The Male Sex Hormones
Kinetics & preparations.
Anabolics; uses and contraindications.
Testosterone and Androsterone
Development and maintenance of the
male sex organs.
Secondary sex characteristics.
Kinetics & Preparations
Testosterone (more active).
They are ineffective orally due to the
extensive 1st pass metabolism in the liver.
Testosterone propionate s.l, i.m or s.c.
Methyl testosterone s.l
Under trial for male contraception (decreases pituitary
gonadotrophins production plus direct testicular action.)
With estrogen in menopausal syndrome (decreases
Metastasizing premenopausal cancer breast (decreases
release of gonadotropines).
Hepatic cirrhosis to stop feminization induced by
impaired estrogen degradation.
Stop itching of biliary obstruction.
Help in some cases of anemia due to bone marrow
Increased libido undesirable sexual activity especially
in mentally unstable patients.
Priapism, impotence, decreased spermatogenesis,
gynecomastia & increased aggression (roid rage).
Virilization, acne, growth of facial hair & baldness in
Premature closure of the epiphyseal plates in children
Increased LDL & decreased HDL CHD.
Fluid retention edema
Liver injury (cholestasis).
Stimulates growth of prostate.
They are steroid competitively inhibit androgens at
Female Hirsutism and verilization
it inhibits 5α-reductase enzyme which
converts testosterone to the more active
It is used in benign prostatic hypertrophy.
it is a potassium-sparing diuretic.
with anti-androgenic activity.
It is used in treatment of hirsutism in
it is an antifungal agent.
It interferes with androgen and
It is used in prostatic carcinoma.
They reduce protein catabolism and
produce +ve nitrogen and +ve calcium
After major operations.
cancer prostate. (All anabolic steroid have
Yong athletes who abuse androgens
should be made aware of the side effects
of these drugs. Which one of the
following is ,however, not of concern?
A. Increased muscle mass.
B. Anemia due to bone marrow failure.
C. Overly aggressive behavior.
D. Decrease spermatogenesis.
E. Stunted growth.
Treatment with which of the following is
inappropriate for treating osteoporosis?