Heep Yuun

							chemistry IN water
Heep Yunn School ( 協恩中學 )
   Wu Hoi Man     ( 胡凱文 )
   Fan Lok Yan    ( 范樂欣 )
   Hui Yuet Man    ( 許悅敏 )
   Tang Tsz Kwan ( 鄧紫君 )
   Cheung Man Ying ( 張敏盈 )
 Epoxidation is an important
      step in making drugs
                                            eg. Triptolide


 R1         R4                                   R1
                 Dioxirane epoxidation                    O       R4
  C     C                                             C       C
 R2         R3                                   R2               R3
                 (in water - organic solvent)
 Alkene                                         Epoxide
1. Generalize the best system
2. Find key factors affecting two-
  phase reaction
3. Find a greener way to conduct
  epoxidation
Novel epoxidation method
                       2.Ketone (catalyst):
                      1,1,1-trifluoroacetone



        R1       R4           CH3COCF3            R1 O      R4
                             Oxone , pH 9

        R2       R3       CH3CN /Water, 10 °C     R2        R3


             6.Substrate : oxidizing agent
                      1 : 2



                                5.Water : organic solvent
                                      1 :      1.1
Strengthen the Proportion of
                                    36 % 
role of water  water as solvent
               Oxone (oxidizing agent) 33% 
Use fewer
               Ketone (catalyst)       90% 
chemicals
               Organic solvent         30% 

Consume less
               0 oC  10 oC
energy
  Finding the topic


Testing of experiment


  Investigation           Problems


   Modifications


  Report + presentation