02 Open-ASA-2 PhD in Informatics_ UMC-University Degrees Online by yaohongmeiyes


									Ph.D. in Informatics at UM-Columbia - Executive Summary

The University of Missouri-Columbia (MU) proposes to establish a doctoral degree in
informatics that builds upon the strengths of MU and offers an interdisciplinary program
to meet local, state and national needs. Informatics is an enabling technology that
provides the tools and methods essential for organizing, analyzing and generating new
knowledge from data in the physical, life and health sciences and thus is essential to our
future successes in life sciences research and education. This point was clearly
articulated by an external review team of experts who visited the University of Missouri
campuses two years ago to evaluate their readiness for informatics programs. Their final
“Bioinformatics Readiness Report” was submitted to the UM Vice President for
Academic Affairs in August 2004 and included the following statements: “The
University of Missouri has an explicit strategic goal of becoming a leader in biomedical
and life sciences research. Informatics research is absolutely critical for biomedical and
life science research programs. PhD training is a critical element for biomedical and life
science research.” They concluded that MU had the research base to support a PhD
program and the MU campus has already committed substantial resources toward the
success of this program.

This proposed PhD program will utilize faculty expertise and course work offered by
several departments and schools. MU strategically hired several additional faculty
members in the area of informatics with a vision to enhance research and education in
this area. Students enrolling in the program will be able to select from among two degree
emphasis areas: Health Informatics and Bioinformatics. Others may be added in the
future. Each emphasis area will stress skill sets and research appropriate to the subfield
within the broad area of informatics. The specialized curriculum of each emphasis area
will be developed jointly between participating departments and the MU Informatics
Institute. This program will offer students educational opportunities not available
elsewhere in the State of Missouri. Courses from the MS in Bioinformatics (UMKC)
have been included as electives, and we plan additional collaborations, including joint
video conferences and seminars, which eventually will be extended throughout the UM
System. The planned enrollment for the first year is seven students, increasing by seven
each year to a steady-state of 28 after four years; a balance between critical mass and
ensuring excellence in training. Graduates are expected to design research projects and
develop and apply computational tools to a variety of problems in the life sciences that
will advance MU life sciences research and lead to a productive academic, healthcare, or
industrial career.

This program will be hosted in the newly funded MU Informatics Institute and this
degree is cost-effective and has been identified as one of the campus’ strategic initiatives.
MU has already invested in the field of informatics through enhancement of the
Computer Science Department (five new faculty) and creating a Department of Health
Management and Informatics (seven new faculty). The MU Informatics Institute also
includes four or five new faculty lines. Establishing this PhD degree program is a critical
next step in MU’s strategic plan in the life sciences and research enhancement.

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No. 2

Recommended Action – Ph.D. in Informatics, UMC

        It was recommended by Senior Vice President Lehmkuhle, endorsed by President

Floyd, recommended by the Academic and Student Affairs Committee, moved by

Curator ______________, seconded by Curator __________________, that the following

action by approved:

        that the University of Missouri-Columbia be authorized to submit the attached
        proposal for a Ph.D. in Informatics to the Coordinating Board for Higher
        Education for approval.

        Roll call vote:                    YES           NO

        Curator Atkins
        Curator Bennett
        Curator Cairns
        Curator Carnahan
        Curator Ream
        Curator Russell
        Curator Walker
        Curator Walsworth
        Curator Wasinger

        President Bennett declared the motion _________ by a vote of _____________.

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                                                     Table of Contents

Executive Summary .............................................................................................................1
Form NP – New Program Proposal Form ..........................................................................1d
Introduction ........................................................................................................................ 1e
           I. Program Need ...............................................................................................1g
                 A. Student Demand ....................................................................................1g
                 B. Market Demand ..................................................................................... 1i
                 C. Societal Need.........................................................................................1o
                 D. Methodology .........................................................................................1p
           II. Duplication and Collaboration ....................................................................1p
           III. Program Structure ......................................................................................1q
                 A. Summary of Program and Two Emphasis Areas .................................. 1s
                 B. General Prerequisites............................................................................. 1s
                 C. Form PS – Requirements....................................................................... 1t
                 D. Form FP – Financial Projections .........................................................1bb
                             1. Expenditures ............................................................................1bb
                             2. Budget Justification ................................................................. 1cc
                 E. Form PG – Program Characteristics and Performance Goals .............1dd
                             1. Student Preparation ..................................................................1dd
                             2. Faculty Characteristics ............................................................. 1ee
                             3. Enrollment Projections.............................................................. 1ff
                             4. Student and Program Outcomes................................................ 1ff
                             5. Program Accreditation .............................................................1hh
                             6. Alumni and Employee Survey .................................................1hh
           IV. Accreditation............................................................................................. 1ii
           V. Institutional Characteristic ......................................................................... 1ii
Appendix A Proposed New Courses................................................................................1yy
Appendix B CBHE Clarifying Comments ....................................................................... 1zz
Appendix C President’s Criteria .................................................................................... 1ccc
External Review .............................................................................................................1ggg
Readiness Report ............................................................................................................. 1jjj
Steinhoff Letter ..............................................................................................................1kkk

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Sponsoring Institutions:                     University of Missouri – Columbia

Program Title:                               Informatics

Degree/Certificate:                          Doctor of Philosophy in Informatics

Options                                      Emphasis areas:
                                               1. Bioinformatics
                                               2. Health Informatics

Delivery Site:                               University of Missouri – Columbia

CIP Classification:                          512706

Implementation Date:                         Fall Semester, 2007

Cooperative Partners:                        N/A

Expected Date of First Graduation:           May, 2011


Stephen W. Lehmkuhle
Senior Vice President for Academic Affairs
Name/Title of Institutional Officer                   Signature                    Date

Stephen Lehmkuhle                                                        573-882-6396
Person to Contact for More Information                                   Telephone

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The University of Missouri-Columbia (MU) is committed to serving the community and
the state by providing education and research training and preparing them for successful
careers as informatics researchers and/or educators. This will certainly enhance research
and education in a number of areas on the MU campus, as well as the state of Missouri,
which are the primary beneficiaries of our educational programs. The schools of
Medicine, Nursing, the Colleges of Engineering, Veterinary Medicine, Arts and Science,
Agriculture, Food and Natural Resources, and the Ellis Fischel Cancer Center, the Dalton
Cardiovascular Center, and the multi-disciplinary Life Sciences Research play critical
roles in the campus mission by educating the next generation of scientists and health care
providers and serving the community and state through undergraduate and graduate
education and outreach activities.

MU has developed an aggressive and successful life sciences initiative, as well as
prominent programs in the physical and quantitative sciences. Informatics is one of the
enabling technologies identified by the campus and the UM system as essential for
success of multiple initiatives. For its part, the UM system committed to building strong
research and educational programs in informatics that can serve the entire four-campus
system and support the growth of the University of Missouri as a key player in the
technology-driven future of research and education. As one example, the UM
Bioinformatics Consortium formed an initial nidus of collaboration that has facilitated
our ability to develop graduate programs, and also to share expensive new computational
technologies and tools across all four campuses.

This proposal represents three years of work by a campus-wide Bioinformatics Task
Force. This interdisciplinary group of individuals comes from multiple academic units
within MU. Currently, no state university offers Ph.D. degree programs in Informatics
and this proposal is designed to fill this gap. Our faculty and partners across the system
believe it is critical to the mission of the university and the development of the
community to offer such a program. The committee has also worked with representatives
of other UM campuses and assessed trends and developments at the national level in
creating the proposed program.

The proposal, which follows, was developed with the following guiding principles:
       • Offer a doctoral-level program in informatics that provides students with the
          core competencies and research skills to be productive independent
       • Meet informatics workforce needs in informatics research within the Midwest
          region, the State of Missouri, and at the national and international levels;
       • Develop a degree offering which utilizes the unique breadth and strengths of
          the MU campus and other UM campuses;
       • Build teams of faculty members and professionals to foster informatics
          education and research;

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       •   Partner and share resources with other campuses of the University of Missouri
           System; and
       •   Develop delivery mechanisms for offering comprehensive educational
           programs to meet student needs.

This degree program is designed to support the education of those students interested in a
career in informatics research and education. All graduates of the doctoral degree
program will be expected to demonstrate competencies consistent with excellence in
teaching and research environments as well as the talent and skill to become an
independent investigator in academia or commercial and public research institutions.
Graduates will be effective team members who can contribute to multidisciplinary
approaches to education, research, and development in the field of informatics. This
program will prepare students to assume responsible positions, which may include basic
and translational research and development, institutional management, public policy,
information systems development in health systems or industry.

What is Informatics?
There are numerous definitions of informatics, some drawing on a set of core skills and
others focused more on applications areas. The National Institutes of Health Biomedical
Information Sciences Technology Initiative identified core skills in informatics as
algorithms, basic mathematics, cognitive/ human factors and interfaces, data structures,
database design, evaluation/research methods, information retrieval, knowledge
representation, modeling, networking/architecture, ontology/vocabulary, probability
statistics, programming languages, simulation and software engineering. They recognize
varying emphases to support different research interests but state that topics should
include representation, modeling, data analysis systems (biological, computational,
organizational) and decision making. Applications areas can be clustered into
bioinformatics, imaging informatics, clinical informatics and public health informatics.
More specialized applications areas are numerous, but the science of informatics is
fundamental and essential to research advancement in these areas. The proposed doctoral
program builds on specialized applications areas that constitute research strengths of the
University of Missouri-Columbia. The two major concentrations include:

     Health Informatics: Research, development, or application of computational tools
     and approaches for expanding the use of biological, medical, behavioral or health
     data, including those to acquire, store, organize, archive, analyze, visualize and
     apply such data. This proposal recognizes applications areas in clinical informatics,
     public health informatics, consumer informatics and health systems informatics.
     Those trained in health informatics pursue research that leads to better health care
     delivery and outcomes, as well as develop methods for better informing not only
     health providers, but also consumers of medical services. This type of education
     will lead to stronger relationships between patients and providers.

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     Bioinformatics: Bioinformatics can be divided largely into two sub-categories:
     biological information management and computational biology.                     NIH
     (http://www.bisti.nih.gov/) defines the former subcategory as “Research,
     development or application of computational tools and approaches for expanding
     the use of biological, medical, behavioral or health data, including those to acquire,
     represent, describe, store, analyze or visualize such data.” The latter subcategory is
     defined as “The development and application of data-analytical and theoretical
     methods, mathematical modeling and computational simulation techniques to the
     study of biological, behavioral and social systems”. The boundaries of these
     subcategories are becoming more diffuse and other subcategories will no doubt
     surface in the future as this field matures. Scientists trained in bioinformatics are
     crucial to develop the tools necessary to analyze the enormous sets of data
     generated though modern high-throughput gene sequencing and gene expression
     profiling experiments. Without such teamwork, life sciences research will not be as
     successful. MU needs bioinformatics research and researchers to continue to
     increase our federal research grant funding. Together, bioinformatics and life
     sciences researchers are a strong and competitive team. However, we need to train
     more bioinformatics scientists to meet this critical need.

I.     Program Need

A.      Student Demand
The entire State is facing critical needs and an extreme shortage of bioinformatics and
medical informatics professionals. A handful of people in bioinformatics have been
trained over the past few years, funded by the National Library of Medicine training
program, but the paths for training are limited and the training is accomplished one-by-
one with existing, cooperative Ph.D. programs and faculty. We have numerous student
inquiries annually about educational opportunities in informatics, but have not had a
defined program of study to offer.

MU has made considerable investment in informatics research and education through the
development of a Master’s of Science in Health Informatics and the enhancement of
research through the Missouri Global Access to the Information Age program. The latter
has enhanced and linked the Computer Science Department in the College of Engineering
and the Health Management and Informatics Program in the School of Medicine. The
current M.S. program in Health Informatics has an enrollment of 54 master’s students
and core curriculum of nine graduate courses. These programs serve as a base for, and
their research programs would be greatly enhanced by, the development of a doctoral
program. There is also a population of master’s students interested in doing doctoral
studies and research in informatics.

MU also has a critical need for additional courses in bioinformatics tools and techniques
commonly used in health and life sciences research. The lack of these courses often
holds up research projects while faculty and staff find an opportunity for training in
specific areas. MU needs an expanded program of semester-long courses to support its
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research agenda. These courses could also be offered to other campuses and the
scientific community on-line or on weekends with a resultant revenue stream.

We have an opportunity at MU to also work with the UMKC and UMR and all campuses
to cooperate in our educational endeavors and through linkages between the new
approved UMKC Bioinformatics M.S. and our MU Ph.D. in Informatics program. These
will be complementary between the campuses rather than competitive, just as there is
synergism, but little overlap in the existing MU MS in Health Informatics and UMKC
Bioinformatics M.S. program. Further, there are numerous opportunities for collaboration
in research with UMR, UMKC and UMSL. Undoubtedly, some UMKC M.S. graduates
will wish to pursue a Ph.D. degree. We need to take action as soon as possible and move
towards this proposed Ph.D. program.

The goal of the program is to have an entering class size of seven students. We intend to
achieve a total class size of 28 incrementally over the first four years of the program.

A recent search revealed a comprehensive listing of informatics training programs
(Suresh Kumar. Bioinformatics Web-Comprehensive educational resource on
Bioinformatics. 6th May, 2005. {http://www.geocities.com/bioinformaticsweb}.) The
limited listing below if of those from the Midwest area from a total of 46 nationally.
Thus, there is a paucity of opportunities in the Midwest and a clear need for such training
programs here in Missouri.

Indiana University                    B.S. and M.S. in Informatics
Iowa State University                 Ph.D. in Bioinformatics and Computational Biology
Northern Illinois University          M.S. specialization in Bioinformatics
Ohio State University                 Graduate Program in Biomedical Informatics
University of Cincinnati              M.S. and Ph.D. Biomedical Eng-Bioinformatics
University of Illinois, Chicago       M.S. and Ph.D. in Bioinformatics
University of Nebraska, Omaha         M.S. and Ph.D. in Bioinformatics
Washington University, St Louis       Ph.D. in Computational Biology

i. Estimated enrollment each year for the first five years for full-time and part-time students.
The planned enrollment for the initial class is seven students, with seven new students each
year until a steady-state of 28 students is reached in year four. This figure represents a balance
between achieving critical mass and ensuring excellence in training of the students. Our
assumption is that it will take students an average of four years to complete this Ph.D. program.
Some will already have completed some of the coursework prior to enrollment.

