Research Associate in Complement Therapeutics
Innate Immunity Section/Division of Transplantation
Immunology and Mucosal Biology
School of Medicine
Reference Number: R6/MJK/1040/12-JE
1. Explanatory notes including application procedure
2. Further particulars, including:
a. Information about King’s College London, and the post
b. Job description and person specification
c. Summary of the terms and conditions of service
Please read carefully before completing the application form
Thank you for your enquiry regarding a post at King’s College London. Enclosed is a set of further particulars
for this post. These comprise: a job description and person specification; general information about the
College, School and Department; as well as the main terms and conditions of the post.
Should you wish to apply for this position, please send the following:
Please complete a Personal details form and Equal opportunities monitoring form
a copy of a short statement setting out your reasons for applying for the post and highlighting the
particular skill and experience which you feel you would bring to the role
a copy of a current curriculum vitae which should include inter alia:
o your full name with title
o details of your present post with date of appointment
degrees (subject, class, institution, date of award)
other academic/professional qualifications (subject, level, institution, date of award)
distinctions other than degrees
o membership of professional and learned societies
o teaching and research experience
o administrative and management experience
o grants obtained
To email: email@example.com
Applications should be made electronically in Word or PDF format.
Please ensure you quote reference number R6/MJK/1040/12-JE on all correspondence.
Closing date: 29 October 2012
Please advise your referees that they may be contacted and asked to provide a reference at short notice.
King's College London recognises that equality of opportunity and the recognition and promotion of diversity
are integral to its academic and economic strengths.
The following principles apply in respect of the College’s commitment to equality and diversity:
To provide and promote equality of opportunity in all areas of its work and activity;
To recognise and develop the diversity of skills and talent within its current and potential community;
To ensure that all College members and prospective members are treated solely on the basis of their
merits, abilities and potential without receiving any unjustified discrimination or unfavourable
treatment on grounds such as age, disability, marital status, pregnancy or maternity, race, religion or
belief, sex, sexual orientation, trans status, socio-economic status or any other irrelevant distinction;
To provide and promote a positive working, learning, and social environment which is free from
prejudice, discrimination and any forms of harassment, bullying or victimisation;
To promote good relations between individuals from different groups.
Applicants with disabilities
King's College London is keen to increase the number of disabled people it employs. We therefore encourage
applications from individuals with a disability who are able to carry out the duties of the post. If you have
special needs in relation to your application please contact the Human Resources Advisor responsible for the
administration of the post.
The College normally reimburses reasonable travel costs to and from interview within the United Kingdom.
Regrettably, only limited contribution to travel costs for applicants from outside the UK may be available.
Please contact the Head of Department before making your reservation.
We very much regret that due to limited resources and the large number of applications we currently receive,
we are only able to inform short listed candidates of the outcome of their application.
If you do not hear from us within four weeks of the closing date, please assume that you have been
unsuccessful on this occasion. We would like to assure you, however, that every application we receive is
considered in detail and a shortlist only drawn up after careful reference to a detailed person specification.
If therefore, your application is not successful, we hope that you will not be discouraged and will still apply for
other suitable vacancies at King’s College London as and when they are advertised.
Thank you for your interest in King’s College London.
King's College London is one of the top 30 universities in the world (2011/12 QS World University Rankings),
and the fourth oldest in England. A research-led university based in the heart of London, King's has nearly
23,500 students (of whom more than 9,000 are graduate students) from nearly 140 countries, and
approximately 9,000 employees. It offers an intellectually rigorous environment supported by welcoming and
caring traditions. King's is in the second phase of a £1 billion redevelopment programme which is transforming
King's has an outstanding reputation for providing world-class teaching and cutting-edge research. In the
2008 Research Assessment Exercise for British universities, 23 departments were ranked in the top quartile of
British universities; over half of our academic staff work in departments that are in the top 10 per cent in the
UK in their field and can thus be classed as world leading. The College is in the top seven UK universities for
research earnings and has an overall annual income of nearly £450 million.
There are nine Schools of Study:
Arts & Humanities
Institute of Psychiatry
Natural and Mathematical Sciences
Florence Nightingale School of Nursing & Midwifery
Social Science & Public Policy
King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range
of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international
affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery
of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.
It is the largest centre for the education of healthcare professionals in Europe; no university has more Medical
Research Council Centres.
King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley
NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences
Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities
and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and
comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.
