Publications - DOC 5 by 699qkw


The Tumour Bank has supported a large number of Research projects investigating
many different aspects of childhood cancers. The supported research projects has led
to a large number of publications in both nationally and internationally recognised
journals. Below is a list of publications.


Albert Chetcuti, Safiye Aktas, Nicole Mackie, Celal Ulger, Gokce Toruner, Mualla
Alkan, Daniel Catchpoole. “Expression profiling reveals MSX1 and EphB2
expression correlates with the invasion capacity of Wilms’ tumors.”, Paediatric Blood
and Cancer. In press, 2011.

Victoria K Hill, Daniel Catchpoole, Anna Brini, Mike Griffiths, Charles Craddock,
Eamonn R Maher, Farida Latif, Frequent epigenetic inactivation of KIBRA an
upstream member of the SWH pathway is associated with specific genetic event in B-
cell acute lymphoblastic leukemia. Epigenetics, 6(3), 2011.


Catchpoole D.R., Mackie N., Chetcuti A., McIver S., Henwood T., Kan A., Graf N.,
and Arbuckle S., “Tape transfer sectioning of tissue microarrays may lead to false
positive immunohistochemistry staining.”, Biotechnic and Histochemistry, In Press,

A. Swarbrick, S.L. Woods, A. Shaw, A. Balakrishnan, Y. Phua, A. Nguyen, Y.
Chanthery, L. Lim, L.J. Ashton, R.L. Judson, N. Huskey, R. Blelloch, M. Haber,
M.D. Norris, P. Lengyel, C.S. Hackett, T. Preiss, A. Chetcuti, C.S. Sullivan, E.G.
Marcusson, W. Weiss, N. L’Etoile, and A. Goga. (2010) miR-380-5p represses p53 to
control cellular survival and is associated with poor outcome in MYCN amplified
neuroblastoma. Nature Medicine, 16(10): 1134-41.

A. Lindblom, V. Bhadri, S. Söderhäll, L. Öhrmalm, M. Wong, O. Norbeck, C.
Lindau, M. Rotzén-Östlund, T. Allander, D. Catchpoole, L. Dalla-Pozza, K. Broliden,
T. Tolfvenstam. Respiratory viruses, a common microbiological finding in
neutropenic children with fever. (2010) Journal of Clinical Virology 47:234-7.

J. Roma, A. Masia, J. Reventos, J.Sanchez de Toledo, and S. Gallego. Notch Pathway
Inhibition Significantly Reduces Rhabdomyosarcoma Invasiveness and Mobility In
Vitro. (2010) Clinical Cancer Research 17(3); 505–13.


Taylor, JG, Cheuk AT, Tsang PS, Chung J, Song YK, Desai K, Yu Y, Chen Q, Shah
K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt
LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock
SJ, and Khan J. Identification of FGFR4 activating mutations in human
rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin
Invest. 2009 Nov;119(11):3395-407

Luke B. Hesson, Thomas L. Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T
Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D. Chalmers, Eamonn R.
Maher, and Farida Latif. The novel RASSF6 and RASSF10 candidate tumour
suppressor genes are frequently epigenetically inactivated in childhood leukaemias.
Mol Cancer. 2009 Jul 1;8:42.

Linda Gomes, Nicole Mackie, Daniel R. Catchpoole, Tony Henwood. Test and Teach
– In a fix about immunohistochemistry on 60 year old tissue blocks? Journal of
Histotechnology, 8, 125, 2008.

Wolf S., Wakelin L.P.G., He Z., Stewart B.W., and Catchpoole D.R. In vitro
assessment of novel transcription inhibitors and topoisomerase poisons in
rhabdomyosarcoma cell lines. Cancer Chemotherapy and Pharmacology, 64(6), 1059-
1069, 2009.