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                             based on market/student demand

         Year                 1             2             3              4             5
         Full-Time            7             7             7              7             7
         Part-Time            0             0             0              0             0
         Total                7             14            21             28            28

                                  YEAR              5
                                  FULL-TIME         23
                                  PART-TIME         0
                                  TOTAL             23

                Enrollment at the end of Year 5 for the program to be
                       Financially and Academically Viable

The projected enrollments based on analyses of market and student demand indicate a
high probability of maintaining a minimum recruitment of five students each year
(assumed completion in 4.5 yrs) for a total of 22.5 (23) steady-state students. More
likely, this number will be higher. Based on the above financial projections, and with the
already funded MUII, the program will be budget neutral.
ii.    Will enrollment be capped in the future?
       Programs such as the Stanford Medical Informatics and the Keck Graduate
       Institute represent opposite ends of the spectrum of training. The former is
       research intensive and takes in four to six students each year, while the latter is
       based on a professional training model and has a projected class size of 60
       students. We envisage limiting our Ph.D. students to about the number of faculty
       members involved in the informatics program. We will maintain the current M.S.
       program in bioinformatics and health informatics at about its current size and
       maintain its current focus primarily as a professional training program. This will
       permit high enrollment in the Ph.D. program, yet provide students engaged in
       research with close supervision and extensive mentoring – thus incorporating both
       models into our program.

B.     Market Demand
National, state, regional or local assessment of labor need for citizens with these skills.

The job market for both faculty and staff with informatics skills is exploding. The
number of training programs has expanded rapidly in the past four years for both the
masters and the doctorate. Demand is high at the national level for individuals with
skills in the field of informatics. In 1999, a national study funded by the Alfred P. Sloan

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Foundation was conducted by Paula E. Stephan and Grant C. Black at Georgia State
University’s Department of Economics, School of Policy Studies, entitled “Hiring
Patterns for Students in Bioinformatics Computational/Biology Programs.” This was
very early in the development of these programs for such a study, but the study found 21
schools to survey and 35 masters students to study. Of the 35 students, 100% found jobs
in industry upon graduation, and the annual salaries ranged from $40,000 to over
$100,000 with the average salary being near $60,000 per year. More recently, a follow-
up study of the labor market during the period 2000-2002 was performed and again found
that the number of newly minted individuals trained in informatics during the five-year
period was small compared to the number of position announcements. They also noted
that the number of academic training programs had grown substantially during this time.

Numerous articles have also appeared in trade magazines over the past few years
regarding the demand for informatics. The following section from an article in Chemical
and Engineering News (January 7, 2002, Volume 80, No. 1, pp. 47-53) is typical of
many: Even with the downturn in the economy, the demand for bioinformaticists does not
seem to have significantly diminished. "The field is somewhat insulated because there is
still such a high demand for skilled bioinformaticists," says Gary M. Wolfe, vice
president of informatics systems, at Large Scale Biology Corp. in Vacaville, Calif., "The
fact is that there is a lot of money going into genomics and proteomics these days."

Opportunities in the State of Missouri are also likely to be high for graduates of the
proposed program, and these are upper tier salaries, although specific labor figures are
not readily available. However, based on the number of life sciences companies in the
state, we expect demand to be robust for the foreseeable future. According to the
Missouri Economic Research and Information Center (MERIC), in a report titled “Life
Sciences in Missouri: Industry Overview, (February 2004),” There are approximately
2,000 life sciences companies employing 170,000 workers and accounting for 13% of the
state’s total economy. Leaders throughout the state have also made a strong commitment
to the field and to make life sciences an even more important part of the state’s economy.
The 2003 Battelle report titled “Life Sciences and Missouri’s Economic Future: An
Opportunity to Build ‘One Missouri’,” outlines a strategy for the State to achieve this
goal. Regarding key policy issues that the state needs to address to leverage its core
research strengths, the report recommends “Specific areas of emphasis should be those
cross-cutting tool areas of bioinformatics, proteomics, bioengineering, and drug design
and development, specifically combinatorial chemistry.” As a specific action item, the
Battelle report also recommends that “For Missouri to be a leader in the life sciences, its
higher education institutions must constantly innovate, ensuring that the necessary
interdisciplinary programs are in place to educate, train, and graduate the future
workforce as well as to keep the existing workforce up to date through life-long learning
efforts. Rapid changes in recent years have already created such fields as bioinformatics,
proteomics, biomaterials, and bioelectronics. For the state to remain competitive, it must
have agile higher education institutions that can quickly respond and change curriculum
and program offerings.”

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Although the fields of bioinformatics and health informatics are too new to show up
in many public databases yet, we offer a few examples of pertinent career titles from
MERIC to illustrate Missouri market demands.

Computer and Information Scientists, Research
Conduct research into fundamental computer and information science as theorists,
designers, or inventors. Solve or develop solutions to problems in the field of computer
hardware and software.
                  Employment          Change          Annual
Occupation        Estimated Projected                 Average Growth
                                      Numeric Percent Openings
                  2002      2012
Missouri          172       206       34      19.77 5          Above
Data produced by Missouri Economic Research and Information Center (MERIC).
Funding provided by U.S. Department of Labor's Employment and Training Administration (ETA)

Computer Programmers
Convert project specifications and statements of problems and procedures to detailed
logical flow charts for coding into computer language. Develop and write computer
programs to store, locate, and retrieve specific documents, data and information.
May program web sites.
                  Employment          Change          Annual
Occupation        Estimated Projected                 Average Growth
                                      Numeric Percent Openings
                  2002      2012
Missouri          11,874    12,346    472     3.98    327      Above

Computer Science Teachers, Postsecondary
Teach courses in computer science. May specialize in a field of computer science such as
the design and function of computers or operations and research analysis. Include both
teachers primarily engaged in teaching and those who do a combination of both teaching
and research.
                  Employment          Change          Annual
Occupation        Estimated Projected                 Average Growth
                                      Numeric Percent Openings
                  2002      2012
Missouri          1,090     1,438     348     31.93 60         Well
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Additional Computer-Related Occupational Data
                       Employment          Change          Annual
Occupation             Estimated Projected                 Average Growth
                                           Numeric Percent Openings
                       2002      2012
Computer           and 172       206       34      19.77 5          Above
Information                                                         Average
Scientists, Research                                                B
Computer               11,874    12,346    472     3.98    327      Above
Programmers                                                         Average
Computer Software 6,570          8,651     2,081   31.67 273        Well
Engineers,                                                          Above
Applications                                                        Avg.
Computer Software 3,284          4,464     1,180   35.93 151        Well
Engineers, Systems                                                  Above
Software                                                            Avg. A-
Computer Support 9,988           12,197    2,209   22.12 344        Well
Specialists                                                         Above
Computer Systems 10,245          12,705    2,460   24.01 362        Well
Analysts                                                            Above
Database               2,081     2,815     734     35.27 95         Well
Administrators                                                      Above
                                                                    Avg. A-
Network            and 5,330     6,938     1,608   30.17 220        Well
Computer Systems                                                    Above
Administrators                                                      Avg. A-
Network       Systems 4,118      6,010     1,892   45.94 238        Well
and               Data                                              Above
Communications                                                      Avg.
Analysts                                                            A+
Computer               1,984     2,481     497     25.05 73         Well
Specialists, All Other                                              Above
                                                                    Avg. A-

To illustrate potential economic impacts, we provide the following wage information
from MERIC. The employment of graduates of our Ph.D. program will provide good-
paying jobs in an excellent economic infusion.

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Computer Science Teachers, Postsecondary
Area        Employment
                       Mean Entry          Experienced Median
Joplin      20         $43,830 $26,730     $52,370     $34,700
Springfield 90         $49,530 $29,940     $59,330      $45,530
St Louis 570           $62,060 $40,950     $72,610      $60,230
Kansas      340        $50,270 $32,650     $59,080      $46,840
City MSA
Missouri 1,020         $54,470 $32,520     $65,450      $51,490
Kansas      240        $52,206 $36,168     $60,226      $49,686
Northwest 40           $52,702 $33,049     $62,529      $46,009
Ozark       100        $49,084 $30,234     $58,509      $45,689
Southwest 20           $43,768 $26,726     $52,288      $34,678
St. Louis 50           $69,371 $41,856     $83,128      $73,684
St. Louis 290          $60,820 $37,721     $72,370      $57,528
St. Louis 410          $60,996 $38,205     $72,392      $57,301

Data Produced by MERIC in cooperation with the U.S. Department of Labor, Bureau of
Labor Statistics (BLS). Occupational Employment and Wage data is based on the
Standard Occupational Classification (SOC) taxonomy.--Indicate that the record contains
confidential information or hourly/annual wage not applicable for the specific

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Computer and Information Scientists, Research
Area     Employment
                      Mean Entry Experienced Median
St Louis 80           $86,260 $51,100 $103,850 $82,310
Kansas 70             $75,410 $53,540 $86,340  $73,420
Missouri 170          $82,400 $54,960 $96,130  $80,640
St.      20           $79,951 $59,548 $90,153  $80,985
St.      30           $99,672 $62,872 $118,072 $94,235
St.      60           $91,465 $61,146 $106,624 $87,199

Data Produced by MERIC in cooperation with the U.S. Department of Labor, Bureau of
Labor Statistics (BLS). Occupational Employment and Wage data is based on the
Standard Occupational Classification (SOC) taxonomy. ---Indicate that the record
contains confidential information or hourly/annual wage not applicable for the specific

To gain a further sense of the current job market, we conducted an analysis of positions
available in Missouri on the Monster.com website in August of 2005. At that time, there
were 640 positions posted under informatics and bioinformatics, and of these,
approximately 80% of the positions posted would utilize the skills of candidates with an
informatics-specific degree, some masters level (Ph.D. preferred) and most were aimed at
Ph.D.-trained applicants.

There is strong support at MU for the development of a doctoral degree in informatics.
Clearly, one of the top priorities at MU, and indeed across the state, is development of
life sciences research and technology-driven industry. Thus, informatics will play a
critical role in these types of research and development, but the number of trained Ph.D.s
is too low. Over the past few years, a number of reports have emphasized the importance
of informatics as part of the regional life sciences development strategy.

In 2004, the UM System arranged for a group of national experts in the field of
informatics to conduct an assessment of bioinformatics on each of the four campuses.
The review committee – consisting of faculty members from Stanford University, the
University of Kansas, Rutgers University and Washington University in St. Louis –
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assessed the development of each of the campuses in the field of bioinformatics and their
ability to offer a degree program in this field. Their final “Bioinformatics Readiness
Report” was submitted to the UM Vice President for Academic Affairs in August of 2004
and included the following statement: The University of Missouri has an explicit strategic
goal of becoming a leader in biomedical and life sciences research. Informatics research
is absolutely critical for biomedical and life science research programs. Ph.D. training is
a critical element for biomedical and life science research. They concluded that MU had
the research base to support a Ph.D. program.

C.     Societal Need
The mission of the University of Missouri is to serve the population of Missouri. This
proposed informatics program is geared towards producing highly skilled graduates who
can occupy top slots in the field of informatics in academia and industry. Because of this
requirement, this rigorous program is expected to attract highly qualified applicants from
Missouri, as well as students from surrounding states. The ultimate goal of this program
is to gain both national and international recognition that will attract students from a
broad range of backgrounds and locales.

The impacts of a strong informatics program address numerous societal needs.
Informatics is research with clear implications for our daily lives. It can impact
everything from treating diseases to understanding drug interactions and from developing
new medical materials to predicting specific diseases.

Informatics will directly impact the health of the citizens of Missouri. For example,
progress in informatics will someday enable physicians to know which therapeutic
modality works best to treat diseases of individual patients. More broadly, it may be
possible to make a similar decision for any disease by using computer analysis of genetic
and other relevant information.

A high quality informatics Ph.D. program at MU will produce high quality graduates.
These graduates will populate the clinical facilities, the research facilities and the
industrial organizations of Missouri driving the “new life sciences economy.” A
principal reason for locating a company in a particular city is the availability of an
educated and skilled work force. University programs produce the educated graduates
that form the base of these work forces.

An additional benefit of establishing this program is the expansion of MU’s research
capacity, which will enhance the competitiveness of faculty members for obtaining
federal and private research funding. The National Institutes of Health and other major
funding agencies are increasingly stressing the importance of interdisciplinary research.
Furthermore, granting agencies and reviewers are expecting researchers to apply the tools
of informatics to an increasing number of biological problems. To stay competitive for
external funding, faculty members must develop collaborations and use the latest tools in
their research projects.

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As the field of informatics grows in importance, we envision recruiting additional faculty
members devoted totally to informatics. Each faculty member is likely to attract and
support graduate students and postdoctoral fellows, and to generate an average of
$250,000 of external funding annually once they are professionally well established.
Based on this estimate, and the recruitment of six new faculty members, the informatics
research program will generate an additional $1.5M n in external research funds annually.
This, added to funded research already on campus, will become a prominent source of
campus funding. Furthermore, we expect this figure to grow at a rate of 10-15% per
year. These external funds will lead directly to new jobs associated with increased
research activity, and to increased tax revenues. According to the U.S. Department of
Commerce, every $1M in research supports 41 jobs in the region; hence, the informatics
program would generate about 250 new jobs and is an essential part of this growth

D.     Methodology
National and state-wide reports, scientific publications, as well as web searches were
used to obtain the information for Market Demand (Missouri Economic and Research
Information Center (MERIC). The information for Societal Need comes from our
discussions with industry and from the letters included under Market Demand (see
attached letter from Mr. Greg Steinhoff, Director, Missouri Department of Economic

II.    Duplication and Collaboration
The MU Ph.D. in informatics is cost effective, competitive and unique. First, no other
public university in Missouri offers a Ph.D. informatics degree program, although
Washington University offers a Ph.D. in Computational Biology. Second, it is a campus-
wide effort. This broad participation by academic units reflects the interdisciplinary
nature of the program and the need for students to acquire knowledge and skills in
multiple fields.

UMKC has an approved Masters in Bioinformatics and a similar, but still distinct,
Masters program in Health Informatics exists at MU. While there are a number of
commonalities, the concentrations of the MU program are different but complementary to
UMKC’s program and the market for the graduates is different. The external reviewers
who prepared the Readiness Report reviewed UMKC’s M.S. in Bioinformatics and
compared it to the Health Management and Informatics program. The conclusion of the
reviewers was “The proposed M.S. degrees in health outcomes and in computational
biology and genomics have clear overlaps with the Columbia Health Informatics MS.
However, we found that local opportunities in Kansas City make this potential
redundancy less worrisome. The industrial and local scientific milieu is rich with
opportunities for collaboration that require M.S.-level trainees and faculty co-mentorship
from campus. There is an emphasis in Kansas City on urban delivery of care, while
Columbia focuses on rural delivery. Kansas City has excellence in dental and medical
care delivery, while Columbia is a medical and veterinary center.”

