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					                                   JOSEPH F. DELLARIA, JR.
                      10423 Kilbirnie Rd. ▪ Woodbury, MN 55129 ▪ (651) 436-6494
                                    jfdellaria@perceptiverealities.com

                                            CAREER PROFILE

Productive and creative synthetic organic chemist with extensive experience in successfully directing,
managing and synthesizing complex organic compounds for drug discovery. Demonstrated ability to solve
problems in multiple areas. Selected competencies fall into four areas:
 Expediting Innovation Discovery: Conceived and co-lead the de novo design and implementation of the
    process for identifying the highest probability innovation projects. The process was used to reduce over
    50 submitted ideas to 7 that were pursued.
 Patent Strategy Development: Designed and executed Structure-Activity-Relationship (SAR) studies
    leading to 47 patents in 9 unique therapeutic areas.
 Innovative Synthesis of New Compounds: discovered three new reactions and published nearly 30
    papers describing new methods to efficiently prepare potent, biologically active compounds.
 Extensive Understanding of Bioavailability Issues: participated and/or lead several teams in the
    identification of potent and bioavailable NCEs.

                                                   RESULTS:
                                  Patents 50 issued U.S. patents in 9 unique therapeutic areas
                                          13 pending U.S. patent applications
                   Medicinal Chemistry Responsible for the discovery of the lead compound for an IND
                                        in post-surgical scarring (effort was terminated with the sale of
                                        the division)
                                       Discovered back-up compounds in four therapeutic areas (Renin,
                                        5-LO and Matrix Metalloproteinase, IRMs for cancer)
                                       Directed the medicinal chemistry efforts of over 40 chemists
                                        (bachelors, masters, and Ph.D.s)
                       Published Papers 29 Publications in major refereed journals
      Presentations and Invited Lectures 23 professional paper presentations
                                         10 invited university and college lectures


                                      PROFESSIONAL EXPERIENCE

Perceptive Realities, LLC, Woodbury, MN                                                    2007-present

President and Founder
Consulting firm dedicated to assisting clients to improve their discovery rate of innovative ideas through:
 Training to identify and control perception driven decisions.
 Building and implementing a custom tailored Innovation Discovery Process™.
        o Saves time and money by learning how to identify and stop programs that cannot work at the
            earliest possible time.
        o Expedites the rate of discovering innovative ideas for late stage New Product Development.
Joseph F. Dellaria, Jr.



3M Pharmaceuticals, St. Paul, MN                                                       2000 – 2007

Lead Research Specialist
Led a group of 11-14 chemists—Ph.D., M.S., and B.S.—in the design, synthesis and patenting of new
compounds in the Immune Response Modifier class of compounds.
 Devised and executed a department wide plan to synthesize compounds and file 26 patents in 6 months.
 Co-inventor on 19 granted U.S. patents for new Immune Response Modifying compounds.
 Initiated and co-lead a team effort to design and implement the process used to select new projects for
   the Pharmaceutical Discovery Division. 7 out of 50 ideas were selected for further scientific
   investigation.
 Lead Chemist on the Discovery Opportunities Team which oversaw allocating resources and scientific
   strategy for potential new research programs.
 Designed and played a leading role in implementing the hiring process to hire over thirty new
   employees over a three year period.
 Co-led the exploratory Multi-Drug Resistance Project. Set overall research direction, priorities, and
   directed medicinal chemistry effort. Lead the team to make a data-driven no-go decision saving
   $1K/year in research expenses.
 Served as the departmental liaison for the design and construction of a new state-of-the-art $2 million
   medicinal chemistry laboratory. Responsible for working with engineers and contractors to identify and
   resolve numerous construction issues.

Abbott Labs, Chicago, IL                                                               1984 – 2000

Associate Research Fellow / Sr. Group Leader, 1992 – 2000
Led teams of 6-8 chemists in discovering new compounds for the inhibition of four unique therapeutic
targets (5-Lipoxygenase, Cyclooxygenase II, Matrix Metalloproteinase, and Urokinase).
 Identified potent (nanomolar to sub-nanomolar) inhibitors in each area.
 Set and executed patent strategies for each area.
 22 U.S. patents were granted during this time.
 Maintained an active lab presence as time permitted.
 Promoted to the first step of the Scientific Ladder (Aug. 1992).

Research Investigator, 1989 – 1992
Responsible for overseeing the work of two assistants and three summer students.
 3 U.S. patents were granted during this period.
 Designed and synthesized new amide-linked compounds for the inhibition of 5-Lipoxygenase.



                                              EDUCATION
           N.I.H. Post-doctoral Fellow: California Institute of Technology, Pasadena, CA and
            Harvard University, Cambridge, MA. Research Advisor: Professor David A. Evans.
           Ph.D., Organic Chemistry, University of Minnesota, Minneapolis, MN. Research
                                     Advisor: Professor T.R. Hoye.
        Bachelor of Arts, Chemistry, Hope College, Holland, MI. Research Advisor: Michael P.
                                                Doyle.




