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					                                                                               MEMPHIS

                                                 MUSCULOSKELETAL INDUSTRY
                                                       CONNECTS PHYSICS
                                                         WITH PHYSIOLOGY
                                                                         VISION OF PROGRESS

                                            (RFID) RADIO FREQUENCY IDENTIFICATION


                                                                                S E P T E M B E R   2 0 0 4



W H E R E B I O S C I E N C E S C O M E T O L I F E . A N D T O M A R K E T.
                                                                                                                                                                                                                                                        MEMPHIS
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                                                                                                                                        5    MUSCULOSKELETAL INDUSTRY CONNECTS
                                                                                                                                             PHYSICS WITH PHYSIOLOGY



      ��������������������������������������������������                                                                                9    VISION OF PROGRESS



                                                                                                                                        11 (RFID) RADIO FREQUENCY IDENTIFICATION
One of the nation’s strongest centers for
musculoskeletal education and research:
                                                                                                                                        12 CALENDAR
Center of Excellence for Diseases of Connective Tissue,                                                                                                                                                                                                             EDITOR
                                                                                                                                                                                                                                                         Steven J. Bares, Ph.D.
housing the country’s only rheumatology                                                                                                 13 BIOSCIENCE BY THE NUMBERS
department with three NIH Center Grants for                                                                                                                                                                                                        EDITOR AT LARGE
                                                                                                                                                                                                                                                                  Virginia Steele
                                                                                                                                        14 ARKANSAS BIOVENTURES
studying connective tissue diseases; ten
                                                                                                                                           GROW BUSINESSES                                                                                     MANAGING EDITOR
patents for connective tissue research.                                                                                                                                                                                                                           Terrell Tenhet

                                                                                                                                             NATURAL PRODUCTS                                                                                           ART DIRECTOR
Department of Orthopaedic Surgery                                                                                                            RESEARCH CENTER TO EXPAND                                                                                         Craig Thompson

consistently ranked in US News and                                                                                                                                                                                                                GRAPHIC DESIGN
World Report’s Top 50.                                                                                                                  15 FROM WEST TENNESSEE                                                                                                    Sean Hufnagel

                                                                                                                                           TO WESTERN EUROPE                                                                            CONTRIBUTING WRITERS
Implant and Biomaterials Laboratory                                                                                                                                                                                         Steven J. Bares, Ph.D.               Greg Krosnes
                                                                                                                                             BUCKMAN LABS                                                                              Ralph Berry              Amy Markham
with research focusing on interactions                                                                                                       RECEIVES EPA AWARD
                                                                                                                                                                                                                                    Gary Bridgman            Barry S. Marshall
                                                                                                                                                                                                                             Dr. Walter Chambliss           Robert R. Milner, III
between bones, proteins and                                                                                                                                                                                                               Ken Hall             Dr. Tim O’Brien
biomaterials; one patent on the                                                                                                         17 BIOMEDICAL FACILITIES BY DESIGN                                                    Dr. Jamie H. Jenkins            Karen R. Watson
                                                                                                                                                                                                                                         Kim Kent
modification of implant surfaces.
                                                                                                                                        19 LOCAL TRANSPLANTS                                                                                          PHOTOGRAPHY
                                                                                                                                           FORECAST TO DOUBLE                                                                                                 Thurman Hobson
New drug development to improve                                                                                                                                                                                                                              Christopher Reyes

muscle growth, prevent muscle wasting,                                                                                                       RESEARCH FOR SAFER FOODS                                     BioWorks covers bioscience news and information in the Memphis Region.
and strengthen bones in men as they age.                                                                                                                                                                  BioWorks is published quarterly for the Memphis Biotech Foundation and
                                                                                                                                                                                                                                                the Memphis Regional Chamber by:
                                                                                                                                        21 GTX’S STOCK PUSHES AGAINST
                                                                                                                                                                                                                                   THOMPSON PHILIPS CUSTOM PUBLISHING
Doctorate degree in physical therapy offered.                                                                                              MARKET UNCERTAINTY                                                                         50 Peabody Place Memphis, TN 38103
                                                                                                                                                                                                                               Phone: (901) 251-5188 - Fax: (901) 527-3697
                                                                                                                                        22 THIRD-GENERATION                                                                                       www.thompsonphilips.com
Master’s degree in occupational therapy                                                                                                    FRACTURE PRODUCTS                                                                                 MEMPHIS BIOTECH FOUNDATION
providing students unique opportunities to work                                                                                                                                                                                                       Steven J. Bares, Ph.D.

with homeless through grant-sponsored program.                                                                                          23 NEW LEADERS FOR NEW SCHOOLS
                                                                                                                                                                                                                                               President and Executive Director

                                                                                                                                                                                                                                                      Jeni Stephens Thompson
                                                                                                                                                                                                                                        Director of Marketing and Development
                                                                                                                                        24 CAREER OPPORTUNITIES

                          www.utmem.edu
                                                                                                                                                                                                                                              MEMPHIS REGIONAL CHAMBER
                                                                                                                                                                                                                                                           R. Marc Jordan
                                                                                                                                                                                                                                                       CCE, President and CEO
                                                                                                   A NOTE FROM STEVEN J. BARES                                                                                                                                    Mike Demster
      The University of Tennessee is an EEO/AA/TitleVI/Title IX Section 504/ADA/ADEA institution                                                                                                                             Vice President BioMedical Business Development
               in the provision of its education and employment programs and services              Welcome to the September issue of the Memphis      from logistics to hospital rooms to grocery bags.
                                                                                                   Bioworks Magazine. This magazine is intended       Finally, we would like to commend Buckman                                                                PUBLISHER
                                                                                                                                                                                                                                                                  Robert Philips
                                                                                                   to communicate the broad range of research,        Labs for their winning of the Presidential Green
                                                                                                   education and commercial programs in the bio-      Chemistry Challenge Award for the company’s         BioWorks contains divergent ideas and opinions from a variety of
                                                                                                   sciences within the Memphis region. Our cover      Optimyze® technology.                               industries and sources within the region which may not necessarily
                                                                                                   story focuses on the business of Musculoskeletal                                                       represent the views of the Memphis Biotech Foundation, the Memphis
                                                                                                                                                      We appreciate you reading this issue and look                                       Regional Chamber, or the publisher.
                                                                                                   and the October Musculoskeletal New Ventures
                                                                                                                                                      forward to contributions of articles, content and
                                                                                                   Conference held in Memphis (mnvc.org). We
                                                                                                                                                      suggestions for this magazine. Please send your                                  PRINTING BY STARR TOOF
                                                                                                   also examine the emerging technology of RFID,
                                                                                                                                                      ideas to the editor, Memphis Bioworks Magazine,
                                                                                                   an important advance penetrating everything
                                                                                                                                                      50 Peabody Place, Memphis TN 38103.
                                                                                                                                                                                                                                         COVER STORY                                               5




                                                                                                                                                                                                                                                                                          Musculoskeletal Indust r y Connects Physics with Physiology
                                                                                                                                                                                       MUSCULOSKELETAL INDUSTRY
                                                                                                                                                                                       CONNECTS PHYSICS
                                                                                                                                                                                        WITH PHYSIOLOGY
                                                                                                                                                                                                                     The 2nd Annual Musculoskeletal
                                                                                                                                                                                                                      NEW VENTURES CONFERENCE
                                                                                                                                                                                       Gathers the Best Minds from Across the Globe

                                                                                                                                                                                       BY RALPH BERRY                                     “Formal goals aside, the October conference
                                                                                                                                                                                       President, Thompson, Baker & Berry                 is a way for leaders from around the world
                                                                                                                                                                                       Public Relations                                   to witness and experience all that is hap-
                                                                                                                                                                                                                                          pening in Memphis,” says Gary Stevenson,
                                                                                                                                                                                       It’s difficult to say just when Memphis’           chairman of this year’s conference and man-
                                                                                                                                                                                       leadership in the musculoskeletal industry         aging partner of MB Venture Partners, a
                                                                                                                                                                                       was first established. Some feel the city’s        Memphis-based venture capital firm that




                                                                                                                                                                                                                                                                                                     BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
                                                                                                                                                                                       role in the industry can be traced back to         provides growth capital and strategic direc-
                                                                                                                                                                                       the publishing of Dr. Willis Campbell’s first      tion to life sciences companies.
                                                                                                                                                                                       orthopedic surgery textbook in 1939. Some
                                                                                                                                                                                       feel it was the launch of Richards Medical         “Last year was an opportunity for Memphis
                                                                                                                                                                                       more than 50 years ago. Still others feel it       to openly declare our position as a national
                                                                                                                                                                                       isn’t any one event, but the convergence           center for musculoskeletal research and
                                                                                                                                                                                       of medical device companies, clinical prac-        commercialization. This year, instead of
                                                                                                                                                                                       tices, medical training facilities, bio-medical    having to prove our position, we can build
                                                                                                                                                                                       venture capital and international distribu-        on our strengths and further establish an
                                                                                                                                                                                       tion leadership that has progressed steadily       image of leadership in thinking, research,
                                                                                                                                                                                       over decades in the city.                          management excellence and financial