                                  OPEN - A&SA – 2p
Neither of these programs is redundant or duplicative with respect to the proposed Ph.D.
program in informatics, and in fact, the masters programs may provide well-trained
candidates who may wish to pursue a Ph.D. degree in informatics.

Under UM System guidelines for a Cooperative Curriculum program, the medical
informatics emphasis area in this Ph.D. proposal includes courses currently being offered
by the Health Management and Informatics program in Columbia and the program at
UMKC and there are numerous opportunities for sharing elective course with UMR as
well. As part of the Ph.D. program, we propose to develop joint video conferences and
seminars and the costs for such programs have been built into the budgets at MU and
UMKC, as well as support from NASA through the UMBC. These collaborative
activities will also support the initiatives started by the University of Missouri
Bioinformatics Consortium (UMBC), which was established in 2001 for the purpose of
promoting bioinformatics within the UM system. A specific goal of the UMBC is to
facilitate the training of a new generation of students and scientists in the
interdisciplinary area of bioinformatics and computational biology; the bridging of life
sciences, clinical sciences and computer applications.

III.   Program Structure
The proposed Ph.D. program will be managed through the MU Informatics Institute.

Vision of the Institute:
To have MU recognized by peers as one of the top universities in informatics research
and training in the U.S., with products acknowledged to have a global impact.
Informatics research and training are broadly applicable to human health, animal, plant,
and microbe sciences as well as other areas, such as geo-spatial, consumer, legal, social,
and management informatics. All aspects of informatics should be present in the Institute
so as to engender synergy and interdisciplinary research and applications. Consistent
with this vision and in recognition of existing faculty strengths and ongoing research
initiatives, initially the Institute will primarily focus on bioinformatics and health
informatics. The Institute will gradually grow to include more areas under the guidance
of its director and affiliated members.

Goals to be Addressed:
The role of the Institute is to provide a structure for developing and administering a broad
range of informatics training, research and services. Included within its goals is
developing and administering a doctoral program in informatics, which will have high
impact on the graduate training and interdisciplinary research across campus. The
doctoral program will additionally strengthen the current National Library of Medicine
(NLM)-funded Biomedical and Health Informatics Research Training Program, as well
as provide an expansion of the MU Masters in Health Informatics programs.

The Ph.D. program will be an MU area program in informatics administered by the MU
Informatics Institute. The Ph.D. curriculum will consist of core courses and approved
concentrations in bioinformatics and health informatics. Faculty from throughout the
                                 OPEN - A&SA – 2q
university will participate in proposed concentrations, and other concentrations may be
added in the future. Specific degree requirements for new concentrations of the Ph.D. in
Informatics program will be under the purview of the Institute, in consultation with the
hosting department(s). Investments (e.g., in the form of new courses) in new
concentrations by the associated dean(s) or department(s) will demonstrate commitment
of those academic units to Institute goals and objectives.

A realistic target date to get the approval at the campus level for the doctoral program is
March 2006. Under such a scenario, we plan to get final approval for the Ph.D. program
by August 2006. This would allow recruiting to begin in September 2006, for students
expected to begin study in Fall 2007.

The set of core courses will address areas of core knowledge required for the degree. The
core courses should not in any way dictate a concentration or a new investment of time
and resources from home departments. The structure will allow departments to offer
degrees in specific concentration areas of the Informatics Ph.D. degree, and each
concentration area should contribute courses to the degree program that would be
available to any one pursuing the degree in informatics.

The MU Informatics Institute (MUII) will market the program, recruit and admit
students, schedule courses and seminars, schedule and support doctoral examinations and
manage the program on behalf of the Graduate School. A student will be hosted by the
department that most closely aligns with the area of concentration of his or her interest.

MU Informatics Institute Organizational Structure
The Institute is named the “MU Informatics Institute (MUII),” keeping the name broad
and unconstrained to permit the scientific interest of the Institute to flower and encourage
synergistic scientific developments.

Within the Institute are a director and three associate directors; one associate director for
each of the areas of education, research and service. The educational director will be
responsible for managing the Ph.D. program with oversight by the director and an
Institute Steering Committee comprised of six representative senior faculty. The research
director will be responsible for developing and facilitating the diverse and synergistic
research areas of participating faculty and staff from all over campus. The service
director will be responsible for providing the basic services needed by the Institute and
campus in the areas of informatics.

An interim director has been selected by the Provost and the Deans of Engineering and
Medicine; Dr. Charles W. Caldwell. The interim director will select the three interim
associate directors. Additionally, a committee for a national search for a permanent
institute director is in progress. Dr. Caldwell chairs this committee.
Faculty resources may be assigned to the Institute in a number of ways:

                                    OPEN - A&SA – 2r
       1) Individual faculty members in departments throughout the university may
          choose to collaborate with faculty of the Institute,
       2) Faculty might arrange with their chairs to become formally identified with the
          Institute and participate as a member,
       3) Faculty might negotiate with their chairs to have time allocated to the Institute,
          or sell time to the Institute to carry out teaching beyond what is currently
       4) Chairs and deans might wish to invest resources to establish and support a
          concentration, working with other faculty of the Institute. New concentrations
          must receive approval of both faculty and of the Institute to assure that they
          are of high quality, and that there are resources available to sustain the

A.     Summary of Program and Emphasis Areas
This program is intended to provide doctoral graduate education in informatics research.
Every student will successfully complete a core curriculum and then a more detailed and
comprehensive specialization in 1 of 2 concentration areas; bioinformatics or health
informatics. The program is multidisciplinary and research focused. Successful
graduates are expected to enhance the informatics workforce and be outstanding
contributors in their area of specialization.

B.     Prerequisites and Admission
Students are accepted into the program with different backgrounds and varying degrees
of experience; however, some prerequisites are expected. Acceptance into the program is
not precluded by minor deficiencies in background, but is conditional on these being
made up before or during the first year of study.

Specific prerequisite courses/competencies include:
          A course or documented work experience in database management (Database
           Applications and Information Systems (CS 3380 or equivalent)
          A course or documented work experience in a programming or application
           language such as C, C++, JAVA, Visual Basic, PASCAL, etc. (CS 1050 and
           2050 or equivalent courses)
          Statistics (STAT 7070 Statistical Methods for Research) or (4710/7710
           Introduction to Mathematical Statistics)

Students entering the bioinformatics concentration will need to take additional
prerequisite quantitative courses. An applicant must meet the general admission
requirements defined by the MU graduate school in order to be considered. The
preferred candidate will have completed a master’s degree in engineering, biological
sciences, informatics, management information systems or clinical sciences with a grade
point average above 3.4 out of 4.0.
          CS 2050 (Algorithm Design and Programming II)
                                   OPEN - A&SA – 2s
          CS 4050 (Design and Analysis of Algorithms I)
          CS 4320 (Software Engineering I) or CS 4330 (Object-Oriented Design)

C.     FORM PS – Requirements
1. Total credits required for graduation: ____________72 hours____________
2. Residency requirements: a minimum of 36 hours must be completed at MU
3. General education (core courses): Total credits: ______18 hours_________

Consistent with policy, 15 hours must be 8000 or 9000 level. The graduates from this
program are expected to conduct independent research in informatics drawing on core
informatics skills with applications in biological and health/medical systems. Core skills
include algorithms, basic mathematics, cognitive/ human factors and interfaces, data
structures, database design, evaluation/research methods, information retrieval,
knowledge representation, modeling, networking/architecture, ontology/vocabulary,
probability statistics, programming languages, simulation and software engineering.
Varying emphases are recognized to support different research interests but topics
include representation, modeling, data analysis systems (biological, computational,
organizational) and decision making. Applications areas include computational biology,
clinical, public health, and health systems informatics and consumer informatics.

The proposed concentrations are based on the strong demand for such graduates in
research and education programs in academic, industrial and governmental institutions.
These concentrations also draw on considerable investment and faculty strength in these

Core Courses (18 credits)
All students in the Ph.D. Degree program will be required to take 18 credit hours from
the following common core courses and concentration-specific core courses below. The
students will consult with the graduate committee or the thesis advisor to determine
which courses to take.

Course #         Course name                                              Hours
HMI 7420         Fundamentals of Bioinformatics                           3
HMI 7430         Design and Management of Health Information              3
New 9XXX         Evaluation of Health and Bioinformatics *                3
New 9XXX         Inquiry into Health and Bioinformatics                   3

* The evaluation course has a six hour graduate statistics prerequisite selected from the
courses below.

                                  OPEN - A&SA – 2t
Course #            Course name
STAT 7510           Regression and Correlation Analysis
STAT 7530           Analysis of Variance
STAT 7450           Applied Statistical Methods for Bioinformatics
STAT 8410           Bioinformatics

In addition to the General Education requirements of all students in the program, each
student will have additional requirements that will vary by emphasis area and are listed
below for each of the options.

Bioinformatics Concentration (24 credits)
A set of core courses are defined for the bioinformatics concentration and each student is
expected to take at least nine credit hours from the core courses. Some sample existing
core courses include:

Course #           Course name                                            Hours
CS 7001            Topics in Bioinformatics                               3
CS 7010            Computational Methods in Bioinformatics                3
CS 7060            String Algorithm                                       3
Biochem 7376       Computer Assisted Sequence Analysis             and    3
                   Molecular Modeling

More core courses will be developed at Computer Science Department. The remainder of
the course requirement defined by the MU graduate school will be filled by graduate-level
courses in Computer Science Department and electives in other departments (especially
statistics and biomedical sciences).

Course #           Course name                                            Hours
7380               Database Management Systems I                          3
7610               Computer Graphics I                                    3
7620               Physically Based Modeling and Animation                3
7650               Image Processing                                       3
7750               Artificial Intelligence I                              3
7810               Multimedia Engineering and Technology                  3
7830               Science and Engineering of the World Wide Web          3
7860               Network Security                                       3
8001               Data Mining and Knowledge Discovery                    3
8050               Design and Analysis of Algorithms II                   3
8090               Computational Geometry                                 3
8320               Software Engineering II                                3
8330               Object Oriented Design II                              3
8380               Database Management Systems II                         3
8390               Information Indexing and Retrieval                     3
8610               Computer Graphics II                                   3
                                    OPEN - A&SA – 2u
    8690               Computer Vision                                       3
    8750               Artificial Intelligence II                            3
    8760               Pattern Recognition                                   3
    8770               Neural Networks                                       3

    Health Informatics Concentration (24 credits)

    Required Courses in the Concentration

    Course #           Course name                                           Hours
    HMI 7460           Administration of Health Care Organizations           3
    HMI 8478           Knowledge Management in Health Care                   3
   HMI 8571          Decision Support in Health Care Systems               3
   HMI 7443           Enterprise Information Architecture                   3
   HMI 7437           Data Repositories and System Integration              3
   HMI 8435           Information Security and Policy                       3

    Any of the Following Courses

    Course #           Course name                                           Hours
    New 9XXX           Public Health Informatics                             3
    New 9XXX           Consumer Informatics                                  3
    HMI 8573           Decision Making for Health Care Organizations         3
    HMI 7524           Health Economics                                      3

    Elective Credits: (12 Credits)
    All students will select additional courses from the lists of electives below. The number
    of credit hours of electives might vary depending on the specific area of research of the
    candidate. For Health Informatics emphasis, elective courses are based on the emphasis
    area (Consumer Health Informatics, Public Health Informatics, Health Systems
    Informatics, Clinical Informatics), graduate courses from the following

    The purpose of the elective courses from other departments is to strengthen students’
    backgrounds in other areas, especially in biology and statistics. Any MU graduate course
    can be an elective course, subject to approval from the student’s advisor or the graduate
    committee. The following lists some elective courses that are relevant to bioinformatics.


    Course #           Course name                                           Hours
    STAT 7020          Statistical Methods in the Health Sciences            3
    STAT 7110          Statistical Software and Data Analysis                3
                                       OPEN - A&SA – 2v
STAT 7210      Applied Nonparametric Methods                        3
STAT 7310      Sampling Techniques                                  3
STAT 7410      Biostatistics                                        3
STAT 7510      Regression and Correlation Analysis                  3
STAT 7530      Analysis of Variance                                 3
STAT 7540      Experimental Design                                  3
STAT 7750      Introduction to Probability Theory                   3
STAT 7760      Statistical Inference                                3
STAT 7810      Nonparametric Methods                                3
STAT 7830      Categorical Data Analysis                            3
STAT 7850      Introduction to Stochastic Processes                 3
STAT 7870      Time Series Analysis                                 3
STAT 7890      Bayesian       Data   Analysis     and   Statistical 3
STAT 8310      Data Analysis I                                      3
STAT 8320      Data Analysis II                                     3
STAT 9210      Bayesian Statistics                                  3
STAT 9310      Theory of Linear Models                              3
STAT 9320      Advanced Linear Models                               3
STAT 9370      Multivariate Analysis                                3
STAT 9410      Reliability Theory and Survival Analysis             3


Course #       Course name                                        Hours
BIOCHEM 7270   Biochemistry                                       3
BIOCHEM 8060   Ethical Conduct of Research                        3
BIOCHEM 8430   Physical Biochemistry                              3
BIOCHEM 8432   Enzymology and Metabolic Regulation                3
BIOCHEM 410    Plant Biochemistry                                 3
BIOCHEM 9430   Molecular Biology I                                4
BIOCHEM 9432   Molecular Biology II                               4
BIOCHEM 9460   Cancer Biology                                     3
BIOCHEM 9464   Neurobiochemistry                                  3
BIOCHEM 9466   Plant Biochemistry                                 3
BIOCHEM 9468   Molecular Biology of Plant Growth              and 3
BIOCHEM 9470   Analytical Biochemistry—Chromatography              3
BIOSCI 7300    Analysis of Biological Macromolecules               3
BIOSCI 7976    Molecular Biology                                   3
BIOSCI 8440    Integrative Neuroscience I                          3
BIOSCI 8442    Integrative Neuroscience II                         3
BIOSCI 8350    Advanced Cell Biology                               3
                             OPEN - A&SA – 2w
BIOEN 7570          Biomedical Imaging                                    3
MICROB 84-4         Microbial Pathogenesis                                3

Health Management and Informatics:

Course #            Course name                                           Hours
HMI 7524            Health Economics                                      3
HMI 7554            Social and Health Impacts of Genomics and             3
                    Bioinformatics: Ethics, science policy, regulations
HMI 8441            Theory     &     Application      of     Controlled   3
HMI 8461            Human Resource Management                             3
HMI 8470            Strategic Planning & Marketing for Health Care        3
HMI 8573            Decision Making for Health Care Organizations         3

Industrial and Manufacturing Systems Engineering:

