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                                                                                :          - s»          5 ƒh      Z )C
          1¶s *                     /          (H /, * O        * $sM                       1 =                      )C       'U (1
              .:/C       CgK )C      c%        5 (H /, c% @ e Z ƒ O                           ¶s         SF/ 1 D $ &=
          !      )J W5 #/ C *K . =4 •                       !        '               S ? / * B Z '/ <                  )C     'U (2
          SK         b 1-           K C „ C SK S*8 O,                          L '‹5 } %? ƒ               )4 1 & ),
                                        .h >        4*                    + Q*9 * Š* [                    50 ~
                               .h )J Z M S/=               /8            *K K !             J )C          'K % B U          QK (3
  K   C „C           S            ' 0          B    - C                  &4                  - C-#           SU* %
                                                                                       .h -K @ &         % ! 1O i




375/ +,- 1950 1         2 ..(208 207/6)     " # $./ ..(3860) +,- (169 195/4)           " # $% % &' () (1)
     .?@' (A B 4 5' + C# ..(339/9) :; ()8 2 < => ..(210/4) 6-7 89 ..(1483) +,- (1152/2) " # 34 ( 34 5'
                                                         118
..(1)«         & ! / * ƒ(                      " * ƒ: - ( % : »                     &        '» :         Y G/L# G
    /         (H /, ( 4- :((                    " *) ƒ L O               Hs :       .K :(: - ( % : »                       &             ')
                            .!        * 3      s?             /          *          - :(         & ! / *) ƒP 5 &L


                                                          :( $=              mL) (dH&K               mH ) >'- & M/ 6$ K$

              G/Z      O              Pf - 5 /" I ! K                        ,           »
                                                                                         W       P          &b9 Á 8K
.% * :          * LO : ! 4                    u"          5                         - :/               O,       {:             4 !
.@ * • Â                    L h4 5 P                    PM* @ ?K B               POH z** P           -P         4     B         @
:        L #8 B       . &"            t O Ã Z ( LO : !                        4         u " ) $# &          c% G/                   ,= *
¼
8             &) . #/ :                       '# * / 8              &"       L #8 (@ = )                        )C ! ^# "
. &"          u O               '* ..               />K t5*                              T MK ! % Ã "I9 !                                &?
                                                                                             :         !&              : ./
                   5 } D*        &) :          5 $8/M/            …& 1 =                     ? , ./                             :8 SU (1
                    ? DU .!! &b9 , 8 # gK .%                        9 / * ƒ Cf L S*8 L*#                            12                   M
               F            >C B         Å5                       SK B       G           .!!… & P           ?       \- :        ^ "
                                                                                                                .P / *               C
                   'U .K ƒ$D I G =IK 1 D            ?             1 = T' ? 5                          1 =            >B                  K (2
                            .            O 1 =                -@                      W
                                                                                    ! h i5                  8K B $#8                     k
w/k                k: *                 1 = -( %                                   SK ! S                   M
                                                                                                       / ' P½ / % *
        $ O    : 1 '/=            5 B U .8€             #/ $8           O SK ! Z 5 ƒ i & P                  ?S&                &~* ƒP 5
      @
S 4'U ½ =          MW * H /                     - >/' C                          ƒ C ÃW" w/ )                                   P        ?
! ^W                J* „H C @i5K B U                G/>/ !4 - t»                         ½
                                                                                         @?*          *K* b* I $
                                                                                                 .                  * :/C - Z


E F G# 2 .7)          (313/4)     =      =D    2 .-/)9 (212/4) +#             (3478) 4 ( (2053) ()8 2 ./                       34 5'     (1)

                                                                          .(99/1) =>      A )H 2      >) I JK 2 E L            (28138)
                                                                  119
          B G                (1100-550) h M         O                     :8 5                 )-             4 T' ?             (3
          ƒ            c% - w/ 4         :        ^ " SK S*8 4                         @J 8               &             SK
                                                                .$ M           5 1 ? C- 5 P " L2 h
          uC                        SK B      G     % *hO             S?                      :8 5 ! C             = SK ?(4
               . i 9 * $s M9 @? d ,' B U .8€                          /        (L * * 1WiO * (H /, @?