�����������                                                                                                                                                                            No matter what date you select as when
                                                                                                                                                                                                                                          wherewithal,” says Stevenson.
                                                                                                                                                                                                                                          Jacqueline Eastwood, president and CEO
                                                                                                                                                                                       Memphis became a player, its leadership
                                                                                                                                                                                       today cannot be questioned. And, perhaps           of TissueLink Medical Inc. of Dover, New
                                                                                                                                                                                       no single event better exemplifies that than       Hampshire, attended the 2003 conference
��������������������������������������������������������������������������������������������������������������������������
                                                                                                                             A surgeon holds a Smith & Nephew Synergy hip with         the second annual Musculoskeletal New              and came away sold on both Memphis and
��������������������������������������������������������������������������������������������������������������������                                                                                                                      new business.
                                                                                                                             an Oxinium™ femoral head. Oxinium™ oxidized               Ventures Conference being held in Memphis
�����������������������������������������������������������������������������������������������������������������������                                                                October 6 and 7, 2004.                             “When we were invited to the confer-
������������������������������������������������������������������������������������������������������������������������     zirconium is the name of the material, and it is now
                                                                                                                                                                                                                                          ence, we already knew Memphis as a music
                                                                                                                                                                                       The goals of the musculoskeletal conference
��������������������������������������������������������������������������������������������������������������������������   being used in hip and knee replacements. Because of
                                                                                                                                                                                                                                          mecca as well as a medical device mecca,”
                                                                                                                                                                                       are simple. As described in the conference
                                                                                                                             its superior hardness, smoothness and resistance to
                                                                                                                                                                                       website, the conference is designed to:            explained Eastwood. “These impressions
�������������������������������������������������������������������������������������������������������������                scratching and abrasion, you can expect an Oxinium                                                           were more than reinforced by what we saw.
                                                                                                                                                                                        • Provide strategies for entre-                   But more than that, we learned just how
                                                                                                                             replacement to be long-lasting and allow you to
                                                                                                                                                                                          preneurs to increase access in                  multi-dimensional this community is from
�������������������������������������������������������������������������������������������������������                      resume normal activities with less fear of undergoing a                                                      both a medical and business perspective. We
                                                                                                                                                                                          building new biomed ventures.
                                                                                                                                                       repeat replacement surgery.                                                        found that Memphis has it all: medical and
                                                                                                                                                                                        • Offer insights to prospective entre-            bio-engineering excellence, financial oppor-
                                                                                                                                                                                          preneurs considering a new venture.             tunity, surgical leadership, and distribution
                                                                                                                                                                                        • Afford entrepreneurs a focused                  leadership.”
                                                                                                                                                                                          forum for raising venture capital.
                  6                                                                                   COVER STORY                                                                                                                                                                                                                                                COVER STORY                                                   7




                                                                         TissueLink, which produces radio frequency tissue                            a 44 percent rise in employment
                                                                                                                                                                                                                                                                                                                   THE BUSINESS OF
Musculoskeletal Indust r y Connects Physics with Physiology




                                                                         sealing devices that prevent or diminish bleeding                            from 1995 to 2002 in the region,
                                                                                                                                                      far outpacing the national growth
                                                                         during surgery, picked up immediate business
                                                                                                                                                                                                                                                                                                                   MUSCULOSKELETAL
                                                                                                                                                      rate of 14 percent.
                                                                         Through contacts made with surgeons during the
                                                                                                                                                      The Battelle study points to
                                                                         conference, TissueLink participated in five surgeries                        three critical areas related to the
                                                                         the next day, all new business for the company.                              medical device business. One                                                                Memphis-based Semmes-Murphey Neurologic and Spine

                                                                                                                                                      is orthopedic firm leadership,                                                              Institute’s 44 physicians are world recognized for their         The term “Musculoskeletal” may be hard to say but its meaning is straightforward.
                                                                         And, following a tour of the
                                                                         Medical Education Research
                                                                                                               Institute of Cleveland, Ohio,          including two of the top ten                                                               Global Musculoskeletal Market
                                                                                                                                                                                                                                                 excellence in neurosurgery, neurology, neuropsychology,
                                                                                                                                                                                                                                                                                                         Musculoskeletal describes the system of muscles, tendons, ligaments, bones, joints and
                                                                                                               Memphis is well positioned for         global companies in orthopedics                                                                                                                    associated tissues that move the body and maintain its form. From a market perspective, the
                                                                         Institute (MERI), Eastwood felt       lasting leadership in musculosk-       – Medtronic Sofamor Danek
                                                                                                                                                                                            Founded in 1909, Campbell Clinic is a                                           physiatry, and pain management.
                                                                                                                                                                                                                                                                                                         industry is an approximately $17 billion market growing at a double digit rate (See table).
                                                                         confident the company would be        eletal and other bioscience areas.     and Smith & Nephew.                   world leader in sports medicine, pedi-                                                                       The musculoskeletal industry may be considered in six categories as defined below:
                                                                                                                                                                                                                                                                               Approximately $15 Billion Market
                                                                         coming to Memphis often to use        But, it is the medical device and                                            atric orthopaedics, joint replacement,




                                                                                                                                                                                                                                                                                                                                                                                                                          The Business of Musculoskeletal
                                                                                                                                                                                                                                                                                                           20%
                                                                         the MERI laboratory and other                                                Another leading company in                                                                                                     26%
                                                                                                                                                                                                                                                                                                                 • Reconstructive devices refer to hips, knees, shoulders, elbows, wrists,
                                                                                                               related businesses where Memphis
                                                                         facilities to train surgeons to use                                          Memphis is Wright Medical. In         physical medicine and rehabilitation,
                                                                                                               has world-class status. According                                                                                                                                                                    ankles and implants.
                                                                         their products. She returns to the                                           fact, Memphis’ device leadership      orthopaedic oncology and surgery of
                                                                                                               to the Battelle study, medical                                                                                                                                                                    • Fracture Fixation describes internal (plates, screws, intramedullary nails, pins,
                                                                         conference this year as a speaker.                                           can be traced back more than                                                                BELOW–The Medical Education & Research Institute
                                                                                                               device businesses employ 2,967                                               the hand, hip, foot, knee, shoulder and                                                9%
                                                                                                                                                                                                                                                                                                             19%
                                                                                                                                                                                                                                                                                                                    wires) fixation and external fixation products.
                                                                                                                                                      50 years to Richards Medical                                                                (MERI), an independent, not-for-profit education and
                                                                         The positive impressions of           workers across 54 establishments                                             spine. Chief Operating Officer Paige C.                                                                              • Arthroscopy/Soft Tissue Repair- Arthroscopy refers to the equipment required
                                                                                                                                                      Company, the organization that
                                                                         Eastwood and the confident nature     in the Memphis region, with a                                                                                                                                          12%
                                                                                                                                                                                                                                                  research facility, hosts research and educational programs
                                                                                                                                                                                                                                                                                                                    for minimally invasive operation to repair a damaged joint such as scopes, cameras,
                                                                                                                                                                                                                                                                                                      14%
                                                                                                                                                      proved to be the genesis for much     LeMay and surgeon G. Andrew Murphy,
                                                                         of Stevenson are both well found-     concentration of activity that is 59                                                                                               for individual researchers and medical device companies.
                                                                                                               percent higher than the national
                                                                                                                                                      of the industry today.                M.D., review patient images using the                                                                                   instruments, soft tissue implants and repair kits.
                                                                         ed. According to a 2003 research                                                                                                                                                            Knees Hips Spine Trauma Arthroscopy Other

                                                                                                               average. In addition, there was        CONTINUED PAGE 8
                                                                                                                                                                                                                                                  In addition to the main anatomical lab where most courses      • Spinal Implants/Instrumentation are internal fixation devices and discectomy
                                                                         study by the Battelle Memorial                                                                                     clinic’s digital x-ray system.
                                                                                                                                                                                                                                                 As the populationoffers four private labs/surgical suites.         and vertebroplasty/kyphoplasty products.
                                                                                                                                                                                                                                                       are held, MERI ages and people expect to maintain an active lifestyle, the
                                                                                                                                                                                                                                                 musculoskeletal and related industries will continue to grow. • Orthobiologics are bone graft substitutes, allograft distribution/processing,
                                                                                                                                                                                                                                                                                                                    autogenous bone and soft tissue placement products and viscoelastics.
                                                                                                                                                                                                                                                                                                                 • Other products include power equipment, casting materials, soft goods, bracing
                                                                                                                                                                                                                                                 $14                                                     18%        systems, bone growth stimulators, craniomaxillofacial fixation products,
                                                                                                                                                                                                                                                                                                         16%        diagnostics, cement and cement mixing/delivery systems, infection control
                                                                                                                                                                                                                                                 $12
                                                                                                                                                                                                                                                                                                         14%
                                                                                                                                                                                                                                                                                                                    equipment, pulsed lavage/irrigation systems, continuous passive motion
                                                                                                                                                                                                                                                                                                                    machines, and image-guided surgery systems.
           BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |




