projection profile of poisoing

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							SUBMITTED BY
        RESHMA P.K
        REMYA RAJAN
        REJINA.N
        2006 MBBS
                           CERTIFICATE

         DEPARTMENT OF COMMUNITY MEDICINE

GOVERNMENT MEDICAL COLLEGE, TRIVANDRUM



         Certified that this report is a bonafide record of a research

project undertaken to fulfil the curriculum requirements of

undergraduate medical education as stipulated by the Medical

Council of India and was done during the year 2009-2010


Guided by




Dr. Reshmi Ramachandran               Dr. K. Vijayakumar
Department of Community Medicine      Professor & Head
Govt. Medical College                 Department of Community Medicine
Trivandrum.                           Govt. Medical College, TVM.



Date :
Place


Office seal                     Submitted
                                      Reshma. P.K
                                      Remya Rajan
                                      Rejina. N.
                    CONTENTS

S.I.NO               TOPIC           PAGE NO


  1      ACKNOWLEDGEMENT                1


  2      BACK GROUND AND RATIONALE     2-6


  3      REVIEW OF LITERATURE          7-9


  4      METHODOLOGY                  10-11


  5      ANALYSIS                     12-43


  6      CONCLUSIONS                  44-47


  7      LIMITATIONS OF THE STUDY      48


  8      REFERENCE                     49
                         ACKNOWLEDGEMENT


        We would like to express our sincere gratitude to Dr. Vijayakumar (Professor and

Head of Department, Community Medicine) for giving us an opportunity for carrying out

are study and for being our guiding lights throughout. We specially thank Dr. Reshmi

(Post Graduate student, Department of Community Medicine) for her invaluable

instructions, suggestions and help.


        We also extend our heartfelt gratitude to Dr. B. Jayakumar            (Head of

Department of Medicine) for giving us permission and helping us to complete our project

successfully.


        We also thank all the patients we included in our study without whose co

operation this study would have been impossible.


        Our science thanks also go out to our family and friends for their encouragement

and support.


        Last, but not the least, we thank God Almighty for blessing us throughout our

humble endeavours.




                                           1
              BACKGROUND AND RATIONAL

     In India, according to Government estimates 113914
people committed suicides in the year 2005. The national
suicide rate for the year 2003 was 103/1,00,000 and it varied
from 0.6/1,00,000 to 52 1/1,00,000 in different parts of India.

     According to the National Crime Record Bureau, the
official agency responsible for suicide data collection in India,
Kerala, a South Indian state has the highest suicide rate among
Indian states. In 2005, Kerala had an estimated suicide rate of
277/1,00,000     compared     to       industrialized   countries,   the
mortality rate for attempted suicide is 10-50 times higher in
rural developing countries.

     Poisons are substances that can cause disturbances to the
organisms usually by chemical reaction or other activity on the
molecular scale whom sufficient quantities are absorbed by
the organism. Acute poisoning is the exposure to a poison on
one occasion or during a short period of time.                 Chronic
poisoning is a long term repeated or continuous exposure to a
poison, where symptoms do not occur immediately or after
each exposure.

     The most common agents responsible for poisoning are
pesticides,   kerosene,   prescription        drugs     and   household


                                   2
chemicals pesticides are widely used in many countries where
agriculture is on important part of economy. Reports from
India, Srilanka and Thailand indicate that common availability
and use of toxic pesticides is responsible for intentional and
unintentional mortality and morbidity.

     In 2006, the WHO estimated that nearly 9,00,000 suicides
occurred each year more than from homicides and wars
combined. Of which 2,50,000 occurred from poisoning by
agricultural chemicals.    Rat poisoning is the one of the
commonest substance used for self poisoning.

     Pesticides poisoning is a significant problem in India.
Organo phosphates compounds cause most self poisoning
deaths in Southern and Control India. Southern India is an area
of intensive agricultural production. So pesticide use is high.

     Drug overdose is also one of the major method of
poisoning.     Drug overdose describes the ingestion or
application of a drug or other substances in quantities greater
than are recommended or generally practiced. An overdose is
widely considered harmful as it can lead to death.