                                                                               .       $=       '%(N 1 <w$Z G$O\P

                                                        : $F          >'NH\7 uP                  T%N          $=
                  .(1)«W • M = 1 c$'F ‡K # uP                   E          1       $= » :             G/L      G
                                   (2)
 &' M S OJ S #*               !%     !       J9 * ;K        B         0 ~               Z!            4' C'K       k
                                                                           .Ehi K                      $ H O @ 5 ƒtC
($ O, ) b I            SK !     J9 B                    CgK !=            ! :G/ ' % ! w /                          5*
 5              0 JK Z ' ! * .u", $ - .8/ * P5 U (                                          Šs' •         5         ZK B
 . /      (H /, *              1 = ! D, *:                 +s' ! c C»- .% • \ - O 2 Q/                                  %
            W
P'9 @ C B Z h /b h K B & PZ* M* ƒ L 4Z f?K* )JK                                         5 ;K          &4C - } %?
S/= 8 = @- ƒP                                   W
                                ;<? T &f -/ > ! h i5 1 -                           W           -* •/           Q        f?K
1Wi           /
           ! cº " $ I &                      : [ - ;K            M V               *                    W
                                                                                            , 8/M* (&4- h 4
                                                                                                 .h         @ = ŠW"-
B               / hC K f?9 * O'9 5 ƒ                  2
                                               4K # J » U !                K ! - ºJ                   Y G/L#*
                                                                 .h             2
                                                                          Z@ = -»U                     - $ H 5 2* @ =


                                                     .(419/1) MN O # 2 P CQF $(28152) E F G# 2 .7)                         (1)

< ) 2    >= V    4W XW . U    4% 7- 2 H           $( MCN    U       4% 7- ) R7                  2 S75K T 8 :               (2)

 =]' 1        < ) (A B #^ _> 9 7 F9 =CA ` K     1 $)a1          < ) 2 Q \@ # / . = A ,7 Y Z74 5 [A75K
                                                           .+C ' bc> d F (A 7F ' 1  2 Q XK e fW .. QLC
                                                    120
•#/ $ C B                     != :("O          1 c $ ) &) P- ? 5 $ 'k >- ( &) G/
                                                                                                       .S 4C
1 = * (H /, P 5 (L               h C 4 S/= B Z / 8 $8/?# )C T4 V 4 SK ?
                                  .hb ,'* ? Z S/=              f?K       |=        B @- ƒ Z &IK* C4


                                                                                                  ˆˆk KL
  [ B * V4 * !                J9 ? O "          Q/       5$          1   Z &) t O 0 MK
^# " : ! 1 C               %J<- . &"        t O : * ƒ( L (35) `- @ =               )C @OLK) •/              w
P'K !»&               &"     1L#        :      % + iJU        -* ƒ Q /        c%        5            V/ I !
  k Q/          c%     5         SK G          ƒ J) * \          *8       e Z ! . #/ : h - ,
                                                                                                    .h -K
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0 J9                 !'/ $        B                Q / 1 # & J2 - P                C        &) t O Ã Z
  - B       hi K } D t&b* .t            B        H MU* !4 * T /           e Z ! t 8 @=,-
t5*       ['9        M T &f B               S? 5 ƒ             &" 1 L #8               MU C ! ' /
                                   .P O "       gK L #8 8       S/'       5y5               \ *    />K




                                                   121
@-   28

             . $C   $=   Mk$ ( >F   •

           .‰ %M    O >k 1    $=    •

                             . k KL •

             .G$F   $=   Mk$ ( >F   •




     130
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:      @? 5                     ! ! ,          F*           u @
                                                         ?D ¼ "I ½ ? B                                  t &) (M/
                                                                  . (1)« $=         EL$< U< » :              , e           ƒ$


