paclitaxel water soluble

Document Sample
paclitaxel water soluble Powered By Docstoc
					                                                 MewTaxel




              Potent, Safe and Patented


A MOLECULE= NON SOLUBLE IN WATER

B MOLECULE= NON SOLUBLE IN WATER

C MOLECULE = SOLUBLE IN WATER

A+B = NON SOLUBLE IN WATER

A+C = NON SOLUBLE IN WATER

A+B+C = IS SOLUBLE IN WATER WHICH IS AN INNOVATION
OR DISCOVERY AND IS THE NEED OF THE DRUG. THE
DISCOVERY DOES NOT ALTER ANY OF THE MOLECULE
PARTNER IN THIS HYBRID.
                                          MewTaxel




              MewTaxel




       HYBRID CPT251(MewTaxel)

     A NEW TREATMENT FOR CANCER

SAFE AND MORE EFFECTIVE CHEMOTHERAPY

            Dr.Mewa Singh
            609-902-7128
    mewasinghsandhu@hotmail.com
www.nanosgroup.com / Meda Biotech , USA
                                                    MewTaxel




 $5B MARKET FREE FROM PATENT

 CAPTURE THE MARKET WITH NEW PATENT PROTECTION

 EITHER BY IMPROVEMENT

 EITHER BY CHANGING THE MOLECULE

 EITHER BY CONJUGATION OR HYBRIDIZATION

 DECREASE TOXICITY

 INCREASE EFFICACY

 OUR TECHNOLOGY IS SIMPLE (WITHOUT ANT POLYMER
  CONJUGATION)- HYBRID

 COMPANIES HAD AND HAVE INVESTED 100M $ ON THIS.
  WE JUST GOT THE SAME IN JUST 1M$!
                                                          MewTaxel




 SOLUBILITY
 TOXICITY (The castor-oil carrier is suspected as the
  culprit behind the misery which includes nausea,
  vomiting, joint pain, appetite loss, brittle hair and
  tingling sensations in hands and feet (neuropathy).
 DRUG RESISTANCE
 MANUFACTURNG AND ADMINISTING COST AT CLINIC
 PATENT PROTECTION (Expired)
 THREAT OF GENERIC TO EXISTING ESTABLISHED
  MARKET
 HIGH PRODUCTION AND ADMINNISTRATION AT SITE
  COST
                                                                        MewTaxel




   WATER SOLUBLE

   HYBRID, DOUBLE EDGE FORMULATION

   LESS TOXIC

   HIGH POTENCY

   LOW MANUFACTURING AND ADMINISTRATION COST AT CLINIC

   NO CHANGE IN INTEGRITY OF THE MOLECULES

   PATENT FILED FOR NEW INVENTION FOR HYBRID.

   NO CASTOR OIL, NO ALCOHOL, NO DETERGENT, NO PROTEIN, NO CHEMISTRY
    CHANGE ON TOP OF THAT IT IS MORE POTENT, LESS TOXIC AND LESS
    MANUFACTURING COST.

   NO COMPLEX CONJUGATION STEP
                                                 MewTaxel




 PROOF OF CONCEPT -------------ESTABLISHED

 R & D---------------------------------BASICS
  UNDERSTANDING ESTABLISHED

 PILOT SCALE MANUFACTURING---ESTABLISHED

 IN-VITRO STUDY-------------------PRELIMINARY
  TESTING ESTABLISHED

 ANIMAL STUDIES-------------- ON-GOING
                                                MewTaxel




 $1M INVESTED

 $3M NEEDED ( ANALYTICAL TOOL, CGMP
  MANUFACTURING, PRE-CLINICAL, IND, CLINICAL)
                                                   MewTaxel




 Scale Manufacturing                  (2012)

 Animal efficacy: Drug Interactions   (2013)

 IND
                                       (2014)

 Phase I
                                       (2015)

 Phase II
                                       (2016-17)

 License submission                   (2017-18)
                                                                  MewTaxel




MewTaxel is Potent at 1.1 nM ( ic50 is 30nM)
MewTAxel is potent at 5nm ( ic50 is >60nM)
            Much lower than taxol


                      10000000
                                  Plate 1
         Live Cells




                       8000000
                       6000000
                       4000000
                       2000000
                             0
                                                      P average
                                         1

                                      0.25
                                       0.5




                                  0.03125
                                   0.0625
                                    0.125



                                 0.015625




                                 Concentration (µg)
                                                              MewTaxel




Paclitaxel in water                          MewTaxel in water

                         Solubility


                      NO CASTOR OIL,
                      NO ALCOHOL,
                      NO DETERGENT,
                      NO PROTEIN,
                      NO CHEMISTRY CHANGE
                      ON TOP OF THAT               MewTaxel
                      IT IS MORE POTENT,
                      LESS TOXIC AND
                      COST EFFECTIVE.
                      Act on multiple site
INNOVATIVE:                                 TAxolMew suppresses production of
                                            proteins needed for uncontrolled growth
                                            and proliferation, inflammation and inhibition
                                            of PGE-2. TAxolMew inactivates NF-kappa B,
                                            genes involved in cell proliferation, such as COX-
                                            2, cyclin D1, and c-myc.
TaxolMew also helps to restore normal
programmed cell death.
In a study, taxol induced NF-kappa B activation
led to cell immortality, reducing the drug's
ability to kill cancer cells. Drug resistance is a
huge problem. But TAxolMew can help to make
chemotherapeutic agents more effective.



         Hybrid Partner
 Arrested stem cell development. TaxolMew
 inhibits growth and renewal of so-called cancer stem                                            Mitotic arrest-Taxol
 cells, aberrant cells now believed to be at the root of
 many cancers, including breast cancer.

  TaxolMew inhibited taxol's inflammatory
  response by blocking nuclear factor-kappa B (NF-kappa
  B) which regulates inflammation, cell proliferation, and
  apoptosis (cell death).
                                                                    MewTaxel




 Now that Celgene has wrapped up its $3 billion-plus buyout of
  Abraxis BioScience, analysts are cheering. That wasn't
  necessarily the case in June, when the companies announced
  their deal--and investors responded by selling off their stock,
  sending the price plummeting to $48. But as Investor's
  Business Daily reports, Celgene shares are now trading at near
  $60, and observers think the combo will eventually transform
  the company into a "biopharmaceutical giant."
   Read more: Abraxis deal done, Celgene eyes cancer franchise -
   FiercePharma http://www.fiercepharma.com/story/abaxis-
   deal-done-celgene-eyes-cancer-franchise/2010-10-
   25#ixzz1ibPApSSD


     We took even albumin out and made it soluble Hybrid
              MewTaxel should has a better deal
Successfully improved Hybrid drugs for solubility
 Paclitaxel       Tadalafil      Rapamycin

 Bexarotene       verdenafil     5-aminosalicylic
                                 acid
 Aspirin          Celecoxib      Docetaxel
 Combretastatin   Ibuprofen      Epothione A
 Prednisone       Quinine        Itraconazole
 Azathioprine     Artemisinin    Cyclosporin
 Nimesulide       Rapamycin      Tadalafil
 Sildenafil
 Aripiprazole     Camptothecin
                  Paliperidone   Statin
                                 Megastrol

 Carbenicillin    verdenafil     5-aminosalicylic
                                 acid
 Ofloxacin        Budesonide     Tamoxifen
 Finofibrate      Clopidogrel    Valsartan

				
DOCUMENT INFO
Shared By:
Tags:
Stats:
views:54
posted:10/30/2012
language:
pages:13
Description: water soluble paclitaxel