     Cerebra Odollum is an Indian tree with poisonous fruit
used by more people to commit suicides than any other plant in
the world studies proved in Kerala death from odollum


                                3
averages almost once a week. Poisoning can be accidental or
intentional.

     In less traditional societies the causes of suicide are more
difficult to establish. The problem has been approached from
two different angles the sociological, which stresses social
pressures and importance of social integration and the
psychoanalytic which centres on the driving force of guilt and
anxiety and the    inverting of aggressive impulses.     Factors
associated with attempted suicide should be analysed
separately. It can be family problems, financial, Academic
problems or psychiatric illnesses.

     General Guidelines for the management include making
the airway clear, assuring that patient is breathing adequately
and circulation in adequately maintained. A standard clinical
examination should be carried out on every poisoned patient.
Needle marks as precious evidence of self harm should be
sought out.       Examination findings such as pupil size,
respiratory rate, heart rate should be noted. In case of toxicity
due to drug ingestion, dose of any antidote at available is to be
calculated.    The Glassgow come scale is the method most
frequently used to assess the degree of impaired consciousness.




                                4
     Some present with eye or skin contamination should be
treated with appropriate washing and irrigation. Only patients
who have ingested significant overdoses need further measures
such as gastric decontamination and methods to increase
elimination.   In the seriously poisoned patient, meticulous
supportive care including the treatment of seizures, coma and
cardiovascular complications is critical to good outcome.

     Cardiovascular support measures are to be taken.
Ventilator support may be required until consciousness returns
and complications such as aspiration pneumonia should be
treated promptly. Patients must be observed closely for signs
of deterioration whilst the effects of the toxin they have taken
wear off.

     The methods of preventing absorption or enhancing
elimination are    (i) removal of clothing or skin washing with
copious amount of soap and water for chemical or pesticides
exposure (ii) Eye irrigation (iii) Gastric lavage – only if a
potentially life threatening amount of toxin has been ingested
within the last hour.    Not to be used for acids, alkali or
petroleum distillates   (iv) whole bowel irrigation         with
polyethylene glycol solution is given for potentially toxic
ingestion of iron, lithium etc. (vi) urinary alkalinisation:




                               5
enhances the elimination of salicylates and some pesticides (vii)
Extracorporeal methods of elimination.

     Eg: hemodialysis or hemoperfusion (viii) Activated
charcoal. Improves outcome when administered within 1 hour
of ingestion of a potentially toxic amount of a poison which
binds to charcoal. It is the most common method to prevent
drug absorption.




                                6
                REVIEW OF LITERATURE

1. Risk factors of acute poisoning in Sri Lanka

Abstract

     Summary:      This report describes the characteristics of
patients with acute pesticide poisoning in a rural area of
Srilanka, and for intentional self poisoning cases, explores the
relative importance of the different determinants. Data were
collected for 239 acid pesticide poisoning cases, which were
admitted to two rural hospitals             in Srilanka.       Socio-
demographic    characteristics,       negative     life   events   and
agricultural practices of the intentional self poisoning cases
were compared with a control group.              Most cases occurred
among young adults and the large majority (84%) was because
of the intentional self-poisoning. Care fatality was 18% with
extremely high care fatality for poisoning with the insecticide
endosulfan and the herbicide paraquat. Cases were generally
younger than controls, of lower educational stabun and were
more often unemployed.      No agricultural risk factors were
found but a family history of pesticide poisoning and having
ended on emotional relationship in the past year was clearly
associated with intentional self – poisoners.         The presence of
mental disorders could only be assesed for a subsample of the



                                  7
cases and controls and this showed that alcohol dependence was
a risk factor. This study shows that acute pesticide poisoning in
Srilanka is determined by a combination of socio demographic
and psychological factors.          Suggestions are given for
interventions that could control the morbidity and mortality due
to a acute pesticide poisoning in developing countries.

2.    Study   conducted    at   Kasturba     Medical      College,
Mangalore, India to characterize the poisoning cases
admitted.