                                                    :‰ %M            O >k 1           $=      G C0 mH<           (%< 2'%<
    f aZ SK Pa C                » a .%a * ÅaZW      !a DU ƒ a        - h a s ha 8            a4 /a C 1 5 SU
!aaaa Baaaa K 1 aaaa ? aaaa                !aaaa S/aaaa&») N/aaaa & aaaa Z     Baaaa Z ! 5 aaaa * aaaaQ * $82/aaaa
! a,        !aaL V/aa5) /aa C a Z                *F* a     ! %aa }aa¶ *K a    a'#      - a ' F*9 &aa4' 1 a (6-3)
G* aC : a @=a,- ƒ - a4                    &a4C |OCa- h a-K a 8 F !a= 2              a b &a4' SK              &) ! * .(h
       .1WiO -                  & X ) * (%10) C u ~ ..PH %k ! Q h /                           Z Ç (20-10) S 4'
c%aa - a4           S/aa? a           !aa $ a &? 1 a ? (aa») N/aa & * a /O) a Z                   S‹aa5 a' ?D a ?*
¿ aL . a            a 'U ƒ        aC a4        %aa h a ? %aa\ a C½ € 2 1 a = c%aa * /aa C #/aab a 5 a Z
  =
h ½ a, a4              a         1a      -* G a ) * a&=         a5 aO   * a          1 a = ai t b ! u C
ƒha&        a ? S/a - (250) ha / a4= ea Z ƒ 4                           M      +/Q/          S*s"               b Z2
SK a - }a D* 1 a = c%a !                       O4 P [           '*       4 5 hDU .           ? S/ - (10)            L @? .K
                                                                                                  (1)
    a4 4-       a          Pa      ? aC& 5 aQU ..PaH C-* c/ ' 5 C             O4      &L C          1W /               /
                                               .($ )J* $ f? @? , 4             •#/            #         .K SU*) 1             !
1 = ! @                         2
                                » U ./     2        C -*         1 = @? !              O4 4              S‹5 C !
            /          O                 1 =         &= ‚W L2            / 5           ! (20) `                 - Kƒ
    Z ,CL             * G ) * &= @? , K & * ƒPC u¿" (                                h &? C …H O R&                    */C
                                                                                                                       .h Z2

2 m / (143/5) [< 9 b% 8 k l 2 .7= g $(112/8) 7 g h i 2 j= 34 5' $(28147) E F G# 2 .7) 34 5' (1)
 MN O # 2 P CQF (21477) E F EG# 2 .7) (114/1) => A )H 2 >) I JK 2 E L           (15) . >)
                                                                                      .(154/2)
C8C8 E L h            3) 7 7 Sg@ + / (%4) 3 >8@ += :[ g4 ( O n ./ [ CD = (                    '1         Xo V              ZF>p (1)
( c># %7A ( Xo             [V     :[ Cv    (%96) +UAK +8< $[ C= 1 s TCA F t MH 7> _ p (A Zc5' u = =C F (
                                   .BcD ..[ $( 7= 8= : = K 3V 7J [ Cv w < I < X' 7F x ^ $+8y ) 7=M 8 =)= K z
                                                              131
                                                              :G/ ' X ,       5 h L/ * @          O      5 $8 F*
s     * .. /i 8 / * '                        >C ƒ            (% 70-65) B ./                                = SU
(2)
    ! -/ k/       ) :           w iJ /          Ã J ! * - (%28-27) $ &?                               ? B            H/Z-
                                                         .         S      B ./            .% / * (Hemoglobin
   /
! S» = …                   C * - sM / * Globin ! -/ k (%96) ! ! -/ k/                                     S/= *
(4) B ./             .% / * ..Heme                       ! (%4) * ...ƒ! L/ ƒ!                4 : C             C K •/ Z
! -/ k/            .sM S‹5 % B ..Protoporphyrin ! 5#/-/ * - B U 5 Q -                                               Z 1 #D
                                                                                .          1 #D ! 8            B ./


