201209281652470A

							STUDIES ON INFLUENCE OF A NOVEL SOLUBLIZER IN LAMOTRIGINE
                   SUBLINGUAL TABLETS

     Pradnya Palekar-Shanbhag, Sujata Gaikwad, Sneha Jog, Manasi Chogale,

               Vivekanand Education Society’s College Of Pharmacy,

Hashu Advani Memorial Complex, Behind Collector Colony, Chembur, Mumbai-74

                           gaikwad.sujata8@gmail.com




 The present work deals with the study of influence of a novel solublizer ‘SEPITRAP-

 80TM’ in sublingual tablets of Lamotrigine. Lamotrigine is used in the treatment of

 epilepsy. Lamotrigine is the model drug candidate with rationale to have rapid onset of

 action in epilepsy. Sublingual route being highly vascularized with good flow of saliva is

 effective in faster penetration and absorption of drugs serving noninvasive alternative to

 injections. The aim was to have enhanced onset of action of Lamotrigine in the form of

 sublingual tablets.


 SEPITRAP-80TM was used as a solublizer in sublingual tablets in the concentration of 5,

 10, 15, 20 and 25% of the tablet weight. Formulations were made with standard tablet

 excipients and superdisintegrants. Superdisintegrant such as Sodium starch glycolate

 were used in the concentration of 6% and 8%. Sublingual tablets were prepared by direct

 compression method.


 Formulations were evaluated for hardness, disintegration, in vitro drug release, in vivo

 dissolution time, wetting time and water absorption test. Formulations using SEPITRAP-

 80TM gives rapid release of drug. All the formulations showed satisfactory release within

 5 minutes. Formulations with SEPITRAP-80TM gave t90% within 2 minutes.
SEPITRAP-80TM can be a promising solubilizer and an effective bioavailability enhancer

for poorly soluble drugs for various novel drug delivery systems.