     All cases admitted to the emergency department of the
hospital between January 2001 to May 2003 evaluated
retrospectively.   Data obtained from the hospital medical
records and included of the following factors Socio –
demographic characteristics agents and route of intake and time
of admission of the acutely poisoned patients.

       Results of the total 33,207 patients admitted in the
hospital for treatment, 325 patients were for the acute
poisoning. This was 1% of all emergency admissions of these
709, well males and 30% females. The majority (36%) cases
were from age group of 21-30 years. Most (72%) poisonings
were intentional and only 27% were unintentional. The most
important agents of acute poisoning were           agrochemical



                                8
pesticides (99%) followed by drugs (17%) and alcohols (13%),
Forty-eight (15%) patients died. The poisons responsible for
most of the mortality were organophosphate pesticides (65%)
and aluminium phosphide (15%). In summary, the prevention
and treatment of poisoning due to organo phosphate and
aluminium phosphide should merit high priority in the health
care of the indigenous population of South India (Dakshina
Kannada district).




                             9
                      METHODOLOGY

Study design       : Hospital based case series study

Study setting      : Medicine wards Govt. Medical College
                    Hospital, Trivandrum.

Study population

Inclusion criteria : All the poisoning cases, admitted in the
                    medicine wards during         3/10/2009 to
                    15/12/2009.

Exclusion criteria : Case admitted due to snake bites and other
                    unknown bites are excluded from the study.

Sample size        : 65 cases

Sampling technique: Purposive Sampling

Data Collection    : Semi structured Questionnaire

Ethical consideration :     Consent was taken from the patient,
                    Head of the department of medicine and
                    community Medicine, Medical College,
                    Trivandrum.

Study period       : 3/10/2009 – 15/12/2009

Data collection method
1. Study subjects were identified and purpose of study
  explained.

2. Consent was obtained from those who agreed to
  participate in the study

3. The data collected was analysed.
DATA ANALYSIS

A)FREQUENCY ANALYSIS
1)TABLE 1

 GENDER FREQUENCY TABLE

            Frequency percentage     Cumulative percentage

  Male      45          69.2         69.2
  Female    20          30.8         100
  Total     65          100



INTERPRETATION:



       Out of total 65 cases, 69.2% of them were males and
30.8% were females.
2) TABLE 2)



RESIDENCE FREQUENCY TABLE

        Frequency percentage Cumulative percentage


Urban 25           38.5         38.5


Rural 40           61.5         100


total   65         100




INTERPRETATION :




       Out of total 65 cases, 61.5% cases were reported from
rural areas.
TABLE 3)

EDUCATION –FREQUENCY TABLE




                 Frequency percentage Cumulative
                                      percentage
Illiterate       3         4.6        4.6

Primary          14          21.5        26.2

Secondary        29          44.6        70.8

Higher           30          20          90.8
secondary
Graduate         6           9.2         100

Total            65          100




INTERPRETATION :



      Majority (44.6%) of the cases had a level of secondary
education
TABLE 4)

OCCUPATION- FREQUENCY TABLE


              Frequency percentage Cumulative percentage

Unskilled     23        35.4       35.4

Semiskilled   5         7.7        43.1

Skilled       6         9.2        52.3

House wife    8         12.3       64.6

Student       8         12.3       76.9

Unemployed 15           23.1       100

Total         65        100




INTERPRETATION : Almost one-third of the cases were
unskilled (35.4%),followed by unemployed(23.1%).
TABLE 5)
 SOCIOECONOMIC STATUS –FREQUENCY TABLE


           Frequency percentage Cumulative percentage

    APL 30            46.2        46.2

    BPL 35            53.8        100

    Total 65          100



APL : Above poverty line


BPL : Below poverty line


INTERPRETATION :


            Out of total 65 cases , 46.2% cases were APL and
53.8% were BPL.
TABLE 6)


   NATURE OF POISONING –FREQUENCY TABLE


                  Frequency percentage Cumulative
                                       percentage
 Organophosphates 23        35.4       35.4
 Drugs                26         40          75.4
 Chemicals            9          13.8        89.2
 Plant products       2          3.1         92.3
 Corrosives           5          7.7         100
 Total                65         100