                                                                                                       2
Joseph F. Dellaria, Jr.




                                        PROFESSIONAL SOCIETY
                                         American Chemical Society


                                         HONORS AND AWARDS
                               National Institute of Health Postdoctoral Fellow
                          L.I. Smith Outstanding Graduate Student Award, U. of MN
                             Graduate School Dissertation Fellowship, U. of MN
                                 E.I. DuPont Research Award, Hope College
                                   Member Phi Beta Kappa, Hope College




                                                PATENTS


50) Dellaria, J. F.; Radmer, M. R.; Merrill, B. A.; “Thioether substituted imidazopyridines”, U.S.
    7,288,550, 10/30/2007.
49) Dellaria, J. F.; Radmer, M. R. “Thioether substituted imidazopyridines”, U.S. 7,276,515,
    10/2/2007.
48) Dellaria, J. F.; Lindstrom, K. J.; Dressel, L. T.; Heppner, P. D.; Jacobsen, J. R.; Moseman, J.
    T.; Moser, W. H.; Radmer, M. R.; Stoermer, D. “Ether substituted imidazopyridines”, U.S.
    7,220,758, 05/22/2007.
47) Dellaria, J. F.; Lindstrom, K. J.; Dressel, L. T.; Duffy, D. E.; Heppner, P. D.; Jacobsen, J. R.;
    Moseman, J. T.; Moser, W. H.; Radmer, M. R.; Stoermer, D.; Zimmermann, B. M. “Ether
    substituted imidazopyridines”, U.S. 7,125,890, 10/24/2006.
46) Heppner, P. D.; Charles, L. J.; Dellaria, J. F.; Merrill, B. A.; Mickelson, J. W. “Aryl Ether
    Substituted Imidazoquinolines", U.S. 6,989,389, 1/24/2006.
45) Dellaria, J. F.; Mickelson, J. W. “Aryl Ether Substituted Imidazoquinolines", U.S. 6,953,804,
    10/11/2005.
44) Bonk, J. D.; Dellaria, J. F.; Merrill, B. A.; Radmer, M. R. “Thioether Substituted
    Imidazoquinolines", U.S. 6,949,649, 09/27/2005.
43) Dellaria, J. F.; Merrill, B. A.; Radmer, M. R. “Thioether Substituted Imidazoquinolines", U.S.
    6,921,826, 07/26/2005.
42) Dellaria, J. F.; Lindstrom, K. J.; Dressel, L. T.; Heppner, P. D.; Jacobsen, J. R.; Radmer, M.
    R.; Stoermer, D. “Ether Substituted Imidazopyridines", U.S. 6,797,718, 09/28/2004.
41) Dellaria, J. F.; Haraldson, C. A.; Lindstrom, K. J.; Merrill, B. A.; “Amide Substituted
    Imidazopyridines", U.S. 6,720,422, 04/13/2004.



                                                                                                 3
Joseph F. Dellaria, Jr.



40) Dellaria, J. F.; Haraldson, C. A., Heppner; P. D.; Lindstrom, K. J.; Merrill, B. A. “Urea
    Substituted Imidazopyridines", U.S. 6,720,334, 04/13/2004.
39) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Amide
    Substituted Imidazopyridines", U.S. 6,720,333, 04/13/2004.
38) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Urea
    Substituted Imidazopyridines ", U.S. 6,716,988, 04/06/2004.
37)    Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A.
      “Sulfonamido Substituted Imiazopyridines", U.S. 6,696,465, 02/24/2004.
36) Heppner, P. D.; Charles, L. J.; Dellaria, J. F.; Merrill, B. A.; Mickelson, J. W. “Aryl Ether
    Substituted Imidazoquinolines", U.S. 6,677,348, 01/13/2004.
35) Charles, L. J.; Dellaria, J. F.; Heppner, P. D.; Merrill, B. A.; Mickelson, J. W. “Aryl Ether
    Substituted Imidazoquinolines", U.S. 6,670,372, 12/30/2003.
34) Bonk, J. D.; Dellaria, J. F.; Merrill, B. A.; Radmer, M. R.; “Thioether Substituted
    Imidazopyridines", U.S. 6,667,312, 12/16/2003.
33) Dellaria, J. F.; Merrill, B. A.; Radmer, M. R. “Thioether Substituted Imidazopyridines", U.S.
    6,664,264, 12/16/2003.
32) Charles, L. J.; Dellaria, J. F.; Griesgraber, G. W.; Heppner, P. D.; Manske, K. J.; Mickelson, J.
    W.; Rice, M. J. “Heteroaryl Ether Substituted Imidazoquinolines”, U.S. 6,664,260, 12/16/2003.
31) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Urea
    Substituted Imidazopyridines", U.S. 6,545,017, 4/8/2003.
30) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Amide
    Substituted Imidazopyridines", U.S. 6,545,016, 4/8/2003..
29) Dellaria, J. F.; Haraldson, C.A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Sulfonamido
    Substituted Imidazopyridines", U.S. 6,525,064, 2/25/2003.
28) Curtin, M. L.; Dai, Y.; Davidsen, S. K.; Dellaria, J. F.; Florjancic, A. S.; Gong, J.; Guo, Y.;
    Heyman, H. R.; Howard, R.; Holms, J. H.; Michaelides, M. R.; Stacey, J. R.; Steinman, D. H.;
    Wada, C. K.; Xu, L. "Preparation of Hydroxamates as Matrix Metalloproteinase Inhibitors",
    U.S. 6,294,573, 2001.
27) Dellaria, J. F. "Benzothiophene-based Urokinase Inhibitors", U.S. 6,207,701, 2001.
26) Dellaria, J. F.; Gane, T. H. "Prostaglandin Synthase-2 Inhibitors", U.S. 5,776,984, 07/07/98.
25) Dellaria, J. F.; Gane, T. H. "Prostaglandin Synthase-2 Inhibitors", U.S. 5,681,842, 1997.
24) Dellaria, J. F.; Chernesky, L. J. "Heteroatom Substituted Propanyl Derivatives Having 5-
    Lipoxygenase Inhibitory Activity", U.S. 5,516,795, 1996.
23) Dellaria, J. F.; Brooks, D. W.; Sallin, K. J. ; Moore, J. L. "Arylamidoalkyl-N-hydroxyurea
    Compounds Having Lipoxygenase Inhibitory Activity", U.S. 5,514,702, 1996.
22) Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "Pyran-4-ylmethyl Substituted
    Arylalkylaryl-, Arylalkenylaryl-, and Arylalkynylary Urea Inhibitors of 5-Lipoxygenase", U. S.
    5,484,786, 1996.

