Bio-implant-Biomedical-devices-Application-Recent-advancement-and-Bio-medical-science.pptx by abbirr

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									          Application
     Adverse effects.
 Recent Advancement
      Current Priority
            Research
         Conclusion.
 Application Of Bio-materials/ medical devices.
 Adverse effects of Biomaterials/Bio-devices.
 Recent Advancement of Bio-materials/ Bio-
   medical Science.
 Current Priority Research on Biomaterial/
  bio-medical science.
      Prepared By-
 Dr. Md Nazrul Islam.
 MBBS, M.sc.(BME).
     Supervised By-
Associate Prof. Ziaul Haq -
 MBBS, MS (Orthopedic).




                              2
 Application Of
 Bio-implant & Biomedical Devices-




                  Biodegradable cranial implant made
                  of PLA-β-TCP produced using SLM.


1. Implants for Eye, ENT, Brain
2. Implants for Heart, Liver and Kidney.
3. Implants for Orthopedic and Dental.
Application Of
Bio-implant & Biomedical Devices-

Implants for Eye, ENT,
Brain-




                           Lens(ocular) Prosthesis        Retinal Prosthesis




                          The Bio-eye (HA)                ARTIFICIAL-CORNEA
                          Hydroxyapatite Ocular implant
Application Of
Bio-implant & Biomedical Devices-

Implants for Eye,
ENT, Brain-




               implanted device            Cochlear Implant:
               to treat balance disorder   Most Commonly Used Ear Implant.
Application Of
Bio-implant & Biomedical Devices-

Implants for
Heart, Liver and Kidney.
                 Implant
                 for Heart:.

       Stent for Heart:.
                                          Implant
                                          for Kidney:
                                    First Implantable
                                    artificial kidney / Technology .
      Metallic Heart Valve:.




      Collagen Heart Valve:.
Application Of
Bio-implant & Biomedical Devices-
 Implants for
 Dental and Orthopedic-
Biomaterial
For Hard Tissue-




                                                                  β-tricalcium synthetic
• Bone Repair                          Osteoset—calcium sulfate   bone product.
                                       pellets.
• Joint Implants
• Joint Replacements




                   Resorbable Tricalcium
                   Phosphate (β-TCP) Implants
                   for bone void
                                                                     Collagen Bone Graft
Application Of
Bio-implant & Biomedical Devices-

Dental
Biomedical Implants:




                                    Metallic Glass-            Glass Orthopedic Bone
                                    New Bioabsorbable          Graft
                                    Option for Bone Implants
                                                               Material For New Bone
                                                               Growth,


                                                                     Timeline of the recent
                                                                     past, near future, and
                                                                     far future for the use of
                                                                     synthetic dental
                                                                     biomaterials versus
                                                                     truly biological
                                                                     materials
        An artificial
        dental crown
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:
Biomaterial
For Hard Tissue- Limbs



          •    Bone Repair
          •   Joint Implants
          •   Joint Replacements
                                    Orthopedic Implant Finger Plate
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:
                                    Biomaterial
                                    For Hard Tissue- Lower Limbs




                                                                      KNEE- prosthesis.
                                                  HIP- prosthesis.




                                                                     ANKLE- prosthesis.
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:
                                           Biomaterial-
                                           For Hard Tissue- Lower Limbs: Application




                                                   5




            Composite–(Metal ,Polymer
            And Ceramic) Hip prostheses.               Composite–(Metal ,Polymer
                                                       And Ceramic) Knee prostheses.
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:
Biomaterial-
For Hard Tissue- Limbs


                                     Patellar
                                     Augmentation implant.




            Ankle-                     Synthetic Biomaterial
            Replacement-Prosthesis     for Tendon Replacement
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:
Biomaterial
For Hard Tissue- Limbs: Application
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:                Biomaterial:
                                    For Hard Tissue- Spine
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:

Biomaterial-
For Hard Tissue- Spine: Application




                      Baguera L - Lumbar Disc
                      Prosthesis. MRI compatible
Application Of
Bio-implant & Biomedical Devices-

Orthopedic
Biomedical Implants:
Biomaterial- Biodegradable:
For Hard Tissue- Limbs & Spine




                                    5
Application Of
Bio-implant & Biomedical Devices-
Biomaterial-
For Soft Tissue-




                                                    Tissue Engineering
                                                    Of Skin - Withy Polymer Scaffold




                         Polyform® Synthetic Mesh      Bio-Engineering
                                                       Hydro-gel for Tissue Repair
Application Of
Bio-implant & Biomedical Devices-
Biomaterial-
For Soft Tissue-




            Tissue Engineering
            Of Skin – for Burn Patients
Application Of
Bio-implant & Biomedical Devices-




                                                        Cancer detection
                                                        from an implantable device,




                 Insulin Pumps - Diabetes

           1. Artificial Device / Organs for Eye, ENT, Brain
           2. Artificial Device / Organs for Heart, Lungs, Liver and Kidney.
           3. Artificial Device/Organs for Dental, Maxillofacial and
           Orthopedic.
Classification:




                   Class I: General controls.