                                                                                                                                                                                                                                                                                                                                                                                                                                BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
                                                                                                                                                                                                                                                 $10
                                                                                                                                                                                                                                                                                                          12%
                                                                                                                                                                                                                                                  $8




                                                                                                                                                                                                                                      Billions
                                                                                                                                                                                                                                                                                                          10%

                                                                                                                                                                                                                                                  $6                                                      8%                                                                                           CHANGE
                                                                                                                                                                                                                                                  $4
                                                                                                                                                                                                                                                                                                          6%             PRODUCT SEGMENT                        U.S.       EX-U.S.       TOTAL         VS. 2001
                                                                                                                                                                                                                                                                                                          4%
                                                                                                                                                                                                                                                  $2
                                                                                                                                                                                                                                                                                                                         Reconstructive Devices                  3.23         2.96          6.19           13.9
                                                                                                                                                                                                                                                                                                          2%

                                                                                                                                                                                                                                                  $0                                                      0%                  Fracture Repair                    0.97         0.89         1.86            13.5
                                                                                                                                                                                                                                                       1994   1996   1998     2000     2002    2004
                                                                                                                                                                                                                                                                                                                    Arthroscopy | Soft Tissue Repair             1.04         0.50         1.54            12.4
                                                                                                                                                                                                                                                                 Revenues            Yr/Yr Growth
                                                                                                                                                                                                                                                                                                                    Spinal Implants Instrumentation              1.64         0.73         2.37            25.7
                                                                                                                                                                                                                                           Revenues musculoskeletal industry have increased a double-
                                                                                                                                                                                                                                          Revenues in thein the musculoskeletal industryathave increased at a double-digit rate for the last
                                                                                                                                                                                                                                                                                                                         Orthobiologics
                                                                                                                                                                                                                                                 decade, with certain niches like spine (20-30% growth) and biologics (25-30% growth)                            0.97         0.34         1.31            14.0
                                                                                                                                                                                                                                          digit rate for the last decade, with certain niches like spine (20-30%
                                                                                                                                                                                                                                            showing particular strength.
                                                                                                                                                                                                                                          growth) and biologics (25-30% growth) showing particular strength.                   Other Products                    2.67         1.17         3.84            16.8

                                                                                                                                                                                                                                                                                                                             TOTAL MARKET                     $10.52        $6.60        $17.12          15.9%

                                                                                                                                                                                                                                                                                                                   2002 MUSCULOSKELETAL WORLDWIDE PRODUCT SALES: BY MARKET SEGMENT AND GEOGRAPHIC REGION ($ BILLIONS)



                                                                                                                                                                                                                                                                                                                   For most of us, “musculoskeletal” simply refers to the pain in the neck or the joint when we over-
                                                                                                                                                                                                                                                                                                                   exert. However for many, it is the vital reconstruction of a failed hip or damaged disk in the back.
                                                                                                                                                                                                                                                                                                                   Years ago, back operations to repair a damaged disk could take hours in the operating room and
                                                                                                                                                                                                                                                                                                                   months to recover. Today, with new arthroscopic techniques and artificial disks, success rates are
                                                                                                                                                                                                                                                                                                                   higher and recovery rates take only weeks. The musculoskeletal products market is driven by an
                                                                                                                                                                                                                                                                                                                   aging global population and tremendous innovation in the field. Prospects for the industry are
                                                                                                                                                                                                                                                                                                                   for continued growth, fueled by new materials that promote bone regeneration, prevent infection
                                                                                                                                                                                                                                                                                                                   and speed the repair and recovery process. The prognosis for the musculoskeletal industry sug-
                                                                                                                                                                                                                                                                                                                   gests that growth is on the horizon, good news for those of us that are getting older!

                                                                                                                                                                                                                                                                                                                     INSERT BY STEVEN J. BARES, PH.D, Executive Director and President, Memphis Biotech Foundation
                                                                                                                                                                                                                                                                                                                                              and KAREN R. WATSON, Consultant
                                                                                                                                                                                                                                                                                FACILITIES                                                           9



                                                                                                                                                              VISION OF PROGRESS
                                                                                                                                                              BY RALPH BERRY, President; AMY MARKHAM, Account Executive; Thompson, Baker & Berry Public Relations
                                                                                                                                                              Memphis’ medical facilities and educational opportunities related to eye care are among the newest and most
                                                                                                                                                              advanced in the country. Between the Southern College of Optometry and the Hamilton Eye Institute at the University of
                                                                                                                                                              Tennessee Health Science Center, the medical community has made a tremendous investment over the last several years.


                                                                                                                                                          1                                                                                                       3. Inside The Eye Center at Southern College of Optometry is a

                                                                                                                                                                                                                                                                  beautiful, full-service optical store with an array of eye wear for every

                                                                                                                                                                                                                                                                  face, purpose and budget.

                                                                                                                                                                                                                                                                  4. The Eye Center at Southern College of Optometry is equipped with 69 exam

                                                                                                                                                                                                                                                                  rooms and staffed by 45 doctors of optometry and 3 ophthalmologists to

                                                                                                                                                                                                                                                                  provide patients with quality, comprehensive eye care in a timely manner.

                                                                                                                                                                                                                                                                  5. The $7.1 million Eye Center at Southern College of Optometry,

                                                                                                                                                                                                    1,2. The Hamilton Eye Institute in Memphis cel-               located at 1225 Madison Ave. in Memphis, opened in September 2002.




                                                                                                                                                                                                                                                                                                                                                    Vision of Progress
                                                                                                                                                          2                                                                                                       The new facility is equipped with the latest technology to aid in the
                                                                                                                                                                                                    ebrated completion of the first phase of their new

                                                                                                                                                                                                    facilities in May of 2004, which include research             diagnosis and treatment of eye and vision problems. The Eye Center

                                                                                                                                                                                                    and administrative areas. The Hamilton Eye Institute          annually serves over 70,000 patients of all ages.

                                                                                                                                                                                                    is ranked eighth in the nation for clinical care. World

                                                                                                                                                                                                    class research facilities allow Dr. Eldon Geisert Jr.
                                                                                                                                                                                                                                                              3
                                                                                                                                                                                                    and others to compete on a national basis.




                                                                                                                                                                                                                                                                                                                                                       BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
COVER STORY (continued from page 6)

A second area of leadership is clinical. Led by Campbell Clinic              “We have put together an agenda that cannot be ignored, whether you
Orthapaedics, Memphis is well known for the excellence of its orthope-       are seeking funding for your work, whether you are looking for invest-
dic clinical activities, according to the study.                             ment opportunities, or whether you want to keep abreast of the latest
                                                                             trends, technologies and advances in the industry,” says Stevenson. “The
The Campbell’s Operative Orthapaedics textbook, first published in                                                                                                                                                                                            4
                                                                             venture capitalists will be attending to hear from leaders of such innova-
1939 and now in its 10th revision, is the standard for most students.
                                                                             tive companies as AxioMed, BioMimetric Pharmaceuticals, St. Francis
Students not only read the book, they also seek out Memphis for their
                                                                             Medical Technologies and TissueLink. Meanwhile, the scientists and
education. Orthopedic residency programs in Memphis are large, and are
                                                                             entrepreneurs will be particularly interested in hearing speakers from
a much higher percentage than found across the nation.
                                                                             Smith & Nephew, Medtronic, JP Morgan and Semmes-Murphy.”
Adding to the clinical position are Semmes Murphy Neurologic and
                                                                             The schedule also features panel discussions with venture capitalists,
Spine Institute, one of the nation’s leading practices for neurological
                                                                             Wall Street analysts and surgeons. Jerry West, President of basketball
and spine disorders, and the Medical Education and Research Institute
                                                                             operations for the Memphis Grizzlies, will be the keynote speaker, deliv-
(MERI), founded in 1995 as a leading center for training physicians and
                                                                             ering his address from the FedEx Institute of Technology on the campus
medical students in surgical techniques for medical implants. Some
                                                                             of the University of Memphis.
2,000 surgeons a month come to Memphis for training involving new
and emerging therapies.                                                      Complete information on the conference can be found at www.mnvc.org.
                                                                             And, for those who still know Memphis more for its music than for its
The third area of critical importance to the region’s position is research
                                                                             medical leadership, the opening reception will take place at the Gibson
and development activity. While the Battelle study identified this area
                                                                             Guitar Lounge, one block away from historic Beale Street. Entertainment
to be weaker compared to the tremendous research track record in such
                                                                             for the event will be provided by the Beale Street Biomed Blues Band.
areas as cancer, cardiovascular disease and pediatrics, it is a growing
opportunity for Memphis. The Center for Biosurfaces at University of         “After all,” says Stevenson. “This is Memphis. Where else can you
Memphis has a growing strength in innovative biomaterials. And, MERI         say both biomedicine and the blues in the same sentence…and still
has unique opportunities for R&D as it relates to implant testing.           be taken seriously?”
With an aging population that expects to stay physically active later in
life, the orthopedic and other musculoskeletal-related business needs will
only expand in the future. That expectation is why the musculoskeletal
conference is so important.