INTERPRETATION:




         The most important agents of acute poisoning were

drugs (40%) followed by organophosphates (35.4%) and

chemicals (13.8%).
TABLE 7)
        MODE OF POISONING FREQUENCY TABLE

              Frequency       Percentage     Cumulative
                                             percentage

Accidental    2               3.1            3.1
Intentional   63              96.9           100
Total         65              100

INTERPRETATION :

                  Most of the poisoning were intentional(96.9%)

And only 3.1% were accidental.
TABLE 8)


CAUSE OF POISONING FREQUENCY TABLE


               Frequency       Percentage      Cumulative
                                               percentage
Family         19              29.3            29.3
problems
Financial      21              32.3            61.5
problems
Love           9               13.8            75.4
failure
Academic       7               10.8            86.2
problems
Others         9               13.8            100

Total          65              100



INTERPRETATION:

               Most of the poisoning cases are caused due to

financial   problems(32.3%).    Family      problems   stand

second(29.3%). Other leading causes are in the order love

failure(13.8%) ,academic problems(10.8%) and others(13.8%).
TABLE 9)
   METHOD OF POISONING FREQUENCY TABLE
                Frequency Percentage Cumulative
                                     percentage
Mixed with food 3         4.6        4.6

Mixed with          24          36.9         41.5
alcohol
Taken as such       38          58.5         100



INTERPRETATION:

                   Of the total cases 58.5 % had taken poison a

such.36.9% of them preferred it along with alcohol and 4.6%

along with food.
TABLE 10)




HISTORY OF MENTAL ILLNESS FREQUENCY TABLE


            Frequency Percentage Cumulative percentage

   Present 13            20           20

   Absent 52             80           100

   Total    65           100



INTERPRETATION:

                 The study revealed that 20% of the total cases

had the history of previous mental illness.
TABLE 11)


ADDICTIONS FREQUENCY TABLE
             Frequency Percentage Cumulative percentage
Alcoholism 12             18.5         18.5
Smoking      10           15.4         33.8
Both         17           26.2         60
Tobacco      2            3.1          63.1
Nil          24           36.9         100
Total        65           100




INTERPRETATION:

                 Out of the total case,26.2% were both

alcoholics and smokers.
TABLE 12)


ASSOCIATED OTHER DISEASES FREQUECY TABLE
         Frequency Percentage Cumulative percentage

Present 22            33.8          33.8

Absent 43             66.2          100

Total    65           100




INTERPRETATION:

                 33% of the cases had associated co-morbid

diseases while the rest were free of co-morbidities.
TABLE 13)


FIRST AID FREQUENCY TABLE


              Frequency Percentage Cumulative
                                   percentage
Received      31            47.7         47.7

Not           34            52.3         100
received
Total         65            100



INTERPRETATION:

                   47.7% of the cases received first aid after

poisoning while the rest did not.
TABLE 14)


PRIOR HOSPITALIZATION FREQUENCY TABLE:


       Frequency     Percentage    Cumulative percentage

Yes    33            50.8          50.8

No     32            49.2          100

Total 65             100




INTERPRETATION:

                 Of the total cases, 50.8% were getting prior

treatment from local hospitals while the rest were taken directly

to the medical college.
TABLE 15)
        STOMACH WASH FREQUENCY TABLE
          Frequency Percentage Cumulative percentage

   Yes    58         89.2        89.2

   No     7          10.8        100

   Total 65          100



INTERPRETATION:
         More than ¾ th of the total cases 89.2% undervent

stomach wash.
TABLE 16)
        ICU ADMISSION FREQUENCY TABLE:
      Frequency Percentage Cumulative percentage

Yes   12        8.5         18.5

No    53        81.5        100

Total 65        100



INTERPRETATION:
              Only 18.5% of the cases needed ICU

admission.
TABLE 17)


