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									- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Bayer
BAYER CORPORATION AGRICULTURE DIVISION 12707 WEST 63rd Shawnee Mission, KS 66216-1846 TRANSPORTATION EMERGENCY: CALL CHEMTREC: 800-424-9300 DISTRICT OF COLUMBIA: 202-483-7616 NON-TRANSPORTATION: BAYER EMERGENCY PHONE: (800) 422-9874 BAYER INFORMATION PHONE: (913) 631-4800 ----------------------------------------------------------1. CHEMICAL PRODUCT IDENTIFICATION: ----------------------------------------------------------PRODUCT NAME: CO-RAL LIVESTOCK INSECTICIDE SPRAY (LIS) PRODUCT CODE: 031326 CHEMICAL FAMILY: Organophosphorus Insecticide CHEMICAL NAME: 0,0-Diethyl 0{3-chloro-4-methyl-2-oxo-(2H)1-benzopyran-7-yl} phosphorothioate SYNONYMS: BAYMIX, MELDANE, CO-RAL FORMULA: C14 H16 C1 05 P S ----------------------------------------------------------2. COMPOSITION/INFORMATION ON INGREDIENTS: ----------------------------------------------------------INGREDIENT NAME CONCENTRATION /CAS NUMBER EXPOSURE LIMITS (%) ----------------------------------------------------------*****HAZARDOUS INGREDIENTS***** CO-RAL (coumaphos) 56-72-4 OSHA: Not Established 6% ACGIH: Not Established Aromatic Petroleum Distillates OSHA: Not Established 80-90% ACGIH: Not Established Naphthalene 91-20-3 OSHA: 10.00 ppm (TWA) % Not Noted ACGIH: 10.00 ppm (TWA) ----------------------------------------------------------3. HAZARDS IDENTIFICATION: ----------------------------------------------------------EMERGENCY OVERVIEW: Color: Brown; Form: Liquid; Liquid in plastic containers; Odor: Aromatic Solvent Odor; Organophosphate Insecticide - Cholinesterase Inhibitor. POTENTIAL HEALTH EFFECTS: ROUTE(S) OF ENTRY: Inhalation; Skin Contact; Skin Absorption HUMAN EFFECTS AND SYMPTOMS OF OVEREXPOSURE: ACUTE EFFECTS OF EXPOSURE: Inhalation, dermal absorption or ingestion of this material may result in systemic intoxication due to inhibition of the enzyme cholinesterase. The sequence of development of systemic effects varies with the route of entry, and the onset of symptoms may be delayed up to 12 hours. First symptoms of poisoning may be nausea, increased salivation, lacrimation, blurred vision and constricted pupils. Other symptoms of systemic poisoning include vomiting, diarrhea, abdominal cramping, dizziness and sweating. After inhalation, respiratory symptoms like tightness of chest, wheezing, and laryngeal spasms, may be pronounced at first. If the poisoning is severe, then symptoms of convulsions, low blood pressure, cardiac irregularities, loss of reflexes and coma may occur. In extreme cases, death may occur due to a combination of factors such as respiratory arrest, paralysis of respiratory muscles or intense bronchoconstrictions. Complete symptomatic recovery from sublethal poisoning usually occurs within one week once the source of exposure is completely removed.

CO-RAL LIVESTOCK INSECTICIDE SPRAY (LIS)
The aromatic solvents in this product can be irritating to the eyes, nose and throat, and may cause central nervous system depression and narcosis, characterized by nausea, lightheadedness and dizziness from overexposure by inhalation. Animal studies have shown that this material is moderately toxic by the oral route and mildly toxic by the dermal route and that it is an eye and dermal irritant. It is not a skin sensitizer. CHRONIC EFFECTS OF EXPOSURE: Cholinesterase inhibition sometimes persists for 2-6 weeks, thus repeated exposure to small amounts of this material may result in unexpected cholinesterase depression causing symptoms such as malaise, weakness, and anorexia that resemble other illnesses such as influenza. Exposure to a concentration that would not have produced symptoms in a person that was not previously exposed may produce severe symptoms of cholinesterase inhibition in a previously exposed person. Repeated skin contact may result in defatting of the skin by solvents in the formulation which can lead to redness and irritation of the skin. Chronic overexposure to these solvent components may cause mucous membrane irritation, nausea, headache, loss of appetite, weakness and alcohol intolerance. CARCINOGENICITY: This product is not listed by NTP, IARC or regulated as a carcinogen by OSHA. MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: No specific medical conditions are known which may be aggravated by exposure to the active ingredient in this product; however, any disease, medication or prior exposure which reduces normal cholinesterase