                                                                                                                                                                                                                                                                                                                                                5
                                                                                                   TECHNOLOGY                                                                11



(RFID) RADIO FREQUENCY
IDENTIFICATION Evolving New Applications
               AN OLD TECHNOLOGY

BY ROBERT R. MILNER, III
Supply Chain Consultant with NCR Systemedia

Although you may not realize it, you probably have used RFID. Radio         Starting in the supply chain, RFID will have a huge effect on many
Frequency Identification (RFID) has thousands of applications. It           different industries. Companies, especially here in Memphis, must
is used to track cattle and identify cats and dogs. ExxonMobils’            begin educating themselves on how RFID can improve their business
SpeedPass has a microchip embedded in it that is identified with            processes. Memphis, the distribution center of the United States will




                                                                                                                                                                             Radio Frequency Identi fication
radio frequencies. Toll booths and security systems use RFID tags on        be strongly affected by this rapidly evolving technology.
cars and in ID badges. FedEx uses RFID in some of their trucks.

Radio Frequency Identification is the process of using radio waves
to transmit and capture information. A microchip with an antenna
can be read without line of sight or contact. For example, a computer
chip, the size of a grain of sand, can be attached to a dog and read
with a radio frequency.

RFID is not a new technology; it was invented in 1948. It was first
used in “Friend or Foe” systems to identify aircraft in World War II.                                                         Alien Technology Radio Frequency Chip.


“Baptist Memorial Hospital for Women has been using Radio frequency in patient care to provide a safe
environment (infant security) for their moms and babies since 1998. Upon moving to the new facility in
May 2001, the technology was enhanced to allow for better tracking and trending and provide an even
safer environment for their patients.” SHANNON HARRIS, CHIEF NURSING OFFICER - BMHCC




                                                                                                                                                                                   BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
Radio Frequency Identification has been a hot topic recently because            The Council of Logistics Management Mid-South Regional Roundtable is hosting
Wal-Mart and the Department of Defense are requiring top suppliers              a RFID Seminar. The objective of the Radio Frequency Identification seminar is to
to start using RFID. Their goal in using this technology is to signifi-
cantly reduce their costs in their supply chain, ideally by as much             provide an opportunity for the logistics and supply chain management professionals in

as 6 to 7%. This calculation is based on the more accurate storing,             the Memphis(Mid-South) area to learn more about RFID technology and its impact on
transporting, and tracking of goods. Over the next couple of years,             manufacturing, retail and logistics. You will have the opportunity to hear from several
suppliers must apply RFID labels to pallets and cases being shipped
                                                                                industry speakers and a panel of experts regarding their experiences using the RFID
to Wal-Mart and the DOD. Eventually labels will be inexpensive
enough to use at the product level. These mandates have spurred                 technology and why they are moving forward with this initiative. There will be speakers
lively discussion about this technology. Many different industries,             from the following companies: NCR, International Paper, GlobeRanger, Red Prairie, and
including biotechnology and pharmaceutical companies, are using
                                                                                Intermec, just to name a few. In addition to the speakers, we will have several demo areas
and experimenting with RFID.
                                                                                for you to see the latest technology and to ask questions of the demonstrators.
In April, Alien Technology successfully completed a RFID trial at the
Trauma Emergency Department at the Shelby County Regional Medical
Center. The MED used RFID to track patients as they were moved                  Event: CLM Mid-South Regional Roundtable RFID Seminar
through the hospital. The military already uses RFID to track patients in       Date: September 15, 2004
its hospitals, and they track 300,000 containers in their supply chain.         Time: Registration 8:30am and Wrap-up at 1:30pm

                                                                                Location: Holiday Inn at the University of Memphis
Counterfeit drugs cost pharmaceutical companies hundreds of mil-
lions of dollars each year. The FDA approves and recommends RFID                Cost: $50 if registering in advance or $75 at the door
as an effective way to track and secure the global supply chain.                Register: www.clmmemphis.org
Pharmaceutical companies plan to have widespread use of RFID
on the case and pallet level in the next few years. With such high
                                                                                For further information please contact:
profit margins and strict regulations, pharmaceutical companies will
probably have item-level tagging by 2008. They will be the first com-           Robert R. Milner, III - NCR Corporation - Mid-South
panies to have widespread use of RFID at the item level.                        901-327-2872 | robert.milner@ncr.com




WEBSITES ON RFID: epcglobalinc.org | rfidjournal.com | usingrfid.com | rfidnews.org
                                                                                                                          BIOSCIENCE BY THE NUMBERS                                                              13
                             S E P T E M B E R

                                 September 24 & 25
                                    Topics in Pediatrics
                                 Memphis Marriot Hotel
                   www.stjude.org/physiciansconference

                       September 21 | 3:30 PM
   BioWorks Marketing and Communications Meeting
      Lobby Conference Room: Saint Francis Hospital

                                 September 21-24
4TH Virtual Conference on Genomics & Bioinformatics
                  “Sharing Knowledge with the World”
                            www.VirtualGenomics.Org

                               September 23 & 24
           8th Annual Tennessee Valley Venture Forum
                       Chattanooga Convention Center
                              Chattanooga, Tennessee
                                         www.tvvf.biz                                                                     BY KIM KENT, BUSINESS ANALYST, MEMPHIS REGIONAL CHAMBER
                  September 29 | 5:30 - 7:30 PM
           Money in Your Mouth Mixer: Rooftop Party                                                                       More than 1,200 bioscience-related patents were issued to researchers
          Sponsored by: Memphis Technology Council                                                                        from the Memphis area between 1979 and 2003. Of these, about 42
     and the Memphis BioWorks Development Council
                                                                                                                          percent were issued in the last five years alone, nearly 75 percent in the




                                                                     CALENDAR
             The Madison Hotel : 79 Madison Avenue
                                Memphis, TN 38103                                                                         last ten years.

                                        O C T O B E R                                                                     The Memphis area has 48 intellectual property lawyers and 77 lawyers
                                     October 6 & 7                                                                        specializing in the field of healthcare.
             Musculoskeletal New Ventures Conference
                         FedEx Institute of Technology                          According to the Battelle study–          The National Institutes of Health awarded more than $105 million to
                                 365 Innovation Drive
                                                                                Strategy for Realizing Memphis’           Memphis area research in 2003 – more than doubling the funds awarded




                                                                                                                                                                                                                  BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET.
                            Memphis, TN 38152-3115
                                        www.mnvc.org                                                                      ten years before in 1994. In the last five years (1999-2003), the total
                                                                                Bioscience Future – Memphis outpaced
                                                                                                                          dollar amount of NIH awards to Memphis area research has nearly doubled.
                                   October 16-18                                the nation’s growth in NIH funding
              Biomaterials in Regenerative Medicine:
                The Advent of Combination Products
                                                                                between 1991 and 2001 – 72% versus        Funding has not simply gone to universities and research powerhouses
               Franklin Plaza : Wyndam, Philadelphia                            42% growth respectively. This places      like St. Jude Children's Research Hospital. Between 1992 and 2003,
       www.biomaterials.org/Meetings/Oct04Meeting/                                                                        NIH awarded private Memphis research and development companies like
                                Oct04mtg_index.htm                              Memphis sixth nationally in terms on
                                                                                                                          Molecular Design International and GTx more than $6 million.
                                                                                funding growth; “biosciences is the
                                           October 27
                               Bioworks Speaker Series                          fastest growing industry in the Memphis   Between 1998 and 2004, bioscience companies relocating or expanding
                   Barry Fortner, Ph.D. (The West Clinic)
                                                                                regional economy.”                        in the Memphis area have made capital investments exceeding $2.3 billion
                                          Location : TBA
                                                                                                                          and have created more than 9,000 new jobs.
                                   N O V E M B E R
                                                                                                                          Six of the top twenty global biotech and pharmaceutical companies have
                                        November 5
                         Bioimaging Symposium 2004                                                                        operations in the Memphis region including Johnson & Johnson, Pfizer,
                  St. Jude Children’s Research Hospital                                                                   Schering-Plough, Baxter International, Syngenta AG, and Monsanto.
                                  Memphis, Tennessee
                  www.bioimagingsymposium2004.com
                                                                                                                          Established in 1911 the University of Tennessee at Memphis is one of only
                                       November 24                                                                        125 accredited M.D.-granting medical schools in the United States. The
                               Bioworks Speaker Series                                                                    average UT med school applicant has an MCAT score of 30 and a GPA of
                    Robert K. Heck, MD (Cambell Clinic)
                                                                                                                          3.7, comparing favorably to a national medical school average MCAT of
                                        Location : TBA
                                                                                                                          27.1 and GPA of 3.47. The UT med school has about 2,000 students.
To Submit an Event, contact Greg Krosnes: Memphis Bioworks Development
       Council, Memphis Regional Chamber of Commerce, 901-543-3567
                               GKROSNES@ MEMPHISCHAMBER.COM
                                                                                                                                                                                 B   I   O   W   O   R   K   S   13
  14                                                                                                  REGIONAL UPDATES                                                                                                                                                                                         REGIONAL UPDATES                                                            15




                                                                                         ARKANSAS BIOVENTURES                                                                                                                                      FROM WEST TENNESSEE