RYLES TUBE INTUBATION FREQUENCY TABLE


          Frequency   Percentage   Cumulative percentage

Present   64          98.5         98.5

Absent    1           1.5          100

Total     65          100



INTERPRETATION:
               98.5% of the case needed ryles tube intubation.
TABLE 18)


PREVIOUS ATTEMPTS OF POISONING FREQUENCY
TABLE


       Frequency    Percentage    Cumulative percentage

Yes    7            10.8          10.8

No     58           89.2          100

Total 65            100



INTERPRETATION:
                 Only 10.8% cases had a history of previous
attempts of poisoning.
TABLE 19)
OUTCOME OF MANAGEMENT FREQUENCY TABLE


            Frequency       Percentage   Cumulative percentage

Survived    51              78.5         78.5

Death       14              21.5         100

Total       65              100



INTERPRETATION:


                 The proportion of survival among poisoning

cases treated in the medical college hospital is 78.5% and the

case fatal rate is 21.5%.
TABLE 20)


ASSOCIATION BETWEEN GENDER AND MODE OF
POISONING


                              Mode

                   Accidental Intentional      Total

          Male          1            44        45
Gender Female           1            19        20



     Total              2            63        65



Chi square value   : 0.358

Degree of freedom : 1

P value             : 0.549

INTERPRETATION :

          There is no association between gender and mode of

poisoning.
TABLE 21)


ASSOCIATION BETWEEN SOCIO ECONOMIC
STATUS AND OUTCOME

                    Outcome                       Percentage
                                       Percentage death
                               Total
                                       survived
             Survived Death
               27       3       30        90        10
      APL
SES            24       11      35       68.5       31.5
      BPL
               51       14      65
 TOTAL
Chi square value     : 4.389
Degree of freedom : 1
P value              : 0.036
INTERPRETATION : There is association between

socioeconomic status and outcome of poisoning.Mortality rates

were found to be high in BPL class(31.5%) as compared to

APL (10%).
TABLE 22)
ASSOCIATION BETWEEN RESIDENCE AND
OUTCOME
                                  Outcome

                        Survived       Death
                                                  Total
             Urban           22         3         25

             Rural           29         11        40
  Residenc
  e


               Total         51        14         65

Chi square value       : 2.187

Degree of freedom      : 1

P value                : 0.139

INTERPRETATION :

               There is no association between residence of the

patient and outcome of poisoning .
TABLE 23)
ASSOCIATION BETWEEN NATURE OF POISON AND
OUTCOME




                               Outcome

                          Survived        Death Total Percentage   Percentage
                                                      survived     death

       Organophosphates        12          11    23     52.17       47.83

       Drugs                   26          0     26      100          0

Nature Chemicals               8           1      9      88.8       11.12

       Plant products          2           0      2      100          0

       Corrosives              3           2      5       60         40

      Total                        51      14    65    78.46       21.54




Chi square value          : 18.679

Degree of freedom         :4

P value                   : 0.001

INTERPRETATON              :            There is significant association

between nature of poisoning and outcome.The highest mortality

rates were found to be in Organophosphates poisonings.
TABLE 24)
ASSOCIATION BETWEEN METHOD OF POISONING
AND OUTCOME
                        Outcome          Total

                        Survived Death

              Mixed
              with
                             3     0              3
              food
        Mixed
 Method with
                         16        8             24
        alcohol
              Taken      32        6             38
              as such
      Total              51        14            65


Chi square value        : 3.542

Degree of freedom       :2

P value                 : 0.170

INTERPRETATION : There is no association between

method of poisoning and outcome
TABLE 25)
ASSOCIATION BETWEEN ADDICTIONS AND
OUTCOME OF POISONING


                           Outcome

                                          Total Percentage Percentage
                                                survived   death
                         Survived Death

               Alchlsm     10        2    12      83.3       16.6

               Smking       8        2    10      80         20

   Addictions Both          8        9    17      47.09      52.95

               Tobaco       2        0     2      100         0

               Nil         23        1    24      95.80       4.17

       Total                51       14    65      78.96      21.54

Chi square value : 14.937

Degree of freedom : 4

P value : 0.005

INTERPRETATION: There is significant association between

addictions and outcome. Mortality rates were higher among

cases with both alcoholism and smoking(52.95%) followed by

smoking(20%) and alcoholism (16.6%).
TABLE 26)
ASSOCIATION BETWEEN FIRST AID AND OUTCOME