activity may increase susceptibility to the toxic effects of the active ingredient. In addition, pre-existing skin, eye, liver and kidney disorders may be aggravated by exposure to this product due to the solvent components. ----------------------------------------------------------4. FIRST AID MEASURES: ----------------------------------------------------------FIRST AID FOR EYES: Hold eyelids open and flush with copious amounts of water for 15 minutes. Call a physician if irritation develops or persists after flushing. FIRST AID FOR SKIN: In cases of skin contact, remove contaminated clothing and wash affected areas with plenty of soap and water. Get medical attention if irritation develops or persists. If signs of intoxication (poisoning) occur, get medical attention immediately. FIRST AID FOR INHALATION: If a person is overcome by excessive exposure to aerosols or vapors of this material, remove to fresh air or uncontaminated area. If not breathing, give artificial respiration, preferably mouth-to-mouth. Get medical attention as soon as possible. FIRST AID FOR INGESTION: If ingestion is suspected, call a physician or poison control center. If medical assistance cannot be given immediately, drink promptly large quantities of water. Avoid alcohol. Do not induce vomiting. Do not attempt to give anything by mouth to an unconscious or convulsing person. NOTE TO PHYSICIAN: This product contains the organophosphorous insecticide, coumaphos, a cholinesterase inhibitor. Cholinesterase inhibition results in stimulaiton of the central nervous system, the parasympathetic nervous system and the somatic motor nerves. If symptoms of organophosphate poisoning are present, the administration of atropine sulfate is indicated. Administer atropine sulfate in large therapeutic doses. In mild cases, start treatmeant by giving 1-2 mg of atropine intravenously every 15 minutes until signs of atropinazation appear (dry mouth, flusing, and dilated pupils if pupils were originally pinpoint). In severe cases start treatment by giving 2-4 mg intravenously every 5-10 minutes until fully atropinized. Dosages for children should be appropriately reduced.

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- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Bayer
2-PAM is also antidotal and may be used in conjunction with atropine. Do not give morphine. Watch for pulmonary edema which may develop in serious cases of poisoning even after 24 hours. At first sign of pulmonary edema, place patient in oxygen tent and treat symptomatically. When treating poisoning victims, be aware that this formulaiton contains 80-90% aromatic petroleum distillates. In case of poisoning, it is alos requested that Bayer Corp., Agriculture Division, Shawnee, KS, be notified. Telephone: 1-800-422-9874 (working hours) or 913-268-2700 (non-working hours). ----------------------------------------------------------5. FIRE FIGHTING MEASURES: ----------------------------------------------------------FLASH POINT: TOC: Greater than 185 deg F EXTINGUISHING MEDIA: Water; Carbon Dioxide; Dry Chemical SPECIAL FIRE FIGHTING PROCEDURES: Fight fire from upwind. Keep out of smoke. Use self contained breathing apparatus if large quantities of product are present. ----------------------------------------------------------6. ACCIDENTAL RELEASE MEASURES: ----------------------------------------------------------SPILL OR LEAK PROCEDURES: Avoid breathing vapors and skin contact. Contain spilled material through the use of diking or absorbent materials. Absorb spilled material with absorbent and place in covered container. Scrub contaminated area with a degreaser detergent and caustic solution. Repeat and rinse with water. ----------------------------------------------------------7. HANDLING AND STORAGE: ----------------------------------------------------------STORAGE TEMPERATURE (MIN/MAX): Avoid sustained temperatures above 100 deg F SHELF LIFE: Not Noted SPECIAL SENSITIVITY: Heat, light and moisture HANDLING/STORAGE PRECAUTIONS: Store in cool dry area. Store in area designated for pesticides. Do not store near any material for use or consumption by humans. ----------------------------------------------------------8. PERSONAL PROTECTION: ----------------------------------------------------------EYE PROTECTION REQUIREMENTS: Splash-proof goggles should be used when needed to prevent liquid splashes from getting into the eyes. SKIN PROTECTION REQUIREMENTS: Avoid skin contact. Wear long sleeves and trousers to