The School of Medicine at Guy’s, King’s College and St. Thomas’ hospitals
The School of Medicine is one of the largest medical schools in the UK and is committed to pursuing excellence
in research and teaching. The School has a population of over 2000 undergraduate and postgraduate students.
The School consists of 9 cross-School research divisions populated by over 600 staff, with a research income of
The School is located across four hospital campuses across South London. Each campus has its own distinctive character
and this diversity is an attractive feature of the School for our staff and students, particularly undergraduates. The
School’s two major partner trusts, Guy’s and St Thomas’ NHS Foundation Trust (GST) and King’s College Hospital NHS
Trust (KCH) have 1,000,000 patient contacts a year combined. Their specialist services include cancer, cardiothoracic,
renal, haematology, children’s services (GST); liver disease and transplantation, foetal medicine, neuroscience, cardiology
Based on UCAS application figures, King’s College London continues to be the most popular choice for
undergraduate medicine in the UK. Applications increased by nearly 20% for 2004 entry. The School has the
largest number of entry routes to medicine in the UK and as such has a diverse undergraduate population. The
School is in its fifth year of offering the flagship Extended Medical Degree programme, the UK’s first widening
access to medicine programme. In 2004, the School admitted the first graduate students to the new fast-track
The School continues to improve teaching and research capacity. In 2004, £7M laboratories were officially
opened to support the School’s infection and immunity programme. A £25M Centre for Cell and Integrative
Biology on the King’s Denmark Hill Campus will provide an international centre focussed on stem-cell
research in cardiovascular disease, organ transplantation and neurodegenerative disease. An Institute of
Clinical Neurosciences is also being planned for the site, to co-exist alongside KCH Trust neuroscience clinical
service. An integrated, cross-disciplinary Imaging Sciences Division has been formed and will move to newly
refurbished laboratories at the St Thomas’ campus in 2006
The NIHR Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and
King's College London
The NIHR Biomedical Research Centre (BRC) at GSTFT and KCL has recently been awarded a further £58.7M
over the period 2012-2017 as part of the Department of Health’s strategy for Research & Development to
deliver world class translational research to benefit the health and wealth of the nation. The first GSTFT/KCL
BRC award from April 2007-2012 allowed us to establish of state of the art research infrastructure including
the development of an Experimental Medicine Hub at Guy’s Hospital. The new BRC’s research is strategically
integrated and managed by five Research Clusters: Experimental Medicine and Therapeutics; Biomarkers,
Codiagnostics and Imaging; Population Sciences; the School of Translational and Experimental Medicine
(STEM) and the Operational Infrastructure Cluster. Research within these Clusters are based around eight
outstanding research themes encompassing Cancer; Cardiovascular Disease; Cutaneous Medicine;
Environmental and Respiratory Health; Imaging & Bio-Engineering; Infection & Immunity; translational
Genetics; and Transplantation. The Experimental Medicine Hub houses state of the art facilities for the
delivery of translational research and includes the BRC/R&D Department Management offices, CLRN, PCRN,
Joint Clinical Trials Offices creating a one stop shop for researchers, as well as the CRF at Guy’s, Immune
Monitoring Core, Good Manufacturing Practice. (GMP) Cell Therapy Suite and Genomics Core, as well as
Quintiles Phase I Clinical Trials Unit, GMP Pharmacy, the Assisted Conception Unit with a GMP stem cell suite
a GMP Flow Sorting Core and BRC Imaging Core.
Figure 4: Interaction of Clusters and Themes
Cluster 1 - Experimental Medicine & Therapeutics Cluster
The Biomedical Research Centre (BRC) will have as a priority the investigation of new medicines in man that
are being developed by BRC investigators and include novel drugs we have developed as well as cell and gene-
based therapies. To facilitate this exciting developmental plan, the relevant activity has been organised into a
designated operational grouping termed the Experimental Medicine & Therapeutics Cluster. This Cluster aims
to integrate and support the Programmes in Cellular, Protein/Peptide and Small Molecule Therapeutics that
will cut across research Themes and integrate shared interests in drug modalities. The Programmes will thrive
on the availability of the BRC’s infrastructure - Immune Monitoring Core, Clinical Research Facility, Protein-
Engineering Facility and GMP Cell Therapy Suite.
