A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma Background: within the past, diffuse malignant peritoneal mesothelioma (DMPM) was considered a preterminal condition. The length of survival was dependent upon the aggressive versus indolent biologic behavior of the neoplasm. the general median survival was ∼1 year when systemic chemotherapy. Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has been used as a treatment different, however the efficacy of this combined treatment remains to be established. Patients and methods: Searches for relevant studies printed in peer-reviewed medical journals on CRS and PIC for DMPM before might 2006 were dole out on six databases. The reference lists of all retrieved articles were reviewed for additional identification of doubtless relevant studies. skilled educational surgeons in Washington, DC, USA were asked whether or not they knew regarding any vital unpublished information. 2 investigators independently evaluated every study in step with predefined criteria. the standard of every study was assessed. Clinical effectiveness was synthesized through a narrative review with full tabulation of results of all included studies. Results: Seven prospective observational studies from six tertiary establishments were accessible, permitting 240 DMPM patients for assessment. The median survival ranged from 34–92 months. The 1-, 3- and 5-year survival varied from hour to half of one mile, forty third to sixty fifth and twenty ninth to fifty nine, respectively. The perioperative morbidity varied from twenty fifth to four-hundredth and mortality ranged from third to eight. Conclusions: This systematic review evaluated this proof for CRS and PIC for DMPM. Seven observational studies were accessible for assessment, that demonstrated an improved overall survival, as compared to historical controls, using systemic chemotherapy and palliative surgery.
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