Course #            Course name                                           Hours
IMSE 7230           Operations Research Models                            3
IMSE 7760           Entrepreneurial       Innovation   Management:        3
                    Advanced Enterprise Design
IMSE 8410           Advanced Management Information Systems               3
IMSE 8730           Strategic Enterprise Management                       3
IMSE 8860           Health Care Systems Operation and Management          3

School of Journalism

Course #            Course name                                           Hours
JOURN 8018          Strategic Communication Research                      3
JOURN 8020          Principles and Tools in Strategic Communication       3
JOURN 8080          Media Ethics                                          3
JOURN 8008          Qualitative Research Methods                          3
JOURN 7416          Science, Health, and Environmental Writing            3

School of Nursing

Course #            Course name                                  Hours
N7140               Advanced Health Assessment and Promotion     3
N8110               Concepts for Specialization in Public Health 3

                                  OPEN - A&SA – 2x
N8120               Community Based Public Health Interventions             3
N8130               Planning and Evaluating Public Health Programs          3

Truman School of Public Affairs

Course #            Course name                                             Hours
PA 8420             Public     Policy   Design,     Evaluation, and         3
PA 8330             Informatics and Governance                              3
PA 8520             Human Resource Management and Development in            3
                    the Public and Nonprofit Sector
PA 8630             Organizational Change in a Community and Global         3
PA 8630             Organizational Change in a Community and Global         3
PA 8710             The Nonprofit and Voluntary Sector                      3

Computer Science

Course #            Course name                                             Hours
7810                Multimedia Engineering and Technology                   3
8090                Computational Geometry                                  3
8670                Multimedia Communication                                3
4320                Software Engineering I                                  3
8320                Software Engineering II                                 3

School of Information Science and Learning Technologies

Course #            Course name                                             Hours
7466                Computers as Cognitive Tools                            3
9409                Digital Libraries                                       3
9410                Doctoral Seminar: Human Information Behavior            3
9455                Formative & Summative Evaluation                        3

Requirements for dissertation, internship or other capstone experience (18 credits)

To enhance the training for the students, the following activities are designed:

   • Lab rotations: Laboratory rotations are required for all students in the
      bioinformatics concentration. Three laboratory rotations are required during the
      first year of graduate studies, including each semester and two months during the
      summer. The lab will be the research lab of one of the participating faculty in the
      Informatics Institute, with at least two different departments.
                                   OPEN - A&SA – 2y
   • Seminars: The program will provide a seminar series, and all students will be
      required to participate for at least two semesters. The students attending two
      thirds of the seminars in a semester will receive one credit hour (New 9XXX).
      Seminars bring experts from around the nation to campus, where they will give
      research presentations and interact with the students.

   There will also be a professional development seminar series where students
      explore careers in industries, academic institutions and government in fields such
      as research and teaching. Students participating in this seminar series will receive
      one credit (New 9XXX) per semester for up to two semesters.

   • Journal club: The students will have a journal club, and all the students will be
       required to participate for two semesters.

• Teaching experience: Each student will be required to have at least one semester of
teaching experience either as a TA or enrollment in a graduate course on college

Preliminary Exam
Each participating department will follow its policy on the organization and conduct of
the qualifying examination. A comprehensive examination will be given after the course
requirements are met, but no later than the end of the sixth semester. An examination
committee, chaired by the major advisor, will conduct a non-public oral examination in
which committee members will examine the candidate on knowledge and critical
thinking skills based on courses and the research domain. A preliminary examination
will include a written dissertation proposal prepared in the format of a federal research
grant, and submitted to the committee at least two weeks prior to that portion of the
examination. There will be a public, oral presentation of the research proposal and a non-
public oral examination in which committee members will examine the candidate on the
research proposal, including domain specific knowledge deemed essential in order to
proceed with the dissertation research.

The outcome of the examinations can be pass, fail or resubmission. In the case that the
committee members unanimously fail the student, the policies for dismissal will be those
of the University. In the case that the committee members are split in opinions and
decide to ask the student to revise the examination material, the student can revise the
material according to the suggestions from the preliminary exam committee and further
prepare for the related health and bioinformatics background.

Graduate Committee and Dissertation
A graduate committee at the Informatics Institute, mainly consisting of faculty members
in the concentrations, will be formed to manage the admission process, evaluate
curricula, and advise students before they identify dissertation advisors.

                                  OPEN - A&SA – 2z
A student should choose a major advisor by the end of the first year (form D1) and a
graduate committee by the end of the 3rd semester (form D2). Each student’s graduate
committee will consist of at least four faculty members. This committee will represent at
least two faculty members from the Health Management and Informatics or Computer
Science Department and at least one participating faculty member of the MU Informatics
Institute from another department. Co-advising by professors in different disciplines will
be welcomed.

The Ph.D. program requires each student to deliver a dissertation. Students will take
research and dissertation credits for related dissertation work. The doctoral dissertations
will demonstrate a high level of scholarly achievement and represent a significant,
original contribution to the field. In addition to the dissertation, students will publish
their work in appropriate peer-reviewed conferences and journals. Students will present
their dissertations publicly at their final defense.

Any unique features such as interdepartmental cooperation: This interdisciplinary Ph.D.
in Informatics program will be administratively housed within the MU Informatics
Institute. However, because of its interdepartmental nature, it will be managed in
cooperation with the faculties of the participating departments. Academic oversight for
the program will be provided by an interdisciplinary curriculum committee with broad
faculty representation. This model of governance is similar to MU’s Area Ph.D. degrees.
In addition, cooperation and resource sharing will occur with the Masters in
Bioinformatics program at the UMKC, and with other campuses of the university as
resources and expertise continue to develop at these sites. Course descriptions are
available from MU’s on-line catalog by clicking on the hyperlink under the course

                                  OPEN - A&SA – 2aa
D. Form FP – Financial Projections
                             YEAR 1            YEAR 2          YEAR 3         YEAR 4         YEAR 5
                             (2008)            (2009)          (2010)         (2011)         (2012)
1. Expenditures
A. One-time
New/renovated space
Total One-time

B. Recurring
   Faculty                      $345,000       $430,350        $443,261       $456,558       $470,255
   Staff                        $20,000        $20,600         $21,218        $21,855        $22,510
   Graduate Assistants          $48,000        $49,440         $50,923        $52,451        $54,024
   Benefits                     $113,900       $141,553        $150,770       $162,900       $167,787
   Expense & Equipment          $70,000        $70,000         $70,000        $70,000        $70,000
   Other (video conf.)          $10,00         $10,000         $10,000        $10,000        $10,000

Total Recurring                 $606,900       $721,943        $746,171       $773,763       $794,576
Total (A + B)

2. Revenues

   State Aid-CBHE
   State Aid-Other
   Tuition/Fees (net rev.)      $22,886        $56,848         $93,159        $131,943       $154,944
   Institutional/Resources      $584,104       $665,095        $653,012       $641,820       $639,632

Total Revenues                  $606,990       $721,943        $746,171       $773,763       $794,576

       Budget Notes
          1. FY07 start up costs covered by Informatics Institute -- Funds have been committed by
              campus administration.
          2. Program has access to $700,000 in permanent funding allocated to Informatics Institute
          3. Faculty salaries at $75K each. Three faculty in FY08 and 4 faculty thereafter.

                                         OPEN - A&SA – 2bb
2. Budget Justification
The budget includes recurring expenses for salaries, fringe benefits, equipment and
operating costs for the degree program. The salaries include the position of a 0.5 FTE
administrative assistant to manage the accounts and records for the program, maintain
records and progress reports for students and prepare promotional materials. Benefits are
calculated at 30% of salaries in all years (as an average). Stipends are included for 1-2
graduate students at $24,000 each. The funding for these will come from resources of the
MU Informatics Institute (MUII). Other graduate assistants associated with the program
are expected to be supported from research and training grants and are not shown in the

Other recurring expenses include computer equipment, maintenance and replacement,
E&E office expenses and video conferencing costs for seminars and intercampus

The proposed Health Informatics Ph.D. concentration is designed to complement and
share resources between the UMKC and MU masters programs. It is expected that initial
collaborations will be primarily between these two campuses, but that interactions among
all four campuses will expand as the informatics programs grow throughout the UM
System. To facilitate this sharing, expenses for video conferencing are included in the
budget. This conferencing capability will be used to promote joint seminars, shared
courses and faculty meetings among the campuses.

Additional faculty members are not needed at this time to start the degree program since
recruitment in recent years has resulted in a strong faculty in the field of informatics.
However, additional recruitments are underway within the MU Informatics Institute and
this follows the recommendations in the Bioinformatics Readiness Report prepared by
MU external consultants. The MU Informatics Institute was identified as one of the MU
campus “strategic initiatives” in 2004 and consequently received $500,000 in start up
funding and will receive recurring funding of $700,000 annually. An early institutional
commitment to a doctoral program is essential in order for the university to be nationally
competitive in the recruitment of new faculty members. New faculty members are
expected to fully participate in teaching and research in informatics, including curriculum
development and the establishment of nationally funded research programs.

Assumptions for calculating tuition revenues for the above table

 1.    Students predicted to take 4-5 years to complete Ph.D. (Average=4.5 years)
 2.    Student credit hours required to complete program is 72. (Annual SCH is
 3.    Assume 3.5% increase in tuition per year. (Year 1 is FY2008)
 4.    One assistantship in years 1 & 2 and two in subsequent years.

                                  OPEN - A&SA – 2cc
E. FORM PG - Program Characteristics and Performance Goals

Institution Name:      The University of Missouri-Columbia

Program Name:          Doctoral Program in Informatics

Date:                  January 5, 2006

1. Student Preparation:
Students entering this program are expected to have a strong yet diverse background from
their undergraduate or graduate courses. For this reason, the program has a small but
strong core of courses that must be completed. While students who have not finished the
core courses will be considered for admission, we are requiring students to have a strong
undergraduate background.

The preferred candidate will have completed a master’s degree in engineering, biological
sciences, informatics, management information systems or clinical sciences with a grade
point average above 3.4. Students having an undergraduate degree will be considered if
they have graduated from an accredited school with a cumulative GPA at the
undergraduate level of 3.5 or higher and will have taken the GRE and scored above the
top 70th percentile. A minimum score on the TOEFL of 550 (paper version: 213 on the
computer version or 80 on the iBT version) is required to enter the program and
demonstrated English proficiency, TOEFL of 600 or higher (250 or higher on the
computer version), or completion of a University proficiency exam is required to serve as
a teaching and/or research assistant. As an alternative, the International English
Language Testing System (IELTS) of at least 5.5 Academic Score may be substituted for
TOEFL. All students enrolled are expected to maintain a GPA of 3.0 or higher.

Students will be expected to furnish two letters of recommendation from professors/
teachers with whom they have had substantial contact. All students who enter the
program will be expected to have a face-to-face interview. However, in cases where the
cost or timing of an interview would be prohibitive, phone interviews may be conducted.
This requirement is due to the personalized nature of the program, and the need to ensure
that the student has a clear understanding of the rigorous nature of the training as well as
the requirements for the program and each emphasis area.

• Characteristics of a specific population to be served, if applicable

Given the nature of the University of Missouri-Columbia, our first goal is to serve the
population of Missouri. This includes both students and the population at large. This
education program is geared towards producing highly skilled graduates who can occupy
top slots in informatics at the academic, industrial and healthcare levels. Because of this
requirement, this rigorous program is expected to attract the top students within the
University of Missouri System, from other top universities within the state as well as
students from surrounding states. The ultimate goal of this program is to gain both
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national and international recognition that will attract students from a broad range of
backgrounds and locales.

2.      Faculty characteristics:
• Any special requirements (degree status, training, etc.) for assignment of teaching for
this degree/certificate

This Doctoral Degree in Informatics is an interdisciplinary program, which will include
participating faculty members from several academic units at MU. This is in keeping
with the goals of the life and health sciences initiatives at MU.

Listed below are individuals who have been involved in the development of this proposal.
The representation of these individuals from several disciplines and academic units
mirrors the breadth of health bioinformatics.

 Name                        Primary Affiliation                                 Campus Unit
 Gary Allen                  IAT                                                 Campus
 Sue Boren                   Health Management and Informatics                   SOM
 Gordon Brown                Health Management and Informatics                   SOM
 Charles Caldwell            Ellis Fischel Cancer Center, Pathology              SOM
 Wade Davis                  Health Management and Informatics                   SOM
 George Demiris              Health Management and Informatics                   SOM
 Nancy Flournoy              Statistics                                          A+S
 Toni Kazic                  Computer Science                                    COE
 Cerry Klein                 Systems Engineering                                 COE
 Gail Ludwig                 Geology                                             A+S
 Chi-Ren Shyu                Computer Science                                    COE
 Gary Stacey                 Plant Sciences                                      CAFNR
 Dong Xu                     Computer Science                                    COE

Faculty members participating in this program are expected to have a Ph.D., M.D., or
other terminal degree of their specialty, and should meet the status for Doctoral and
Graduate faculty as specified by the appropriate academic units at MU. Specific
requirements include an active research or clinical program, a sufficient number of peer-
reviewed publications to meet the requirements of each specific department and the MU
Graduate Faculty Senate, and experience in a classroom environment. The addition of
new faculty members is expected once the program is approved. Individuals will apply
to the director of the program and the program committee will review their application.

• Estimated percentage of credit hours that will be assigned to full-time faculty.

Approximately 100% of courses will be taught by full time faculty at the University of

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• Expectations for professional activities, special student contact, teaching/learning

Faculty involved in this program will be expected to teach courses and/or host seminars
and other scholarly gatherings in informatics. Many of the faculty members are teaching
these courses already under the aegis of their teaching duties within the academic unit
where they have a primary appointment. Faculty will also be encouraged to train
students within laboratory settings. All students will be assigned faculty advisors who
are expected to train the students within their laboratories.

In addition, faculty will be encouraged to participate in the special integrative seminar
within this program. This will involve lecturing to students from all option areas in
special seminars at least once a semester on current research or a topical area for which
they have expertise. Faculty will also be required to participate in the ethics seminar held
once a year to educate student trainees about their special ethical obligations within the
bioinformatics discipline.

3. Enrollment Projections:
• Student FTE majoring in program by the end of five years.

The planned enrollment for the initial class is seven students, with seven new admitted
each year to a steady-state of 28 students by four years. This figure represents a balance
between achieving critical mass and ensuring excellence in training of the students.

The eventual goal of the program is to have a total of 28 students throughout the year.
This is in line with projections made by other existing informatics programs and with the
enrollment by graduate students in courses in informatics that are currently being offered.
We intend to achieve this total class size incrementally over the first four years of the
program. Programs such as Stanford Medical Informatics and the Keck Graduate
Institute represent opposite ends of the spectrum of training. The former is research
intensive and takes in 4-6 students each year, while the latter is based on a professional
training model and has a projected class size of 60 students.

