmetochem, Switzerland Discussion
8:40
9:00 9:10
9:30 9:40
10:00 10:10
10:30
10:40 11:10
Break The View of Industry Bernd Eberwein, German Medicines Manufacturers' Association, Germany Discussion Safety Evaluation of Herbal Products Egon Koch, European Self Medication Industry (AESGP) / Schwabe, Germany Discussion Lunch Hair Dyes: Is a Cancer Risk Biologically Plausible? Chair: James Swenberg, University of North Carolina, USA
11:30 11:40
12:00 12:10
SESSION VI
13:30
Introduction Chair Scientific Review of Hair Dye Safety in the EU Günter Speit, University of Ulm, Germany Discussion Regulation of Hair Dyes in the EU Roman Mocry, Cosmetics Sector, DG Enterprise and Industry, European Commission, Brussels Discussion Hair Dye Use and Bladder Cancer Risk Manolis Kogevinas, IMIM, Spain / National Cancer Institute, USA Discussion Break Hair Dyes Exposure Assessment: An Occupational Exposure Study of Hairdressers Gerhard Nohynek, L’Oreal, France Discussion Metabolism of Oxidative Hair Dyes: A Key Consideration for Safety Assessment Julie Skare, Procter & Gamble, USA Discussion Investigations of Oxidative Hair Dye Reaction Products Dominic Pratt, Kao Professional Salon Services, Germany Discussion Panel Discussion Kurt Straif, International Agency for Research on Cancer, France All Speakers Meeting adjourned
13:40
14:00 14:10
14:30 14:40
15:00 15:10 15:40
16:00 16:10
16:30 16:50
17:00 17:10
17:40