                                                                                                 4
Joseph F. Dellaria, Jr.



21) Chernesky, L. J.; Dellaria, J. F. "1,2-Dialkoxylethanes as 5-Lipoxygenase Inhibitors", U.S.
    5,475,009, 1995.
20)    Brooks, D. W.; Carter, G. W.; Dellaria, J. F.; Maki, R. G.; Rodriquez, K. E. "Indole
      Derivatives Which Inhibit Leukotriene Biosynthesis", U.S. 5,459,150, 1995.
19) Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(4-Alkoxypyran-4-yl)
    Substituted Ether, Arylalkyl-, Arylalkenyl-, and Arylalkynyl)urea Inhibitors of 5-
    Liopxygenase", U. S. 5,446,062, 1995.
18) Dellaria, J. F.; Ratajczyk, J. R.; Brooks, C. D. W.; Basha, A. "Polyether Napthalenic Lignan
    Lactones as Inhibitors of 5-Lipoxygenase", U.S. 5,446,055, 1995.
17)    Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(4-Alkoxypyran-4-yl)
      Substituted Arylalkylaryl-, Arylalkenylaryl-, and Alrylalkynylarylurea Inhibitors of 5-
      Lipoxygenase", U. S. 5,432,194, 1995.
16) Dellaria, Joseph F.; Ratajczyk, J. D.; Brooks, C. D.W.; Basha, A. “[Alkoxy-, alkenyloxy-,
    alkynyloxy-, and phenylmethyloxyalkoxycycloalkyl or alkoxycycloheteroalkyl]naphtho[2,3-c]
    furan-1(3H)-one inhibitors of 5-lipoxygenase”, U.S. 5,426,111, 06/20/95.
15)      Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(Trans-1,4-
      dialkoxycyclohexyl) Substituted Arylalkylaryl-, Arylalkenylaryl-, and Alrylalkynyl-arylurea
      Inhibitors of 5-Liopxygenase", U.S. 5,407,959, 1995.
14) Dellaria, J. F.; Brooks, D. W.; Dorn, L. J. "Phenylmethyl Derivatives Having 5-Lipoxygenase
    Inhibitory Activity", U.S. 5,354,865, 1994.
13) Dellaria, J. F.; Brooks, D. W.; Moore, J. L. "Ether Containing Inhibitors of 5-Lipoxygenase",
    U.S. 5,350,765, 1994.
12)    Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(4-Alkoxypyran-4-yl)
      Substituted arylalkylaryl-, arylalkenylaryl-, and alrylalkynylarylurea inhibitors of 5-
      Lipoxygenase", U.S. 5,346,914, 1994.
11) Dellaria, J. F.; Brooks, D. W.; Moore, J. L. "Ether Containing Inhibitors of 5-Lipoxygenase",
    U.S. 5,268,379, 1993.
9) Dellaria, J. F.; Brooks, D. W.; Sallin, K. J. ; Moore, J. L. "Arylamidoalkyl-N-hydroxyurea
    Compounds Having Lipoxygenase Inhibitory Activity", U.S. 5,214,204, 1993.
8)    De, B.; Zydowsky, T. N.; Baker, W. R.; Dellaria, J. F.; Rosenberg, S. H.; Jae, H. S.
      “Heterocyclic peptide renin inhibitors”, U.S. 5,164,388, 11/17/92.
7)    Brooks, D. W.; Dellaria, J. F.; Maki, R. G.; Rodriquez, K. E.: Carter, G. W.             "Indole
      Derivatives Which Inhibit Leukotriene Biosynthesis", U.S. 5,095,031, 1992.
6) Brooks, D. W.; Summers, J. B.; Gunn, B. P.; Dellaria, J. F.; Holms, J. H.; Maki, R. G.;
   Martin, J. G.; Moore, J. L.; Rodriques, K. E.; Stewart, A. O. , "Heteroaryl N-Hydroxy Amides
   and Ureas With Polar Substituents As 5-Lipoxygenase Inhibitors", U.S. 4,992,464, 1991.
5) Rosenberg, S. H.; Dellaria, J. F.; Fung, A. K. L.; Kempf, D. J.; Luly, J. R.; Plattner, J. J. "Renin
    Inhibiting Compounds", U.S. 4,857,507, 1989.