                                                                                                                                                                                                                                                                                                                                                                       T E N N E S S E E
                                                                 A R K A N S A S




                                                                                         GROW BUSINESSES                                                                                                                                             TO WESTERN EUROPE
                                                                                                                                                                                                                                                                 Representatives of both Memphis and Nashville
                                                                                         BY DR. TIM O’BRIEN
                                                                                         Director, University of Arkansas for Medical Science
                                                                                                                                                                                                                                                                 are spending time with European peers this year.
                                                                                                                                                                                                                             Earlier in the year, Mike Demster, vice president for the           The Nashville Health Care Council and the Nashville Area
                                                                                         The College of Medicine at the University of Arkansas        several UAMS patents developed by Daniel Eaton while                   Memphis BioWorks Development Council, visited two of                Chamber of Commerce are planning the fifth annual Health
                                                                                         for Medical Sciences (UAMS) established the Biomedical       working as a member of the faculty in otolaryngology.                  Germany’s leading clusters, North Rhineland Westphalia and          Care Trade Mission to Budapest, Hungary and Prague, Czech
                                                                                         Biotechnology Center (BBC) as the university’s intellectual                                                                         Baden Wurtenburg. The talks were intended to stimulate col-         Republic, scheduled for September 26 - October 1, 2004.
                                                                                         property management center in 1994. In March 1997 the BBC    Since 1997, 17 new UAMS life science-based companies have              laborative efforts between Memphis and the German clusters,
                                                                                         launched UAMS Arkansas BioVentures (ABV), Arkansas’          been identified. Eleven of these companies are operational                                                                                 During the mission, the delegation of senior health care exec-
                                                                                                                                                                                                                             and were the first stage of a broader plan to establish closer
                                                                                         only biomedical business incubator. In that same month,      and five are in ABV’s startup pipeline.                                                                                                    utives from Nashville and elsewhere in the U.S. will meet with
                                                                                                                                                                                                                             ties to the European bioscience community.
Regional Updates




                                                                                                                                                                                                                                                                                                                                                                                           Regional Updates
                                                                                         ABV supported the incorporation of UAMS’ first biomedical/                                                                                                                                              top-level Hungarian and Czech health care policy makers,
                                                                                         biotechnology startup company,                                                                                                      “BioWorks Development Council members now have access to            senior health ministry officials, key industry leaders, industry
                                                                                         ContourMed, Inc. This company ABV offers its client companies access to many university resources                                   a dedicated European business consultant,” said Mike Demster,       analysts, and U.S. ambassadors and commercial staff.
                                                                                         designs, manufactures and and a new 16,500 square foot incubator facility. The client company                                       VP of the Council. “We are planning for joint discussions
                                                                                                                                                                                                                                                                                                 Mission delegates will have the benefit of top-level briefings,
                                                                                         markets anatomically accurate                                                                                                       and missions to exchange ideas and identify opportunities
                                                                                                                                                                                                                                                                                                 as well as dialogue on common health care challenges and
                                                                                         external custom breast prosthesis. support in this facility includes an office, wet lab, access to Arkansas’                        for collaborations in biotechnology.” Continuing with such
                                                                                                                                                                                                                                                                                                 business models.
                                                                                         These products are based on                                                                                                         outreach, in October Demster will be hosting Belgian biotech
                                                                                                                             first cGMP laboratory, and many of UAMS’ support services.                                      officials in Memphis.                                               Contributions from CAROLINE YOUNG, Nashville HealthCare
                                                                                                                                                                                                                                                                                                 Council, and KEN HALL, Memphis Regional Chamber
   BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |




                                                                                                                                                                                                                                                                                                                                                                                              BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
                                                                                         NATURAL PRODUCTS                                                                                                                                                     BUCKMAN LABS
                                                                 M I S S I S S I P P I




                                                                                         RESEARCH CENTER TO EXPAND                                                                                                                                       RECEIVES EPA AWARD
                                                                                         BY DR. WALTER CHAMBLISS                     scientists, faculty, staff and students.   clinical trials include an adjunct therapy   Buckman Laboratories recently was awarded the United States Environmental Protection
                                                                                         Associate Director, National Ctr.           A second facility is being designed        for multiple sclerosis, an improved oral
                                                                                                                                                                                                                             Agency’s Presidential Green Chemistry Challenge Award for the company’s Optimyze® tech-
                                                                                         for Natural Products Research,              to provide for continued expansion.        care delivery system and an improved
                                                                                                                                     Partnerships have been established         antifungal combination therapy;              nology, an enzymatic product for the removal of waste products in recycled paper.
                                                                                         University of Mississippi
                                                                                                                                     with the USDA, FDA, CDC, NIH and           potential new drugs for cancer and
                                                                                         The National Center for Natural             many universities and non-profit insti-    malaria are in preclinical development.      As the demand for recovered         Optimyze is a unique enzyme     novative developments in and       the goal of pollution preven-
                                                                                         Products Research (NCNPR) was               tutions around the world. Collaborative
                                                                                                                                                                                The economic impact of the NCNPR             fiber rises, the quality of prod-   technology that replaces haz-   uses of green chemistry for        tion. The EPA’s Office of Pol-
                                                                                         opened at the University of Mississippi     research is ongoing with startup and
                                                                                                                                                                                includes not only the increase of            uct inevitably deteriorates ev-     ardous chemistries and makes    pollution prevention through       lution Prevention and Toxics
                                                                                         School of Pharmacy in 1995. It is one       multibillion dollar pharmaceutical and
                                                                                                                                                                                NCNPR/USDA researchers from 25               ery time it is reused. Recycled     the use of recycled paper       an EPA partnership with the        leads the voluntary partner-
                                                                                         of two centers within the Research          agrochemical companies, as well as
                                                                                                                                                                                in 1995 to 120, but also the attrac-         paper systems contain de-           more attractive to industry.    chemistry community. The           ship program with other EPA
                                                                                         Institute of Pharmaceutical Sciences.       with the other research universities in
                                                                                                                                                                                tion of companies. Two pharmaceutical        posits called stickies that are     Optimize technology pre-        Challenge Award Program            offices, other federal agencies,
                                                                                         It was created to be a partnership of the   Mississippi and the region.
                                                                                                                                                                                companies are located in Oxford and dis-     composed of adhesives and           miered in May 2002 and was      gives national recognition to      members of the chemical in-
                                                                                         School of Pharmacy, the federal and
                                                                                                                                     The NCNPR/School of Pharmacy               cussions are ongoing for the relocation      other organic contaminants.         in development in Buckman’s     outstanding chemical tech-         dustry family, trade associa-
                                                                                         state governments, and private entities
                                                                                                                                     patent portfolio includes more than 30     or start-up of four additional companies.    These stickies produce an           research and development        nologies that incorporate          tions, scientific organizations
                                                                                         to discover and commercialize phar-
                                                                                                                                     issued/pending patents covering novel      The NCNPR is a model of the economic         off-quality product, an inter-      labs for many years.            green chemistry principles         and academia.
                                                                                         maceutical and agrochemical products
                                                                                                                                     compositions and extraction process.       benefits that a community can derive         ruption of paper production,                                        into chemical design, manu-
                                                                                         derived from nature. The USDA funded
                                                                                                                                     Sixteen technologies have been             from a public: private partnership in        increased landfill costs and        The Presidential Green Chem-    facture and use that can be uti-
                                                                                         construction of the 115,000 square foot
                                                                                                                                     licensed to industry. Several others       biopharmaceutical research.                  buildup of waste materials.         istry Challenge promotes in-    lized by industry in achieving
                                                                                         research facility completed in 1999.
                                                                                         Currently 38 USDA employees work            are under development in partnership
                                                                                                                                                                                                                                                                                                 Contributions from RALPH BERRY, President, Thompson, Baker
                                                                                         with more than 80 university research       with the USDA. Licensed products in
                                                                                                                                                                                                                                                                                                 & Berry Public Relations; and BUCKMAN LABS STAFF
                                                                                                          BUSINESS                                                    17



BIOMEDICAL
FACILITIES BY DESIGN
BY RALPH BERRY                                        Because architects may not always know who
President, Thompson, Baker & Berry                    the final tenant is going to be, they have to
Public Relations                                      design the space to be as flexible as possible,
                                                      giving companies the ability to specialize the




                                                                                                                                                                      Biomedical facilities by design
As planners, engineers and architects com-            labs once they are built.
plete the designs and specifications that will
eventually become the bricks and mortar               “The technology in lab instrumentation,
buildings of the Memphis Biotech Foundation           air-filtration systems, humidity and tem-
Research Park and other clinical or research          perature controls, and power conditioning
projects in the area, they will focus on              changes at ever-increasing speeds,” said
developing facilities to meet the needs of            Berger. “Cutting edge research demands
highly specialized tenants. Fortunately, as           cutting edge technologies. The challenge
the needs for specialized facilities have grown       to lab architects and engineers is staying up
in Memphis, so has the depth of expertise             with these developing technologies.”
within local architectural and design firms.          Safety is another issue architects have to con-
Design considerations and special features            sider as they plan their designs. According to
include broad requirements like flexibility of        Tucker, biotechnology laboratories generally
space, physical and system needs, biosafety           require additional biohazard security.
requirements, and zoning issues. Even the             “Typically, HEPA filters are required to pre-
most basic laboratories have general fea-             vent contamination,” said Tucker. “But if you
tures such as fume hoods, purified water,             are designing a biosafety level 3 laboratory,
gases, autoclaves, refrigerators, and freezers.       you must also include negative pressure and
But, unlike laboratories used for teaching or         filtered exhaust systems.”                          TRO The Ritchie Organization designed this new research
clinical and diagnostic purposes, architects
                                                      “Security systems are also an important ele-




