201209150226490A

							     DEVELOPMENT AND INVITRO EVALUATION OF BIODEGRADABLE ALBUMIN
                    MICROSPHERES OF ACECLOFENAC

     Rakesh Kumar G*,Yeswanth Reddy D, Prasad G, Jaganmohan S, Ramu A, Vijaya Kumar B
                                   Department of Pharmaceutics,
                           Jangaon Institute of Pharmaceutical Sciences,
                  Yeshwanthapur, Jangaon, Warangal, Andhra Pradesh, India-506167.

       Aceclofenac is one of the emerging NSAID molecules for arthritis treatment. It is a phenyl acetic
acid derivative [2-(2',6’-dichlorophenyl) amino] phenylacetoxyacetic acid], a novel NSAID indicated for
the symptomatic treatment of pain and inflammation.2 Aceclofenac has a very short biological half-life
(about 4 hours) which makes aceclofenac an ideal candidate for prolong release. The high concentration
with rapid absorption of aceclofenac causes adverse effect to GIT. To improve the therapeutic efficacy
of aceclofenac and reduce the severity of upper GI tract side effect, altering dosage form, it can be
formulated in polymeric microspheres. The use of polymeric carriers in formulations of therapeutic drug
delivery systems has gained widespread application, due to their advantage of being biodegradable and
biocompatible. Among the microparticulate systems, microspheres have a special importance since it is
possible to target drugs and provide controlled release. In this present study, it was aimed to prepare
microsphere formulations of Aceclofenac using a natural biodegradable polymer as a carrier for
administration to extend the duration period of the dosage form. Microsphere formulations of DS which
were prepared were evaluated in vitro for particle size, yield value, encapsulation efficiency, surface
morphology, and in vitro drug release. The percentage yield of the different microsphere formulations
was found to be in the range of 88.34±5.34% to 96.44±5.67% The percentage entrapment efficiency and
particle size were found within the range of 38.27±4.44% to 66.39±4.20% and 467±7.79 μm to
567±6.62μm Based on the above findings, it was observed that formulation F6 showed optimum release
characteristics. The release rate of drug from the microspheres could be properly controlled for about
24h. Appropriate variation in the proportions of drug; polymer and stabilizer can lead to a product with
the desired controlled release features.