                                                                                                  5
Joseph F. Dellaria, Jr.



4) Dellaria, J. F.; Fung, A. K. L; Kempf, D. J.; Luly, J. R.; Plattner, J. J.;; Rosenberg, S. H.; Sham,
    H. L. "Renin Inhibiting Analogs", U. S. 4,826,958, 1989.
3) Luly, J. R.; Dellaria, J. F.; Fung, A. K. L.; Kempf, D. J.; Plattner, J. J.; Rosenberg, S. H.; Sham,
    H. L. "Renin Inhibiting Compounds", U.S. 4,826,815, 1989.
2) Luly, J. R.; Plattner, J. J.; Dellaria, J. F. "Renin Inhibiting Compounds", U.S. 4,652,551, 1987.
1) Luly, J. R.; Plattner, J. J.; Dellaria, J. F. "Renin Inhibiting Compounds", U.S. 4,645,759, 1987.


Published and Pending Patent Applications: 14

Unpublished Pending Patent Applications: 2


                                            Publications

30) Dellaria, Joseph F. “Telescoping Light for Perfect Sight”, Wood, 2007, 117, p.10.
29) Bruncko, M.; McClellan, W. J.; Wendt, M. D.; Sauer, D. R.; Geyer, A.; Dalton, C. R.;
Kaminski, M. A.; Weitzberg, M.; Gong, J.; Dellaria, J. F.; Mantei, R.; Zhao, X.; Nienaber, V. L.;
Stewart, K.; Klinghofer, V.; Bouska, J.; Rockway, T. W.; Giranda, V. L. “Naphthamidine
Urokinase, Plasminogen Activator Inhibitors with Improved Pharmacokinetic Properties”, Biorg.
Med. Chem. Lett., 2005, 15, 93-98.
28) Curtin, M. L.; Florjancic, A. S.; Heyman, H. R.; Michaelides, M. R.; Garland, R. B.; Holms, J.
H.; Steinman, D. H.; Dellaria, J. F.; Gong, J.; Wada, C.K.; Guo, Y.; Elmore, I. B.; Tapang, P.;
Albert, D. H.; Magoc, T. J.; Marcotte, P. A.; Bouska, J. J.;Goodfellow, C. L.; Bauch, J. L.; Marsh,
K. C.; Morgan, D. W.; Davidsen, S. K. “Discovery and Characterization of the Potent, Selective,
and Orally Bioavailable, MMP Inhibitor ABT-770”, Biorg. Med. Chem. Lett., 2001, 11 (12),
1557-1560.
27) Michaelides, M. R.; Dellaria, J. F.; Gong, J.; Holms, J. H.; Bouska, J. J.; Stacey, J.; Wada, C.K.;
Heyman, H. R.; Curtin, M. L.; Guo, Y.; Goodfellow, C. L.; Elmore, I. B.; Albert, D. H.; Magoc, T.
J.; Marcotte, P. A.; Garland, R. B.; Morgan, D. W.; Davidsen, S. K. “Biaryl Ether Retohydroxamtes
as Potent Long-lived Orally Bioavailable MMP Inhibitors”, Biorg. Med. Chem. Lett., 2001, 11
(12), 1553-1556.
26) Kolasa, T.; Brooks, C. D. W.; Rodriques, K. E.; Summers, J. B.; Dellaria, J. F.; Hulkower, K.
I.; Bouska, J.; Bell, R. L.; Carter, G. W. "Nonsteroidal Anti-Inflammatory Drugs As Scaffolds For
The Design Of 5-Lipoxygenase Inhibitors", J. Med. Chem., 1997, 40 (5), 819-824.
25) Dellaria*, J. F.; Sallin, K. J. ; Rodriques, K. "Synthesis of New Amide-linked N-hydroxyurea
5-Lipoxygenase Inhibitors by an Intramolecular Oxygen to Nitrogen Acyl Transfer", Biorg. Med.
Chem. Lett., 1993, 3 (2), 305-309.
24) Luly*, J. R.; Dellaria, J. F.; Davidsen, S.K. “Anti-Inflammatory Patents Highlights From the
First Half of 1992”, Current Opinion in Therapeutic Patents, 1992, 2(10), 1577.
23) Dellaria*, J. F.; Sallin, K. J. "Wittig Olefination in the Absence of an Exogenous Base: a New
Synthesis of -Substituted Primary Allylic Amines", Tetrahedron Lett., 1990, 31, 2661.