• Percent of full-time and part-time enrollment by the end of five years.

We expect that virtually all of the students enrolled in the Ph.D. program will be full

4.     Student and Program Outcomes:

• Number of graduates per annum at three and five years after implementation.

We anticipate each student will need 4-5 years to complete a Ph.D. degree, thus having
no graduates per annum at the end of three years (unless a student is admitted with
advanced placement due to transfer from another program). This is based on seven
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students entering in year one and seven entering each additional year. We anticipate
seven Ph.D. graduates per annum at the end of year five, and each year thereafter.

• Special skills specific to the program.

Students leaving the program will be able to integrate an understanding of basic
biological and clinical sciences, healthcare, statistical data analysis and computational
knowledge to carry out the diverse tasks required to successfully fill niches within the
broad field of informatics. This includes skills such as the analysis at a high level of
primary biological data contained in databases, the creation and maintenance of
databases, the use of information technology to improve health care delivery, the
development of clinical decision support systems integrating genomic and disease data
bases, the development of knowledge systems clinical applications, the use and
development of statistical tools for biological analysis and the creation of new algorithms
for carrying out biological interpretation. While some of these skills are already covered
under existing degrees, there is currently no program that draws on the core informatics
skills for application in the clinical and biological sciences.

• Proportion of students who will achieve licensing, certification or registration.

There is currently no licensing or registration specific to informatics. It is possible that
some students will achieve certification for specific software packages/operating systems
that currently exist, such as ORACLE, or Microsoft packages. However, it is difficult to
estimate the proportion of students that will achieve such certification because it will
depend upon the number of students who pursue jobs where such certification may be
required. It is expected that a percentage of students will also be Health Insurance
Portability and Accountability Act of 1996 (HIPAA) certified prior to leaving the
program, and others might obtain laboratory skills that would allow them to be certified
for handling radioactivity and certain hazardous chemicals.

• Performance on national and/or local assessments, e.g., percent of students scoring
above the 50th percentile on normed tests; percent of students achieving minimal cut-
scores on criterion-referenced tests. Include expected results on assessments of general
education and on exit assessments in a particular discipline as well as the name of any
nationally recognized assessments used.

Since this is a doctoral degree program with no accreditation, it is not expected that
students will take further standardized tests after graduation or during the program.
• Placement rates in related fields, in other fields, unemployed.

We expect that virtually all students who complete their Ph.D. degree will find
employment within a related field (health informatics, academic or industrial research,
education, governmental positions, etc.). Likely, a very small number will find
employment in other fields, which might be remotely related (such as industrial analysis,
computation not relating to this informatics training). It is unlikely that any significant
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portion will be unemployed, given trends for hiring in the informatics, life sciences and
related fields.

• Transfer rates, continuous study.

We anticipate nearly a 75% retention rate. Some portion of students (25%) may desire to
transfer to other programs for spousal or personal reasons or may be asked to leave.

5.       Program Accreditation:
Institutional plans for accreditation, if applicable, including accrediting agency and
timeline. If there are no plans to seek specialized accreditation, please provide reasons.

There is currently no accrediting body for informatics.

6.     Alumni and Employer Survey:
Expected satisfaction rates for alumni, including timing and method of surveys.

Alumni will be surveyed on a rigorous schedule.

1)     One month post graduation, to assess their satisfaction with the program and
       employment status.
2)     One year post graduation, to assess how the program helped them prepare for
       their current job.
3)     Three, six, and nine years post graduation, short surveys will be sent to assess
       their long-    term satisfaction with the program, assess their employment status,
       and determine what focus areas they feel are most applicable in the current

Surveys will be mailed to alumni, either by physical mail or by e-mail. Alumni will be
tracked by the University alumni office to ensure that their current addresses and contacts
are on file. Surveys will consist of a ten question “numeric” section, which will gauge
alumni satisfaction with the program, and a short five question short answer section
which will poll alumni about changes in the field and allow for feedback on what they
believe needs to be changed within the program. This survey will also allow us to gauge
the employment status of alumni and tell how many are in industry, in professional
practice or in academics.
• Expected satisfaction rates for employers, including timing and method of surveys.

Employers will be polled yearly to find out if their employment needs have changed and
to determine how satisfied they are with the quality of applications received from
program graduates. Assuming they have also employed graduates, they will receive the
employment survey to assess their satisfaction with specific employees’ skills.
Employers will be surveyed once every three years to determine the level of satisfaction
they have with the quality of students they see from the program, and in particular those
that have been employed in their workplace within the past three years. Surveys will be
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mailed to the Human Resource departments of identified companies and will consist of a
fifteen question “numeric” survey as well as a section for open comments on the program
and their contact with employees.

IV.    Accreditation
There is no accreditation available for a Ph.D. program in Informatics at this time.

V.     Institutional Characteristics


The University of Missouri-Columbia (MU), founded in 1839, is Missouri's first, largest
and most comprehensive public university and research institution. In 1870, the
University was approved as a land-grant university. MU is the largest of the four
campuses of the University of Missouri System and the oldest state university west of the
Mississippi River.

MU has been a leader in informatics training for over forty years and is considered one of
the founding institutions in the development of the field of Informatics. We are one of a
select number of 18 Universities that have federal funding for postdoctoral and
predoctoral training in several areas of informatics including bioinformatics and health
informatics. We currently offer a masters degree in health informatics and have a new
concentration in the informatics masters to focus on bioinformatics. For over twenty-five
years, MU students have been receiving Ph.D. degrees doing informatics research in
cooperation with multiple graduate programs including computer science, computer
engineering, information science, statistics, pathobiology, nursing, biochemistry,
educational technology and educational leadership and policy analysis, but this is
insufficient for the future. MU has a tradition of multidisciplinary, cooperative training
in informatics, including bioinformatics. It is time to capitalize on these strong traditions
and create a new cooperative Ph.D. program.

A.1. The Local Community
Our world-class research university serves a predominantly rural, agricultural state with a
total population of ~6 million. An important advantage of MU's location is our ready
access to racial/ethnic groups from a predominantly rural population. With a population
of ~800,000 within a primary catchment area of 30 counties in central Missouri and more
than 200,000 in the immediate Boone County area, we are well situated to recruit Ph.D.
trainees locally and nationally. Our strong programs in computer sciences, biostatistics,
health, physical and life sciences research will facilitate research training. We view this
training in bioinformatics program as an exciting mechanism for furthering our
institutionally significant, interdisciplinary collaborations.

A.2. The Institution
The University of Missouri-Columbia (MU), the flagship of a four-campus system, offers
an extensive array of professional, graduate, and undergraduate programs, with nearly
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250 degree programs in 13 schools and colleges, more than 25,000 students, and 5,000
faculty and staff. MU is one of only six universities nationwide with schools of
medicine, veterinary medicine, agriculture, engineering and law, and an outstanding
healthcare environment including a nationally recognized cancer center, all on the same
campus. Faculty from these disciplines and those from arts and science, human
environmental sciences, nursing and MU's Research Reactor comprise one of our biggest
assets: a unique combination of resources that makes groundbreaking collaborative
research and research training possible. As a result, a wide range of faculty work in
multidisciplinary research programs that heavily emphasize informatics research and
development, providing a strong and stable infrastructure to promote interdisciplinary
research and training. The exceptional quality and breadth of funded cancer research
through the Ellis Fischel Cancer Center (EFCC) also provides unique capabilities and
expertise to support trainee activities in health informatics and in research bioinformatics.

MU is accredited by the North Central Association of Colleges and Secondary Schools.
As a member of the American Association of Universities (AAU) and a university
classified "Doctoral/Research Universities – Extensive" by the Carnegie Foundation for
the Advancement of Teaching, MU is a premier provider of undergraduate, graduate and
professional education and is perfectly suited to host this new Ph.D. training program.

Approximately one-third of MU's budget comes from state appropriations. The sources
of the remainder of the budget include private gifts, grants, contracts, student tuition and
fees, auxiliary enterprises and University Hospitals and Clinics. In FY 2004, MU
expenditures from externally sponsored grants and contracts totaled over $162M

MU’s 25,000 select and diverse students include 5,527 graduate and 1,100 professional
students from all 50 states and over 100 countries. Approximately 85% of MU’s
undergraduate students are Missouri residents. The number of MU students who are
National Merit/Achievement Scholars places MU among the top 20 public institutions
nationally. The Columbia campus has approximately 1,500 full-time faculty. It is
unusual to find a major research university, rich in academic resources, in a rural,
Midwestern setting. At MU, a nationally known Cancer Center, School of Medicine
(SOM), College of Veterinary Medicine (CVM), College of Agriculture and Natural
Resources (CAFNR), College of Engineering (COE), School of Public Policy, a world-
class Research Reactor (MURR), perhaps the best Journalism School in the country, and
basic sciences departments housed within a College of Arts and Science are all located at
a single contiguous site. As a result, this campus houses numerous interdisciplinary
research and training programs that heavily emphasize biomedical research and
development that crosses many boundaries.

Support via the University of Missouri Bioinformatics Consortium (UMBC).
Nationally recognized programs and investigators in the Life Sciences exist throughout
the University of Missouri (UM) System. Outstanding programs in the areas of
medicine, molecular biology, genetics, structural biology, and molecular evolution are
already in place, and are being strategically strengthened through the multi-year Mission
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Enhancement program. In recognition of existing strengths and opportunities for
development of programs of excellence, the University has identified Bioinformatics and
Health Informatics as a specific target for long-term enhancement. In the fall of 2000,
representatives from the four University of Missouri campuses, in coordination with
representatives from the University's General Officers, proposed the development of the
University of Missouri Bioinformatics Consortium (UMBC). In July, 2001, the
Chancellors of the four UM campuses approved creation of the UMBC, and it was
presented to the UM Board of Curators. The UMBC is a System-wide resource for high-
performance computational infrastructure, which will emphasize and facilitate inter-
campus communication and informatics research collaborations. Specific goals are to:

          Provide resources for the UM System in the form of accessible and sharable
           computational capabilities and databases for collaborating investigators on
           any campus.
          Foster the development of advanced information technology applications in
           the Life Sciences in collaboration with peer Internet2 institutions.
          Facilitate the training of a new generation of students and scientists in the
           interdisciplinary area of bioinformatics and computational biology; the
           bridging of Life Sciences, clinical sciences and computer applications.
          Provide necessary resources for bioinformatics and Life Sciences research that
           will result in improved education and healthcare for Missourians and will
           enhance food and animal genome research.
          Enhance the connections of UM to rapidly developing trends in bioinformatics
           in the private sector.
To satisfy these objectives, the UMBC will provide:
          High-performance computational systems to analyze massive sets of data.
          Very large storage devices to house major data collections.
          High speed networking services to facilitate location-independent access and
           collaboration among investigators.
          Software applications supporting research in bioinformatics (e.g. sequence
           analysis, microarray data storage and analysis).
          Technical support staff.

Another measure of the local and state market demand comes from letters of support
from several individuals from the Columbia area and nationally. Excerpts from those
letters follow:

The UMBC and Compaq Computer Corporation entered a collaboration that has
greatly enhanced bioinformatic research across the four UM campuses. Working
together, the UMBC and Compaq participated in the joint development of a long-term
technology and performance strategic plan to enhance bioinformatics research. Compaq
provides the UM System with early access to emerging technologies, visiting lecturers by
Compaq experts, and AlphasServer-based high performance computer systems. In turn

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the UMBC publishes papers on the implementation of scientific applications on Compaq
platforms. The University also intends to develop world-class expertise on optimizing
large scientific applications and report experience and knowledge gained to Compaq to
assist other researchers. “This is a tremendous opportunity for the University of Missouri
to assume an accelerated role in bioinformatics research,” UMBC Executive Director
Gary Allen said. “This collaboration will greatly strengthen research across our four
campuses and will be an invaluable part of our mission to make the University of
Missouri a key component of the Missouri life sciences corridor.” Bill Blake, Compaq’s
vice president of High Performance Technical Computing, said “Compaq is pleased to
work with the UMBC to provide the technology and support so critical today for
successful collaborative research in the rapidly expanding areas of bioinformatics and
life sciences.”

The UMBC, jointly with the MU Life Sciences Center, hosted the 2005 Life Sciences
week research program that was streamed via high-bandwidth computer and video
connections across the State. This informatics approach is already improving our ability
to deliver high-quality education to students at multiple campuses
(http://lifesciencesweek.missouri.edu/). The MU Molecular Biology Program and
University of Missouri Bioinformatics Consortium, in partnership with the Donald
Danforth Plant Science Center and the Stowers Institute for Medical Research, present an
outstanding research forum for faculty and students from life sciences. This week-long
program features a dynamic series of distinguished seminar speakers, workshops, and
forums. Programs are broadcast in a live, interactive format via Internet2 to central
venues in Columbia, St. Louis, and Kansas City, and streaming video of these events may
be viewed live on the Internet from anywhere in the world. MUTREC faculty and
students will participate in this venue in order to promote our research and to recruit
additional transdisciplinary researchers. Dr. Peter Agre, Professor of Biological
Chemistry at the Johns Hopkins University School of Medicine and winner of the 2003
Nobel Prize in Chemistry, was the featured seminar speaker during Missouri Life
Sciences Week 2004.

With help from Senator Kit Bond, MU and the Missouri Innovation Center will
receive a grant from the Economic Development Administration to construct a new
facility. The estimated cost of the incubator is $8.7M, and MU will match the grant from
the EDA, bringing the amount raised to $6.6M. According to Senator Bond, “It is great
to be here to celebrate yet another milestone in Missouri’s journey to become the premier
biotechnology corridor of the United States and the world,” The business incubator is
expected to offer facilities and business mentoring to assist in the creation of new life
sciences companies. Representative Jeff Harris, who is Minority Floor Leader in the
General Assembly, also at the event, shared the positive outlook. “The University and
Columbia are well positioned to be leaders in the life sciences movement.”

The MU campus was also a host site for the Fifth Virtual Conference on Genomics
and Bioinformatics held October 25-28, 2005. The theme was Sharing Knowledge with
the World. The Virtual Conference provided an advanced collaborative environment
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where high profile researchers discussed the challenges and opportunities in the
understanding of living systems. In order to provide a meaningful discussion, the Virtual
Conference sought to accomplish three main objectives:

       *   Transcend geographical and economical barriers for the exchange of ideas that
           facilitate the interaction and collaboration among scientists and educators
           around the world.
       *   Address the benefits and limitations of the newest developments in post-
           genomic technologies.
       *   Explore the social and ethical implications of genomic and bioinformatic
       *   Establish new ways to introduce the high school community to today's
           multidisciplinary science.