prevent dermal exposure. HAND PROTECTION REQUIREMENTS: Chemical-resistant gloves VENTILATION REQUIREMENTS: Maintain exposure levels below the applicable exposure limits through the use of general and local exhaust ventilation RESPIRATOR REQUIREMENTS: When needed, based on the conditions of use, wear NIOSH-approved organic vapor respirator with particulate pre-filter. ADDITIONAL PROTECTIVE MEASURES: Clean water should be available for washing in case of eye or skin contamination. Educate and train employees in safe use of the product. Follow all label instructions. Launder clothing separately after use. Wash thoroughly after handling. ----------------------------------------------------------9. PHYSICAL AND CHEMICAL PROPERTIES: ----------------------------------------------------------PHYSICAL FORM: Liquid APPEARANCE: Liquid in plastic containers COLOR: Brown ODOR: Aromatic Solvent Odor ODOR THRESHOLD: Not available MOLECULAR WEIGHT: 362.78 (for coumaphos) BOILING POINT: Not available MELTING/FREEZING POINT: FREEZING: <10 deg F

CO-RAL LIVESTOCK INSECTICIDE SPRAY (LIS)
SOLUBILITY IN WATER: Forms emulsion SPECIFIC GRAVITY: 1.02 (20/20 deg C) BULK DENSITY: 8.5 lb/gal % VOLATILE BY VOLUME: 90% VAPOR PRESSURE: 0.15 mm Hg (20 deg C) (Panasol AN 3N) VAPOR DENSITY: Not available (Air = 1) ----------------------------------------------------------10. STABILITY AND REACTIVITY: ----------------------------------------------------------STABILITY: This is a stable material. HAZARDOUS POLYMERIZATION: Will not occur. INCOMPATIBILITIES: Alkaline materials, strong oxidizing agents. INSTABILITY CONDITIONS: Not Noted DECOMPOSITION PRODUCTS: Carbon monoxide, phosphorous pentoxide, sulfur dioxide, other oxides of sulfur and phosphorous, and chlorine if heated to decomposition. ----------------------------------------------------------11. TOXICOLOGICAL INFORMATION: ----------------------------------------------------------Only acute studies have been performed on this product as formulated. The non-acute information pertains to the active ingredient, coumaphos. ACUTE TOXICITY ORAL LD50: Rat: 395 mg/kg DERMAL LD50: Rabbit: >3000 mg/kg INHALATION LC50: Rat: >1.089 mg/L EYE EFFECTS: Irritant: effects are reversible within 7 days. SENSITIZATION: Not a dermal sensitizer. SUBCHRONIC TOXICITY: In dermal toxicity studies, rats were administered the active ingredient, technical grade coumaphos, for 6 hours/day for a total of 17-18 applications over a 3 week period. Doses tested ranged from 0.1 to 100 mg/kg. Effects observed included clinical sings of toxicity and cholinesterase inhibition. The overall no-observed-effect-level (NOEL) from these studies were 0.5 mg/kg based on cholinesterase inhibition. CHRONIC TOXICITY: In a 1 year study, dogs were administered technical grade coumaphos at dietary concentrations of 1, 30 or 90 ppm. The only compound-related effects produced in this study involved the inhibition of cholinesterase activities. Based on inhibition of plasma and erythrocyte cholinesterase activity, the overall NOEL was 1 ppm while the systemic NOEL was 30 ppm based on inhibition of ocular tissue and brain cholinesterase activity. Technical grade coumaphos was administered to rats at dietary concentrations of 1, 5 or 25 ppm for 24 months. At 25 ppm, there was a reduction in body weight gains and cholinesterase activities (plasma & erythrocyte). The NOEL was 5 ppm. CARCINOGENICITY: Technical grade coumaphos was investigated for carcinogenicity in chronic feeding studies using mice and rats at maximum levels of 20 and 25 ppm, respectively. There was no evidence of a carcinogenic potential observed in either species. MUTAGENICITY: Numerous in vitro and in vivo mutagenicity studies have been conducted on technical grade cumaphos, all of which are negative. DEVELOPMENTAL TOXICITY: Technical grade coumaphos was administered by oral gavage to rats during gestation at doses of 1, 5 or 25 mg/kg. Maternal toxicity, exhibited by tremors, was observed at the highest dose. There was no indication of any developmental effects. The NOELs for maternal and developmental toxicity were 5 and 25 mg/kg, respectively. Rabbits were administered technical grade coumaphos by oral gavage at doses of 0.25, 2 or 18 mg/kg during gestation. Maternal toxic effects observed at the high dose included tremors, reduced body weight gains and mortality. There was no indication of any developmental toxic effects. The NOELs for maternal and developmental toxicity were 2 and 18 mg/kg, respectively.