                                                                                                   6
Joseph F. Dellaria, Jr.



22) Rosenberg*, S. H., Dellaria*, J. F.; Kempf*, D. J.; Hutchins, C. W.; Woods, K. W.; Maki, R.
G.; de Lara, E.; Spina, K. P.; Stein H. H.; Cohen, J.; Baker, W. R.; Plattner, J. J.; Kleinert, H. D.;
Perun, T. J. "Potent, Low Molecular Weight Renin Inhibitors Containing a C-Terminal Heterocycle:
Hydrogen Bonding at the Active Site", J. Med. Chem., 1990, 32, 1582.
21) Dellaria*, J. F.; Maki, R. G.; Stein,H. H.; Cohen, J. "New Inhibitors of Human Renin That
Contain Novel Phospho-Statine Derived Leu-Val Replacements" , J. Med. Chem., 1990, 32, 534.
20) Dellaria*, J. F.; Denissen, J. F.; Kerdesky, F.; Maki, R. M.; Nellans, H.N. "An Iterative
Synthesis of Radiolabelled Polyethylene Oligomers", J. Label. Cmpds. Radiopharm., 1989, 27
(12), 1438-1450.
19) Dellaria*, J. F.; Santarsiero, B. D. "The Enantioselective Synthesis of Amino Acid
Derivatives via the Stereoselective Alkylation of a Homochiral Glycine Enolate Synthon", J. Org.
Chem., 1989, 54, 3916-3926.
18) Evans*, D. A., Britton, T. C., Dorow, R. L., Dellaria, J. F. "The Asymmetric Synthesis of -
Amino and -Hydrazino Acid Derivatives via The Stereoselective Amination of Chiral Enolates
with Azodicarboxylate Esters", Tetrahedron, 1988, 44(17), 5525-5540.
17) Plattner*, J. J.; Marcotte, P. A.; Kleinert, H. D.; Stein, H.H.; Greer, J.; Bolis, G.; Fung, A. K.
L.; Bopp, B. A.; Luly, J. R.; Sham, H. L.; Kempf, D. J.; Rosenberg, S. H.; Dellaria, J. F.; De, B.;
Merits, I.; Perun, T. J. "Renin Inhibitors. Dipeptide Analogues of Angiotensinogen Utilizing a
Structurally Modified Phenylalanine Residue to Impart Proteolytic Stability" J. Med. Chem., 1988,
31, 2277-2288.
16) Zydowsky, T. M.; Dellaria*, J. F.; Nellans, H. N.     "Efficient and Versatile Synthesis of
Dipeptide Isosteres Containing Gamma- or Delta-Lactams" , J. Org. Chem, 1988, 53, 5607-5616.
15) Dellaria*, J. F.; Santarsiero, B. D. "Stereoselective Alkylation of Chiral Glycine Enolate
Synthons. The Enantioselective Synthesis of -Amino Acid Derivatives" Tetrahedron Lett.,
1988, 29, 6079-6082.
14) Luly*, J. R.; Bolis, G.; BaMaung, N.; Soderquist, J.; Dellaria, J. F.; Stein, H.; Cohen, J.; Perun,
T. J.; Greer, J.; Plattner, J. J. "New Inhibitors of Human Renin That Contain Novel Leu-Val
Replacements. Examination of the P1 Site" , J. Med. Chem., 1988, 31, 532-539.

13) Dellaria*, J. F.; Maki, R. G.; Bopp, B. A.; Cohen, J.; Kleinert, H.D .; Luly, J. R.; Merits, I.;
Plattner, J. J.; Stein, H. H. "Optimization and in Vivo Evaluations of a Series of Small, Potent, and
Specific Renin Inhibitors Containing a Novel Leu-Val Replacement" , J. Med. Chem., 1987, 30,
2137.
12) Luly*, J. R.; Dellaria, J. F.; Plattner, J. J.; Soderquist, J. L.; Yi, N. "A Synthesis of Protected
Aminoalkyl Epoxides from Alpha-Amino Acids" , J. Org. Chem., 1987, 52, 1487.
11) Dellaria*, J. F.; Maki, R. G. "The Enantio- and Diastereoselective Synthesis of the First
Phospho-Statine Derivative" , Tetrahedron Lett., 1986, 27, 2337.
10) Dellaria*, J. F.; Nordeen, C.; Swett, L. R. "The Facile and Efficient Preparation of Phenolic
and Thiol Esters" , Synth. Commun. , 1986, 16, 1043.