The conference was broadcast around the world using Access Grid and real-time video
streaming technologies. In addition to the real-time virtual conference, presentations
(visual and audio) were made available on the web for delayed streaming.

Through a recently acquired grant from NASA, the UMBC has received $1.9M to expand
access to the Access Grid technology for use in collaborative educational endeavors
between UM System campuses. This will clearly strengthen our collaborative abilities to
deliver the coursework and seminars necessary for a robust graduate degree program on
both the UMKC campus (masters level) and the MU campus (doctoral level). There are
many potential opportunities for shared course work and research collaborations with the
UMR faculty as well.

The University of Missouri-Columbia has long and successful history of interdisciplinary
research in the Life Sciences. Several of these interdisciplinary programs are particularly
relevant as resources and infrastructure upon which the MU Biostatistics Predoctoral
Research Training Grant will build including the Life Science Mission Enhancement
investment and the Life Sciences Center

B.1. Life Sciences Mission Enhancement
Over a period of four years, the State of Missouri committed nearly $11M as a permanent
increment to MU's budget for the enhancement of its research in the life sciences. The
first year's funding was approved by the legislature and began in 1999. This funding was
distributed with a priority on interdisciplinary teams to fund approximately 40 new
tenure-stream faculty members, along with numerous postdoctoral fellows and students.

Areas of enhancement included nutritional sciences, human genetics and functional
genomics, radiopharmaceutical science, lung function in cystic fibrosis, membrane
transport research, animal reproductive biology, crop genomics, agroforestry,
cardiovascular health, comparative oncology, a plant transformation core facility, protein

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expression core facility and a competitive fellowships program. These all provide
excellent areas in which to collaboratively train Ph.D. students in informatics research.

B.2. Life Sciences Center
The Life Sciences Center opened its doors in July of 2004 and while currently recruiting
new researchers, it is already operating at 2/3 capacity. Founded on the belief that
complex problems cannot be addressed by a single discipline, when mature, the LSC will
be comprised of 40 researchers from fifteen academic departments, principally from the
School of Medicine, Colleges of Engineering, Arts and Science, and Agriculture, Food
and Natural Resources. The investigators in the LSC are organized into clusters focused
on interdisciplinary problems such as inflammation and environmental stress, cellular
development and programming, neural basis of learning and behavior, biophotonics,
microbial pathogenesis and gene therapy, and bioinformatics. These add greatly to the
interdisciplinary training and research opportunities at MU.

The Life Sciences Center is also features an NIH funded T32 training program known as
the Life Sciences Fellowship Program (LSF). The LSF is a campus-wide program that
supports MU life sciences trainees with four-year stipends including tuition and fees.
Departments nominate candidates to the LSF Program from their applicant pools. A six-
member committee representative of life science research recommends acceptances based
upon undergraduate training, GRE scores, and research interests and career goals. The
Life Science Fellows must meet all of the academic requirements of their home
department. Three additional requirements come with the Fellowship stipend and are
purpose-fully designed to broaden the exposure of the individual students to biological
research outside of their chosen discipline. These requirements include (1) an upper level
undergraduate or introductory graduate course in an area of science outside of their
discipline; (2) annual participation in a semester-long student seminar program with the
other LS Fellows; and (3) presentation of their research during the annual Life Sciences
Week. Progress towards their degree is monitored on an individual basis during an
annual meeting with members of the Awards Committee.

D.3. Dalton Cardiovascular Research Center (Dalton)
The Dalton Center brings together researchers from the College of Veterinary Medicine,
School of Medicine, and Division of Biological Sciences to study cardiovascular disease
and the role of exercise in preventing heart disease. The Dalton, a truly outstanding
research center at MU, is making great strides toward elucidating the causes of many
diseases, including hypertension, cystic fibrosis, heart disease and cancer. This
knowledge leads to new and improved therapies–the ultimate goal of our biomedical
researchers. The investigators (currently 32) have earned national and international
reputations for their prolific publications, their extraordinary success at winning grants
from nationally competitive sources, and their frequent presentations at scientific
meetings. The Dalton’s 2003-2004 annual report lists nearly $10M in total direct costs
from existing research grants.

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D.4. Food for the 21st Century Program
The Food for the 21st Century (F21C) program is a unique investment by the state that
began at $1M in 1984 and increased to $4M/year by 1988, F21C has put MU on the
cutting edge of interdisciplinary research in agricultural and food biotechnology. About
100 faculty members participate in four cluster groups: interdisciplinary plant group;
animal reproductive physiology; nutrition; and foods, feeds, and products. F21C has
fostered strong interdisciplinary linkages, and has a substantial list of accomplishments,
including competitive grants, peer-reviewed articles in top journals, annual symposia,
many graduate and postdoctoral trainees, collaborations with the private sector, and


C.1. Ellis Fischel Cancer Center (EFCC)
In 1937–the same year President Franklin Roosevelt signed into law the National Cancer
Institute Act, which established the National Cancer Institute (NCI) and set the stage for a
coordinated war on cancer–Governor Lloyd Stark approved the construction of Ellis
Fischel Cancer Center (EFCC). Today, EFCC remains Missouri’s only hospital
dedicated solely to cancer care and EFCC was recently named the cancer institute of the
state of Missouri through bipartisan legislation.

Dr. Charles Caldwell is the Director of the Ellis Fischel Cancer Center, including its
academic and clinical programs, thus ensuring this project’s close interactions with
cancer researchers. The modern EFCC Research Program comprises more than 80
principal and co-investigators and 45 postdoctoral fellows, technicians, and
administrative personnel. Many of these investigators could serve as valuable
collaborators for this research training grant. They work in some of today's most
promising areas of cancer research, as recognized by competitive funding of >$40M from
the National Cancer Institute, National Institutes of Health, American Cancer Society,
and Departments of Defense, Energy, Education, and others.

An extensive tumor registry program is supported at EFCC and is part of the Missouri
Cancer Registry (MCR) Enhancement Project and the Missouri Behavioral Risk Factor
Surveillance System (BRFSS), with $1.28M in funding through the Centers for Disease
Control and Prevention’s National Program of Cancer Registries (CDC/NPCR). The
Missouri BRFSS, with an annual sample size of 4,200, can produce prevalence rates for
seven regions as well as the state. It has developed and will continue to develop special
surveys, with sample sizes ranging from < 500 to > 15,000, targeting high-risk groups
such as African Americans and older adults or focusing on specific topics such as
nutrition, obesity reduction, and cancer prevention and control. The Ph.D. training
program will use these types of activities and data as well as biostatistical analysis–
another example of MU’s integration of resources.

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C.2. University of Missouri Health Care
The flagship hospital of the University of Missouri Health Sciences Center is a 240-bed
tertiary care center that provides a full range of medical services. Physicians from
throughout the state refer many of their most complicated patient cases to the medical and
surgical specialists. Twenty-five percent of the beds–more than twice that of the average
community hospital–are dedicated to intensive care, which reflects the severity of patient
illness and injury for which the hospital provides. An extensive electronic medical record
and the Center for Health Care Quality provide good hosting opportunities for Ph.D.
trainees in health informatics.

C.3. University Physicians
University Physicians is the group practice plan for the faculty of the University of
Missouri, School of Medicine. University Physicians staff University Hospitals and
outpatient clinics, which are located throughout Columbia and in surrounding
communities. With more than 300 physicians, University Physicians is the largest group
practice plan in mid-Missouri. Ninety percent of these physicians are board certified.
The patient pool for research studies is surprisingly large and thus represents an
outstanding resource for Ph.D. training in informatics research.

C.4. School of Medicine
MU’s School of Medicine was the first publicly supported medical school west of the
Mississippi River. It was established as a two-year school in 1872 and became a four-
year program in 1957. Today the school offers an outstanding program that emphasizes a
thorough medical education founded on clinical experience and research. A faculty of 70
basic scientists and 260 clinicians joins 350 residents in more than 60 specialties and
subspecialties to supervise patient care and teaching of 96 medical students in each class
year. The school provides postgraduate medical training in virtually all specialties and

C.4.a. Thompson Family Center for Autism and Neurodevelopmental Disorders
Funded in April of 2005, by a private donation of $8.5 million, the Thompson Family
Center for Autism and Neurodevelopmental Disorders will integrate autism research,
service and teaching at the University of Missouri. As Director of this interdisciplinary
initiative, Dr. Janet Farmer is responsible for establishing a research center of excellence
on autism and other brain-related disorders in children and for enhancing growth in
related service and educational programs. Academic divisions that initially will
participate in the center include the School of Medicine, the School of Health
Professions, the College of Education, the College of Human Environmental Sciences
and the Truman School of Public Affairs. Other faculty from across campus also will be
invited to enhance MU's programs for children with autism and other neurological
conditions. Additionally, MU will strengthen its partnerships with the Missouri
Department of Mental Health and the Department of Health and Senior Services.

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C.4.b. The Biostatistics Support Group of the Office of Medical Research
Part of the MU School of Medicine, the Biostatistics Support Group has a mission to
provide statistical support for biomedical researchers involved in the MU Health Care
enterprise. Our view of “statistical support” is fairly broad and includes statisticians
serving as partners in the research effort. As such, they can be of greatest service when
they are involved early in planning the research. This group offers services and
collaboration in grant proposal development, experimental design, sample size
determination, the development and application of new statistical methodologies,
statistical analysis of all types, the interpretation and presentation of results for
manuscripts and meeting presentations and data management. The group also provides
education in experimental design and statistics including topic-specific seminars, and full
or mini-courses on topics of the biomedical researchers’ choice.

Faculty and staff are available to provide biostatistical consulting and collaboration for
ongoing research projects at the Health Sciences Center. Faculty and staff have extensive
experience in many statistical areas including experimental design, sample size selection,
linear models (regression and analysis of variance), nonparametric statistics, descriptive
statistics, Monte Carlo simulations, randomized clinical trials, logistic regression and
multivariate analysis.

C.4.c. The Department of Health Management and Informatics
This department within the School of Medicine hosts master’s degree programs Health
and Bioinformatics and in Health Services Management and a $3.8M predoctoral and
postdoctoral training grant funded by the National Library of Medicine, the Biomedical
and Health Informatics Research Training (BHIRT) program (Dr. Caldwell is the
director). The development of this proposed Ph.D. in Informatics program would allow
these predoctoral students (5-7 each year) to pursue a Ph.D. in informatics. They must
now acquire their Ph.D. through other existing programs such as biology, nursing,
chemistry, etc. The National Library of Medicine site visit team during their visit in 2004
indicated that the next round of training grant awards would probably not include
universities without doctoral programs in informatics (See attached letters of support).
The HMI department does not currently have a doctoral program but does have a critical
mass of faculty (20) to support such a program.

C.5. College of Veterinary Medicine
The MU College of Veterinary Medicine is the only Missouri institution that awards the
Doctor of Veterinary Medicine degree, graduating about 64 new veterinarians each year.
The College also offers post-graduate training to interns, residents in various specialties
and graduate students. Through its research mission, the College fulfills a solemn
obligation to advance the level of understanding of diseases affecting not just animals but
also people. To pursue the causes of these conditions, faculties of the College of
Veterinary Medicine now collaborate extensively with colleagues in agriculture, human
medicine, and other scientific disciplines. As an example, the College recently received a
$7M NIH grant to study the protective effects of exercise on cardiovascular function.
The Veterinary Medicine faculty members are working closely with other MU faculty to
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develop a comprehensive program to better understand and treat cancer. In addition,
faculty continue to seek a better understanding of diseases affecting farm animals, with
particular emphasis on infectious conditions and reproductive disorders. Faculty are
supported by the College’s Comparative Medicine program, a leader in training
laboratory animal veterinarians and in providing diagnostic support to scientists around
the world. A large veterinary medical database provides a valuable platform to study
medical informatics as part of our proposed Ph.D. in informatics program. In fact, one of
the current postdoctoral fellows in the BHIRT program is a veterinarian.

C.6. Sinclair School of Nursing
The Sinclair School of Nursing (SON) offers a full range of degree programs: Bachelor
of Science in Nursing, Master of Science in Nursing, and Doctor of Philosophy in
Nursing, as well as continuing education offerings through Nursing Outreach and
Distance Education. The education of persons of diverse ethnic backgrounds is a high
priority, and the SON offers fellowships and assistantships to qualified applicants. The
SON has a fine history of securing federal funding for cutting-edge academic programs.
Currently, there are federal grants supporting a Web-based career mobility program for
public health nurses, a master’s program for school nurses, an RN/BSN outreach program
and a pediatric nursing practitioner program offered cooperatively by the University of
Missouri-Columbia, University of Missouri-St. Louis and the University of Missouri-
Kansas City. Faculty are active mentors in the BHIRT program and several nursing
students have been BHIRT trainees. Thus, there is clear support for a Ph.D. program in
informatics within this group of faculty.

The Elmer Ellis Library, the main library in the MU system, occupies a central block on
campus. Six branch libraries, including Veterinary Medicine and Health Sciences Center
Libraries, are located throughout the campus. The MU Libraries comprise the 47th
largest research collection in North America with holdings of 2.6M books and 5 million
microforms. The MU Libraries subscribe to over 16,000 periodical titles in various
disciplines. Approximately 45 professional librarians, 118 support staff, and many part-
time student assistants staff the Libraries. Ellis Library contains the principal resources
for research in the humanities, the social sciences, and the basic sciences. The building
has several specialized collections, such as Government Documents, Recorded Sound,
Rare Books, and an extensive microform collection. Subject librarians provide reference
assistance, collection development, database searching and bibliographic instruction in
their fields. They work closely with their faculty liaisons in academic departments.

The Research Support Computing (RSC) group within the Information and Technology
Services organization is focused on supporting the research community at MU. This
support involves soliciting input from researchers throughout the campus to assess needs
for specialized, high performance computing and networking resources, ensuring that the
campus' computing and networking infrastructure is positioned to support these needs

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and to provide education, training and consulting to take maximum advantage of the
resources available.

The UM Bioinformatics Consortium is a four-campus collaboration to provide
centralized high-capacity data storage and analytical tools that can be used over our high-
speed Internet2 connections. The Research Support Computing (RSC) group in
Information and Technology Services supports the research community at MU by
soliciting input from researchers across campus to assess needs for specialized, high-
performance computing and networking resources, ensuring that the campus computing
and networking infrastructure is positioned to support these needs and to provide
education, training and consulting to take maximum advantage of the resources available.
Additionally, as noted above, we have one of the best statewide telehealth networks in the


F.1. Department of Statistics
The Faculty of MU’s Department of Statistics are recognized internationally for their
contribution to statistical theory and application. Few small departments have as many
distinguished faculty members as MU’s Statistics Department. Of the 14 faculty
members, four are Fellows of the American Statistical Association, four are Fellows of
the Institute of Mathematical Statistics and elected members of the International
Statistical Society, one is a Fellow of the American Association for the Advancement of
Science, one is a Fellow of the Washington Academy of Science and one is a Fellow of
the World Academy of Art and Science. These accomplishments put them at the frontier
of modern statistics, which is being shaped by collaborative research of teams of
scientists using computer-intensive statistical methodology.