                                                                                                                                                                            BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
                                                                                                          facility for the University of Alabama Birmingham.
must incorporate additional amenities and
features into biotech labs.                           ment of biotech designs,” added Berger. “You
Biotech labs also must be designed so they can be adapted over
time. As businesses grow or change their research protocols, the
laboratories must be able to accommodate the changes.
“When we design spaces for biotechnology, we          have to be able to protect personnel, proprietary
have to make sure the water supply is sufficient,     research and to minimize the risks associated
and that there is an adequate data and com-           with the rise of bioterrorism threats.”
munications infrastructure, which is important
                                                                                                          S t ate-of-t he-a r t biotechnolog y laborator ie s mus t
in the day-to-day operations of the facility,” said   State-of-the-art research facilities are not
Jimmie Tucker, a principal with Self Tucker           only essential to the work itself; they also        be flexible in order to incorporate features such as
Architects, a Memphis-based firm. “Because            play a vital role in attracting and retain-         special instrumentation, air/exhaust systems, biohazard
some organisms and analytical tools are sensi-        ing talent. According to Tucker, increased
                                                                                                          measures, and special access controls.
tive to vibration and noise, we also have to          competition in both the private industry
create spaces that prevent the equipment from         and among academics has put a premium
being affected by outside influences.”                on being able to successfully recruit top
                                                      scientists. He says that in addition to the
Steve Berger, vice president and managing             labs, amenities such as deluxe office suites,
principal of TRO The Richie Organization in           health clubs, and even dining facilities have
Memphis, says architects must look beyond             helped some biotech research firms recruit
the basics when creating biotechnology space.         and retain top talents in the field.
“Biotech labs often have unique features to
serve unique research projects. Researchers may       As Memphis’ role in the biosciences grows,
require special instrumentation, special air/         there is no doubt that the talent and experi-
exhaust quality control requirements, special         ence of its architectural and design firms will
access controls, and other services.”                 play an important role.

Additional measures may include redundancy
provisions such as generators to ensure continuous
operations of critical utility and safety systems.
                                                                                                                                                                                                          CLINICAL                                                   19



                                                                                   LOCAL TRANSPLANTS
                                                                                   FOR ECAST TO DOU BLE
                                                                                   BY BARRY S. MARSHALL,                                transplants, 11 kidney/pancreas transplants,                      clinic, an attached dialysis unit, and two
                                                                                   Administrative Director, Transplant                  and 5 liver/kidney transplants. By 2007, those                    brand new operating rooms. Construction of
                                                                                   Institute, Methodist Healthcare                      volumes are expected to double thanks to the                      all areas will be completed by January 2005.
                                                                                                                                        commitment made by Methodist Healthcare.                          However, 16 inpatient rooms, the ICU and
                                                                                                                                                                                                          the administrative offices are already open
                                                                                   Methodist Healthcare assumed the man-                UT Bowld services moved to Methodist

                        �������������������
                                                                                                                                                                                                          and functioning. The new space has been




                                                                                                                                                                                                                                                                     Transplant Institute : Safer Foods
                                                                                   agement of UT Bowld Hospital from the                University Hospital July 26, 2004, and is
                                                                                                                                                                                                          renovated into a technologically advanced
                                                                                   University of Tennessee Health Science               now the new Methodist University Hospital
                                                                                                                                                                                                          facility that includes ventilation that moves
                       ��������������������                                        Center in November 2002. UT Bowld spe-
                                                                                   cialized in solid organ transplants of the
                                                                                                                                        Transplant Institute. The institute’s first
                                                                                                                                        order of business is to expand the living-
                                                                                                                                        donor program for both kidney and liver
                                                                                                                                                                                                          air out instead of in. The total cost of this
                                                                                                                                                                                                          endeavor? Over $9,000,000. The benefits seen
                                                                                   kidney, liver and pancreas as well as the                                                                              by both recipients and donors? Priceless.
                                                                                   treatment of chronic diseases.                       transplants as well as to increase organ
                                                                                                                                        donation in the Memphis area.                                     The transplant institute is a partnership
                                                                                   In 1970, UT Bowld became the sixth medi-                                                                               between Methodist and UT Health Science
                                                                                   cal center in the nation to perform kidney           A pancreas transplant and two kidney
                                                                                                                                                                                                          Center. Moving the UT Bowld transplant ser-
                                                                                   transplants. In 1982 the program became              transplants were performed at Methodist
                                                                                                                                                                                                          vices to Methodist’s flagship hospital was part
                                                                                   the third in the country to perform liver            University Hospital Transplant Institute on
                                                                                                                                                                                                          of the master plan as Methodist University
                                                                                   transplants. And in 1989 UT Bowld began              Friday, July 23. A liver transplant was per-

full page west clinic
                                                                                                                                                                                                          Hospital and UT fulfill a vision of becoming
                                                                                   offering pancreas and kidney/pancreas trans-         formed on Saturday, July 24.
                                                                                                                                                                                                          one of the best academic medical centers
                                                                                   plants to diabetics. More than 1,500 people          The new institute has been designed to allow                      in the country. This move follows a formal
                                                                                   have received organ transplants since the            future transplant recipients and donors to be                     affiliation between Methodist and UTHSC
                                                                                   first kidney transplant was performed in             evaluated, transplanted and medically fol-                        in March 2002. The institute is managed
                                                                                   1970. Today, there are over 85,000 people            lowed for the rest of their life, all under one                   medically by Dr. Osama Gaber, M.D., and the
                                                                                   waiting for an organ in this country.                roof. Not too many transplant centers in the                      daily oversight of the institute is managed by
                                                                                   In November 2002, Methodist Healthcare               country (there are only 261 of them housed                        Victor J. Perini, V.P. of Transplant Services,
                                                                                   assumed the management of the UT Bowld               in less than 3% of the hospitals) can say                         Barry S. Marshall, Administrative Director of
                                                                                   Hospital and made a commitment to not                that. The new transplant area at Methodist                        the institute, and Trudy Davis-Short, admin-
                                                                                   only improving the level of transplant ser-          University Hospital consists of 31 dedicated                      istrative director of nursing services. If you




                                                                                                                                                                                                                                                                           BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
                                                                                   vices offered, but the volume as well. In 2003,      inpatient beds, eight transplant ICU beds,                        have any questions about the institute, please
                                                                                   UT Bowld performed 64 kidney transplants,            two dedicated outpatient procedure rooms                          call (866) 805-7710.
                                                                                   40 liver transplants, four pancreas alone            with five recovery bays, a 15 exam room


                                                                                                                                                                                                AGRICULTURE



                                                                                   RESEARCH FOR SAFER FOODS
                                                                                                                                     1. Jamie Jenkins Ph.D. (Research Director) and John Tom Williams (Farm Manager) review research cotton square development.
                                                                                   BY JAMIE H. JENKINS, PH.D.
                                                                                                                                                                                                                     2. Rice Research at Agricenter International.
                                                                                   Director of Research, Agricenter International
                                                                                   Many great scientific scholars had predicted that the world would over populate its food supply long
                                                                                                                                                                                                                1
                                                                                   before now. Agricenter International on Walnut Grove Road in Memphis Tennessee is conducting
                                                                                   agricultural research to help maintain a plentiful and safe food supply for the safety of the consumer.