                                Outcome
                         Survived   Death         Total

                           25                 6    31
              Yes
  First aid
                    No     26             8        34


          Total            51         14           65


Chi sqare value : 0.167

Degree of freedom : 1

P value : 0.683

INTERPRETATION : There is no association between

outcome of poisoning and first aid
TABLE 27)


ASSOCIATION BETWEEN OTHER CO-MORBID
DISEASE AND OUTCOME


                    Outcome

                                      Total   Percentage   Percentage
                  Survived    Death                        death
                                              survived



            Yes     8          14     22        36.36         63.64

Co-
morbid
diseases    No      43          0     43        100            0



    Total            51        14     65         78.46        21.54

Chi square value          : 38.875

Degree of freedom : 1

P value                   : o.ooo

INTERPRETATION : There is significant association etween

the outcome and co-morbid diseases. Mortality rates among

cases with other co-morbid diseases were found to be 63.64%.
TABTE 28)
ASSOCIATION BETWEEN OUTCOME AND OTHER
HOSPITAL ADMISSIONS
                                 Outcome
                            Survived Death        Total


Other      Present            27           6        33
hospital
admissions
           Absent                24        8         32


    Total                        51        14        65


Chi square value       : 0.447

Degree of freedom       :    1

P value                : 0.504

INTERPRETATION :

                     There is no association between outcome in

cases getting prior treatment in other hospitals and those getting

directly admitted.
TABLE 29)
ASSOCIATION BETWEEN NATURE OF POISONING
AND ICU ADMISSIONS


                                     ICU
                                  admission
                                              Total    %
                                                      ICU
                                  Yes   No            Admn

            organophosphates 11          12   23       47.82
            drugs                  1     25    26      3.84
Nature of chemicals                0     9      9       0
poisoning
          Plant products           0     2      2       0
            corrosives             0     5      5       0
          Total                    12    53     65     18.86


Chi square value    :    20.487
Degree of freedom :      4
P value             :    0.000
INTERPRETATION : there is association between nature of
poisoning and ICU admissions.Majority of ICU admissions
were seen in cases of organophosphate poisoning.(47.9%).
TABLE 30)
ASSOCIATION BETWEEN OTHER CO-MORBID
DISEASES AND ICU ADMISSIONS


                        ICU                     Percentage
                     admissions                 of ICU
                                        Total
                                                admissions

                     Yes       No
  Co –     Present     11      11        22        50
  morbid
  diseases
           Absent      1        42       43        2.3

          Total       12        53       65



Chi square value           :   21.974
Degree of freedom          :   1
P value                    :   0.000
INTERPRETATION :
                    There is association between ICU
admissions & presence of other co- morbid diseases in the
poisoning cases.Almost 50% of the cases with co-morbid
conditions needed ICU admissions.
TABLE 31)
ASSOCIATION BETWEEN ICU ADMISSIONS AND
OUTCOME
                    Outcome                    %        %
                                     Total   survived   death
                    Survived Death


ICU        Yes         3        9     12      25         75
admissions

             No        48       5     53      90.5       9.5

    Total              51       14    65     78.46      21.54



Chi square value     : 24.890
Degree of freedom     :1
P value              : 0.000


INTERPRETATION : There is association between outcome

and ICU admission of cases.Mortality rate among ICU

admissions were found to be 75%.
TABLE 32)
ASSOCIATION BETWEEN SOCIOECONOMIC STATUS
AND CAUSE OF POISONING
                                          SES           Total       Percentage



                                APL         BPL                     APL     BPL

               Family
               problems
                                     12             5       17       40     14.2

Causes of      Financial
poisoning      problems
                                      4          17         21      13.3     48.5

               Love failure           5         4          9         16.6    11.4

               Academic               5         2               7    16.6    5.71
               problems