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- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Bayer
REPRODUCTION: In a reproduction study using rats, technical grade coumaphos was administered for 2 generations at dietary concentrations of 1, 5 or 25 ppm. There were no compound-related effects on adult reproductive or litter parameters. At concentrations of 5 ppm and greater, parental cholinesterase activities were inhibited. The NOELs for parental and reproductive effects were 1 and 25 ppm, respectively. NEUROTOXICITY: Technical grade coumaphos was investigated for acute delayed neurotoxicity using atropine-protected hens. The active ingredient was administered once orally at a dose of 50 mg/kg followed 3 weeks later with a second dose of 100 mg/kg. No evidence of delayed neurotoxicity was observed in the treated hens. ----------------------------------------------------------12. ECOLOGICAL INFORMATION: ----------------------------------------------------------This compound has been thoroughly evaluated for ecological effects. Bayer will provide a summary of specific data upon written request. As with any pesticide, this product should be used according to label directions and should be kept out of streams,lakes and othe aquatic habitats of concern. ----------------------------------------------------------13. DISPOSAL CONSIDERATIONS: ----------------------------------------------------------WASTE DISPOSAL METHOD: Follow container label instructions for disposal of wastes generated during use in compliance with the product label. In other situations, bury in an EPA-approved landfill or burn in an incinerator approved for pesticide destruction. Do not reuse container. ----------------------------------------------------------14. TRANSPORTATION INFORMATION: ----------------------------------------------------------TECHNICAL SHIPPING NAME: Coumaphos - 6% FREIGHT CLASS BULK: Not Applicable FREIGHT CLASS PACKAGE: Insecticides, N.O.I. NMFC 102100 PRODUCT LABEL: Not Noted DOT (DOMESTIC SURFACE): PROPER SHIPPING NAME: Organophosphorus Pesticides, Liquid, Toxic,* HAZARD CLASS OR DIVISION: 6.1 UN/NA NUMBER: UN3018 PACKAGING GROUP: PG III DOT PRODUCT RQ LBS (kgs): 166* lbs (75.3 kgs) HAZARD LABEL(S): Keep Away From Food HAZARD PLACARD(S): Keep Away From Food * Marine Pollutant if shipped in Bulk, or Non-Bulk by water. "RQ" must be added before or after proper shipping name if packaged in quantities of more than 165 lbs. IMO / IMDG CODE (OCEAN): PROPER SHIPPING NAME: Organophosphorus Pesticides, Liquid, Toxic, Marine Pollutant HAZARD CLASS DIVISION NUMBER: 6.1 UN NUMBER: UN3018 PACKAGING GROUP: III HAZARD LABEL(S): Keep Away From Food; Marine Pollutant (Marking) HAZARD PLACARD(S): Keep Away From Food; Marine Pollutant ICAO / IATA (AIR): PROPER SHIPPING NAME: Organophosphorus Pesticides, Liquid, Toxic, HAZARD CLASS DIVISION NUMBER: 6.1 UN NUMBER: UN3018 SUBSIDIARY RISK: None PACKING GROUP: III HAZARD LABEL(S): Keep Away From Food RADIOACTIVE?: Non-Radioactive

CO-RAL LIVESTOCK INSECTICIDE SPRAY (LIS)
----------------------------------------------------------15. REGULATORY INFORMATION: ----------------------------------------------------------OSHA STATUS: This product is hazardous under the criteria of the Federal OSHA Hazard Communication Standard 29 CFR 1910.1200. TSCA STATUS: R&D Use Only, Section 5 (h)(3) Limitations Apply CERCLA REPORTABLE QUANTITY: COUMAPHOS: 10 lbs. SARA TITLE III: SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES: Coumaphos SECTION 311/312 HAZARD CATEGORIES: Immediate Health Hazard; Delayed Health Hazard; Fire Hazard SECTION 313 TOXIC CHEMICALS: Naphthalene (10%) RCRA STATUS: If discarded in its purchased form, this product would not be a hazardous waste either by listing or by characteristic. However, under RCRA, it is the responsibility of the product user to determine at the time of disposal, whether a material containing the product or derived from the product should be classified as a hazardous waste. (40 CFR 261.20-24) ----------------------------------------------------------16. OTHER INFORMATION: ----------------------------------------------------------NFPA 704M RATINGS: 0=Insignificant; 1=Slight; 2=Moderate; 3=High; 4=Extreme HEALTH: 3 FLAMMABILITY: 2 REACTIVITY: 0 OTHER: 0 Bayer's method of hazard communication is comprised of Product Labels and Material Safety Data Sheets. NFPA ratings are provided by Bayer Corporation as a customer service. REASON FOR ISSUE: To revise Sections 4 (Note to Physician); 8 (Respirator Requirements); 11 (add long-term toxicity data); 14 (Transportation); revise to ANSI format. PREPARED BY: V. C. Standart APPROVED BY: D. C. Eberhart TITLE: Product Safety Manager APPROVAL DATE: 09/12/97 SUPERSEDES DATE: 03/11/94 MSDS NUMBER: 16541 ----------------------------------------------------------This information is furnished without warranty, expressed or implied, except that it is accurate to the best knowledge of Bayer Corporation. The data on this sheet relates only to the specific material designated herein. Bayer Corporation assumes no legal responsibility for use or reliance upon these data. ----------------------------------------------------------PRODUCT CODE: 031326 APPROVAL DATE: 09/12/97 ----------------------------------------------------------DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: although preparer and owner have taken reasonable care in the preparation of this document, we extend no warranties and make no representation as to the accuracy or completeness of the information contained herein, and assume no responsibility regarding the suitability of this information for the user's intended purposes or for the consequences of its use. Each user should make a determination as to the suitability of the information for their particular purpose(s). A request has been made to the manufacturer to approve the contents of this material safety data sheet. Upon receipt of any changes a new MSDS will be made available. ----------------------------------------------------------COMPAS Code: 28280042

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