Docstoc

curriculum vitae - The University of Tennessee Health Science Center

Document Sample
curriculum vitae - The University of Tennessee Health Science Center Powered By Docstoc
					                              CURRICULUM VITAE (As of October 2012)
                                                Wei Li
                      Department of Pharmaceutical Sciences, College of Pharmacy
                            University of Tennessee Health Science Center
                          847 Monroe Avenue, room 327, Memphis, TN 38163
                              Tel: (901)448-7532; Email: wli@uthsc.edu

                      Webpage: http://www.uthsc.edu/pharmacy/pharmsci/faculty/wli/

EDUCATION HISTORY
     B. S. 1992     (Chemistry) University of Science and Technology of China (USTC)
     Ph.D. 1999     (Chemistry) Columbia University in the City of New York
PROFESSIONAL EXPERIENCE
     1992-1994      Graduate Research Assistant, Dalian Institute of Chemical Physics, Chinese Academy
                    of Sciences
     1994 - 1999    Graduate Research Assistant, Columbia University in the City of New York
     1999 - 2001    Instructor and Director of Instrument Facility, University of Tennessee HSC (UTHSC)
     2001 - 2004    Assistant Professor and Faculty Director of Instrument Facility, UTHSC
     2004 - 2009    Assistant Professor (tenure-track) and Faculty Director of Instrument Facility, UTHSC
     2009-present Associate Professor (tenured) and Faculty Director of Instrument Facility, UTHSC
HONORS/AWARDS
     Faculty Fellowship, Columbia University, 1994-1999
     Zhang ZhongZhi Fellowship, University of Science and Technology of China, 1991
     Innovation Award, University of Tennessee Research Foundation, 2010
     Research Award, University of Tennessee Research Foundation, 2012
SOCIETY MEMBERSHIPS
     American Chemical Society
     American Association for Cancer Research
     Association of Managers in Magnetic Resonance Laboratories
COURSES TAUGHT
     Medicinal Chemistry I (MEDC612/812),     instructor (2006-present)
     Introduction to Pharmacy (PHSC115),      co-facilitator (2008)
     Research Techniques in Medicinal Chemistry (MEDC813), course director (2005-present)
     Research Techniques in Medicinal Chemistry II (MEDC823), course director (2005-present)
CURRENT FUNDING
     PI: 1R01CA148706-01A1
     NIH/NCI
     Title: “Discovery of novel thiazole compounds for treating advanced melanoma”
     1/2011-12/2015
     Estimated five year total direct: $1,037,500, estimated total: $1,535,500

     PI: 1S10OD010678-01
     NIH
     Title: “Acquisition of a Q-TOF Mass Spectrometer”
     05/01/2012-04/30/2013
                                                     1
       Direct cost: $325,000

       Co-I: 1R01AR056666-01A2 (PI: Andrzej T. Slominski)
       NIH
       Title: “Role of exogenous melatonin in skin biology”
       08/01/2011-07/31/2016
       Estimated five year total: $1,662,408.
       Role: Co-investigator

PENDING FUNDING:

       PI: 1R21AR063242-01A1, MPI: Wei Li (NIH contact); Duane Miller
       NIH
       Title: “Discovery of tissue-selective, nonhypercalcemic VDR modulators for RA treatment”
       Estimated total: $412,500
       Priority score: 13
       Percentile: 2.0

COMPLETED SUPPORT
    Co-I: 1RO1 AR052190-01A2 (PI: Andrzej T. Slominski)
    NIH
    Title: “Novel Biosynthetic Pathway for Secosteroids and the Skin”
    08/2006-07/2011 (no cost extension to 07/2012)
    Five year total award amount: $1,922,190

       PI: Dean’s Enhancement Program for Research Equipment
       College of Pharmacy, University of Tennessee Health Science Center
       Title: “Purchase of an inverted fluorescence microscope ”
       05/2012-06/2012
       Total cost: $15,000

       PI: Pilot Study to Assess Blood Chemistry at High Dose 20S/R-OH-D3 in Mice
       University of Tennessee Research Foundation
       03/2012-06/2012
       Total cost: $3,000.

       PI: Technology Maturation Award
       University of Tennessee Research Foundation
       Title: “Preclinical studies of new vitamin D analogs as potential agents for arthritis”
       1/2011-10/2011
       Total direct: $15,000; total amount: $15,000.

       PI: RR-026377-01
       NIH/NCRR
       Title: "Acquistion of a 400M NMR with an autosampler"
       08/23/2010-08/22/2011
       Total direct: $252,900, total amount: $252,900

       PI: 1R15CA125623-01A2
       National Cancer Institute, NIH
       Title: “Discovery of Novel Cytotoxic Agents for Advanced Melanoma”
       3/2008 – 2/2011.
                                                         2
       Total direct: $150,000, total amount: $219,000

       PI: Technology Maturation Award
       University of Tennessee Research Foundation, University of Tennessee
       Title “In vivo Assessment of Efficacy of Novel Thiazole Compounds”
       2/2009-10/2009
       Total direct: $15,000; Total amount: $15,000.

       PI: College of Pharmacy Seed Research Fund
       University of Tennessee
       Title: “Development of Novel Cytotoxic Agents towards Advanced Melanoma”
       2006-2007
       Total direct: $9,300; total amount: $9,300

       Co-I: 1R03AI054798-01 (PI: Richard Lee)
       NIH/NIAID
       Title: “Whole Cell NMR Studies of MYcobacteria”
       05/2003-12/2006
       Total direct: $100,000; Total amount: $146,000

       Co-I: DAMD17-01-0830 (PI: Duane Miller)
       Department of Defense
       Title: “Selective Cytotoxic Phospholipids for Prostate Cancer”
       9/20/2001-10/20/2005
       Total cost: $556,364
       Role: Investigator

       College of Pharmacy, faculty start-up fund for Dr. Wei Li, 2004-2007.

INVITED LECTURES
  1.    Wei Li: "Application of Zeolites as Microreactors", Seminar, Department of Chemistry, Columbia
        University, New York, NY, 1998.
  2.    Li, Wei; Lee, Robin E. B.; Lee, Richard E. Implementation and Optimization of In-Cell Multi-
        dimensional HRMAS NMR. Invited talk, 57th Southeast/61st Southwest Joint Regional Meeting of the
        American Chemical Society, Memphis, TN, United States, November 1-4 (2005)
  3.    Lee, Richard; Li, Wei; Lee, E. B. HR-MAS NMR as a Tool to Study Live Mycobacterial Metabolism.
        Invited talk, 57th Southeast/61st Southwest Joint Regional Meeting of the American Chemical Society,
        Memphis, TN, United States, November 1-4 (2005)
  4.    Wei Li: “Application of multi-dimensional HRMAS NMR in intact cells”, Workshop on Metabonomics: a
        new tool for exploring biocomplexity, session chairman, Valencia, Spain, October 21st-24th, 2008.
  5.    Wei Li: “Noncalcemic vitamin D metabolites: from structure elucidation to in vivo efficacy studies”,
        College of Pharmacy, the University of Mississippi, Feb 14, 2012.


EDITORIAL APPOINTMENTS:
      Guest editor, Pharmaceutical Sciences, Theme Issue on tubulin inhibitors, 2012.
      Reviewer, Bioorganic Medicinal Chemistry Letters, Bioorganic Medicinal Chemistry, 2008-present
      Reviewer, Royal Society of Chemistry Journals, 2008-present
      Ad hoc reviewer:


                                                        3
            Journal of American Chemical Society; The Open Magnetic Resonance Journal; Molecular
             Diversity; European Journal of Medicinal Chemistry; Journal of Medicinal Chemistry;
             International Journal of Nanomedicine, PLoS ONE, etc.

CONSULTANT:
     ad hoc consultant, MEDACorp, Leerink Swann LLC, 2006-present
     consultant, GTx Inc., 05/2012-present
     ad hoc consultant, RxBio Inc., 2012.

GRANT REVIEW
     National Institute of Health
         o   2011/03: ZRG1 BCMB-U 30
         o   2012/03: ZRG1 BCMB-R 30
         o   2012/07: ZRG1 BCMB-D 30
         o   2012/11: CDDT OTC (10)
     National Science Foundation
     US Army
     Human Frontier Science Program
     American Chemical Society
     Florida Department of Health
     Estonian Science Foundation (ETF)


COMMITTEES AND OFFICES HELD
  1. Member - Computing and Telecommunication Committee, 2003 – 2006
  2. Member - Webpage Committee, College of Pharmacy, 2001-2003
  3. Member - Physical Facility Committee, College of Pharmacy, 2001-2002
  4. Member - New Pharmacy Building Planning Committee, College of Pharmacy, 2004-2005
  5. Member - Faculty Enrichment Committee, College of Pharmacy, 2005-present
  6. Member – Faculty Search Committee for Medicinal Chemistry, 2009-2010
  7. Member (Chair, 2011-2012)- Web and Technology Committee, College of Pharmacy, 2005-2012.
  8. Chair - NMR Advisory Committee, Department of Pharmaceutical Sciences, 2010-present
  9. Chair – Facility and Space subcommittee, Department of Pharmaceutical Science self-study, 2012.
  10. Member - Exam Integration and Writing Committee, 2012-present
  11. Chair – HRMS Advisory Committee, Department of Pharmaceutical Sciences, 2012-present.


