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The male sex hormones.ppt

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The male sex hormones.ppt Powered By Docstoc
					The Male Sex Hormones
                     Objectives
 Function.
 Kinetics & preparations.
 Clinical uses.
 Adverse effects.
 Contraindications.
 Anabolics; uses and contraindications.
             Androgens
     Testosterone and Androsterone
Function:
 Development and maintenance of the
 male sex organs.
 Secondary sex characteristics.
 Anabolic action
      Kinetics & Preparations
Natural:
  Androsterone.
  Testosterone (more active).
They are ineffective orally due to the
extensive 1st pass metabolism in the liver.
Synthetic:
  Testosterone propionate s.l, i.m or s.c.
  Methyl testosterone s.l
                      Uses
Male hypogonadism.
Under trial for male contraception (decreases pituitary
gonadotrophins production plus direct testicular action.)
With estrogen in menopausal syndrome (decreases
FSH).
Metastasizing premenopausal cancer breast (decreases
release of gonadotropines).
Hepatic cirrhosis to stop feminization induced by
impaired estrogen degradation.
Stop itching of biliary obstruction.
Help in some cases of anemia due to bone marrow
failure.
            Adverse Effects
Increased libido  undesirable sexual activity especially
in mentally unstable patients.
Priapism, impotence, decreased spermatogenesis,
gynecomastia & increased aggression (roid rage).
Virilization, acne, growth of facial hair & baldness in
women.
Premature closure of the epiphyseal plates in children 
stunted growth.
Increased LDL & decreased HDL  CHD.
Fluid retention  edema
Liver injury (cholestasis).
Stimulates growth of prostate.
Contraindications:
 Cancer prostate.
            Anti-androgens
  Cyproterone
  Flutamide
They are steroid competitively inhibit androgens at
their receptors.
Uses:
  Hypersexuality.
  Cancer prostate.
  Precocious puberty
  Male baldness
  Female Hirsutism and verilization
      Other anti-androgens
Finasteride:
  it inhibits 5α-reductase enzyme which
  converts testosterone to the more active
  metabolite dihydrotestosterone.
  It is used in benign prostatic hypertrophy.
Spironolactone:
  it is a potassium-sparing diuretic.
  with anti-androgenic activity.
  It is used in treatment of hirsutism in
 women.
Ketoconazole:
 it is an antifungal agent.
 It interferes with androgen and
 corticosteroid synthesis.
 It is used in prostatic carcinoma.
        Anabolic Steroids
 They reduce protein catabolism and
 produce +ve nitrogen and +ve calcium
 balance
Uses:
 After major operations.
 Senile osteoporosis
 Renal failure
 Aplastic anemia
Contraindications:
  cancer prostate. (All anabolic steroid have
 androgenic effects)
Preparations:
 Nandrolone (durabolin),
 Norethandrolone (nilevar),
 Methanolone &
 Methandrolone.
                Study Quiz
     Yong athletes who abuse androgens
     should be made aware of the side effects
     of these drugs. Which one of the
     following is ,however, not of concern?
A.   Increased muscle mass.
B.   Anemia due to bone marrow failure.
C.   Overly aggressive behavior.
D.   Decrease spermatogenesis.
E.   Stunted growth.
     Treatment with which of the following is
     inappropriate for treating osteoporosis?
A.   Androsterone.
B.   Premarin.
C.   Tamoxifen.
D.   Norethindrone.
E.   Nandrolone.
A 70

				
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posted:11/6/2012
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