                                                                                                  7
Joseph F. Dellaria, Jr.



9) Evans*, D. A.; Britton, T. C.; Dorow, R. L.; Dellaria, J. F. "Stereoselective Amination of Chiral
Enolates. A New Approach to the Asymmetric Synthesis of Alpha-Hydrazino and Alpha-Amino
Acids" , J. Am. Chem. Soc., 1986,108, 6395.
8) Luly*, J. R.; Plattner, J. J.; Stein, H. H.; Yi, N.; Cohen, J.; Tricarico, K.; Dellaria, J. F. "Renin
Inhibitors: Peptide Analogs of Angiotensinogen Which Display Potent and Specific Inhibition of
Human Renin" , Pharmacologist, 1985, 27, 260.
7) Hoye*, T. R.; Caruso, A. J.; Dellaria, J. F.; Kurth, M. J. "Two Syntheses of dl-Aplysistatin" , J.
Am. Chem. Soc., 1982, 104, 6704.
6) Hoye*, T. R.; Bottorff, K. J.; Caruso, A. J.; Dellaria, J. F. "Regio- and Stereoselectivity in the
Ene Reaction of N-Phenyl-1,2,4-triazoline-3,5-dione With Alpha,Beta-Unsaturated Carbonyl
Substrates" , J. Org. Chem., 1980, 45, 4287.
5) Doyle*, M. P.; Buhro, W. E.; Dellaria, J. F. "A Facile Synthesis of 1,2-Disubstituted
Cyclopropyl-carbonyl Compounds of High Isomeric Purity" , Tetrahedron Lett., 1979, 4429.
4) Doyle*, M. P.; Elliott, R. C.; Dellaria, J. F. "Ring-size Effects in Lewis Acid Promoted
Reactions of n-(1-Phenylcyclopropyl)alkanoyl Chlorides" , J. Org. Chem., 1978, 43, 4459.
3) Doyle*, M. P.; Dellaria, J. F.; Siegfried, B.; Bishop, S. W. "Reductive Deamination of
Arylamines to Aromatic Hydrocarbons" , J. Org. Chem., 1977, 42, 3494.
2) Doyle*, M. P.; Siegfried, B.; Dellaria, J. F. "Copper(II) Halide Catalyzed Conversion of Aryl
Amines to Aryl Halides" , J. Org. Chem., 1977, 42, 2426.
1) Doyle*, M. P.; Siegfried, B.; Elliott, R. C.; Dellaria, J. F. "A Convenient and Effective
Variation of the Meerwein Arylation Reaction" , J. Org. Chem., 1977, 42, 2431.


                                      PRESENTED PAPERS

22) Dellaria, Joseph F. “Shaping and Harnessing Your Innovation Process: the Interplay Between
Perception and Reality”, Front End of Innovation Conference, Pre-Conference Symposium 2,
Boston, Massachusetts, May 8-11, 2007.
21) Kshirsagar, Tushar A.; Griesgraber, George W.; Stoermer, Doris; Amos, David T.; Lindstrom,
Kyle J.; Rice, Michael J.; Crooks, Stephen L.; Bonk, Jason D.; Dellaria, Joseph F.; Heppner,
Philip D.; Gerster, John F.; Merrill, Bryon A.; Johannessen, Sarah C.; Zimmermann, Bernhard M.;
Marszalek, Gregory; Dresssel, Luke T.; Haraldson, Chad A.; Squire, David J.; Wurst, Joshua R.;
Radmer, Matthew R.; Manske, Karl J.; Spessard, Sarah J.; Langer, Scott E.; Karp, Gregory P.;
Gibson, Sheila J.; Wurst, Lindsay R. “Imidazo[4,5-c]quinoline-based TLR7 and TLR8 immune
response modifiers: Structure-activity-relationships relating to potency, selectivity, and therapeutic
applications.”    Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United
States, Sept. 10-14, 2006 (2006), MEDI-573.
20) Krepski, Larry R.; Manske, Karl J.; Griesgraber, George W.; Duffy, Daniel E.; Moseman, Joan
T.; Dressel, Luke T.; Stoermer, Doris; Heppner, Philip D.; Kshirsagar, Tushar A.; Dellaria, Joseph