Division of Transplantation Immunology and Mucosal Biology
The Division of Transplantation Immunology and Mucosal Biology is a newly created division built out of the Department
of Nephrology and Transplantation and extended to include Liver and Gastrointestinal Tract studies. It has several major
research programmes including complement, coagulation and inflammation and immune biology, T cell differentiation
and T cell regulation, as well as cell and protein therapeutics. It also includes a section of Surgical Innovation and a
section on Research Ethics. The Division serves as a base for two major cross-cutting centres: The MRC Centre for
Transplantation and The NIHR Comprehensive Biomedical Research Centre Transplant Theme
MRC Centre for Transplantation
The MRC Centre for Transplantation aims to translate basic discovery into new therapeutic, diagnostic and prognostic
applications. The MRC Centre spans several programmes of research, including innate immunity (Hayday), complement
(Sacks), coagulation (Dorling), immune biology (Noelle) immune regulation (Lechler; Lombardi; Lord), humanised
models (Nestle), stem cell biology (Sharpe), genetics (Solomon) and imaging (Razavi). Its science base cuts across liver,
kidney, pancreas, bone marrow, islets, hepatocyte and stem cell transplantation, in what is one of the largest patient
groups in Europe. The Centre incorporates a training theme in research ethics and legislation via links with the Centre for
Medical Law and Ethics at KCL. The MRC Centre is closely linked with the Transplant theme of the NIHR Comprehensive
Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust.
The Centre’s work is closely aligned with the Division of Immunology, Infection and Inflammatory Disease (DIIID). The
Division of Immunology, Infection and Inflammatory Diseases undertakes field-leading basic biomolecular research in
infectious diseases and vaccines, tumour immunology, autoimmunity, immune deficiencies, hypersensitivities,
inflammation and transplant rejection. Its results provide a foundation for bridging the gap between pre-clinical and
clinical studies, thus maximising the potential to provide individualized therapeutics and improved diagnostics for the
large and immensely varied patient cohorts in our affiliated hospitals.
The work will be based in the Protein Therapeutics Laboratory (PTL) at the MRC Centre for Transplantation,
Guy’s campus. The objective of the PTL is to discover and carry out translational research on novel protein
and peptide therapeutic agents in the general areas of immunology and inflammatory disease but with a
special emphasis on therapies that can have a near-term impact on transplantation outcomes. The PTL has
developed a novel and generic protein engineering technology termed cytotopic modification which enables
soluble proteins or peptides to bind to cell surfaces. This approach permits organs to be perfused with
engineered proteins prior to transplantation so that both innate and adaptive immune responses can be
manipulated within the transplanted organ rather than through systemic treatment of the organ recipient.
One agent using this technology has entered pilot clinical studies in renal transplantation. The laboratory has
research collaborations with a number of academic groups in the UK and elsewhere and these include an active
programme with the imaging group at KCL. The PTL will also develop relationships with biotechnology and
pharmaceutical companies to assist translation of its agents to the clinic.
The Research Associate will assist in the development of these novel therapeutic agents working closely with
laboratory director, Dr Richard Smith.
Post title: Research Associate in Complement Therapeutics
Department/Division/Directorate: Innate Immunity Section/Division of Transplantation Immunology and
Accountable to: The post is situated within the Experimental Medicine & Therapeutics Cluster (1)
and has accountability to the Cluster Board, Cluster lead and Cluster manager.
The post will report directly to Dr Richard Smith
Key Contacts: Cluster Board members, Experimental Medicine & Therapeutics Cluster lead,
Experimental Medicine & Therapeutics Cluster Manager, R&D Department,
King’s Health Partners Clinical Trials Office, Senior Administrators KCL,
Academic Staff in KCL, Consultants and Junior Medical Staff, administrative and
Clerical Support Staff, Professional and Technical staff. Staff within the Medical
School and other relevant hospitals and Trusts, non commercial bodies and
Pharmaceutical companies and/or sponsors
To support the EMPIRIKAL clinical trial with the complement regulator therapeutic agent Mirococept
by performing critical assays for components of the complement system using human samples
To carry out in vitro research on membrane-interactive regulators of complement activation and blood
To apply and develop techniques for the study of complement and coagulation activation on cells and
in tissues including human ones
To participate and contribute to the development and implementation of research programmes within
the PTL and MRC Centre for Transplantation
Role outline – main responsibilities
To actively participate in the research programme of the PTL
To produce accurate and consistent results for experiments performed
To disseminate the results of this research to both internal and external audiences
Communication & networking:
Maintain accurate written records of all research work undertaken
Prepare progress reports
Disseminate results of research to internal and external audiences
Publish results of work in peer reviewed scientific journals
Collaborate with colleagues within the PTL and at other research laboratories both within in and
external to the Centre/Division
Decision making, planning & problem solving:
To contribute to the running and internal organisation and quality assurance processes of the PTL.