F.2. Division of Biological Sciences
The Division of Biological Sciences is unique among all life science units at MU with
respect to its responsibilities and contributions in research, graduate training,
undergraduate instruction and service.

Faculty members work in three highly interrelated areas at the cutting edge of modern
biology: (1) the genetic and cellular regulation of development, (2) neurobiology and the
regulation of behavior; and (3) ecological and evolutionary biology. Although strongly
focused, their research is integrated across all levels of biological organization from
organelles to populations. Many faculty members work at the interfaces between these
areas and graduate and undergraduate students are encouraged to do likewise. The
division’s 32 faculty members published 141 refereed papers, served on 57 editorial
boards and grant review panels, and held 80 extramural grants worth $11.1 million in last
year. Research and graduate education are inextricably intertwined. The research
component of graduate training is provided in individual faculty laboratories, taking full
advantage of the rich mixture of interdisciplinary opportunities available on this campus.
The instructional component is provided through graduate seminars led by experts at the
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frontiers of their field. More than one third of the division’s 68 Ph.D. candidates are
supported by competitive Predoctoral training grants. Students complete their doctoral
program in an average of 5.3 years compared to the 6.8-year national average. Four years
after graduation, over 75% hold independent scientist positions in academia or industry
or government, 10% are employed in science-related fields, and 10% have advanced from
their postdoctoral to a senior research associate position. In undergraduate education, the
Division serves non-majors and majors alike, emphasizing the excitement of discovery
and the development of individual creativity and critical reasoning skills. The Division
prepares 1030 biology majors for either direct entry into the workplace or advanced study
in graduate or professional school with laboratory courses that investigate real-world
problems in biology and research under the personal guidance of faculty mentors. More
than 70 undergraduates a year conduct research projects with faculty mentors.

The Division of Biological Sciences also contributes in several ways to the extension
mission of the campus. Basic research in the Division is translated into applied research,
frequently in collaboration with faculty in other units at MU. That in turn strengthens the
State's economy and quality of life for its citizens. Because science exposure in the pre-
college years is critical to the development of both scientists and informed citizens, the
Division also offers special outreach programs for secondary school science teachers in

F.3. Department of Computer Science
Computer Science is a fast-growing and research-active entity at the University of
Missouri. In fact, it is the hub of all campus computer science activities that involve well
established research programs in multimedia communications and networking,
computational biology, sensor network and nonlinear optimization, spoken language
processing and human-machine interfaces, large dataset scientific visualization,
distributed computing, geospatial information mining and retrieval, etc. Additionally,
members of the department lead the University's institutional efforts in developing
infrastructure for bioinformatics, computational biology, high-performance computing
and networking. Major active research projects are heavily funded by both federal
governments and industries. While the National Science Foundation (NSF), National
Institutes of Health (NIH), National Geospatial-Intelligence Agency (NGA), and the
Department of Energy (DoE) are examples for federal funding, Raytheon and Monsanto
are representatives for industrial funding.

The Department of Computer Science currently has 16 tenured or tenure track faculty,
400 undergraduate students and 85 graduate students including 40 Ph.D. students. It
offers B.A., B.S., M.S., and Ph.D. degrees, and a B.S. degree in Information Technology.
With foundations in computational theories, algorithms, compilers, and operating
systems, the undergraduate and graduate programs are integrated over bioinformatics and
computational biology, distributed computing and networking, human-computer
interaction and intelligent systems and Information management systems.

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F.3.a. Computer Science, Digital Biology Laboratory
The research focus of Digital Biology Laboratory (DBL) is Bioinformatics and
Computational Biology. We are interested in various topics including protein structure
prediction, high-throughput biological data analyses, computational proteomics, in silicon
studies of plant, microbes, neural systems, and many more.

F.4. Department of Psychological Sciences
The department of Psychological Sciences at the University of Missouri-Columbia has a
long and distinguished history of excellence in teaching and research that continues
today.     Several years ago, the Department created two new Ph.D. programs:
developmental psychology and quantitative psychology. Dr. Phillip Wood is among a
unique core of clinical and basic scientists studying the dynamics of addictive behaviors.
On the basis of reviews by the National Research Council and other sources,
Psychological Sciences is one of the most visible and effective departments in the four-
campus University of Missouri system. It is, in fact, a highly visible and highly respected
department, nationally. The most recent US News & World Report survey placed the
department at 41st in terms of national reputation (there are 800 psychology departments
in the U.S.), and a recent survey by the National Science Foundation (NSF) placed it at
36th, in terms of combined NSF and National Institutes of Health funding. The latter
reflects the fact federal funding for scientific activities in the department is at an all time
high and comparable to the funding levels of many psychology departments in Ivy
League universities. Faculty members are among the most productive in the country. In
the past six years, they have published more than 400 scientific papers, nearly 100 book
chapters, and 12 books, and have been cited in the scientific literature more than 10,000

The department’s undergraduate program is approaching 1,000 majors, and the graduate
program includes 77 students across five training areas. The department’s graduate
students are among the best at MU and, once their training is completed, they
successfully compete for academic and professional positions. Some recent graduates are
in post-doctoral positions at Duke, Carnegie Mellon, University of Minnesota, and
University of Illinois, among other highly respected places. Other graduates hold
academic positions at the University of North Carolina, Louisiana State University,
University of Connecticut, University of Minnesota, University of Maryland, University
of Oregon Health Sciences, and Baylor University, among many other universities and
medical centers. Still other graduates hold professional positions throughout the country.

F.5.   MU Informatics Institute
       Described above.


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Current and Pending Training Support of Participating Faculty & Departments

Title                        Source &
                                                                         Number          of
Active/Pending Status        Award            Director
                                                                         Trainee Positions
The Health & Activity        US Dept of       Martin    Childers,         4 Postdocs
Rehab Research Training      Education,       Medicine and Rehabilitation
Center                       NIDRR
ACTIVE                       H133P050005
An Innovative Doctoral       US Dept of       Matthew Lucy               4 Ph.D. Fellows
Training Program to          Agriculture,     Animal Science
Prepare      the     Next    CSREES,
Generation of Cross-         National Needs
Disciplinary Scholars in     Fellowships
Animal       Reproductive
From        Clinic      to   NIH          Mark Milanick           2 Predocs (first
Bench&Back:Clinical          T90 DK70105- Medical                     &
                                                     Pharmacology year); 6 positions
Biodetective Training        01           Physiology              total
From        Clinic      to   NIH          Mark     Milanick,       2 Predocs (first
Bench&Back:Clinical          T90 DK71510- Pharmacology & Physiologyyear); 6 positions
Biodetective Training        01                                    total
Minority       Biomedical    NIH, NIGMS                            5 Predocs
                                          Catherine Vogelweid, Veterinary
Researchers       Training   5        R25 Pathobiology             5 Postdocs
Initiative                   GM056901-07
University of Missouri       Merck Research Craig    Franklin,          5 Predocs
Veterinary       Research    Labs           Pathobiology                5 Postdocs
Scholars Program             204321
Molecular Basis of Gene      NIH, NIGMS                               6 Predocs
                                              Mark Hannink, Biochemistry &
Expression                   5         T32    Life Sciences Center    6 Postdocs
ACTIVE                       GM008396-15
Cardiovascular/Renal         NIH NHLBI        Virginia   Huxley,       3 Predocs
Physiology,                  5         T32    Pharmacology & Physiology3 Postdocs
Pharmacology            &    HL007094-30
Biochemistry      Training

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Post-doctoral Training in   NIH, NCRR    Craig    Franklin,        6 Postdocs
Comparative Medicine        5        T32 Pathobiology
ACTIVE                      RR007004
Exercise      &   Health:   NIH, NIAMS   Ronald Terjung, Ph.D.     2 Predocs
Integration from Molecule   T32AR048523-                           2 Postdocs
to Patient                  02
MU     PREP     Scholars NIH, NIGMS         John David, Ph.D.        Undergraduates
GAANN Fellowships in US Dept of Ed          Sudarshan Loyalka, Ph.D. 4 Fellows
Environmental Health and P200A040038

GAANN: A Proposal for       US Dept of Ed   Mark Prelas, Ph.D.       5 Fellows
Fellowship Support in the   P200A030182
Area      of     Nuclear
Comprehensive Geriatric   Donald     W. Steve Zweig, MD              5 Postdocs
Training Programs         Reynolds
Rural            Missouri DHHS, HRSA Brick Johnstone, Ph.D.          4 Predocs
Rehabilitation Psychology D40 HP00004-
Internship Program        02
MU- Minority Graduate NSF               Suzanne Ortega, Ph.D.        17 Predocs
Education Project

IGERT:        Integrative   NSF EHR     Shubhra                   7 Predocs
Biosensing Technology                   Gangopadhayay
and Education                           Ph.D.
Biomedical and Health    National       Charles W. Caldwell       7 Predocs
Informatics     Research Library     of Pathology     and         5 Postdocs
Training                 Medicine       Sciences
ACTIVE                   5T15LM00708
Molecular, Cellular, and NIH NHLBI      Virginia     Huxley,      5 Predocs
Systems Biomedicine      5          T32 Pharmacology & Physiology3 Postdocs
PENDING                  HL007094-31-
Molecular Basis of Gene NIH, NIGMS                                8 Predocs
                                        Mark Hannink, Biochemistry &
Expression               2          T32 Life Sciences Center
PENDING                  GM008396
Post Genomic Biomedical Howard Hughes William Folk, Biochemistry 6 Predocs
Scientist Training       Medical                                  6 Postdocs
PENDING                  Institute
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Graduate Training     in NIH, NIBIB    Silvia Jurisson,       4 Predocs
Radiopharmaceutical      T32 EB004822- Chemistry and Radiology and
Chemistry                01A1          MU Research Reactor

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Appendix A

Proposed new courses for the Informatics Ph.D.:

Biostatistics (Statistics XXX): Random variables; Probability distributions; Point
estimation; Statistical inferences; Likelihood principle; Analysis of variance; Power
analysis; Gene expression analysis; Prerequisites: Math 436, Math 441, or instructor's

Inquiry into Health and Bioinformatics (HMI XXX): This course will introduce concepts
of research design applied to establishing testable hypotheses, study design, statistical
analyses, data interpretation and causal inferences. It will explore a range of research
methods and support a depth of analysis for students to develop an appropriate and
rigorous research design for health and bioinformatics.

Evaluation of Health and Bioinformatics (HMI XXX) The role of informatics in clinical
decision making, process improvement, cost-effectiveness analysis and quality of life
assessment will be introduced. At the conclusion of the course, the student will have an
understanding of evaluation techniques to assess health and bioinformatics applications.

Computational Medical Genomics (Med XXX): This course is intended to introduce
advanced undergraduates and graduate students to critical concepts in human genetics
and genomics. It will focus on molecular mechanisms of disease and exploit recently
available genomic studies to understand critical concepts in pathogenetics and to a lesser
extent population genetics. Prerequisites: LS Bioc 360 or LS Bioc 430.

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Appendix B

CBHE Clarifying Comments

1.      Alignment with the mission of the campus
Our goal, echoing that of the UM System and MU campus strategic plans, is to
participate in the building of a "premier, world-class destination university with an
exceptional and richly diverse student body, faculty, and staff." Five of the six strategic
themes for the UM System include goals that intersect with the research enterprise here at

Some of these are familiar: boosting our investment in selected programs, enhancing
interdisciplinary research, becoming a leader in life sciences, fostering economic
development, and improving the research infrastructure. Others, however, will give us
pause this year as we develop plans for their achievement by 2010. Among these goals
are recruiting additional faculty members who are members of the National Academy of
Sciences, improving financial compensation for MU's faculty and staff, building the
highest quality information technology infrastructure, and raising the total of our annual
external research expenditures to the $300M mark.

The campus plan speaks to our stewardship of a "priceless state resource" as a land-grant
university for the 21st century that offers a new model for a university in the public
service, a public-private partnership university. Our land-grant status carries a unique
obligation to improve the civic, economic, health and educational well-being of all

This proposed Ph.D. Degree in Informatics is aligned with the mission of the MU
Research Division. The Research Division's goals for the 2004-05 academic year have
been chosen to build on existing strengths while also addressing areas of need.

Goal 1: Provide top-notch services and compliance functions that enhance the ability of
MU faculty to do research, creation, scholarship, and innovation.

Goal 2: Create a research-centered academic and educational environment by developing
connections between the research enterprise and all of the institution's other activities and
by creating a broader foundation for research support with internal and external

Goal 3: Develop and promote investment strategies to sustain and grow the research
enterprise. Such growth will allow students greater access to our world-class faculty and
state-of-the-art facilities, and will ensure that MU research continues to enhance the lives
of people in our state, nation and the world.

This new Ph.D. degree program will be the first such degree program in the State of
Missouri and will respond to identified regional needs, statewide and national needs. The
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combined resources in the health sciences, biology, physical sciences, computer sciences
and mathematics that have been brought together in this new degree program are an
important strength of the program and were developed in response to recommendations
and advice from respected leaders
2.      Market demand and importance to Missouri’s economic and educational
The demand for individuals trained in the field of bioinformatics has been growing
rapidly as solutions to the problems in genomics, proteomics, and clinical medicine have
increasingly required computer analysis. To meet this demand, universities throughout
the world are adding new degree programs to train the skilled workforce necessary to
meet the growing need. As an illustration at the local level, faculty members at the Life
Sciences Center, the EFCC, and other important research centers, have cooperated in the
development of this new degree because their research programs involve some
component of informatics.

3.     Efficient use of resources
This new program represents a unique opportunity to combine existing resources from
several departments and schools within MU (and other UM campuses) to develop a
program of national quality that meets the needs of our students and the State of
Missouri. Most of the courses for the proposed degree are currently being taught as part
of existing graduate degree programs housed in the participating schools and
departments. By supplementing these courses with selective new ones and organizing
them into degree tracks, we will be able to offer students unique educational

4.      Benefits of collaborations and lack of duplication
By drawing upon the resources and expertise from many departments and schools, this
informatics program has avoided course duplication. In addition, students will have
contact with and access to faculty members in a diverse range of fields, and we anticipate
that the interdisciplinary environment created by this program will result in new ideas,
projects, research and educational opportunities.

