Documents
Resources
Learning Center
Upload
Plans & pricing Sign in
Sign Out

Mechanistic Investigation on Gold-Catalyzed Microwave-assisted

VIEWS: 15 PAGES: 1

									Mechanistic Investigation on Gold-catalyzed Microwave-assisted Annulation
Reaction

Tim Dunn, Erica Amato, Lili Ma

Department of Chemistry, Northern Kentucky University, Nunn Drive, Highland Heights, KY
41099

Abstract

         Here we report our recent findings on the mechanistic study of gold(I) cyanide - catalyzed
annulation reactions of hydroxyaldehydes and aryl alkynes under heat via a silicone oil bath. The reaction
yields and intermediates were monitored by 1H and 13C NMR spectroscopy. Reaction conditions such as
gold/ligand ratio, hydroxyaldehyde/gold ratio, alkyne/gold ratio, and optimal internal reference
compounds were studied.13C NMR spectroscopy showed evidence for an intermediate formed by reacting
AuCN and alkyne. Optimal reaction conditions established from this study include a AuCN to
hydroxyaldehyde ratio of 1 to 2, an alkyne to AuCN ratio of 2 to 1, and benzyl ether as an acceptable
internal reference compound.

								
To top