To contribute to the supervision and coaching of visiting scientists and postgraduate students
Respond to requests for information both internal and external in a timely manner
Ensure research milestones are met as requested by the laboratory director
Ensure attendance is maintained at required research meetings
Analysis & research:
Undertake all laboratory work to obtain necessary data for ongoing projects
Work closely with the PTL Director and other members of the research team to ensure the required
research is completed
Team work, teaching & learning support:
Mentor and support postgraduate students based in the PTL.
Work closely with other PTL based staff to ensure a high quality research is carried out
Sensory/physical demands & work environment:
Ensure all work is carried out in compliance with KCL Health and Safety Guidelines
Ensure compliance with all ethical regulations imposed by KCL and Guy’s and St Thomas’ NHS Trust
Ensure compliance with patient confidentiality and the Data Protection Act 1998
Ensure compliance with requirements of intellectual property law
Ensure compliance with Good Laboratory Practice established in the Clinical Transplantation
Specific Aspects: indicate frequency D (daily), W (weekly), M (monthly) where applicable:
Intensive DSE work (eg. data entry or n/a Direct patient contact involving exposure n/a
digital microscopy): prone procedures (EPP):
Heavy manual handling: n/a Direct patient contact, no EPP n/a
Highly repetitive tasks (eg. pipetting or re- n/a Work with patient specimens (eg. blood or M
shelving books): tissue samples):
Shift work, night work or call-out duties: n/a Work with GM organisms or biological M
agents that may pose a hazard to human
Work involving risk of exposure to n/a Hazards which require health surveillance eg. n/a
environmental or human pathogens (eg in respiratory sensitisers (allergens, substances
waste streams or soils): with risk phrase R42, wood dust etc) or loud
Driving vehicles on College business: n/a Food handling or preparation: n/a
Work at height (eg. ladders, scaffolds etc) n/a Work in confined spaces (eg. sump rooms, n/a
The post holder will support other members of the laboratory staff and mentor junior staff and students
Professor Steven Sacks
(Head of Division)
Dr Richard Smith
(Director, Protein therapeutics
You will be required to work irregular hours in accordance with the needs of the role;
Information of a confidential nature must be kept strictly confidential and should never be disclosed
either inside or outside work. It should be noted that breach of confidentiality is a serious offence which
may lead to dismissal;
This appointment is subject to Occupational Health clearance. Should you be offered this post you will
be sent an Occupational Health Questionnaire along with your contract of employment. When the
Occupational Health Department have evaluated your questionnaire and declared that you are fit for
appointment, your appointment will be formally confirmed.
You may be expected to teach and/or assist, as appropriate, using both traditional and innovative
methods in such areas as eLearning, short courses, blended learning, summer courses, distance
learning, multi-media learning, this list is not exhaustive but to give an indication of the type of areas
All staff are expected to adhere to King’s policies and procedures.
15 October 2012
This job description reflects the core activities of the role and as the College and the post-holder develop there
will inevitably be changes in the emphasis of duties. It is expected that the post-holder recognise this and adopt
a flexible approach to work and be willing to participate in training.
If changes to the job become significant, the job description should be reviewed formally by the post-holder
and line manger. The Human Resources department should then be consulted as to the implications of the
Eligibility to work in the United Kingdom
International applications will be considered for this position. If you do not have permission to enter, remain
and work in the United Kingdom you will need to pass a points-based immigration assessment. Before you
apply for this job you must ascertain whether you have sufficient points to qualify under Tier 1 and/or Tier 2
schemes 1. If you do not have sufficient points please do not apply as you will not be granted permission to
enter the United Kingdom. Click on the following link to the points calculator: Border & Immigration Agency
At the interview you will be asked to furnish the panel with the details of the route (Tier 1 and/or Tier 2) you
would be eligible to follow. Please note that should you have sufficient points this does not mean your
application will be successful. In the event your application is successful there is no guarantee that your
application for a visa will be granted, in which event the offer will be withdrawn.