FELLOWS/STUDENTS TRAINED
  Research Associate
  Dr. Jianjun Chen                   2010-present




                                                    4
   Graduate Student Dissertation Committees:
   Previous years:
   1. Dr. Bin Fang                2003-2006
   2. Mr. Jin Xu                  2005-2007
   3. Dr. Engy Marhous            2006-2009
   4. Mr. Jinghu Li               2004-2005 (Chair, student transferred to UIC in 2005)
   5. Dr. Zhao Wang               2005-2010 (Chair)
   6. Dr. Li Chen                 2005-2009
   7. Dr. Kui Zeng                2005-2010
   8. Dr. Josh Brown              2005-2010
   9. Dr. Renuka Gupte            2005-2011
   10. Dr. Jianjun Chen           2006-2011 (Chair)
   11. Dr. Steve Gurley           2005-2010
   12. Dr. Ningning Yang          2008-2011
   13. Dr. Feng Li                2008-2011
   14. Mr. Les Stuart             2008-2010
   15. Dr. Chikezie Madu          2008-2012


Current:
   1. Mr. Min Xiao                2010-present (Chair)
   2. Ms. Jin Wang                2010-present (Chair)
   3. Ms. Shan Sun                2010-present
   4. Dr. Bret Koertge            2010-present
   5. Mr. Jerrod Scarborough      2010-present
   6. Mr. Zongtao Lin             2012-present (Chair)
   7. Ms. Gorgina Nabil           2012-present (Chair)


Summer Undergraduate Students:
   1. Mr. Rodeck Slominski        Emory University                    Summer of 2004
   2. Mr. Chris Scheid            College of William and Mary         Summer of 2008
   3. Ms. Ashley Vorenkamp        Louisiana University                Summer of 2010
   4. Ms. Victoria Strong         Tennessee State University          Summer of 2011
   5. Mr. Devaughn Reece          Tennessee Tech University           Summer of 2012

FELLOWSHIP/AWARD RECEIVED BY STUDENTS
   1. Dr. Zhao Wang (PhD student from 2005-2010), Alma and Hal Reagan Fellowship, $22,000 fellowship
      plus $1,000 travel/supplies, UTHSC College of Graduate Health Sciences, 2007-2008. Dr. Wang was
      the only receipt for this fellowship out of all graduate students at UTHSC campus working on cancer
      related projects for the year.



                                                     5
     2. Dr. Zhao Wang (PhD student from 2005-2010), Alma and Hal Reagan Fellowship, $22,000 fellowship
        plus $1,000 travel/supplies, UTHSC College of Graduate Health Sciences, 2008-2009. Dr. Wang
        successfully renewed this fellowship (a maximum of two years is allowed).
     3. Dr. Zhao Wang, Travel Award for AACR national meeting, University of Tennessee HSC, $500, 2009
     4. Dr. Zhao Wang, Travel Award for AAPS national meetings, University of Tennessee HSC, $500, 2010
     5. Dr. Zhao Wang, Travel Grant, 15th Pan American Society for Pigment Cell Research, 2009
     6. Dr. Jianjun Chen (PhD student from 2005-2010), Travel Grant, 15th Pan American Society for Pigment
        Cell Research, 2009
     7. Dr. Jianjun Chen (PhD student from 2005-2010), Travel Award for ACS national meetings, University of
        Tennessee HSC, $500, 2010
     8. Ms Jin Wang (PhD student from 2010-present), Alma and Hal Reagan Fellowship, $23,000 fellowship
        plus $1,000 travel/supplies, 2012-2013.


PEER-REVIEWED JOURNAL ARTICLES (* indicates corresponding author)


(Prior to tenure-track at UTHSC, 2003 and earlier)
1. Nicholas J. Turro, Xuegong Lei, Wei Li, Ann McDermott, Lloyd Abrams, M. Francesca Ottaviani and Hege
   Stogard Beard, " Photochemistry and magnetic resonance spectroscopy as probes of supramolecular
   structures and migration pathways of organic molecules and radicals adsorbed on zeolites", Chem.
   Commun., 695-696 (1998).
2. Nicholas J. Turro, Ann McDermott, Xuegong Lei, Wei Li, Lloyd Abrams, M. Francesca Ottaviani, Hege
   Stogard Beard, Kendall N. Houk, Brett R. Beno and Patrick S. Lee, "Photochemistry of ketones adsorbed
   on size/shape selective zeolites. A superamolecular approach to persistent carbon centered radicals",
   Chem. Commun., 697-698 (1998)
3. Wei Li, Xuegong Lei, George Lem, Ann McDermott, Nicholas J. Turro, Nils Bottke and Waldemar Adam,
   "Oxygen and structural effect on silicalite 29Si spin-lattice relaxation studied by high resolution 29Si solid
   state NMR", Chem. Mater., 2000, 12, 731-737
4.   Takashi Hirano,Wei Li, Lloyd Abrams,Paul J. Krusic, M. Francesca Ottaviani and N. J. Turro, "Reversible
     Oxygenationof a Diphenylmethyl Radical Rendered Supramolecularly Persistent"J. Am.Chem. Soc.,
     1999,121, 7170-7171
5. Takashi Hirano, Wei Li, Lloyd Abrams, Paul J. Krusic, M. Francesca Ottaviani and N. J. Turro, "
   Supramolecular Steric Effects as the Means of Making Reactive Carbon Radicals Persistent. Quantitative
   Characterization of the External Surface of MFI Zeolites through a Persistent Radical Probe and a
   Langmuir Adsorption Isotherm", J. Org. Chem. 2000, 65, 1319-1330
6. Nicholas J. Turro, Xue-Gong Lei, Wei Li, Zhiqiang Liu, Ann McDermott, M. Francesca Ottaviani, and Lloyd
   Abrams, "Photochemical and Magnetic Resonance Investigations of the Supramolecular Structure and
   Dynamics of Molecules and Reactive Radicals on the External and Internal Surface of MFI Zeolites", J.
   Am. Chem. Soc., 2000, 122, 11649-11659
7. Nicholas J. Turro, Xue-Gong Lei, Wei Li, Zhiqiang Liu, and M. Francesca Ottaviani, "Adsorption of Cyclic
   Ketones on the External and Internal Surfaces of a Faujasite Zeolite (CaX). A Solid-State 2H NMR, 13C
   NMR, FT-IR, and EPR Investigation", J. Am. Chem. Soc., 2000, 122, 12571-12581
8. Yali He, Donghua Yin, Minoli Perera, Leonid Kirkovsky, Nina Stourman, Wei Li, James T. Dalton, and
   Duane D. Miller, "Novel Nonsteroidal Ligands with High Binding Affinity and Potent functional Activity for
   the Androgen Receptor", Europ. J. Med. Chem., 2002, 37, 619-6
9. Nicholas J. Turro, Xue-gong Lei, Steffen Jockusch, Wei Li, Zhiqiang Liu, Lloyd Abrams and M. Francesca
   Ottaviani, “EPR Investigation of Persistent Radicals Produced from the Photolysis of Dibenzyl Ketones
   Adsorbed on ZSM-5 Zeolites”, J. Org. Chem., 2002, 67(8), 2606-2618
                                                       6
10. Asha K. Nadipuram, Mathangi Krishnamurthy, Antonio M.Ferreira, Wei Li and Bob M. Moore, II, "Synthesis
    and Testing ofNovel Classical Cannabinoids: Exploring the Side Chain Ligand Binding Pocket ofthe CB1
    and CB2 Receptors", Bioorganic & Medicinal Chemistry, 2003,11, 3121-3132.