                   Class II: General controls with special controls
                    (infusion pumps, and surgical drapes…).

                   Class III: General controls and premarket
                    approval (implantable pacemaker, pulse
                    generators, automated external defibrillators).
Application Of
Bio-implant & Biomedical Devices-
Artificial
Device/ Organs for Eye, ENT,
Brain

                                              Scientists Set Sights on an
                                              Implantable Prosthetic for
                                              the Blind .




                                                             Implantable Miniature
                                                             Telescope for Macular Degeneration




                           Implantable Smart Chip            implantable-
                                                             device- seizure
                            Fights Chronic Pain -
Application Of
Bio-implant & Biomedical Devices-
Artificial Device/ Organs
For Heart,Lungs,Liver,Kidney and
Stomach.




                                                Artificial Lung
                                                Without Need for Extra Oxygen
                         Artificial Heart




                                    ivad
                                            Device blocking stomach nerve
                                            signals shows promise in obesity
Application Of
Bio-implant & Biomedical Devices-



                                                           Application:
                                                           Pace-maker in-situ.




           First_pacemaker_
           Siemens-Elema_19581




            Blood-power-hydroelectric-turbine... devices that use
            Small turbines designed to fit inside a human artery.
Application Of
Bio-implant & Biomedical Devices-

Artificial Device/ Organs
For Heart, Lungs, Liver and Kidney.
                              Liver device helps man
                              survive until transplant –
                              FGate


                                         6
Application Of
Bio-implant & Biomedical Devices-

Artificial Device/ Organs
For Heart, Lungs, Liver and Kidney.




                                                  5




                              Artificial mechanical kidney
Application Of
Bio-implant & Biomedical Devices-
Artificial Device/ Organs
for Dental and Orthopedic
Implantation.




                                                      Surgically implanted titanium
                                                      And stainless steel plates
                         Flexible (nylon)
                         dental prostheses.




                        Composite– (Metal and         Orthopedic /Dental
                        Ceramic) dental prostheses.   Implants Pulse Generators (CRMs) .
Application Of
Bio-implant & Biomedical Devices-
Artificial Device/ Organs
for Dental and Orthopedic
Implantation.
                                               Wireless Implantable Chip
                                               Delivers Osteoporosis Drug-
                                               When It Is Needed.


                                    Remote
                                    Control-
                                    Microchips...
                                           9
Adverse
Effects Of Biomaterial/Bio-device:


         Hemolysis,Thrombosis & Coagulation.
                         (Exaggerated)
         Inflammation
                          Acute Inflammation
                         (Exaggerated)
                         Chronic Inflammation
                          (Specific for foreign body)
         Immunogenicity and toxicity
         Infection
         Corrosion/ Wear/ Tear
         Loosening
         Fracture of implant and bone
         Rejection of Implant
         Tumorogenesis /Carcinogenesis.
              Recent Advancement
              Of Biomaterial/Biomedical Science.




Mesh_Titanium_
orthopedic implant.
Recent Advancement
Of Biomaterial Science.

Biodegradable Biomaterial.
Recent Advancement
Of Biomaterial Science.


                                Biomaterials that form bonds with the living
                                tissues and perform specific biological
                               response at the interface -
                                    • Capable of direct chemical bonding with
                                      the host tissue.
                                    • Stimulatory effects on bone-building
                                    cells.

                                   o      Bioglass SiO2,
                                   o      CaO and Na2O,
                               Ideal
                                   o      bone Phosphate.
                                       as Calciumcement fillerand coating
                               due to its biological activity– Cannot be
                               used for load bearing applications-
    Bone ingrowth around
    synthetic hydroxyapatite
Recent Advancement
Of Biomaterial Science.
Biologic
Biomaterials.              Are Biological components- either from-
                           Natural (Plant), or xeno, allo or auto biological
                           components-
                           Whole /part of Cell- adult /stem, Cell-secreted
                           extracellular matrix or fluid,
                           Living Tissue Components (e.g. Collagen, liver
                           or pancreatic tissue) or
                           Lab grown biological cell, fluid/ tissue or organ
                           to augment, regenerate, replace or implantation
                           in the living biological system.

                           Implantation of cell / tissue / fluid for regeneration.
  Research of interest     Restorable Collagen- Based Medical Implant/ tissue.
  -
                           Tissue Engineering for Tissue and Organ Regeneration.
 Recent Advancement
 Of Biomaterial Science.
 Tissue Engineering
 For Tissue and Organ Regeneration.
 Stem Cell Researchers –
 A Step Closer to Growing                                    An artificial human trachea implanted in
 New Organs-                                                 Sweden: A cancer patient has received
                                                             the first synthetic windpipe transplant.




                                                                  5




The synthetic scaffold of an ear sits bathed in cartilage-
producing cells, part of an effort to grow new ears for
wounded soldiers.
Recent Advancement
Of Biomaterial Science.
Restorable Collagen-
Based Medical Implant.



 Collagen is an important ECM
 molecule and is the major
 structural component in the body.
 It is biocompatible and degrades
 into harmless products that are
 metabolized or excreted. a very           5

 poor antigen , non-toxic.