               Others                 4             7       11      I3.3     20

            Total                     30         35         65      100      100


Chi square value           : 13.019
Degree of freedom : 5
P value                    : 0.023


INTERPRETATION : There is association between causes of
poisoning & SES of the cases.The major cause of poisoning
among APL group was family problems(40%), while financial
problems were found to be the major cause among
BPL(48.5%).
                       CONCLUSION

     Of the total 65 patients admitted in the Medical College
Hospital for the treatment of poisoning, 69.2% were males of
30.8% females. The majority of the poisoning were intentional
(96.9%) and only 3.1% were accidental. The most important
agents of acute poisoning were drugs (40%) followed by
organophosphates (35.4%) ,chemicals (13.8%), corrosives
(7.7%) and plant products (3.1%). Of the total cases 14 patients
(21.5%) died.      The poisons responsible for most of the
mortality were organophosphates (48%)             followed by
corrosives (40%). If the total cases 61.5% cases were reported
from rural areas. Majority of cases (44.6%) had a secondary
level education.    Almost 2/3rd of the cases were unskilled
workers( 35%) followed by unemployed(23%). 45% of the
cases belong to APL group while rest 54% were BPL. The
cause of poisoning were mostly attributed due to financial
problems (32%), family problems (29%), love failure (13%),
academic problems (10%) and others (13%).

     If the total cases, 58.5% had taken poison as such 36%
preferred it along with alcohol and 4.6% with food. The study
revealed that 20% of total cases had history of previous mental
illness. 26% of total cases were both alcoholics and smokers.
33% of cases were also associated with other co-morbid
conditions. Only 10% of cases had previous attempts.

     It is found that 52% of cases didn’t receive any first aid.

     If the 50.8% of cases were getting critical treatment from
local hospitals while the rest were taken directly to Medical
College. More than 3/4th of cases (89%) underwent stomach
wash either at MCH or at periphery only 18% of cases needed
ICU admission. 98% of cases were Ryles tube intubated.

     The proportion of          survival among poisoning cases
treated in Medical College hospital is 78.5% and case fatality
rate is 21.5%.

     According to the study , there is significant association
between outcome and socioeconomic status, nature of
poisoning,    addition     associated   co-morbidities    and   ICU
admissions.

     It was found out that there is significant association
between      nature   of    poisoning    and    ICU      admissions,
socioeconomic status and cause of poisoning, death rate among
APL cases were less (10%) as compared to that of BPL cases
(31%).
     Organophosphates causes the highest mortality rate of
4%, followed by corrosives (40%) and chemicals (11%). 47%
of organophosphorus poisoned cases were admitted in ICU.

     Death rate were found to be highest in persons having
both smoking and alcoholism (53%).           Death rate among
persons with co morbid diseases were found to be             high
(63.6%). Mortality rate among ICU admissions were found to
be 75%,

     It was found that 30% of the cases having co morbid
diseases required ICU admission while only 2.8% of other
category required it.

     There is an urgent need to improve hospital facilities for
the treatment of acute poisoning including intension care and
assistance ventilation.

     Preventive intervention should be multi pronged.         For
primary prevention, community based social support systems
should be commenced to enhance the coping skills of youth.
There should also be improvement in community mental health
services to detect early and treat serious mental illness. The
easy availability of pesticides and toxic chemicals should be
restricted, although this world probably be of short term benefit.
For secondary prevention to be effective, the negative attitudes
of health personnel towards parasuicides should be changed.
This can changed. This can only be achieved by fundamental
changes in curriculum so as to emphasize the importance of a
holistic approach to patient case.
    LIMITATIONS OF THE STUDY

 Small sample size




 Sampling errors




 Small period of time




 Discrepancies in the administration of the questionnaire
            REFERENCES


 PARK’S TEXTBOOK OF PREVENTIVE AND
 SOCIAL MEDICINE




 DAVIDSONS’ TEXTBOOK OF INTERNAL
  MEDICINE




 WWW.WIKEPEDIA.COM




 WWW.WHO.COM

						
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