(2004)
11. Shilpa G. Lalchandani, Xiaoyang Zhang, Seoung Soo Hong, Stephen B. Liggett, Wei Li, Bob M. Moore II,
    Duane D. Miller and Dennis R. Feller, "Medetomidine Analogs As Selective Agonists for the Human alfa2-
    Adrenoceptors" Biochem. Pharmacol., 2004, 67(1), 87-96.
12. Mathangi Krishnamurthy, Wei Li and Bob M. Moore II, “Synthesis, Biological Evaluation, and Structural
    Studies on N1 and C5 Substituted Cycloalkyl Analogs of Pyrazole Class of CB1 and CB2 Ligands”,
    Bioorg. & Med. Chem., 2004, 12, 393-404


(2005)
13. Robin E. B. Lee, Wei Li, Delphi Chatterjee and Richard E. Lee, "Structural Characterization of the Intact
    Mycobacterial Cell Wall Using 2D and 3D High-Resolution Magic-Angle Spinning NMR Spectroscopy",
    Glycobiology, 2005,15 (2), 139-151
14. Andrzej Slominski, Igor Semak, Jordan Zjawiony, Jacobo Wortsman, Michael N. Gandy, Jinghu Li, Blazej
   Zbytek, Wei Li and Robert C. Tuckey, “Enzymatic metabolism of ergosterol by cytochrome P450scc
   (CYP11A1) to biologically active 17a,24-dihydroxyergosterol”, Chemistry & Biology, 12(8), 931-939
   (2005).
15. Andrzej Slominski, Igor Semak, Jordan Zjawiony, Jacobo Wortsman, Wei Li, Andre Szczesniewski, Robert
   C. Tuckey, “The cytochrome P450scc system opens an alternate pathway of vitamin D3metabolism.”,
   FEBS Journal, 272, 4080-4090, (2005).
16. Wei Li*, Robin E. B. Lee, Richard E. Lee and Jinghu Li, “Methods for Acquisition and Assignment of Multi-
   Dimensional High-Resolution Magic Angle Spinning NMR of Whole Cell Mycobacteria”, Anal. Chem., 77,
   5785-5792, (2005). This paper was selected as an accelerated paper featured in the cover of the issue,
   and a "Research Profiles" with the title "Hitting the magic angle for cell wall analysis" written by Joe Alper
   based on phone interview was published in the next issue (Anal. Chem., October 1, 2005, page 371A)


(2006)
17. Renukadevi Patil, Wei Li, Charles R. Ross II, Elfi Kraka, Dieter Cremer, Michael L. Mohler, James T.
    Dalton, Duane D. Miller, "Cesium fluoride and tetra-n-butylammonium fluoride mediated 1,4-N→O shift of
    disubstituted phenyl ring of a bicalutamide derivative", Tetrahedron Letters, 47(13), 3941-3944 (2006).
18. Andrzej Slominski, Igor Semak, Jacobo Wortsman, Jordan Zjawiony, Wei Li and Robert C. Tuckey,
    “Alternative metabolism of vitamin D2 via P450scc system to 20-hydroxyvitamin D2 and 17,20-
    dihydroxyvitamin D2”, FEBS J., 273, 2891-2901 (2006)
19. Wei Li*, "Multidimensional HRMAS NMR: a platform for in vivo studies using intact bacteria cells", invited
    review, Analyst, 131, 777-781 (2006). This article is also highlighted in the news section of Chemical
    Biology from Royal Society of Chemistry in the issue of July 21, 2006.
20. Michael L. Mohler, Gyong-Suk Kang, Seoung-Soo Hong, Renukadevi Patil, Oleg V. Kirichenko, Wei Li,
    Igor M. Rakov, Eldon E. Geisert, and Duane D. Miller, "Discovery of Antiglioma Activity of Biaryl 1,2,3,4-
    Tetrahydroisoquinoline Derivatives and Conformationally Flexible Analogs", J. Med. Chem., 49(19), 5845-
    5848, (2006)


(2007)



                                                       7
21. Wei Li*, Zhao Wang, Veeresa Gududuru, Blazej Zbytek, Andrzej T. Slominski, James T. Dalton, and
    Duane D. Miller, "Structure-Activity Relationship Studies of Arylthiazolidine Amides as Selective Cytotoxic
    Agents for Melanoma", Anticancer Research, 27, 883-888, (2007).
22. Wei Li*, Yan Lu, Zhao Wang, James T. Dalton, and Duane D. Miller, "Synthesis and antiproliferative
    activity of thiazolidine analogs for melanoma", Bioorg. Med. Chem. Lett., 17(15), 4113-4117, (2007).


(2008)
23. Robert C. Tuckey, Wei Li, Jordan K. Zjawiony, Michal A. Zmijewski, Minh N. Nguyen, Trevor Sweatman,
   Duane Miller and Andrzej Slominski, "Pathways and Products for the Metabolism of Vitamin D3 by
   Cytochrome P450scc", FEBS J. (2008), 275(10), 2585-2596.
24. Shivaputra Patil, Anna N. Bukiya, Wei Li, Alejandro M. Dopico, and Duane Miller, "Design and synthesis of
    hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels", Bioorg. Med. Chem.
    Lett., 18, 3427-3430, (2008).
25. Jianjun Chen, Zhao Wang, Yan Lu, James T. Dalton, Duane D. Miller, and Wei Li*, "Synthesis and
    antiproliferative activity of imidazole and imidazoline analogs for melanoma", Bioorg. Med. Chem. Lett.,
    18, 3183-3187, (2008).
26. Michal A. Zmijewski, Wei Li, Jordan K. Zjawiony, Trevor W. Sweatman, Jianjun Chen, Duane D. Miller and
    Andrzej T. Slominski, "Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-
    like derivatives", Photochem. Photobiol. Sci., (2008), 7(12), 1570-1576
27. Hongyu Zhou, Fenfang Du, Xi Li, Bin Zhang, Wei Li*, Bing Yan*, "Characterization of Organic Molecules
    Attached to Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning NMR", J. Phys.
    Chem. (2008), 112 (49), 19360–19366.
28. Robert C. Tuckey, Zorica Janjetovic, Wei Li, Minh N. Nguyen, Michal A. Zmijewski, Jordan Zjawiony and
    Andrzej Slominski, "Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc", J Steroid
    Biochem Molec Biol., (2008), 112, 213-219.


(2009)
29. Wei Li, Dong Jin Hwang, Dieter Cremer, Henry Joo, Elfi Kraka, Juhyun Kim, Charles R. Ross II, Viet Q.
    Nguyen, James T. Dalton, and Duane D. Miller, “Absolute configuration determination of epimeric
    sulfoxide-linked bicalutamide derivatives”, Chirality, 21(6):578-83 (2009).
30. Hong-Bin Fang, Guo-Liang Tian, Wei Li and Ming Tan, "Design and Sample Size for Evaluating
    Combinations of Drugs of Linear and Loglinear Dose Response Curves", Journal of Biopharmaceutical
    Statistics, 19:625-640, (2009).
31. Michal A. Zmijewski, Wei Li, Jordan K. Zjawiony, Trevor W. Sweatman, Jianjun Chen, Duane D. Miller and
    Andrzej T. Slominski, "Synthesis and photo-conversion of two enantiomers (20R or S) of 3β, 17α, 20-
    trihydroxypregna-5,7-diene", Steroids, (2009), 74(2):218-28, PMID: 19028513.
32. A.T. Slominski, M.A. Zmijewski, I. Semak, T. Sweatman, Z. Janjetovic, W. Li, J. Zjawiony, R.C. Tuckey,
    "Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological
    implication in the skin", PLOS One, (2009), 4(2):e4309.
33. Minh N Nguyen, Andrzej Slominski, Wei Li, Yun R Ng, and Robert C Tuckey, "Metabolism of vitamin D2 to
    17,20,24-trihydroxyvitamin D2 by cytochrome P450scc (CYP11A1)", Drug Metabolism and Disposition,
    37: 761-767, (2009).
34. Wei Li*, Radomir Slominski, Andrzej T. Slominski, "HRMAS NMR Analysis of Metabolic Changes in
    Melanoma Cells After induction of Melanogenesis", Anal. Biochem., 386(2):282-4, (2009).
35. Yan Lu, Chien-Ming Li, Zhao Wang, Charles R. Ross, II, Jianjun Chen, James Dalton, Wei Li, Duane. D.
    Miller, "Discovery of 4-Substituted Methoxybenzoyl-Aryl-Thiazole as Novel Anticancer Agents: Synthesis,
    Biological Evaluation and Structure-Activity Relationships", J. Med. Chem., 52(6):1701-1711, (2009).
                                                      8
36. Jianjun Chen, Jiangwei Zhang, Ling Yang and Wei Li*, “Structure elucidation of major metabolites from
    medroxyprogesterone acetate by P450”, Chem. Pharm. Bull., 57(8), 835-839, (2009).
37. Zhao Wang, Yan Lu, William Seibel, Duane D. Miller, and Wei Li*, “ Identifying Novel Molecular Structures
    for Advanced Melanoma by Ligand-Based Virtual Screening”, J. Chem. Info. Model., 49(6):1420-7, (2009).