                          Pulpal
                          Regeneration -
Recent Advancement
Antibiotic-coated
Of Biomaterial Science.
Bio-implants/device
-

                           New multifunctional ciprofloxacin-
                            releasing
                            SR-PLGA 80/20 screws (A).
                           Screws that do not contain ciprofloxacin
                            (B).
Recent Advancement
Of Biomaterial Science.

Aesthetic/
Cosmetic Biomaterial.


                                                    Nose
                                                  implants



                                                             Popular- cosmetic-dental-
                                                             treatments-




     Porous-polyethylene-implant-Reconstruction of
     the total external ear has two major approaches-
     alloplastic prosthesis implantation.
                                                                Cosmetic-dentistry-
Recent Advancement
Of Biomaterial Science.
Aesthetic Biomaterial.



                 Popular- Aesthetic
                 Replacement of Testis-




                                          5
Recent Advancement
Of Biomaterial Science.

Cosmetic Biomaterial.
Biomaterials in
plastic - surgery-
                                                Saline-breast implant




                                   5




      Autogenous-cartilage-graft


                                       Silicone-breast implant in-situ
Recent Advancement
Of Biomaterial Science.
Micro-chip
Controlled Bionic
Devices.


   Bionic bodies have been depicted in
   science fiction for decades.
   Now, researchers are making bionics
   the new frontier of medical science, by
   creating hi-tech devices to help people
   walk, see and hear again.
                                             8
Recent Advancement
Of Biomaterial Science.                                 • Positron emission tomography (PET)
                                                        • Single photon emission computed
Innovation-                                               tomography (SPECT)
                                                        • Magnetic resonance imaging (MRI)
Molecular Imaging Technique›                            • Computed tomography (CT)
                                                        • Optical bioluminescence imaging
                                                        • Optical fluorescence imaging
                                                        • Ultrasound.


                                       Molecular imaging is a new biomedical research
                                            discipline enabling the visualization,
                                        characterization, and quantification of biologic
                                       processes taking place at the cellular and sub-
                                                        cellular levels.
         Human Bone Osteosarcoma
         Cells (Fluorescent Digital
         Image technology)
                                       It provides a number of unique advantages
                                       over more traditional tools such as histology:
                                        Non-Invasive
                                        Real-Time
                                        Physiological Conditions
                                        Intact Tissue
                                        Living Subject
                                        Longitudinal and Quantitative
                                        Assessments Complementary to Histology.
         Bimolecular Image of Chest-
Current Priority Research
On Biomedical/ Biomaterial Science.
                   Application:
                   Genomic and personalized medicine.
                   Nano -technology oriented Medical
                    science and Regenerative Medicine.
                   3rd And 4th Generation Biomaterial –
                     • Tissue Engineered- Cell and Gene
                         activating Biomaterials.
                     • Adult/Stem Cell derived
   Advanced              cell, tissue/Organ and Medication.
 Biomaterial-
 Regenerative
   medicine,       Innovation:
     able to
 interact with
                   Biodegradable and Bioactive-
      living
  cells, and to
                    biomaterial8 /drug delivery system.
    promote        Biocompatible and comfortable bionic
 tissue repair.
                    limbs/ Organs.
                   Newer technology for
                    Aesthetic,Cosmetic,Dental,Orthopedic &
                    Maxillofacial Surgery.
                   Bio-fuel/auto-fueled/ Self controlled
                    Biomedical devices.
Current Priority Research
On Biomedical/ Biomaterial Science-

Stem Cell
Research:
Live human lungs grown in lab using stem
cells in potential transplant breakthrough -




                                      8
Current Priority Research
On Biomedical/ Biomaterial Science-

Stem Cell
Research:
Live human heart grown in lab using stem
cells in potential transplant breakthrough-




                                       6
Current Priority Research
On Biomedical/ Biomaterial Science-

Stem Cell
Research:
Dr. Anthony Ata-la and his team has grown
bladders and blood vessels using Stem Cell.




                                      Tissue Engineered Bladder
Current Priority Research
On Biomedical/ Biomaterial Science-
Stem Cell
Research:
                                      Spray On Stem Cells for Treating
                                      Burns and Open Wounds–Regenerative
                                  Most current applications of biomaterials
                                 /biomedical device involve structural
                                 functions, or very simple chemical or electrical
                                 functions.
                                          Complex chemical functions (e.g.,
                                          those of liver), and
                                          Complex electrical or
                                          electrochemical functions (e.g., those
                                          of brain and sense organs) – cannot
                                          be carried out by biomaterials.
                                  Transplantation of organs and tissues is
Regenerative Medicine            inevitable when biomaterials are not
In 2012- Assessing Predictions
                                 available.
 Tissue engineering will change the face of
biomaterials.
 Regenerative medicine will reduce the need
for synthetic materials in the body.
 In the near-future, biomaterials will be
incorporated with biological factors (such as
bone growth) directly into an implant’s surface
to improve biocompatibility and bioactivity.
 Bionic device- Now researchers are making
bionics, the new frontier of medical science,
by creating hi-tech devices to help people
walk, see and hear again.
&
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