ThomasL. Dunwell, Luke B.Hesson, Tatiana Pavlova, Veronika Zabarovska,
Vladimir Kashuba, Daniel Catchpoole, Raffaella Chiaramonte, Anna T. Brini, Mike
Griffiths, Eamonn R. Maher, Eugene Zadarovsky, and Farida Latiff. Epigenetic
Analysis of childhood acute lymphoblastic leukaemia. Epigenitcs 4:3,1-9, 1 April

ThomasL. Dunwell, Daniel Catchpoole, Eamonn R. Maher, Farida Latiff. Frequent
epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic
leukaemia. Epigenitcs 4:4,1-5, 16 May 2009

Thomas L. Dunwell, Luke B. Hesson, Tatiana Pavlova, Veronika Zabarovska, Daniel
Catchpoole, Raffaella Chiaramonte, Anna T. Brini, Mike Griffiths, Eamonn R.
Maher, Eugene Zabarovsky, Farida Latif. Epigenetic analysis of childhood acute
lymphoblastic leukaemia. Epigenetics, 4(3), 185-193, 2009.

Thomas L. Dunwell, Rachel E Dickinson, Tatjana Stankovic, Ashraf Dallol, Victoria
Weston, Belinda Austen, Daniel Catchpoole, Eamonn R Maher, Farida Latif.
Frequent epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic
leukemia. Epigenetics, 4(4), 265-269, 2009.

Kadupitige S.R., Leung K.C., Sellmeier J., Sivieng J., Catchpoole D.R., Bain M.E.
and Gaëta B.A. MINER: Exploratory analysis of gene interaction networks by
machine learning from microarray data. BMC Genomics, 10, Supp 3, 2009.


Catchpoole D.R., Guo D., Jiang H., Biesheuvel C. Predicting outcome in childhood
acute lymphoblastic leukaemia using gene expression profiling: Prognostication or
protocol selection? Blood, 111(4), 2486-2487, 2008.

Margetts C.D.E., Morris M., Astuti D., Gentle D.C., Cascon A., McRonald F.E.,
Catchpoole D.R., Robledo M., Neumann H.P.H., Latif F. and Maher E.R. Evaluation
of a functional epigenetic approach to identify promoter region methylation in
phaeochromocytoma. Endocrine-Related Cancer, 15, 777-786, 2008.

Natrajan R, Warren W, Messahel B, Reis-Filho JS, Brundler MA, Dome JS, Grundy
PE, Vujanic G, Pritchard Jones K, Jones C. Complex patterns of chromosome 9
alterations including the p16INK4a locus in Wilms tumours. J Clin Pathol. 2008


Whiteford CC, Bilke S, Greer BT, Chen Q, Braunschweig TA, Cenacchi N, Wei JS,
Smith MA, Houghton P, Morton C, Reynolds CP, Lock R, Gorlick R, Khanna C,
Thiele CJ, Takikita M, Catchpoole D, Hewitt SM, Khan J. Credentialing preclinical
pediatric xenograft models using gene expression and tissue microarray analysis.
Cancer Research 2007;67 (1):32-40.

R Natrajan, , S E. Little, N Sodha, J. S. Reis-Filho, A Mackay, K Fenwick, A
Ashworth, EJ Perlman, P E. Grundy, Jeffrey S. Dome, , Kathy Pritchard-Jones and
Chris Jones. Analysis by array CGH of genomic changes associated with the
progression or relapse of Wilms’ tumour. Journal of Pathology 2007; 211; 52-59

Catchpoole D.R., Lail A., Guo D., Chen Q., Khan J. Identification of gene expression
profiles that segregate patients with childhood acute lymphoblastic leukaemia: An
independent validation study. Leukaemia Research, 31(12), 1741-1747, 2007.

Catchpoole D., DeFazio A., Devereux L., Fleming M., Hof M., Schmidt C., Thorne
H., and Zeps N. The importance of biorepository networks: The Australian
Biospecimen Network-Oncology”. Australian Journal for Medical Science, 28(1), 16-
20, 2007.


Stallings RL, Nair P, Maris JM, Catchpoole D, McDermott M, O'Meara A, Breatnach
F. High Resolution Analysis of Chromosomal breakpoints and genomic instability
identifies PTPRD as a candidate tumour suppressor gene in Neuroblastoma. Cancer
Res. 2006 Apr 1;66(7):3673-80.

R Natrajan, , RD Williams, SN Hing, , A Mackay J. S. Reis-Filho, K Fenwick, M
Iravani, H Valgeirsson, A Grigoriadis, CF Langford, O Dovey, SG Gregory, BL
Webber, A Ashworth, P E. Grundy, Kathy Pritchard-Jones and Chris Jones. Array
CGH profiling of favourable histology Wilms tumours reveals novel gains and losses
associated with relapse. Journal of Pathology 2006; 210; 49-58.