(2010)
38. Yan Lu, Zhao Wang, Chien-Ming Li, Jianjun Chen, James T. Dalton, Wei Li, Duane D. Miller, “Synthesis, in
    vitro structure–activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as
    anticancer agents, Bioorg. Med. Chem., 18(2):477-95 (2010).
39. Andrzej T. Slominski, Zorica Janjetovic, Brian E. Fuller, Michal A. Zmijewski, Robert C. Tuckey, Minh N.
    Nguyen,Trevor Sweatman, Wei Li, Jordan Zjawiony, Duane Miller, Tai C. Chen, Gerard Lozanski, Michael
    F. Holick, “Novel products of vitamin D3 or pro-vitamin D3 (7-dehydrocholesterol) metabolism by
    cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity”, PLOS One,
    5(3):e9907 (2010).
40. Tae-Kang Kim, Jianjun Chen, Wei Li, Jordan Zjawiony, Duane Miller, Zorica Janjetovic, Robert C Tuckey,
    and Andrzej Slominski, “A New Steroidal 5,7-Diene Derivative, 3beta-Hydroxyandrosta-5, 7-Diene-17beta-
    Carboxylic Acid, Shows Potent Anti-proliferative Activity”, Steroids, 75(3):230-9 (2010).
41. Feng Li, Yan Lu, Wei Li, Duane D. Miller and Ram I. Mahato, “Synthesis, Formulation and in vitro
    Evaluation of a Novel Microtubule Stabilizer, SMART-100”, J. Controlled Release, 143(1):151-8 (2010).
42. El-Boubbou, Kheireddine; Zhu, David; Vasileiou, Chrysoula; Borhan, Babak; Prosperi, Davide; Li, Wei;
    Huang, Xuefei, "Magnetic Glyco-Nanoparticles: A Tool to Detect, Differentiate and Characterize
    Carbohydrate-binding Profiles of Cancer Cells via Magnetic Resonance Imaging", J. Am. Chem. Soc.,
    132, 4490–4499 (2010).
43. Wei Li*, Jianjun Chen, Zorica Janjetovic, Tae-Kang Kim, Trevor Sweatman, Yan Lu, Jordan Zjawiony,
    Robert C Tuckey, Duane Miller, Andrzej Slominski, “Chemical Synthesis of 20S-hydroxyvitamin D3, which
    shows anti-proliferative activity”, Steroids, 75(12):926-35, (2010).
44. Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu, James T. Dalton, Duane D. Miller, Wei Li*, “Discovery
    of novel 2-aryl-4-benzoyl-imidazoles targeting tubulin polymerization as potential agents for resistant
    cancer treatment”, J. Med. Chem., 53 (20), pp 7414–7427, (2010).
45. Dergunov, Sergey; Kesterson, Katrina; Li, Wei; Wang, Zhao; Pinkhassik, Eugene. “Synthesis,
    Characterization, and Long-Term Stability of Hollow Polymer Nanocapsules with Nanometer-Thin Walls”,
    Macromolecules, 43(18), 7785-92, (2010).
46. Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski,and Robert C.
    Tuckey, “Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1alfa,20,23-
    Trihydroxyvitamin D3, Which Has Altered Biological Activity”, Drug Metab Dispos, 38(9):1553-9, (2010).
47. Gupte R, Siddam A, Lu Y, Li W, Fujiwara Y, Panupinthu N, Pham TC, Baker DL, Parrill AL, Gotoh M,
    Murakami-Murofushi K, Kobayashi S, Mills GB, Tigyi G, Miller DD., “Synthesis and pharmacological
    evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid”, Bioorg Med Chem Lett. 20(24):7525-
    8, (2010).
48. Medha Kamat, Kheireddine El-Boubbou, David C. Zhu, Teri Lansdell, Xiaowei Lu, Wei Li, and Xuefei
    Huang, "Hyaluronic Acid Immobilized Magnetic Nanoparticles for Active Targeting and Imaging of
    Macrophages", Bioconjugate Chemistry, 21(11):2128-35, (2010).


(2011)
49. Renukadevi Patil, Shivaputra Patil, XiangDi Wang, Fei Ma, William E. Orr, Wei Li, Charles R. Yates, Eldon
    E. Geisert, Duane D. Miller, “Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as
    antiglioma agents”, Medicinal Chemistry Research, 20, 131-137, (2011).

                                                       9
50. Chien-Ming Li#, Zhao Wang#, Yan Lu, Wei Li*, Sunjoo Ahn, Ramesh Narayanan, Jeffrey D. Kearbey,
    Deanna N. Parke, Duane D. Miller, James T. Dalton*, “Biological activity of 4-Substituted Methoxybenzoyl-
    Aryl-Thiazole (SMART): An active microtubule inhibitor”, Cancer Res, 71(1), 216-224, (2011). (# Li and
    Zhao are equal first authors. * both Li and Dalton are corresponding authors).
51. Michal A. Zmijewski, Wei Li, Jordan K. Zjawiony, Jianjun Chen,Trevor W. Sweatman, Duane D. Miller and
    Andrzej T. Slominski, “Synthesis and photochemical transformation of 3beta,21-dihydroxypregna-5,7-dien-
    20-one to novel secosteroids that show anti-melanoma activity Steroids”, Steroids, 76, 193–203, (2011).
52. Andrzej T. Slominski, Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Radoslaw Bieniek, Junming
    Yue, Wei Li, Jianjun Chen, Minh N. Nguyen, Edith K.Y. Tang, Duane Miller, Tai C. Chen, Michael Holick,
    "20-hydroxyvitamin D2 is a non-calcemic analog of vitamin D with potent antiproliferative and
    prodifferentiation activities in normal and malignant cells", Am J Physiol. Cell Physiol., 300(3):C526-41,
    (2011).
53. Andrzej Slominski, Wei Li, Syamal K. Bhattacharya, Jianjun Chen, Robert C Tuckey, Duane Miller, Arnold
    E. Postlethwaite, " Vitamin D Analogs 17,20S(OH)(2)pD and 17,20R(OH)(2)pD Are Noncalcemic and
    Exhibit Antifibrotic Activity", J Invest Dermatol., 131(5):1167-9, (2011).
54. Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Michael L. Mohler, Wei Li, James T. Dalton, Duane D.
    Miller, “Design, Synthesis and SAR Studies of Novel Colchicine Binding Site Tubulin Inhibitors as Potent
    and Orally Bioavailable Anticancer Agents”, J. Med. Chem., 54(13):4678-93, (2011).
55. Robert C. Tuckey, Wei Li, Haleem Shehabi, Zorica Janjetovic, Minh N. Nguyen, Tae-Kang Kim, Jianjun
    Chen, Danielle E. Howell, Heather Benson, Trevor Sweatman, Donna M. Baldisseri, and Andrzej
    Slominski, “Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and
    analysis of their biological activities on skin cells”, Drug Metab Dispos, 39(9), 1577-1588, (2011).
56. Jianjun Chen, Chien-Ming Li, Jin Wang, Sunjoo Ahn, Zhao Wang, Yan Lu, James T. Dalton, Duane D.
    Miller, Wei Li*, “Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives
    targeting tubulin polymerization”, Bioorg. Med. Chem., 19(16):4782-95, (2011).
57. Chien-Ming Li, Jianjun Chen, Yan Lu, Ramesh Narayanan, Deanna N. Parke, Wei Li, Duane D. Miller, and
    James T. Dalton, "Pharmacokinetic Optimization of 4-Substituted Methoxybenzoyl-Aryl-Thiazole (SMART)
    and 2-Aryl-4-Benzoyl-Imidazole (ABI) for Improving Oral Bioavailability", Drug Metab Dispos, 39(10):1833-
    1839, (2011).


(2012)
58. Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W.
    Tieu, Jordan K. Zjawiony, and Wei Li, "Human cytochrome P450scc (CYP11A1) catalyses epoxide
    formation with ergosterol", Drug Metab Dispos, 40(3):436-444, (2012).
59. Elaine W. Tieu, Wei Li, Jianjun Chen, Donna M. Baldisseri, Andrzej T. Slominski, Robert C. Tuckey,
    “Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles
    by human CYP27A1”, J Steroid Biochem Molec Biol., 129(3-5):163-71, (2012).
60. Jin Wang, Andrzej Slominski, Robert Tuckey, Zorica Janjetovic, Anand Kulkarni, Jianjun Chen, Arnold E.
    Postlethwaite, Duane Miller, Wei Li*, "20-Hydroxylvitamin D3 possesses high efficacy against proliferation
    of cancer cells while being non-toxic", Anticancer Research, 32: 739-746, (2012).
61. Zhao Wang, Jianjun Chen, Jin Wang, Sunjoo Ahn, Chien-Ming Li, Yan Lu, Vivian S. Loveless, James T.
    Dalton, Duane D. Miller, Wei Li*, “Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance
    and Reduce Melanoma Lung Metastasis”, Pharmaceutical Research, 29, 3040-3052, (2012).
62. Mohammad H. El-Dakdouki; David C. Zhu; Kheireddine El-Boubbou; Medha Kamat; Jianjun Chen, Wei Li,
    Xuefei Huang, "Development of Multifunctional Hyaluronic Acid Coated Nanoparticles: Targeted Imaging
    and Drug Delivery to Cancer Cells in vitro" , Biomacromolecules, 13(4):1144-51, (2012).
63. Yan Lu, Jianjun Chen, Zorica Janjetovic, Phillip Michaels, Edith K Y Tang, Jin Wang, Robert C. Tuckey,
    Andrzej T. Slominski, Wei Li*, Duane D. Miller*, " Design, synthesis, and biological action of 20R-