                                                                                   Agricenter farms more than 700 acres of cotton, soybeans and corn, and conducts research in
                                                                                   other crops including rice and horticultural crops. It is the only facility in North America of its size
            �����������������������������������������������������������������      and scope where farmers and agribusinesses can see the most effective products, equipment and
        ������������������������������������������������������������������������   practices best suited for use on farms. The primary purpose of Agricenter International is to assist
                                                                                   farmers through educational programs and to demonstrate the most advanced technologies and
         ��������������� ������������������������������������������������������    products by providing opportunities for them to share first-hand with each other. It also provides
              �����������������������������������������������������������������    for face-to-face contacts with researchers, educators, manufacturers and government agencies.
                                                                                                                                                                                                                2
             ���������������������������������������������������������������
                                                                                   Currently, there are 18 different researchers conducting research to improve production and supply
          ����������������������������������������������������������������         through varieties, herbicides, insecticides, tillage practices, and their interaction. Research focuses on
                                                                            �      newer pesticide technologies and chemistries to enhance commercial food and fiber growth. This re-
                                          ��������������������������������         search will provide a more effective control of pests, thereby creating a safer food and environment.
                                                                                     VENTURE EDITORIAL                                                          21



GTX’S STOCK PUSHES AGAINST




                                                                                                                                                                GTX’s Stock Pushes Against Market Uncertainty
MARKET UNCERTAINTY
STEVEN J. BARES, PH.D.,                               clinical programs. In the first clinical program,
Executive Director and President,                     GTx is developing ACAPODENE™, its most
Memphis Biotech Foundation                            advanced product candidate for two separate
                                                      indications: (1) a pivotal Phase III clinical
GTx’s (NASDAQ: GTXI) Initial Public Of-               trial for the treatment of serious side effects of
fering (IPO) launched February 3 of this year         advanced prostate cancer therapy and (2) its
at an initial price of $14.50, raising over $80       completed Phase IIb clinical trial for the reduc-
million for the Memphis-based biopharmaceu-           tion in the incidence of prostate cancer in high
tical company. Like many Biotech companies,           risk men with precancerous prostate lesions.
in its early years the company is investing
heavily into product development. Real rev-           Prostate cancer, one of the most commonly di-
enues are on the horizon, after the long, hard,       agnosed cancers in men, is the second leading
risky road to develop a new drug. Fears about         cause of cancer-related deaths in the United
the economy and global security are putting           States. In the U.S., there are more than
a damper on investor appetite for such high-          115,000 new cases of precancerous prostate
risk investments, as evidenced by a 15 % drop         lesions diagnosed each year, and an estimat-
                                                      ed 9.4 million men unknowingly harbor this           Phase II clinical trial this year. GTx retains all
in the biotech index (NBI) since the start of
                                                      condition. GTx’s drug development assumes            rights to the discovery, development, and com-
the year. The company’s stock price has fallen
                                                      that by treating the precancerous lesions of         mercialization of the rest of its SARM program
since its initial sale and is currently trading
                                                      prostate cancer known as high-grade PIN,             including its other specific product candidates
just over $9, a drop of 38 percent.
                                                      prostate cancer may be prevented. GTx is also        ostarine, prostarine and andromustine.
So, is there good news for the stock? GTx is dedi-    focused on treating the serious side effects of
                                                      androgen deprivation therapy in men treated          Phase IIb clinical trials typically evaluate effi-
cated to the discovery, development and com-
                                                      with Lupron® or Zoledex®. Currently, there           cacy and safety, while pivotal Phase III clinical
mercialization of therapeutics primarily related to
                                                      is no therapy to treat multiple sides effects.       trials test an expanded patient population.
the treatment of men's serious health conditions.
                                                                                                           Once Phase III trials are complete and the




                                                                                                                                                                        BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |
                                                      In the second clinical program, GTx is devel-        Food and Drug Administration have approved
According to their prospectus, the company’s
                                                      oping andarine and other specified backup            the drug, it is ready for sale. The prognosis
drug discovery and development programs are
                                                      compounds, with its partner, Ortho Biotech           for GTx, like so many companies in the bio-
focused on small molecules that selectively
                                                      Products, L.P., a subsidiary of Johnson &            technology arena, depends on the lottery-like
modulate the effects of estrogens and androgens,
                                                      Johnson. Andarine will be entering a planned         results of their drug trials.
two essential classes of hormones. GTx has two




                                                                                            HEALTH SCIENCE CENTER
  TransnetYX, Inc. announces an                                           Greystone Medical Group and UTHSC
  express ordering option for the                                       Receive $1 Million for Hemostatic Research
  rapid-turnaround mouse geno-
  typing service. The automated                            Memphis, Tennessee (August 20, 2004) –University of Tennessee
  system, originally launched this                         Health Science Center (UTHSC) researcher Bob Moore, II PhD and
  past March, provides online re-                          Greystone Medical Group have been awarded $1 million from the
  porting of genotyping results in                         U.S. Department of Defense to research and develop hemostatic
  as little as 24 hours. Now “Quick-                       agents for treating battlefield injuries.
  Order” allows returning customers
  to place an order (and get back                                          For more information, visit: www.utmem.edu
  to their research) in three quick
  steps. More at www.transnetyx.                           Or contact: Susan Hadley, Greystone Medical Group– (901) 452-2395
  com or (888) 321-2113.                                          or Elizabeth Maynard-Garrett, UTHSC– (901) 448-4957
22                                                                                               RESEARCH                                                                                                                                                                               EDUCATION




                                                                    THIRD-GENERATION                                                                                                  S m it h & Ne phew ’s b r e a k-
                                                                                                                                                                                      throughs in intramedullary
                                                                                                                                                                                                                                          MEMPHIS JOINS CHICAGO, NEW YORK
                                                                                                                                                                                                                                             AND WASHINGTON D.C. IN

                                                                    FRACTURE PRODUCTS                                                                                                                                                     NEW LEADERS
                                                                                                                                                                                      (IM) nails, culminating in
                                                                                                                                                                                      its TriGen system, offers the
                                                                                                                                                                                      most illustrative example of its
                                                                    Only the Beginning for Smith & Nephew Orthopaedics                                                                leadership in innovation.                            FOR NEW SCHOOLS
Third Generation Fracture Products




                                                                    BY GARY BRIDGMAN,                                  In 1984, Smith & Nephew (then Richards              “Seeing the competitors copy what you have                     BY RALPH BERRY,
                                                                    Freelance Writer                                   Medical) and its Russell-Taylor IM nail revolu-     done is both flattering and motivating, since I
                                                                                                                                                                                                                                          President, Thompson, Baker & Berry Public Relations
                                                                                                                       tionized treatment of these fractures and moved     know we are moving on to better designs – like
                                                                    Memphis’ history is dotted with momentous          treatment from traction and extended bed rest       our new TriGen Humeral Nail – while they are                   Experts agree the first step toward public school excellence is
                                                                    creative breakthroughs. In addition to rock ‘n     to early ambulation, rapid recovery, and signifi-   still catching up,” James added. “From a busi-                 the right leadership in place. As most school districts across the
                                                                    roll, enterprising Memphians have recognized       cantly fewer complications.                         ness process perspective, we’re already building               nation struggle with issues of student performance and strong
                                                                    and leveraged global demand for such diverse                                                           clearer linkages between product development,                  leadership, Memphis is taking aggressive steps forward. Selected
                                                                    concepts as supermarkets, family-friendly          Today, a third-generation system, appropri-
                                                                                                                                                                           product management and research to deter-                      earlier this year as the fourth school district in the nation for
                                                                    motels, and overnight package delivery.            ately dubbed the TriGen IM Nail, comprises
                                                                                                                                                                           mine uses of emerging technologies.”                           the New Leaders for New Schools Program, Memphis will see
                                                                                                                       surgeon-friendly instrumentation and supple-
                                                                    Within the health sciences field, this city has                                                                                                                       62 principals trained over the next three years.
                                                                                                                       mentary implants that streamline surgeries.         The heat of competition is a motivator for
                                                                    also witnessed numerous breakthroughs in the                                                           James and his product development team, but                    Billy Kearney is heading the New Leaders for New Schools effort
                                                                    evolution of orthopaedic medical devices, thanks   “TriGen built on the foundation of the
                                                                                                                                                                           Smith & Nephew’s Trauma Division’s over-                       in Memphis. The former teacher and engineer recruited from D.C.
                                                                    to Smith & Nephew Orthopaedics, Medtronic          Russell-Taylor nail–not by changing the gen-
                                                                                                                                                                           arching goal of improving the patient’s life is                has a flair for the dramatic when speaking and a tendency to use
                                                                    Sofamor-Danek and Wright Medical.                  eral gains that had been made in treatment
                                                                                                                                                                           what really makes it all worthwhile.                           poetry to emphasize important points. The combination makes for
                                                                                                                       of fractures, but by making it easier for
                                                                    Founded in 1934 as Richards Manufacturing                                                                                                                             the kind of leader that instills both confidence and inspiration.
                                                                                                                       surgeons to treat the wide range of frac-           “It’s the fact that we are developing prod-
                                                                    Company and merged into London-based Smith         tures seen,” explains Anthony James, Vice           ucts that are used in the human body and                       “Our goal is to make positive systemic change in the Memphis
                                                                    & Nephew plc in 1986, Smith & Nephew               President–Trauma Product Development.               significantly improve the quality of life of                   City School System, not to apply a band aid,” says Kearney. “New
                                                                    Orthopaedics is a leading provider of joint        “The TriGen experience yielded a nail system        thousands of people,” said James. “Let’s face it.              Leaders for New Schools selected Memphis because of the extraor-
                                                                    reconstruction, trauma and clinical therapy        that was comprehensive–but not complex,             You [the patient] don’t want anything we, or                   dinary alliance of local and national leaders united to make a
                                                                    products. The company has built a reputation       and included the instruments and tools to           our competitors, sell if you can help it – espe-               difference. The commitment of the local university community,
                                                                    on delivering simpler, less invasive and more      allow surgeons to get the nails in and out          cially trauma products. But, if you have the                   the business community and other key leaders was unlike that
                                                                    cost-effective procedures to the orthopaedic       with minimal disruption to the patient’s soft       misfortune of being injured, our products are                  found in all of the other cities that applied to join the program.”
      BIOWORKS | WHERE BIOSCIENCES COME TO LIFE. AND TO MARKET. |