Natrajan R, Reis-Filho JS, Little SE, Messahel B, Brundler MA, Dome JS, Grundy
PE, Vujanic GM, Pritchard-Jones K, Jones C. Blastemal expression of type I insulin-
like growth factor receptor in Wilms' tumors is driven by increased copy number and
correlates with relapse. Cancer Res. 2006 Dec 1;66(23):11148-55.

Natrajan R, Little SE, Reis-Filho JS, Hing L, Messahel B, Grundy PE, Dome JS,
Schneider T, Vujanic GM, Pritchard-Jones K, Jones C. Amplification and
overexpression of CACNA1E correlates with relapse in favorable histology Wilms'
tumors. Clin Cancer Res. 2006 Dec 15;12(24):7284-93.

Bilke S., Chen Q-R., Westerman F., Schwab M., Catchpoole D.R., and Khan J.
Inferring a tumour progression model for neuroblastoma from genomic data. J.
Clinical Oncology, 23 (29), 7322-7331, 2005.

Barbaric D, Byth K, Dalla-Pozza L, Byrne JA. Expression of tumor protein D52-like
genes in childhood leukemia at diagnosis: clinical and sample considerations. Leuk
Res. 2006 Nov;30(11):1355-63.


Margetts C.D.E., Astuti D., Gentle D.C., Cooper W.N., Cascon A., Catchpoole D.R.,
Robledo M., Neumann H.P.H., Latif F. and Maher E.R. Epigenetic analysis of HIC1,
CASP8, FLIP, TSP1, DcR1, DcR2, DR4, DR5, KvDMR1, H19 and preferential
11p15.5 maternal allele loss in VHL and sporadic phaeochromocytomas. Endocrine-
Related Cancer, 12, 161-172, 2005.

Astuti D., Latif F., Wagner K., Gentle D., Cooper W.N., Catchpoole D.R., Grundy R.,
Ferguson-Smith A.C. and Maher E. Epigenetic alteration at the DLK-GTL2 imprinted
domain in human neoplasia provides evidence for trans interaction between DLK1
and GTL2. British Journal of Cancer, 92, 1574-1580, 2005.

Henson JD, Hannay JA, McCarthy SW, Royds JA, Yeager TR, Robinson RA,
Wharton SB, Jellinek DA, Arbuckle SM, Yoo J, Robinson BG, Learoyd DL, Stalley
PD, Bonar SF, Yu D, Pollock RE, Reddel RR. A robust assay for alternative
lengthening of telomeres in tumors shows the significance of alternative lengthening
of telomeres in sarcomas and astrocytomas. Clin Cancer Res. 2005 Jan 1;11(1):217-

P.B. Dallas, N.G. Gottardo, M.J. Firth, A.H. Beesley, K. Hoffmann, P.A. Terry, J.R.
Freitas, J.M. Boag, A. J. Cummings and U.R. Kees. Gene expression levels assessed
by oligonucleotide microarray analysis and quantitative real-time RT-PCR – how well
do they correlate? BMC Genomics 2005, 6:59


Wei JS, Greer BT, Westermann F, Steinberg SM, Son CG, Chen QR, Whiteford CC,
Bilke S, Krasnoselsky AL, Cenacchi N, Catchpoole D, Berthold F, Schwab M, Khan
J. Prediction of clinical outcome using gene expression profiling and artificial neural
networks for patients with neuroblastoma. Cancer Res. 2004 Oct 1;64(19):6883-91.

Gajjar A, Hernan R, Kocak M, Fuller C, Lee Y, McKinnon PJ, Wallace D, Lau C,
Chintagumpala M, Ashley DM, Kellie SJ, Kun L, Gilbertson RJ. Clinical,
histopathologic, and molecular markers of prognosis: toward a new disease risk
stratification system for medulloblastoma. J Clin Oncol. 2004 Mar 15;22(6):984-93.

McArdle L, McDermott M, Purcell R, Grehan D, O'Meara A, Breatnach F,
Catchpoole D, Culhane AC, Jeffery I, Gallagher WM, Stallings RL. Oligonucleotide
microarray analysis of gene expression in neuroblastoma displaying loss of
chromosome 11q. Carcinogenesis. 2004 Sep;25(9):1599-609.