                                                     10
   hydroxyvitamin D3", (*: both Li and Miller are corresponding authors), J. Med. Chem., 55(7):3573-7,
   (2012).
64. Tae-Kang Kim#, Jin Wang#, Zorica Janjetovic, Jianjun Chen, Robert C. Tuckey, Minh N. Nguyen, Edith K.
    Y. Tang, Duane Miller, Wei Li*, and Andrzej T. Slominski*, "Correlation between secosteroid induced
    vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength" (#: equal
    first authors; *: both Li and Slominski are corresponding authors), Mol. Cell. Endocrinol., 36, 143-152,
    (2012).
65. Shivaputra A. Patil*, Jin Wang, Xiaochen S. Li, Jianjun Chen,Terreia S. Jones, Amira H. Ahmed,
   Renukadevi Patil, William L. Seibel, Wei Li*, and Duane D. Miller*, " New substituted 4H-chromenes as
   anticancer agents", (*: corresponding authors). Bioorg. Med. Chem. Lett., 22(13):4458-61, (2012).
66. Andrzej T. Slominski, Tae-Kang Kim, Haleem Z. Shehabi, Igor Semak, Edith K.Y. Tang, Minh N. Nguyen,
    Heather A. E. Benson, Elena Korik, Zorica Janjetovic, Jianjun Chen, Charles R. Yates, Arnold
    Postlethwaite, Wei Li, and Robert C. Tuckey, "In vivo evidence for a novel pathway of vitamin D3
    metabolism initiated by P450scc and modified by CYP27B1", FASEB J., 26, 3901-3915, (2012).
67. Yan Lu, Jianjun Chen, Min Xiao, Wei Li, Duane D. Miller, "An Overview of Tubulin Inhibitors That Interact
    with the Colchicine Binding Site", Pharm. Res., 29, 2943-2971, (2012)
68. Chien-Ming Li, Yan Lu, Jianjun Chen, Terrence A. Costello, Ramesh Narayanan, Mara N. Dalton, Linda M.
    Snyder, Sunjoo Ahn, Wei Li, Duane D. Miller, and James T. Dalton, "Orally Bioavailable Tubulin
    Antagonists for Paclitaxel-Refractory Cancer", Pharm. Res., 29, 3053-3063, (2012)

69. Jianjun Chen, Sunjoo Ahn, Jin Wang, Yan Lu, James T. Dalton, Duane D. Miller, and Wei Li*, “Discovery
    of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative
    agents”, J. Med. Chem., 55, 7285-7289, (2012) Cover figure for the issue selected by the editor’s office.
    http://pubs.acs.org/action/showLargeCover?jcode=jmcmar&vol=55&issue=19.

70. Andrzej T. Slominski, Tae-Kang Kim, Jianjun Chen, Minh N. Nguyen, Wei Li, Charles R. Yates, Trevor
    Sweatman, Zorica Janjetovic, Robert C. Tuckey, "Cytochrome P450scc-dependent metabolism of 7-
    dehydrocholesterol in placenta and epidermal keratinocytes", International Journal of Biochemistry &
    Cell Biology, 44, 2003–2018, (2012).
71. Anna N. Bukiya, Shivaputra Patil, Wei Li, Duane Miller, and Alex M. Dopico, “Ca2+- and voltage-gated
    potassium (BK) channel activators in 5beta-cholanic acid-3alpha-ol analogue series with modifications in
    lateral chain”, ChemMedChem, 7, 1784-1792, (2012).
72. Vaibhav Mundra, Yan Lu, Michael Danquah, Wei Li, Duane D. Miller and Ram I. Mahato, "Formulation and
    Characterization of Polyester/Polycarbonate Nanoparticles for Delivery of a Novel Microtubule Destabilizing
    Agent", Pharm Res, 29, 3064-3074, (2012).
73. Wei Li*, “Drugs Targeting Tubulin Polymerization”, Pharm Res, 29, 2939-2942, (2012).
74. Elaine W. Tieu, Edith K. Y. Tang, Jianjun Chen, Wei Li, Minh N. Nguyen, Zorica Janjetovic, Andrzej
    Slominski and Robert C. Tuckey, "Rat CYP24A1 acts on 20-hydroxyvitamin D3 producing hydroxylated
    products with increased biological activity", Biochemical Pharmacology, in press, (2012).


Submitted:


1. Arnold E. Postlethwaite, Robert C. Tuckey, Wei Li, Keka G. Bhattacharya, Linda K. Myers, David D. Brand,
    Duane Miller, and Andrzej T. Slominski “Natural Noncalcemic 20(OH)D3 Vitamin D Metabolite Inhibits
    Autoimmune Arthritis”, submitted.
2. Andrzej Slominski, Zorica Janjetovic, Robert C. Tuckey, Minh N. Nguyen, Syamal K. Bhattacharya, Wei Li,
    Arnold E. Postlethwaite, "20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3,
    exhibits potent antifibrotic activity", submitted.

                                                       11
3. Andrzej Slominski, Michal Zmijewski, Igor Semak, Blazej Zbytek, Alexander Pisarchik, Wei Li, Jordan
   Zjawiony, and Robert C. Tuckey, "Cytochromes P450 and Skin Cancer: Role of Local Endocrine
   Pathways", submitted.


PATENT APPLICATIONS
1. Novel enzymatic method for shortening of the 7-dehydrocholesterol or vitamin D3 side chain to produce 7-
   dehydropregnenolone, vitamins D like compounds and their derivatives, US 61/189,798; USES OF
   HYDROXYLATED VITAMIN D3 DERIVATIVES PRODUCED BY CYTOCHROME P450SCC; US
   61/067,461. The above two application were converted on 3/2/2009 into PCT application
   PCT/US09/001324. Slominski, Li, Zbytek, Tuckey, Zjawiony, Nguyen, Zmijewski, Janjetovic, Sweatman,
   Miller, Chen. “Enzymatic Production or Chemical Synthesis and Uses for 5.7-Dienes and UVB Conversion
   Products Thereof”.
2. Design and synthesis of hydroxyl-alkynoic acids and their methyl esters as novel activators of BK channels,
   Dopico, Alejandro M.; Miller Duane, D.; Li, Wei; Bukiya, Anna; Patil, Shivaputra. US 61/078,855, provision
   filed on 7/8/2008 by UTRF.
3. Design, synthesis and biological studies of a new class of cytotoxic agents, 2-arylthiazolidine-4-carboxylic
   acid amides for prostate cancer, compounds for treatment of cancer, Miller, Duane D.; Dalton, James T.;
   Li, Wei; Lu, Yan; Wang, Zhao; Chen, Jianjun; US 61/061,875, provision filed by UTRF on 6/16/2008.
4. COMPOUNDS FOR TREATMENT OF CANCER. Miller, Li, Wang, Lu, Chen, Dalton, Li. US 12/485,881
   filed on 6/16/2009. Licensed to GTx, Inc (Memphis, TN) for commercial development since 2009.
5. Aryl-benzoyl Imidazoles and Methods of Use Thereof. Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu,
   Duane Miller, James Dalton, Wei Li. US provisional 61/309,360 filed on 3/1/2010, pending. Licensed to
   GTx, Inc (Memphis, TN) for commercial development since 2009.
6. THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES,
   INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS.
   US/7,662,842, Duane Miller, Jim Dalton, Veeresa Gududuru, Eunju Hurh, Wei Li.


ABSTRACTS PUBLISHED
1. Wei Li, Xue-Gong Lei, Ann McDermott and Nick Turro, "Interactions between DBKs and MFI type zeolite
   studied by solid state NMR", Industrial Association Program, Columbia University, April, 1997
2. Xue-Gong Lei, Wei Li, Ann McDermott, Nick Turro, Lloyd Abrams and Francesca Ottaviani, "Monolayer
   properties of otho-Methyl Dibenzyl Ketone on MFI zeolites studied by solid state deturium NMR and ESR"
   38th Experimental NMR Conference, Orlando, Florida, March 23-27, 1997 (Paper 260).
3. Wei Li, Xue-Gong Lei and Nick Turro, "High resolution Si-29 solid state NMR study of interactions between
   MFI zeolite and photactive ketones" 216th ACS National Meeting, Boston, MA, August 23-27, 1998
   (Physical Chemistry, Paper 281).
4. Xue-Gong Lei, Wei Li and N. J. Turro "Stabilization of benzyl and benzyl peroxy radicals in MFI zeolites"
   216th ACS National Meeting, Boston, MA, August 23-27, 1998 (Physical Chemistry Division, Paper 446)
5. Wei Li, Ann McDermott and N. J. Turro "Effect of Oxygen on Si-29 spin- lattice relaxation by high resolution
   solid state NMR", 40th Experimental NMR Conference, Orlando, Florida, February 28-March 5, 1999
6. Wei Li, Steven Gurley and Bob M. Moore II, “The effect of antineoplastic drug avanil on cellular metabolites
   of prostate cancer cells studied by HR-MAS”, 43rd Experimental Nuclear Magnetic Resonance Conference,
   Pacific Grove, CA, April 14-19, 2002
7. Wei Li, Robin E. B. Lee and Richard E. Lee, "HRMAS NMR Studies of Whole Cell Mycobacteria", 45th
   Experimental NMR Conference, Pacific Grove, CA, 2004