                                                                    community, with a long history in trauma.          tissue, thus improving healing.”                    second to none in restoring limb function
                                                                                                                                                                                                                                          “As with any enterprise, success begins with leadership,” says
                                                                    “Speaking for many who came before me,                                                                 and quality of life.”
                                                                                                                       Both innovations, released 20 years apart,                                                                         Dr. Steve J. Bares Ph.D, president and executive director of the
                                                                    we were undoubtedly on the forefront of            have dramatically changed the competitive                                                                          Memphis Biotech Foundation. “A key to our success in building
                                                                    the orthopaedic trauma industry,” explains         landscape in the industry.                                                                                         a strong biotech industry in Memphis is developing a capable
                                                                    Senior Vice President Scott Flora, who leads                                                                                                                          workforce. That begins with innovation at the schools. I believe
                                                                    the company’s Trauma Division, which pro-          “When Russell-Taylor was released, the                Inset: A TriGen Trochanteric Antegrade Nail is implanted
                                                                                                                                                                                                                                          the goals and focus of New Leaders for New Schools is just the
                                                                    duces fracture-healing internal and external       Howmedica G-K nail owned more than 80                 into the femur’s intramedullary (IM) canal.
                                                                                                                                                                                                                                          kind of innovation we need to set us apart.”
                                                                    fixation systems. Flora credits the company’s      percent of the IM nail market,” explains
                                                                    legacy of innovations to a culture of respon-      Mark Augusti, Vice President –Trauma                  Doc Parson, a finisher on Smith & Nephew Orthopaedics’       Nationwide it is expected that 50 percent of the principals could
                                                                    siveness, creativity and affiliation with the      Marketing. “Within three years, we had the            IM Nail production line, and Anthony James, Vice President   retire in the next five years. In Memphis the number is 56 percent.
                                                                    world’s leading orthopaedic surgeons.              market leader and never gave up that lead.                                                                         That means there has never been a better time to build a new lead-
                                                                                                                                                                             –Trauma Product Development, inspect a batch of TriGen
                                                                                                                       Now TriGen is the market leader and the                                                                            ership base. The 62 principal candidates, representing one third of
                                                                    Smith & Nephew’s breakthroughs in intra-           competition is still chasing us.”                     Humeral IM Nails, the company’s latest trauma innovation.    Memphis’ schools, that will go through the training program over
                                                                    medullary (IM) nails, culminating in its newly                                                                                                                        the next three years begin with an extensive five week summer
                                                                    extended TriGen system, offers the most illus-                                                                                                                        classroom-style seminar. Following graduation from the training,
                                                                    trative example of its leadership in innovation.                                                                                                                      the leaders are offered two years of post training support.
                                                                    Developed over the past 40 years, stainless
                                                                    steel (now titanium) IM nails have been
                                                                                                                                                                                                                                          “So many programs leave the individuals to
                                                                    used to align and stabilize fractures. They are                                                                                                                       thrive or flounder on their own after training.
                                                                    inserted into the bone marrow canal in the                                                                                                                            This program is made to both train and
                                                                    center of the long bones of the extremities.                                                                                                                          support, which will help ensure success of the
                                                                    The nails work wonders, but getting them                                                                                                                              participants and help them transfer knowledge
                                                                    inside the patient was historically a biome-
                                                                                                                                                                                                                                          to others,” says Kearney.
                                                                    chanical puzzle, forcing surgeons to adopt
                                                                    unfamiliar or difficult techniques and requir-                                                                                                                        Core Beliefs:
                                                                    ing hospitals to keep on hand many cases of                                                                                                                            1. Every child can learn and reach high levels of academic achievement.
                                                                    costly instruments for a single procedure. The                                                                                                                         2. High-quality public schools are indispensable to close the severe achievement gap.
                                                                    earliest IM nails were also only applicable to a
                                                                                                                                                                                                                                           3. Great schools typically have great principals.
                                                                    limited number of fracture cases.
                                                                                                                                                                                                                                           4. Dramatic improvements of urban school systems depend on systemic strategies.
                                                                                                                                                                                                                                              New Leaders must be accountable for the academic achievement of every student
                                                                                                                                                                                                                                              in our schools.
24                                R E G I O N A L          B I O S C I E N C E                       C A R E E R                   O P P O R T U N I T I E S




                                                          U N I V. O F T N .                       math teacher and 1 from another person of
       Healthcare Career Opportunities at
                                                    HE ALTH SCIENCE CENTER                         students' choosing. •Demonstrated interest in        BAPTIST MEMORIAL
      SAINT FRANCIS HOSPITAL                                                                       health careers indicated by success in previous      H E A LT H C A R E C O R P.
           CELEBRATING A 30 YEAR                    The Health Careers Opportunity Program         math/science courses and prior experience
                                                                                                                                                     At Baptist, we owe our success to our
           TRADITION OF HEALING.                    Offers an Invitation to Discover Health                 within the health community.
                                                                                                                                                     employees, who dedicate their lives to
                                                    Careers Through the Health Careers                                                               healing people. Their technical exper-
     Our employees make the difference by                                                          OFFICE OF HEALTH CAREERS PROGRAM
                                                    Opportunity Program (HCOP). If your                                                              tise and compassionate attitude is one
     delivering personalized care to all our                                                          308 Randolph Residence Hall
                                                    are considering a career in medicine,                                                            of the reasons we have been able to
     patients. For thirty years, Saint Francis                                                             Memphis, TN 38163
                                                    dentistry, pharmacy, or one of the Allied                                                        serve the Mid-South since 1912. They
     Hospital has been a leader in the Mid-                                                         901-448-8418 | 800-998-8654
                                                    Health Sciences and are a disadvantaged                                                          carry out Christ's three-fold ministry-
     South healthcare industry. It was the                                                                 Fax: 901-448-7291
                                                    student, the Health Careers Opportunity                                                          preaching, teaching and healing-every
     first hospital to serve its community from     Program (HCOP) is your special invitation                 COLLEGE OF MEDICINE                    day in our 17 hospitals and 30 sub-
     an East Memphis location. Saint Francis        to discover health career opportunities        N e l s o n S t rot he r, A s s t.D e a n fo r    sidiaries. We reward their efforts with
     Hospital is a full-service facility and pro-               in these disciplines.              Admissions and Student Affairs (UTHSC)            a compensation and benefits package
     vides the Memphis and the Mid-South                                                           nstrother@utmem.edu or (901) 448-                 that is second to none in the Mid-
                                                    With the shortage of disadvantaged health
     with a wide range of medical services                                                         5561 or Steve Ellis, Dir for Student                    South's health care industry.
                                                    professionals, The University of Tennessee
     and specialty centers, from Cancer Care                                                       Support Services & Asst. Dean for
                                                    Health Science Center is committed to                                                            Applicants are encouraged to apply
     to Family Birthing, and Sports Medicine/                                                      Student Affairs (ETSU) elliss@etsu.edu
                                                    assisting you to enter and graduate from a                                                       in person but resumes can be mailed
     Rehab to our Cardiac Care Center, good                                                        or (423) 439-2037
                                                             health professions school.                                                                           or faxed to:
     healthcare begins with our people. Come
                                                    H ealt h Car e e r s O ppor t unit y                 COLLEGE OF DENTISTRY
     join our healthcare team and enjoy the                                                                                                          Baptist Memorial Health Care Corp.
                                                    Program Eligibility Requirements               Wisdom Colemen, Assoc. Prof. and
                  benefits we offer.                                                                                                                        Employment Services
                                                    for Freshman and Sophomore                     Assoc. Dean for Admissions and                    6141 Walnut Grove Road, Suite 200
     For employment opportunities please            •Current college classification as fresh. or   Student Affairs wcoleman@utmem.edu                        Memphis, TN 38120
     contact our Human Resources Dept.              soph. •Completion of one semester of math               or (901) 448-6200                        (901) 226-4500 — (800) 526-8773
               9 0 1-7 6 5 -19 5 0                  and science •Minimum ACT score of 16
                                                                                                                                                            Fax: (901) 226-4519
                                                                                                         COLLEGE OF PHARMACY
                                                    •Compliance of federal income guidelines
           Saint Francis Hospital                                                                  Exec. Associate Dean for Admissions               You may also e-mail a resume to us:
                                                    •Residency in Shelby County (Tennessee)
     5959 Park Ave., Memphis, TN 38119                                                             and Student Affairs: jeoff@utmem.edu              employment@bmhcc.org or apply in per-
                                                    •2.5. minimum GPA •Three letters of recom-
                                                                                                            or (901) 448-6120                         son M-F (8-4) at Employment Services.
                                                    mendation; 1 from science teacher, 1 from
              MEMPHIS
               ROCKS
                     THE BIOMED WORLD


                           THE 2ND ANNUAL
              M U S C U L O S K E L E TA L N E W V E N T U R E S
                             CONFERENCE




               OCTOBER 6-7




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