Stalling R.L., Carty P., McArdle L., Mullarkey M., McDermott M., O’Meara A.,
Ryan E., Catchpoole D.R. and Breatnach F. Evolution of unbalanced gain of distal
chromosome 2p in neuroblastoma. Cytogenetics and Genome Research, 106(1), 49-
54, 2004.

Chen Q-R., Bilke S., Wei J.S., Whiteford C.C., Cenacchi N., Krasnoselsky A.L.,
Greer B., Son C-G., Westermann F., Berthold F., Schwab M., Catchpoole D.R., and
Khan J. cDNA Array-CGH profiling identifies genomic alterations specific to stage
and MYCN-amplification in neuroblastoma. BMC Genomics, 5, 70, 2004.

Mitchell S.A., Brown K.M., Mintz M., Henry M.M., Lafleur B., Catchpoole D.R. and
Stephan D.A. Interplatform comparability of microarrays in acute lymphoblastic
leukemia. BMC Genomics, 5, 71, 2004.

Richard D. Williams, Sandra N. Hing, Braden T. Greer, Craig C. Whiteford, Jun S.
Wei, Rachael Natrajan, Anna Kelsey, Simon Rogers, Colin Campbell, Kathy
Pritchard-Jones, and Javed Khan. Prognostic classification of relapsing favorable
histology wilms tumor using cdna microarray expression profiling and support vector
machines. Genes, Chromosomes & Cancer 41:65–79 (2004).


Guo D. and Catchpoole D.R. Isolation of intact RNA following cryosection of
archived frozen tissue. Biotechniques, 34(1), 48-50, 2003.

Stallings RL, Carty P, McArdle L, Mullarkey M, McDermott M, O'Meara A, Ryan E,
Catchpoole D, Breatnach F. Evolution of unbalanced gain of distal chromosome 2p
in neuroblastoma. Cytogenet Genome Res. 2004;106(1):49-54.

O’Neill G.M., Catchpoole D.R. and Golemis E.A. From correlation to causality:
microarrays, cancer, and cancer treatment. Biotechniques, March Suppl, 64-71, 2003.

A. Agathanggelou, I. Bie`che, J. Ahmed-Choudhury, B. Nicke, R. Dammann, S.
Baksh, B. Gao, J.D. Minna, J. Downward, E.R. Maher, and F. Latif. Identification of
Novel Gene Expression Targets for the Ras Association Domain Family 1 (RASSF1A)
Tumor Suppressor Gene in Non-Small Cell Lung Cancer and Neuroblastoma. Cancer
Research 63, 5344–5351, 2003.


Barbaric D, Dalla-Pozza L, Byrne JA. A reliable method for total RNA extraction
from frozen human bone marrow. J Clin Pathol. 2002 Nov;55(11):865-7

Ramirez C.D. and Catchpoole D.R. Etoposide-induced apoptosis in lymphoblastoid
leukaemic MOLT-4 cells: Evidence that chromatin condensation, loss of
phosphatidylserine asymmetry and apoptotic body formation can occur
independently. Apoptosis, 7(1), 59-68, 2002.

Catchpoole D.R. and Lock R.B. The potential tumour suppressor role for caspase-9
(CASP9) in the childhood malignancy, neuroblastoma. European Journal of Cancer,
37(17), 2217-2221, 2001.

Peaston A.E., Gardenah M., Franco V.A., Hocker J.E., Murphy K.M., Farnsworth
M.L., Catchpoole D.R., Haber M., Norris M.D., Lock R.B. and Marshall G. MRP1
gene expression level regulates the death and differentiation response of
neuroblastoma cells. British Journal of Cancer, 85(10), 1564-1571, 2001.


Ramirez C.D., Catchpoole D.R., and Stewart B.W. Morphological and molecular
evidence of differentiation during etoposide-induced apoptosis in human
lymphoblastoid cells. Cell Death and Differentiation, 7 (6), 548-555, 2000.


Tumour Bank
Children's Cancer Research Unit
The Children's Hospital at Westmead
Locked Bag 4001, Westmead 2145

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