                                                      12
8. Robin E. B. Lee, Wei Li and Richard E. Lee, "Multi-Dimensional High-Resolution Magic Angle Spinning
   NMR Investigation of the Cell Wall Structure in Living Mycobacteria", 104th General Meeting for America
   Society for Microbiology, New Orleans, LA, 2004
9. Wei Li, Robin E. B. Lee, Richard E. Lee and Jinghu Li, “in vivo mycobacteria cell wall structure
   characterization by 2D and 3D HRMAS NMR”, poster 111 in Analytical section, 229th ACS National
   Meeting, San Diego, CA, March 13-17, 2005.
10. Wei Li, Robin E. B. Lee, Richard E. Lee and Jinghu Li, “Application of 2D and 3D HRMAS NMR for in vivo
    Cell Wall Structure Characterization Using Live Mycobacteria”, poster number 206, 46th Experimental NMR
    Conference, Providence, RI, April 10-15, 2005
11. Zhao Wang, Yan Lu, Veeresa Gududuru, Blazej Zbytek, Michal A. Zmijewski, Andrzej T. Slominski, James
    T. Dalton, Duane D. Miller, Wei Li, “Synthesis and SAR Studies of Novel thiazolidine analogs for
    melanoma”, 2007, American Association for Cancer Research Annual Meeting, April 13-18, Los Angeles,
    CA. Poster #3963
12. Wei Li, Radomir Slominski, Andrzej T. Slominski, “HRMAS NMR monitoring of changes in metabolic profile
    of melanoma cells after induction of melanin synthesis”, 2007, 48th Experimental NMR Conference, April
    22-27, Daytona Beach, FL. Poster #190
13. Zhao Wang, Yan Lu, Veeresa Gududuru, Blazej Zbytek, Andrzej T. Slominski, James T. Dalton, Duane D.
    Miller, and Wei Li, "Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic
    agents for melanoma”, 34th MALTO meeting, Monroe, LA, May 20-22, 2007
14. Jianjun Chen, Zhao Wang, Yan Lu, Duane Miller and Wei Li, "Synthesis and Anti-melanoma research of 2-
    Arylimidazole-4-carboxylic Acid Amides and 2-Arylimidazoline-4-carboxylic Acid Amides", 34th MALTO
    meeting, Monroe, LA, May 20-22, 2007
15. Yan Lu, Zhao Wang, Chien-Ming Li, Wei Li, James T. Dalton, and Duane D. Miller, "Synthesis and
    biological evaluation of 2-arylthiazolidine-4-caboxylic acid amides for melanoma and prostate cancer",
    234th ACS National Meeting, Boston, MA, August 19-23, 2007.
16. Robert C. Tuckey, Wei Li, Minh N. Nguyen, Jordan Zjawiony, Zorica Janjetovic, Michal A. Zmijewski and
    Andrzej Slominski, "Production of Biologically Active 1a,20-Dihydroxyvitamin D3 by the Action of
    Cytochrome P450scc (CYP11A1) on 1a-Hydroxyvitamin D3", The Endocrine Society's 90th Annual
    Meeting, June 15-18, San Francisco, 2008.
17. Shivaputra Patil, Anna Bukiya, Wei Li, Alejandro M Dopico and Duane Miller, "Design and Synthesis of
    Hydroxy-alkynoic acid methyl ester as novel activators of BK channel", American Chemical Society, New
    Orleans, 2008.
18. Michal A. Zmijewski, Wei Li, Jordan K. Zjawiony, Trevor W. Sweatman, Jianjun Chen, Janjetovic Z, Duane
    D. Miller and Andrzej T. Slominski, "Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to
    vitamin D3-like derivatives", The Endocrine Society's 90th Annual Meeting, June 15-18, San Francisco,
    2008.
19. Wei Li, Robert C. Tuckey, Minh N. Nguyen, Jordan Zjawiony, Zorica Janjetovic, Michal A. Zmijewski and
    Andrzej Slominski, "Structure elucidation of novel metabolites of Vitamin D3 by cytochrome P450scc", 49th
    Experimental NMR Conference, March 9-14, Pacific Grove, CA, 2008.
20. Jianjun Chen, Zhao Wang, Yan Lu, James T. Dalton, Duane D. Miller, Wei Li, "Synthesis and
    antiproliferative activity of metabolically stable thiazolidine analogs for melanoma", Annual Meeting for
    American Association for Cancer Research, April 12-16, San Diego, CA, 2008.
21. J. Chen, M. A. Zmijewski, W. Li, J. K. Zjawiony, T. W. Sweatman, Z. Janjetovic, D. D. Miller, A. T.
    Slominski, “Synthesis and photo-derivatization of androsta- and pregna-5, 7-dienes”, 35th MALTO Meeting,
    May 18-20, 2008, Little rock, Arkansas, U.S.A.
22. Z. Wang, Y. Lu, J. Chen, J. T. Dalton, D. D. Miller, W. Li, “DISVOVERY OF THIAZOLE DERIVATIVES AS
    NOVEL POTENT AND SELECTIVE BROAD-SPECTRUM ANTICANCER AGENTS”, Pharm Forum, May
    18-20, 2008, Little rock, Arkansas, U.S.A.

