VIEWS: 15 PAGES: 1 POSTED ON: 1/6/2013
Mechanistic Investigation on Gold-catalyzed Microwave-assisted Annulation Reaction Tim Dunn, Erica Amato, Lili Ma Department of Chemistry, Northern Kentucky University, Nunn Drive, Highland Heights, KY 41099 Abstract Here we report our recent findings on the mechanistic study of gold(I) cyanide - catalyzed annulation reactions of hydroxyaldehydes and aryl alkynes under heat via a silicone oil bath. The reaction yields and intermediates were monitored by 1H and 13C NMR spectroscopy. Reaction conditions such as gold/ligand ratio, hydroxyaldehyde/gold ratio, alkyne/gold ratio, and optimal internal reference compounds were studied.13C NMR spectroscopy showed evidence for an intermediate formed by reacting AuCN and alkyne. Optimal reaction conditions established from this study include a AuCN to hydroxyaldehyde ratio of 1 to 2, an alkyne to AuCN ratio of 2 to 1, and benzyl ether as an acceptable internal reference compound.
"Mechanistic Investigation on Gold-Catalyzed Microwave-assisted "