S S AND ASSESSED
AP = application
AS = assessment
I B I = interview
A L P = presentation
L E R = references
EDUCATION/QUALIFICATION AND TRAINING
PhD or equivalent in Biochemistry,
Biological Chemistry or Molecular and x AP
Experience of general laboratory operations X AP/I
Handling and safety of recombinant microorganisms X AP/I
Working with radioisotopes X AP/I
Experience of sterile handling techniques X AP/I
Experience with animal experimentation (rodents) X AP/I
Bacterial cell culture & basic microbiology
In vitro mammalian cell culture X AP/I
Bacterial fermenter operation & protocols X AP/I
Protein analysis and purification X AP/I
Knowledge of the immune molecular immunology
Specific knowledge of the complement system X
Use of computers/software including
Molecular biology software X AP/I
Organised and systematic approach to work on multiple projects X AP/I
Ability to relate to and support colleagues,
other staff, visitors and students
Ability to work in a team
Ability to use own initiative
1 There are two classifications – Tier 1 (Highly skilled workers) and Tier 2 (Skilled workers). Highly skilled
migrants are encouraged to apply under the Tier 1 route. If you do not qualify under the Tier 1 route, you may
qualify under the Tier 2 route, however this is dependent on King’s College London at its sole discretion issuing
you with a Certificate of Sponsorship.
Summary of terms and conditions of service
This appointment is made under the King’s College London Terms and Conditions of Service for Non
Academic staff , a copy of which is available from the Human Resources department on request.
Period of Appointment Fixed term contract for 2 years
Salary £31,020 - £37,012 per annum, plus £2,323 London Allowance per annum
Annual leave 27 working days
Staff receive four additional closure days. Notification as to how these days are taken is circulated at the start
of the academic year.
This appointment is superannuable under the USS pension scheme. Staff already superannuated under the
NHS Superannuation Scheme may opt to remain in that scheme provided an application to do so is received by
the NHS scheme trustees within three months of appointment to King’s College London. Alternatively staff
may opt to participate in SERPS or take out a personal pension. Please note that the College does not provide
an employer's contribution towards a private pension plan.
The College operates PensionsPlus by which individuals increase their take home pay by reducing their NI
contributions. Staff who join the USS pension scheme will automatically be entered into PensionsPlus
(provided you would benefit from doing so). As a result your salary will be reduced so that you receive the
PensionsPlus salary and a payment is made into your pension scheme instead.
NB - NHS Superannuation Scheme: Medical Schools are classed as “Direction Employers” and some benefits
of the NHS Scheme are not available to Direction members.
For further information please contact Ms Pauline Job, Payroll & Pensions Manager, King’s College London,
James Clerk Maxwell Building, 57 Waterloo Road, London SE1 8WA.
All appointments to King’s are subject to Occupational Health clearance. Should you be offered this post you
will be sent an Occupational Health Questionnaire along with your contract of employment. When the
Occupational Health Department have evaluated your questionnaire and declared that you are fit for
appointment, your appointment will be formally confirmed.
In the course of your work you may have access to personal or confidential information which must not be
disclosed or made available to any other person unless in the performance of your duties or with specific
permission from your Head of School/Department/Division. (In particular if your work involves the handling
of clinical samples and/or patient data, NHS policies for the maintenance of security and confidentiality of
NHS systems and data must be observed). Breaches in confidentiality may lead to disciplinary action.
Training and Education
King’s College London recognises the importance of training in achieving its objective of pursuing excellence in
teaching, research and clinical practice through the activities of its staff. We are committed to providing
training for all members of staff so that they can perform their jobs effectively and offering them opportunities
for further development. Most training and development will occur "on the job" and formal training
opportunities are also available within King’s College London associated hospitals trusts and through other
All members of staff with teaching responsibilities are encouraged to obtain formal recognition of their
professional expertise in teaching. It is the normal expectation that staff new to teaching in higher education
will register for the Post Graduate Certificate in Academic Practice (PGCAP) unless they already possess a
teaching qualification in higher education. The PGCAP is taught and managed by the King's Learning Institute
(KLI); information about the certificate and other programmes run by KLI can be found in their web site –
No Smoking Policy
King’s College London is committed to maintaining a healthy environment for staff, students and visitors.
Therefore, please note that smoking is not permitted in any of the College buildings or in College vehicles.
Smoking is also not permitted immediately outside the entrances to College buildings or near to windows and
air intake units. Staff working at associated NHS trust sites or other premises should adhere to whatever policy
is in place at these locations.