                                                       13
23. Zhao Wang, Yan Lu, Ching-Ming Li, Jianjun Chen, James T. Dalton, Duane D. Miller, Wei Li, "Novel
    Thiazole Derivatives as Potent and Selective Broad-Spectrum Anticancer Agents", AAPS annual meeting,
    Atlanta, GA, Nov 17-19, 2008.
24. Zhao Wang, Yan Lu, Jianjun Chen, Vivian S. Loveless, James T. Dalton, Duane D. Miller, and Wei Li, “ In
    vitro and in vivo evaluation of substituted methoxylbenzoyl-aryl-thiazole derivatives as potent anticancer
    agents for advanced melanoma”, American Association for Cancer Research Annual Meeting, Denver, CO,
    April 17-22, 2009
25. "Characterization of organic molecules attached to gold nanoparticle surface using high resolution magic
   angle spinning NMR" (paper number: 27), American Chemical Society Annual Meeting, Salt Lake City, UT,
   March 21-27, 2009.
26. Li, Wei; Zmijewski, Michal A.; Chen, Jianjun; Janjetovic, Zorica; Zjawiony, Jordan K.; Sweatman, Trevor;
    Miller, Duane D.; Slominski, Andrzej T, “Synthesis and biological evaluation of novel vitamin D3
    derivatives”, 237th ACS National Meeting, March 22-26, 2009, Salt Lake City, UT, United States.
27. H. Zhou, W. Li, B. Yan, “Characterization of Organic Molecules Attached to Gold Nanoparticle Surface
    Using High Resolution Magic Angle Spinning 1H NMR and LC/MS/UV/CLND”, Nanotech, May 3 - 7, 2009,
    Houston, Texas, U.S.A.
28. J. Chen, M. A. Zmijewski, W. Li, J. K. Zjawiony, T. W. Sweatman, Z. Janjetovic, D. D. Miller, A. T.
    Slominski, “Synthesis, photoconversion of novel Vitamin D3 analogs and their biological activity against
    melanoma”, 36th MALTO Meeting, May 18-20, 2009, Memphis, TN, U.S.A.
29. Z. Wang, Y. Lu, J. Chen, C. Barrett, V. S. Loveless, J. T. Dalton, D. D. Miller, W. Li, “New class of tubulin
    targeting compounds as potential therapeutic agent for advanced melanoma”, 36th MALTO Meeting, May
    18-20, 2009, Memphis, TN, U.S.A.
30. Andrzej T Slominski, Zorica Janjetovic, Brian Fuller, Michal A Zmijewski, Robert C Tuckey, Minh Nguyen,
    Trevor Sweatman, Wei Li, Jordan Zjawiony, Duane Miller, Tai C Chen and Michael F Holick, “Novel
    products of vitamin D3 metabolism by cytochrome P450scc inhibit proliferation and stimulate differentiation
    of leukemia cells, have very low or absent calcemic activity and show anti-tumor effect in other cancer
    lines”, The Endocrine Society's 91st Annual Meeting, Washington, DC, June 10-13, 2009.
31. Ming T. Tan, Hong-Bin Fang, Douglas D. Ross, Martin J. Edelman, Edward A. Sausville, and Wei Li,
    “Maximal Power Design and Analysis of Drug Synergy in Therapeutic Development: Applications to
    Vorinostat with Cytosine Arabinoside and Etoposide and Other Combination Studies”, National Cancer
    Institute (NCI) Translational Science Meeting (TSM2), Vienna, VA, November 5-7, 2009.
32. T. Kim, J. Chen, W. Li, J. Zjawiony, D. Miller, A. Slominski, “3-hydroxy-androsta-5,7-diene-17-carboxylic
    acid, a novel steroidal 5,7-diene derivative, inhibits proliferation in melanoma cell lines and HaCaT
    keratinocytes”, XVth PASPCR Conference, 2009, Memphis, TN, U.S.A.
33. M. A. Zmijewski, J. Chen, W. Li, T. W. Sweatman, J. Zjawiony, A. Slominski, “ New Secosteroidal (Vitamin
    D-Like) Derivatives As Potential Anti-Melanoma Therapeutics”, XVth PASPCR Conference, 2009, Memphis,
    TN, U.S.A.
34. M. A. Zmijewski, J. Chen, W. Li, T. W. Sweatman, J. Zjawiony, A. Slominski, “Pregna-5,7-diene-3β,21-diol
    and its vitamin D-like derivatives as potential anti-melanoma factors”, 15th ESPCR Meeting, Sep 20-23,
    2009, Munster, Germany.
35. T. Kim, J. Chen, W. Li, J. Zjawiony, D. Miller, A. Slominski, “3-hydroxy-androsta-5,7-diene-17-carboxylic
    acid, a novel steroidal 5,7-diene derivative, inhibits proliferation in melanoma cell lines and HaCaT
    keratinocytes”, 2nd Annual UT postdoctoral research day, December 10th, 2009, Memphis, TN, U.S.A.
36. A. T. Slominski, Z. Janjetovic, T. Kim, M. A. Zmijewski, R. C. Tuckey, T. Sweatman, W. Li, J. Zjawiony, J.
    Chen, D. Miller, R. Bieniek, M. N. Nguyen, T. Chen, M. Holick, “Novel 5,7-unsaturated steroidal and
    secosteroidal products of cytochrome P450scc show antimelanoma activity”, SID conference, Atlanta, GA,
    2010
37. Edith KY Tang, Zorica Janjetovic, Wei Li, Minh Nguyen, Andrzej Slominski and Robert C Tuckey, “Purified
    mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3 producing 1α,20,23-trihydroxyvitamin which
                                                       14
   has altered biological activity.”, Australian Society of Biochemistry and Molecuar Biology Annual Meeting,
   Melbourne, Australia, 2010.
38. Wei Li, Zhao Wang, Jianjun Chen, Yan Lu, Chien-Ming Li, James T. Dalton, Duane Miller, “Targeting
    colchicine binding site in tubulin for the treatment of advanced melanoma”, 101st American Association for
    Cancer Research Annual Meeting, Washington, DC, April 17-22, 2010.
39. Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu, James T. Dalton, Duane D. Miller, Wei Li, “Synthesis
    and antiproliferative activity of novel imidazole analogs”, American Chemical Society annual meeting, San
    Francisco, March 21-25, 2010.
40. Shivaputra Patil, Anna N. Bukiya, Wei Li, Alejandro M. Dopico, and Duane Miller, “Lithocholic acid-nitriles
    and tetrazoles as activators of large-conductance, Ca2+-activated K+ (BK) channels”, American Chemical
    Society annual meeting, San Francisco, March 21-25, 2010.
41. Andrzej T. Slominski, Zorica Janjetovic, Tae-Kang Kim, Michal A. Zmijewski, Robert C. Tuckey, Trevor
    Sweatman, Wei Li, Jordan Zjawiony, Jianjun Chen, Duane Miller, Radoslaw Bieniek, Minh N. Nguyen, Tai
    Chen, Michael Holick, “Novel 5,7-unsaturated steroidal and secosteroidal products of cytochrome P450scc
    show antimelanoma activity”, SID (The Society for Investigative Dermatology) conference, May 5-8, 2010,
    Atlanta, GA.
42. Wei Li, Zhao Wang, Jianjun Chen, Yan Lu, Chien-Ming Li, James T. Dalton, Duane Miller, “Targeting
    colchicine binding site in Tubulin for the treatment of advanced melanoma”, AACR 101st annual meeting,
    April 17-21, 2010, Washington DC.
43. Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu, James T. Dalton, Duane D. Miller, Wei Li, “SYNTHESIS
    AND ANTIPROLIFERATIVE ACTIVITY OF NOVEL 2-ARYL-4-BENZOYL-IMIDAZOLE DERIVATIVES”,
    May 6th, 2010, Graduate Research Day, UTHSC.
44. Zhao Wang, Jianjun Chen, Chien-Ming Li,Yan Lu, Christina Barrett, Vivian S. Loveless, James T. Dalton,
    Duane Miller,Wei Li, “Novel tubulininhibitor overcome multidrug resistance and show good in vitro and in
    vivo anti-melanoma activity”, 2010 AAPS National Biotechnology Conference (NBC), May 16-19, 2010,
    San Francisco, CA.
45. AT Slominski, RC Tuckey, A Postethwaite, W Li, Z Janjetovic, T-K Kim, M Zmijewski, T Sweatman, J
    Chen, J Zjawiony, TC Chen, MF Holick, D Miller. “Novel secosteroidogenic pathway initiated by CYP11A1
    produces biologicalLy active metabolites”, ADRENAL 2010, Conference on the Adrenal Cortex XIV. June
    19-22, San Diego,CA.
46. Wei Li, Jianjun Chen, Zorica Janjetovic, Tae-Kang Kim, Trevor Sweatsman, Yan Lu, Jordan Zjawiony,
    Robert C Tuckey, Duane Miller, Andrzej Slominski, “Chemical Synthesis of 20S-hydroxyvitamin D3, which
    shows anti-proliferative activity”, The Endocrine Society's 92th Annual Meeting, June 19-22, 2010, San
    Diego, CA.
47. Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Radoslaw Bieniek, Junming Yue, Wei Li, Jianjun
    Chen, Minh N. Nguyen, Duane Miller, Tai C. Chen, Michael Holick, Andrzej T. Slominski, “20-
    hydroxyvitamin D2, a product of cytochrome P450scc hydroxylation, inhibits proliferation of melanoma and
    melanocytes through vitamin D receptor”, 15th PASPCR Conference (PanAmerican Society for Pigment
    Cell Research), Sep 3-Oct 2, 2010, Vancouver, BC, CANADA.
48. Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu, James T. Dalton, Duane D. Miller, Wei Li, “Synthesis
    and anticancer activity of novel 2-aryl-4-benzoyl-imidazole derivatives”, 37th MALTO Medicinal Chemistry-
    Pharmacognosy Meeting –in–Miniature. May 21-24, 2010, Oxford, Mississippi.
49. Anthony C. Samsa, Anju Siddam, Wei Li, Duane Miller, and Hassan Almoazen, Synthesis, Design, and In
    Vitro Testing of Camptothecin-PSMA Prodrug for the SelectiveTargeting of Prostate Cancer, 2010 AAPS
    meeting and exposition, 2010.
50. Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Wei Li, James T. Dalton, and Duane D. Miller,
    “Synthesis, biological evaluation and SAR of 4-substituted methoxybenzoyl aryl thiazole s(SMART) as
    anticancer agents”, 239th ACS national meeting, Paper ID: 11418. March 21-25, 2010, Boston,
    Massachusetts.
                                                      15