On a broader scale, the development effort for this program has already strengthened our
partnerships with other organizations, the Cerner Corporation as well as the other
University of Missouri campuses via the UM Bioinformatics Consortium.

This program does not duplicate any existing programs in Missouri. The only similar
program in a public university in Missouri is the Health Informatics masters program at
MU. While the doctoral program will utilize the existing master’s program resources, its
primary focus is research. There is also a strong synergy that has been tapped by
coordinating efforts between the MU and UMKC masters programs in informatics.
There is an emphasis in Kansas City on urban delivery of care, while Columbia focuses

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on rural delivery. Kansas City has excellence in dental and medical care delivery, while
Columbia is a medical and veterinary center.

Furthermore, this proposed Ph.D. program complements and will share pertinent
resources with the Health Informatics masters program at MU and UMKC and will seek
additional collaborations to benefit the two campuses and other system campuses as new
opportunities arise and as interest and need for informatics educational and research
programs grow.

Under UM System guidelines for a Cooperative Curriculum program, the health
informatics emphasis area in this Ph.D. proposal includes courses currently being offered
by the Health and Bioinformatics Master’s program in Columbia and the masters in
bioinformatics at UMKC. In addition, we propose to develop joint video conferences and
seminars and the costs for such programs have been built into the budget, as well as
supplemented through a recent grant from NASA. These collaborative activities will also
support the initiatives started by the University of Missouri Bioinformatics Consortium
(UMBC), which was established in 2001 for the purpose of promoting bioinformatics
within the UM system. A specific goal of the UMBC is to facilitate the training of a new
generation of students and scientists in the interdisciplinary area of bioinformatics and
computational biology; the bridging of life sciences, clinical sciences and
computer applications.

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Appendix C

The University of Missouri President’s Criteria

1.      The new Ph.D. in Informatics program will not reduce the quality of existing
By building upon existing courses and fostering interdisciplinary collaborations, the new
degree program will strengthen existing programs and provide new opportunities for
students and faculty members. Informatics is a truly interdisciplinary field that exists at
the interface of the biological and physical sciences, computer science, and medicine.
Multiple benefits, including the following, will result from the establishment of the

       •   A conceptual focus for informatics research and training at MU;
       •   Informatics research collaborations among faculty in biology, computer
           science, engineering, mathematics, health sciences, and other fields;
       •   Collaborations throughout the UM System and stronger partnerships with
           neighboring institutions;
       •   Expanded research and new applications in health promotion, disease
           prevention, biotechnology, the pharmaceutical industry, and related areas; and
       •   Education for students in the field of informatics and produce graduates who
           are highly sought for their knowledge, skills and leadership.

The value of the new informatics Ph.D. degree to existing programs is indicated by the
strong support that it has received from faculty members and administrators throughout
the university. The proposed program arose from a campus-wide effort with faculty
members from virtually every School and College on the MU campus. This broad
participation by academic units and community partners reflects the interdisciplinary
nature of the program and the need for students to acquire knowledge and skills in
multiple fields.

2.     A verified market analysis has been conducted
See the section on “Program Need” and letter from Mr. Steinhoff (attached) in the main
proposal above for information about the market analysis and the local, statewide, and
national demand for informatics programs.

3.     A strong Business Plan guides development of the program

A.     MU’s Commitment
This proposed new Ph.D. degree in Informatics is a cost-effective program that will
require few additional resources to establish. MU made a commitment over two years
ago to develop education and research programs in the field of informatics. At that time,
we perceived informatics as an essential component of any modern life science research
program and consequently we have been building the infrastructure and recruiting faculty
members with expertise in this field. Moreover, MU has made a commitment to our
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community partners and the other stakeholders in the Columbia area that we would
develop this important field as part of the overall plan to make MU (and UM) a leading
center for life science education, research and commercial development.

As part of the broader initiative in informatics, MU has made a commitment to build
strong education and research programs in the field of clinical informatics. One of the
deep commitments by Dr. William Crist, Dean of the MU School of Medicine, is to
improve health care by creating the foundations of a program to create health care
delivery systems and health professionals who will deliver the right care to the right
patient at the right time. Critical to this effort is the ability of future physicians to work
with the electronic medical record (including genomic information) as a key "member" of
the health care team and the application of advanced information systems to support
clinical process improvement. He is discussing with the Cerner Corporation a plan to
work jointly to set the standard for such programs across the nation.

This program proposes to achieve these goals by:

1. Creating Exemplary Learning Sites: Clinical teaching settings where the information
   system is a key member of the health care team. The goal is to deliver the right care
   at the right time for each patient while at the same time achieving outstanding results
   in health professional education.
2. Designing Patient-Centered, Informatics-Assisted Learning Experiences: Starting day
   one of their professional training, preparing trainees to engage meaningfully and
   productively as members of exemplary learning site teams.
3. Supporting Research in Informatics and Personalized Health Care: Emphasizing
   bioinformatics, health informatics and consumer informatics. This includes research
   that will address changes in health care stemming from the Human Genome Project.

Modern medicine has been markedly hampered in its ability to translate important
medical advances to the bedside by a lack of readily available, up-to-date medical
information at the point of care. An example is the argument that genomic medicine
should advance to the bedside as quickly as possible to the benefit of patients. We must
also train the workforce to use this information.

This Ph.D. degree in Informatics is essential if we are to successfully continue the
development plan for research and educational programs in this field. As an example,
our Biomedical and Health Informatics Research Training Program, which has been
funded by the National Library of Medicine for over 13 years, provides for pre- and post-
doctoral research training in informatics, but we have no Ph.D. degree in informatics to
award currently, and therefore each pre-doctoral student must receive their degree in
another discipline such as biology, nursing, chemistry, computer science, etc.
Implementation of a new, unique Ph.D. in Informatics would clearly strengthen our
ability to retain this NLM funding during our next competitive renewal.
The successful recruitment of highly capable research faculty members is also greatly
facilitated by the presence of strong doctoral programs. The lack of a doctoral program

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in informatics is a hindrance to recruitment, and the establishment of this Ph.D. degree
will demonstrate to prospective new faculty members the university’s commitment to
informatics research. The ability to effectively recruit faculty members is the single most
important determinant of the quality of the university’s programs. In addition to the
benefit of improving the quality of our academic programs, we expect the newly recruited
faculty members to attract additional financial resources to the university through grant
funding. Other potential financial benefits from successful recruitment efforts include
private fund raising, and the royalties and license fees from intellectual property.

We now have the capability to initiate this new degree program as the next stage of our
development plan. MU has approximately 15l faculty members who teach in informatics
and whose primary research is in health or medical informatics. Furthermore, the faculty
team that planned this degree program identified 14 existing courses in health and
bioinformatics that will be a part of this new degree program either as curricular
requirements and a sufficient base of courses to support the prerequisite and elective
requirements. Once the degree program is approved, four new courses will be developed,
to be followed by additional courses as the need arises and the field of informatics
evolves (see Appendix A for a description of the courses). Substantial additional
resources, including computers and other instrumentation, already exist within MU
laboratories and classrooms, and within the UM System as part of the UM Bioinformatics

B.     Budget for the Ph.D. Degree
The principal expenses in the budget for this degree program are salaries, student
stipends, and equipment (see Form FP for details). Nevertheless, the MU campus has
adopted this program as one of their “strategic initiatives” and provided $700,000 of
ongoing support to develop the Ph.D. program in informatics and recruit additional
faculty to teach in this program. In addition, the campus is put up $500,000 for faculty
and program start up in addition to the $700,000 for ongoing support. The program,
based on collection of tuition, ongoing funding as described, and the expectation that
existing and new faculty will be competitive for external research funding, will provide a
sustainable, robust program that is critical to our future successes in biomedical and life
sciences research.

C.      Recruitment of Students
Recruitment of graduate students for the informatics program will be incorporated into
the recruitment activities of the participating units. Recruitment efforts will be directed at
the local, regional national and international areas. MU has multiple training programs
that have been successful in recruitment of under-represented minority students, and we
will link into these tightly. Locally, recruitment will focus on baccalaureate colleges and
universities, as well as employees working in the area who have a baccalaureate or
masters degree and wish to advance in their careers by acquiring the skills of informatics.
Recruitment will also take place at graduate recruitment fairs in the Midwest region,
including Missouri, Kansas, Iowa, Nebraska, Arkansas, and Okalahoma. National
recruiting is conducted principally by faculty members who give seminars at universities
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and by printed material that is distributed to individual universities or published by
national recruitment companies, such as Peterson’s. International recruiting is conducted
through established contacts with individual universities overseas and by the International
Student Affairs Office at MU. Increasingly, students are using the internet to access
information and learn about educational opportunities. MU has responded by redesigning
and upgrading our web sites and our on-line application systems.

D.       Student Retention and Assessment
Students in the program will be assigned to an advisor, who will assist students with
developing their plans of study and who will monitor their academic progress. Regular
meetings of the students with their advisors will help assure that students meet all the
program requirements and that they receive appropriate guidance regarding their progress
in the program and career opportunities. Students will be assigned to advisors who are
affiliated with the students chosen “track”. The progress of each student in the program
will be reviewed at least annually by the program’s Curriculum Committee, which will
consist of an interdisciplinary group of faculty members from the MU Informatics
Institute and participating departments who oversee the program. Students who are not
making adequate progress may be subject to remedial work, probation or dismissal.

Records will be maintained on each student in the program and will be used in aggregate
to assess and improve the program. The information collected will include entering grade
point average, undergraduate school, GRE, program grade point average, publications,
honors, awards, job placement and other characteristics. Exit surveys and regular alumni
surveys will assess student attitudes, post-graduation activities and other information that
may be used to improve the quality of the program. The program will be subject to five-
year reviews in accordance with university policies and procedures.

E.      Employment
Our analysis of the market demand for individuals knowledgeable in informatics suggests
that graduates will be highly sought after (see section above on Market Demand). Each
of the tracks in the program is sufficiently different that the graduates of the students are
likely to pursue various career tracks. Therefore, we expect the graduates to find
employment in a variety of organizations and industries in Missouri and throughout the
country. Likely employers include hospitals, university research laboratories, the
pharmaceutical industry, biotechnology companies, software developers and many

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External Review of Proposed Ph.D. Program in Informatics
at the University of Missouri-Columbia.

Prepared by:
Gary D. Stormo
Joseph Erlanger Professor of Genetics
Washington University School of Medicine
St. Louis, Missouri

In 2004 I served on an external review committee to ascertain whether there was a need
for a Ph.D. program in Informatics and, if so, whether the University of Missouri was
adequately prepared to offer such a program. The conclusion of that committee was that
Informatics is an essential component of modern biomedical and life sciences research
and that there is a critical need for Ph.D. programs in that field. We further concluded
that the University of Missouri-Columbia (MU) had sufficient strengths in the
appropriate fields to offer a high quality program in this interdisciplinary area. I have
now read the proposal for a new Ph.D. degree program in Informatics at MU and the
following is my evaluation of that proposal, organized according to specific questions
raised by the Associate Vice President for Academic Affairs, Steve Graham.

Will the curriculum produce high-quality graduates who are capable of making
significant contributions in their selected fields of study?
The curriculum offers a wide range of courses that includes a set of core courses for all
students and more specialized core courses for those with concentrations in either
bioinformatics or health informatics. These core courses cover the several disciplines
brought together within the informatics umbrella. There are also many elective courses,
from each of the disciplines that provide specialized in-depth training on a wide variety
of topics. It is clearly the case that the proposed curriculum will provide the students
with ample training to become highly qualified practitioners in their field.
In addition, each student will complete a dissertation that will demonstrate the student’s
ability to do original research that makes a significant contribution to the field. The
students who emerge from this program will be well-trained and highly capable scientists
ready to contribute in important ways to the biomedical and health fields.

There is one aspect of the proposed training that may need further consideration. The
course requirements for this program are extensive, with 30 hours of core courses and
electives, along with requirements for teaching experience, seminar and journal club
participation and research rotations. The proposal also states that students are expected to
complete their degrees within 4 to 5 years. That may be possible for some students, such
as the “preferred candidate” who will enter the program after having completed a related
Master’s degree program. However, while such a student is fairly common in some
fields of engineering and statistics, the top biomedical students often come directly from
undergraduate degrees. In such cases, completing all of the above requirements and a
significant dissertation usually takes a minimum of 5 years and an average length of 6

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years is fairly common in similar programs. If that also turns out to be the case here, it
will affect some of the student and budget projections.

How does this Ph.D. program compare with other similar programs in the field?
There are currently not a lot of Ph.D. programs in biomedical and health informatics in
existence. The proposed program is similar to the existing ones in many ways, although
each has it own characteristics. The strong inter-disciplinary and inter-departmental
character of this program stands out as one of its strengths. Students will be broadly
trained in several relevant sub-areas and will be able to choose from among many
specific topics for their in-depth dissertation research. I believe this program can quickly
become among the top ones in the country.

Do the courses and faculty involved in the program sufficiently provide the
resources and content necessary for doctoral level education in bioinformatics and
health informatics?
This program has a large number of faculty who cover a variety of sub-disciplines and
offer a broad collection of courses that are important to informatics research. Both the
content of the coursework and the resources necessary to facilitate high quality education
and research are in place. The plans for additional faculty lines in this area will augment
and strengthen the overall program and speed up its rise to prominence.

Does this program complement other related programs at the University of
The University of Missouri has a long history of prominence in the life sciences fields
and is also well known in other areas of science and engineering. Informatics has been
an important component of many scientific and engineering fields, and especially in the
life sciences over the last twenty years, largely due to technological advances that have
significantly increased the rate at which new knowledge is generated. The addition of
this program to the MU campus should have a strong synergistic affect on other life
sciences programs as well as on certain related areas, such as Computer Science and
Statistics. It should help bring those fields into closer communication and foster valuable

What potential benefits would this program have on the State of Missouri and the
region in advancing life science research and in economic development?
Life science research is already an important economic contributor to the State of
Missouri. The State has leading academic institutions and prominent health care facilities
and a large collection of companies involved in research and development of products for
the life sciences. Informatics is becoming an increasingly important component for all of
those entities. By providing a high quality Ph.D. program in Informatics at MU, the State
will gain a valuable source of in-state trained researchers, many of whom are likely to
stay here and contribute to the field and some of whom may start new, valuable
enterprises. In addition, this program will help garner research investments in the form of
grants and contracts that will have a direct economic impact on the State, as well as
stimulate private investments in local institutions and companies. Given the growing

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importance of informatics in all areas of life sciences, I think it makes good economic
sense to initiate this program to foster the development of talent locally.

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