                                                                                                   8
Joseph F. Dellaria, Jr.



F.; Gibson, Sheila J.; Wurst, Lindsay R. “Synthesis and SAR of TLR7 and TLR8 small molecule
immune response modifiers: Novel alkylamino and alkoxy functionalized imidazo[4,5-
c]quinolines.” Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United
States, Sept. 10-14, 2006 (2006), MEDI-218.
19) Rockway, T. W.; McClellan, W. J.; Dellaria, J. F.; Gong, J.; Mantei, R. A.; Wendt, M.; Zhao,
X.; Weitzberg, M.; Sauer, D.; Bruncko, M.; Dalton, C.; Kaminski, M.; Giranda, V.; Butler, C.;
Linghofer, V.; Joseph, M.; Nienaber, V.; Stewart, K. “Structure-based Design of Novel Urokinase
Inhibitors Derived from 2-Naphthamidine” 220th American Chemical Society National Meeting,
New Orleans, LA, Aug 20-244, 2000, MEDI-ABSTRACT #030.
18) Dellaria,* J. F.; Moore, J. L.; Hulkower, K. I.; Bouska, J.; Grayson, G. K.; Harris, R. R.: Bell,
R. L.; Brooks, C. D. W.; Carter, G. W. "Novel -Unsaturated Ethers Of 4-Methoxy
tetrahydropyran Are Orally Active 5-Lipoxygenase Inhibitors ." 211th American Chemical Society
National Meeting, New Orleans, LA, March 24-28, 1996, MEDI-ABSTRACT #246.
17) Black, * L. A.; Dellaria, J. F., Brooks,C. D. W., Bell, R. L., Harris, R.; Bouska, J.; Bures, M.
G. "Dialkoxycycloalkanes as Leukotriene Biosynthesis Inhibitors" 1989 International Chemical
Congress of Pacific Basin Societies, Honolulu, Hawaii, Dec 21, 1995, ORGN-ABSTRACT #532.
16) Dellaria, * J. F., Moore, J. L., Hulkower, K. I., Bouska, J., Bell, R. L., Brooks,C. D. W.,
Carter, G. W. "New Orally Active 5-Lipoxygenase Inhibitors: Unsaturated Ethers Of 4-
Methoxytetrahydropyran" 6th Interscience World Conference on Inflammation, Antirheumatics,
Analgesics, Immunomodulators, Geneva, Switzerland, March 28-30, 1995, Abstract # 53.
15) Dellaria,* J. F.; Sallin, K. J.; Moore, J. L.; Bell, R. L.; Lanni, C.; Bouska, J.; Young, P. R.;
Brooks, D. W.; Carter, G. W. "Amide-linked N-Hydroxyureas: A New Class of Potent, Long-lived,
and Orally Active 5-Lipoxygenase Inhibitors" 204th American Chemical Society National Meeting,
Washington, DC, August 23-28, 1992, MEDI-ABSTRACT #104.
14) Moore,* J. L.; Brooks, D. W.; Kolasa, T.; Rodriques, K. E.; Dellaria, J. F.; Lanni, C.; Young,
P. R.; Bell, R. L.; Carter, G. W. “5-Lipoxygenase Inhibitory Activity of Alkyl Hydroxyureas”
Abstracts 23rd National Med.Chem.Sym., Buffalo, NY., June 14-18, 1992, Abstract #49.
13) Zydowsky,* T. M.; Dellaria, J. F.; deLara, E.; Nellans, H. N.; Baker, W. R.; Barlow, J.;
Calzadilla, S.; Cohen, J.; Kleinert, H.; Klinghofer, V.; Polakowski, J.; Stein, H.; Verburg, K.;
Perun, T. J. “Synthesis of Renin Inhibitors Containing Conformationally Constrained Gamma- or
Delta-lactams as P-3 Site Replacements” XIIth International Symposium on Medicinal Chemistry,
Switzerland, September 13-17, 1992, 66, Abstract #OC-04.4.
12) Dellaria,* J. F.; Brooks, D. W.; Summers, J. B.; Sallin, K. J.; DeNinno, S. L.; Martin, M. B.;
Martin, J. G.;. G.; Moore, J. L.; Holms, J. H.; Lanni, C.; Bouska, J.; Young, SP. R.; Bell, R. L.;
Carter, G. W. "A-69412, a Long Lived, Orally Active, and Selective 5-Lipoxygenase Inhibitor" 4th
Chemical Congress of North America, New York, New York, August 25-30, 1991. MEDI-
ABSTRACT #176.
11) Dellaria,* J. F.; Sallin, K. J. "Allylic Amines, Via In situ Ylide Formation from N-acyl
Aziridines and Triphenylphosphine" 32nd Organic Chemistry Symposium, University of
Minnesota, Minneapolis, Minnesota, June 16-20, 1991, Abstract #A-11.
10) Dellaria,* J. F.; Brooks, D. W.; Summers, J. B.; DeNinno, S. L.; Martin, M. B.; Martin, J. G.;.
G.; Stewart, A. O.; Sallin, K. J.; Bouska, J.; Young, SP. R.; Bell, R. L.; Carter, G. W. "Thiophene-