51. Arnold E. Postlethwaite, Wei Li, Jianjun Chen, Duane Miller, Weikuan Gu, Yan Jiao and Andrzej Slominski,
    “Non-Calcemic Natural Vitamin D Analogue, 20(OH)D3, Protects Mice from Bleomycin Induced
    Scleroderma”, 71th SID (The Society for Investigative Dermatology) conference, May 4-7, 2011, Phoenix,
    Arizona.
52. Robert C. Tuckey, Wei Li, Haleem Shehabi, Zorica Janjetovic, Minh N. Nguyen, Tae-Kang Kim, Danielle
    E. Howell, Jianjun Chen, Trevor Sweatman Duane Miller and Andrzej Slominski, “Production of 22-hydroxy
    metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on
    keratinocytes”. 2011 AAPS National Biotechnology Conference, May 16-18, 2011, San Francisco, CA.
53. Wei Li, Jianjun Chen, Yan Lu, Zorica Janjetovic, Tae-Kang Kim, Trevor Sweatman, Robert C Tuckey,
    Arnold E. Postlethwaite, Duane Miller, Andrzej Slominski. Chemical Synthesis of Biologically Active 20S/R-
    hydroxyvitamin D3. 25th AAPS, Oct 23-27, 2011, Washington DC.
54. Arnold E. Postlethwaite, Wei Li, Jianjun Chen, Duane Miller, Weikuan Gu, Yan Jiao and Andrzej Slominski.
    Non-Calcemic Natural Vitamin D Analogue, 20(OH)D3, Protects Mice from Bleomycin Induced
    Scleroderma. 2011 SID, May 15-20, 2011, Los Angeles, California.
55. A Slominski1, Z Janjetovic1, RC Tuckey3, A Postethwaite, W Li, T-K Kim, M Zmijewski, T Sweatman1, J
    Chen, J Zjawiony, MN Nguyen, TC Chen, MF Holick, D Miller. Novel secosteroids regulate melanocytic
    activity. 2011 SID poster, May 15-20, 2011, Los Angeles, California.
56. Robert C. Tuckey, Wei Li, Haleem Shehabi, Zorica Janjetovic, Minh N. Nguyen, Tae-Kang Kim, Danielle
    E. Howell, Jianjun Chen, Trevor Sweatman, Duane Miller and Andrzej Slominski. Production of 22-hydroxy
    metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on
    keratinocytes. 93rd ENDO, June 4-7, 2011, Boston, Massachusetts.
57. Elaine W Tieu, Wei Li, Jianjun Chen, Minh N Nguyen, Andrzej T Slominski, Robert C Tuckey. Kinetics of
    human CYP27A1 metabolism of substrates incorporated into phospholipid vesicles and the identification of
    products of 20-hydroxyvitamin D3 metabolism. 17th International Conference on Cytochrome P450, June
    26-30, 2011, Manchester, UK.
58. Wei Li, Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu, James T. Dalton, Duane Miller. Novel ABI
    analogs target the colchicine site in tubulin and overcome multidrug resistance in metastatic melanoma.
    AACR 102nd Annual Meeting, April 2-6, 2011, Orlando, Florida.
59. Tae-Kang Kim, Jianjun Chen, Jin Wang, Robert C. Tuckey, Duane Miller, Wei Li, and Andrzej T. Slominski.
    Correlation between secosteroids induced VDR activity in melanoma cells with computer modeling based
    on the receptor crystal structure. 2011 IFPC.
60. Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Radoslaw Bieniek, Junming Yue, Wei Li, Jianjun
    Chen, Minh N. Nguyen, Duane Miller, Tai C. Chen, Michael Holick, Andrzej T. Slominski. 20-
    hydroxyvitamin D2, a product of cytochrome P450scc hydroxylation, inhibits proliferation of melanoma and
    melanocytes through vitamin D receptor.
61. Wei Li, Jianjun Chen, Yan Lu, Zorica Janjetovic, Tae-Kang Kim, Trevor Sweatman, Robert C Tuckey,
    Arnold E. Postlethwaite, Duane Miller, Andrzej Slominski, Chemical Synthesis of Biologically Active 20S/R-
    hydroxyvitamin D3, 2011 AAPS Annual Meeting and Exposition, Washington, DC, Oct 23-27, 2011
62. A. E. Postlethwaite, W. Li, J. Chen, D. Miller, W. Gu, Y. Jiao and A. Slominski, Non-calcemic natural
    vitamin D analogue, 20(OH)D3, protects mice from bleomycin induced scleroderma, ASRT meeting, 2011.
63. Tae-Kang Kim, Zorica Janjetovic, Danielle L. Peacock, Stanislav Tolkacjov, Radomir Slominski, Wei Li,
    Tiffany N. Seagroves, and Andrzej T. Slominski, Melanogenesis stimulates HIF-1α expression and
    accumulation of downstream genes mRNAs with attendant changes in cellular metabolism, IFCS meeting,
    2011.
64. Shivaputra Patil, Xiaochen S Li, Wei Li and Duane Miller, “Design and synthesis of chromones as novel
    anti-melanoma agents”, 242nd ACS National Meeting Denver, Colorado, August 28 - September 1, 2011.
65. Yan Lu, Chien-Ming Li, Zhao Wang, Jin Wang, Jianjun Chen, Wei Li, James T. Dalton, Duane D. Miller,
    "Synthesis and SAR Studies of Colchicine Binding Site Tubulin Inhibitors as Potent and Orally Bioavailable
    Anticancer Agents", 242nd ACS National Meeting Denver, Colorado, August 28 - September 1, 2011.
                                                     16
66. Tae-Kang Kim, Zorica Janjetovic, Danielle L. Peacock, Stanislav N. Tolkachjov, Radomir M. Slominski, Wei
    Li, Tiffany N. Seagroves and Andrzej T. Slominski, “Melanogenesis stimulates HIF-1α expression and
    accumulation of downstream genes mRNA with attendant changes in cellular metabolism”, International
    Pigment Cell Conference, Bordeaux, France, September 21 to 24, 2011.
67. Wei Li, Jianjun Chen, Yan Lu, Zorica Janjetovic, Tae-Kang Kim, Trevor Sweatman, Robert Tuckey, Arnold
    Postlethwaite, Duane Miller, Andrzej Slominski, “Chemical Synthesis of Biologically Active 20S/R-
    hydroxyvitamin D3”, 2011 AAPS Annual Meeting and Exposition, Washington, D.C., October 23-27, 2011.
68. Jin Wang, Andrzej Slominski, Robert Tuckey, Zorica Janjetovic, Anand Kulkarni, Jianjun Chen, Arnold E.
    Postlethwaite, Duane Miller, and Wei Li, “20-Hydroxylvitamin D3 possesses high efficacy against
    proliferation of cancer cells while being non-toxic”, 2012 SID Annual Meeting & 75th Anniversary
    Celebration, Raleigh Convention Center Raleigh, North Carolina, May 9 - 12, 2012.
69. Kim T-K, Wang J, Janjetovic Z, Chen J, Tuckey RC, Nguyen MN, Tang EKY, Miller D, Li W, Slominski AT,
    "Secosteroids with a long side chain interact more strongly with the vitamin D receptor (VDR) than those
    with a shorter side chain", 72nd SID Annual Meeting & 75th Anniversary Celebration, Raleigh Convention
    Center Raleigh, North Carolina, May 9 - 12, 2012. Published in J. Inv. Dermot., 2012.
70. Andrzej T. Slominski, Tae-Kang Kim, Haleem Z. Shehabi, Igor Semak, Edith K Y Tang, Minh N. Nguyen,
    Heather A. E. Benson, Elena Korik, Zorica Janjetovic, Jianjun Chen, Charles R. Yates, Arnold
    Postlethwaite, Wei Li, Robert C. Tuckey, “In vivo evidence for novel pathway of vitamin D3 metabolism
    initiated by P450scc”, Endocrine society annual meeting, Houston, TX, June 23-26, 2012.
71. LindaK Myers, ArnoldE Postlethwaite, Wei Li, DuaneD Miller, RobertC Tuckey and Andrzej Slominski ,
    “Noncalcemic natural vitamin D analog, 20(OH)D3, enhances immunosuppressive properties of an altered
    peptide ligand”, 72nd SID Annual Meeting & 75th Anniversary Celebration, Raleigh Convention Center
    Raleigh, North Carolina, May 9 - 12, 2012. Published in J. Inv. Dermot., 2012.
72. Shivaputra A. Patil, Terreia S. Jones, Amira Hosni-Ahmed, Jin Wang, Renukadevi Patil, Wei Li and Duane
    D. Miller, “New Substituted 4H-Chromenes as antiglioma agents”, 244th ACS National Meeting &
    Exposition, Philadelphia, Pennsylvania, August 19-23, 2012.
73. Sunjoo Ahn, Chien-Ming Li, Christina M. Barrett, Jianjun Chen, Wei Li, Yan Lu, Duane D. Miller, James T.
    Dalton, "GTx-230: an orally available novel tubulin inhibitor that disrupts tumor vasculature and displays
    single-agent antitumor efficacy in multidrug-resistant prostate cancer with less neurotoxicity", 2012 AACR
    Annual Meeting, Chicago, IL, March 31-April 4, 2012.
74. Min Xiao, Jianjun Cheng, Jin Wang, Duane D. Miller, and Wei Li, “Structural Modifications of 2-Aryl-4-
    benzoyl-imidazoles and Structure-Activity Relationships Analysis”, 2012 MALTO annual meeting, Monroe,
    LA, May 20-22, 2012.
75. Jin Wang, Jianjun Chen, Renukadevi Patil, Duan Miller and Wei Li, "Synergistic studies of novel tubulin
    inhibitors with targeted agents in cultured melanoma cell lines", 2012 MALTO annual meeting, Monroe, LA,
    May 20-22, 2012.
76. Tae-Kang Kim, Zorica Janjetovic, Wei Li, Tobias Fischer and Andrzej T. Slominski, "Metabolism of
    melatonin and biological activity of intermediates of melatoninergic pathway in skin cells”, Pan American
    Society for Pigment Cell Research, Park City, UT, September 19-22, 2012.
77. Andrzej T. Slominski, Tae-Kang Kim, Haleem Z. Shehabi, Igor Semak, Edith K.Y. Tang, Minh N. Nguyen,
    Heather A. E. Benson, Elena Korik, Zorica Janjetovic, Jianjun Chen, Charles R. Yates, Arnold
    Postlethwaite, Wei Li, Robert C. Tuckey, “In vivo evidence for a novel pathway of vitamin D3 metabolism
    initiated by P450scc and modified by CYP27B1”, Australian Endocrine Society Meeting, August 2012.




                                                     17

				
DOCUMENT INFO
Shared By:
Categories:
Tags:
Stats:
views:3
posted:12/7/2012
language:Latin
pages:17