                                                                                                9
Joseph F. Dellaria, Jr.



Derived Inhibitors of 5-Lipoxygenase: Small, Potent, and Bioavailable N-Hydroxy Ureas" 199th
American Chemical Society National Meeting, Boston, Massachusetts, April 22-27, 1990. Abstr.
Pap. Am. Chem. Soc. 1990, 199(0). MEDI-ABSTRACT #76.
9) Brooks,* D. W.; Summers, J. B.; Gunn, B. P.; Dellaria, J. F.; Holms, J. H.; Maki, R. G.; Martin,
J. G.; Martin M. b.; Moore J. L.; Rodriquez, K. E.; Stewart, A. O.; Albert, D. H.; Bell, R. L.;
Bouska, J. B.; Dyer, R. D.; Malo, P. E; Young, P. R.; Rubin, P. Kesterson, J.; Carter, G. W.
"Abbott-64077, a Promising Therapeutic Agent for Treating Leukotriene Mediated Diseases", 199th
American Chemical Society National Meeting, Boston, Massachusetts, April 22-27, 1990. Abstr.
Pap. Am. Chem. Soc. 1990, 199(0). MEDI-ABSTRACT #148.
8) Rosenberg*, S. H.; Dellaria, J. F.; Kempf, D. J.; Woods, K. W.; Maki, R. G.; de Lara, E.;
Kleinert, H. D.;, Stein, H. H.; Cohen, J.; Plattner, J. J.; Baker, W. R.; Perun, T. J. "Renin Inhibitors
Containing A C-terminal Heterocycle", In Proceedings of the 11th Peptide Symposium; Rivier, J. E.
; Marshall, G. R., Eds; Escom: Leiden, 1990; pp402-403.
7) Dellaria*, J. F.; Sallin, K. J.; Maki, R. G.; De Ninno, S. L. "A New Primary Allylic Amine
Synthesis: In Situ Formation And Trapping Of An Ylide From The Reaction Of An N-Acyl
Aziridine, Triphenylphosphine, And An Aldehyde", 1989 International Chemical Congress of
Pacific Basin Societies, Honolulu, Hawaii, Dec 21, 1989, ORGN-ABSTRACT #532.
6) Dellaria*, J. F.; Maki, R. G.; Stein, H. H.; Cohen, J. "Phospho-Statine Derived Renin
Inhibitors" 194th American Chemical Society National Meeting, New Orleans, Louisiana, Sept. 2,
1987. Abstr. Pap. Am. Chem. Soc. 1987, 194(0). MEDI-ABSTRACT #86.
5) Luly*, J. R.; Soderquist, J. L.; Yi, N.; Plattner, J. J.; Dellaria, J. F.; Kleinert, H. D.; Stein, H. H.;
Perun, T. J. "Design and Synthesis of Novel Inhibitors of Renin" , 192nd American Chemical
Society National Meeting, Anaheim, California, September 7-12, 1986. Abstr. Pap. Am. Chem.
Soc., 1986, 192(0). MEDI-ABSTRACT #7.
4) Luly*, J. R.; Dellaria, J. F.; Plattner, J. J.; Soderquist, J. L.; Yi, N. "The Wittig Olefination of
Alpha-Amino Aldehydes with Minimal Racemization. Synthesis of Protected Aminomethyl
Epoxides" , 191st American Chemical Society National Meeting, New York, NY, April 13-18,
1986. Abstr. Pap. Am. Chem. Soc. 1986, 191(0). ORG-ABSTRACT # 42.
3) Luly*, J. R.; Soderquist, J. L.; Yi, N.; Plattner, J. J.; Dellaria, J. F.; Kleinert, H. D.; Maki, R.;
Stein, H. H.; Bopp, B. A.; Perun, T. J. "Low Molecular Weight, Nanomolar Renin Inhibitors" ,
191st American Chemical Society National Meeting, New York, NY, April 13-18, 1986. Abstr.
Pap. Am Chem. Soc. 1986, 191(0). MEDI-ABSTRACT #9.
2) Plattner*, J. J.; Fung, A. K. L.; Stein, H.; Kleinert, H. D.; Marcotte, P.; Smital, J.; Dellaria,J. F.;
Sham, H. L.; Luly, J. R.; Rosenberg, S. H.; Kempf, D. J.; Greer, J.; Perun, T. J. "Specific Inhibition
of Human Renin by a Small Peptide, Transition-State Analogs" , 191st American Chemical Society
National Meeting, New York, NY, April 13-18, 1986. Abstr. Pap. Am. Chem. Soc. 1986,191(0),
MEDI-ABSTRACT #28.
1) Dellaria*, J. F.; Evans, D. A. "The Enantioselective Synthesis of Alpha-Amino Acids
Employing a New Chiral Glycine Enolate Synthon" International Symposium of the Chemistry of
Natural Products, Edmonton, Alberta, Canada, June 23-26, 1985. Abstract #-CO-13.




                                                                                                      10
Joseph F. Dellaria, Jr.



                                    INVITED LECTURES

10) "Medicinal Chemistry: A Mother Of Invention: Uses of Azridine Olefination and
Peptidomimetic Synthesis in Drug Discovery”, Macalester College, St. Paul, Minnesota, November
6, 2002.
9)    "Medicinal Chemistry: A Mother Of Invention: Uses of Azridine Olefination and
Peptidomimetic Synthesis in Drug Discovery”, 2001 St. Louis Award Symposium, University of
Missouri-St. Louis, St. Louis, Missouri, April 20, 2001.
8) "Medicinal Chemistry: A Mother Of Invention" University of Kansas, Lawrence, Kansas,
September 9, 1993.
7) "Medicinal Chemistry: A Mother Of Invention" North Dakota State University , Fargo, ND,
November 9, 1989.
6) "Medicinal Chemistry: A Mother Of Invention" University of Minnesota, Minneapolis, MN,
November 8, 1989.
5) "Chemistry Enroute to Renin Inhibitors" University of California, Davis, February 23, 1989.
4) "Optimization of Renin Inhibitors Containing a Novel Leu-Val Replacements and Other
Pharmacological Evaluations" Reno, Nevada, American Association of Pharmaceutical Scientists
Western Regional Meeting, February 27, 1989.
3) "Chemistry Enroute to Renin Inhibitors" University of Nevada, Reno, March 1, 1989.
2) "In Search of Amide Bond Replacements" University of California, Davis, Chemistry
Department Industrial Symposium Program, October 10, 1986.
1) "Cardiovascular Drugs and Some Related Chemistry", Associated Colleges of the Chicago Area,
Argonne Labs, Chicago, Illinois, October 21, 1986.




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