    5 ! -/ k/            &4' *K              1 = 8            SK       C5 P K Z# 5 ! C          B U S{ @ CC
! 4?*9 G8 & -/ > B U 8/ } D 5 (&4 * ƒ! \ &                                           T'#/             DU h M    O      P8
8      2 ! - 2 hD‹5 .. - SW                                           ½
                                               º P H# SK DU ƒP 4M 5 8 b - $ s                         /C 1           :FW
       -*           1 = 8               $8 F !          -2     &= ^ Z2 %                 )\ B Z* ƒ} D 5 P K B
    C :        …/               4* $ Hs 1 =                  4= 5 $82/       - K.P 8 5 ! -/ k/                  &4' $8 F
8/ * >C                    -* ! -/ \ *                  h>/ J*          4= „ /' !           4          O4* $             b


. 7 1 8 2 74 V           - <M    @ = h= y          I7        # 2 b% 4       =8M)V v>| .I7 " {5 T 8 :Hemoglobin (Hb)      (2)

                                                                                            . - <e}     @ = wF> (O = = )
 •( X          ) 1# ( = • € $ M ' • €) 7= > 1 } h -' ( (: 5K - <M wF - = ) = 7j h=~ 2 [ CD = .g4 #
 • b7J       7= >> C8C8C „ gy X€ …    †C> wƒ (146) = • C8C wƒ (141) TCA M ' • C8C . l .‚= ' wƒ 150
[ CD = C                       „ gy                 X€                   X               /                          (16100)
porphyrin ( ce- I U@ 3   heme += 3‰ ‚=V      cD _s 74    globin [ CD T 8 ./ [ CD = C ‚=V ; X 9 ‡W e fˆ              (64500)
[Q8# K …>V R=J $+8y ( MC Š9 Q8@K ‡W [ ( [Q8# K 1<) ‚ ce- > _ I < .(Fe+2) € 7 7 X ' 3                                    <CJ
           .Hb [ CD = O2 [Q8# K [ b7 7 offinity M K ' "^ Q >8 = g=e ) $ = = =# cD … 7 7                                 -/
.g4 X =C (1000) 1ƒ TCA b-% , [ CD = .g4 X =C (250) • TCA . l                        I7     # X€ ( (%34) • 1j‹ [ CD =
                                                                                                    .7J \, 2 [Q8# '
mygolobin   [ C4 =9 @- <   sigmoidal-curve   K ŒL)9 + • k F9 ŒL)9 ,}F h{ Z U ) Z# C [Q8# K [ CD = Ž >V- xC8
                                                        . J 9 Po2 [Q8# K Ž vf h=~ 7)A [Q8# K 1ƒ TCA ;#' b-7, 3 ./
( (%30) • TCA =            B/ . l .( = /I D146) Tj@K 2 )= (I% = /I D160) • #/ † > X 8@ˆ I% 2 [ CD = = # †C>V
                                                                                        .+8y 2 =C 7 7 = #
                                                       132
B *9                 - L9       5 (1)hC CM S ? » * @& ! .0 JK                     Z1 ?              /       5* c/ ' 5 0 J9
c% @ C g ƒYolk Sac R                          | ? 5 »/                  H&                 P    ? T' ? C C                  P Z!
     * G ) SK !                 k        B    @         $     ! yL*9 e f                    CgK } D* &=               »             O z/
S/= 5 $82/            -* @          ! $ J<         $ O        5 K. C             &L C h8        K P4O' T /            5 ½/            O
                                                        .Bone Marrow y 5 : [                            ' 5                     1 =
:[          ' R&      *          !       4 " !L B Z                          :     WJ 4           : [ @?              ' ½/
!L      -    K .w/&C[ * i                      [        /      :49                     ( O>K) h             I }D            -        /)
u * +WQ9 * 1 O ? H ,\ : [                                      'B                      :       1 ? ¿/                      5! ,
c O4             4        & ) (/ C             / !L @& ) $ 4=                              1 =5             C -* hDU . O                  *
hi K #* Q ! -/ \ ? 0 JK 8 / * > C * P .#* Q                                                Z ! P/                     B      h C- C
1 /C4                                                          c%                                                                         b
                          . 4M b " 4                    •#/ 1 = c% # * (/ C                                 / B Z $82/ ! )
u '* SF/             &4' 1           (6-3) #        -              ( b …O"' e Z / C                          /            - K
.#* Q $ L O *                       1 = ! u " 5 . ?%                             - 4 $ O ! 0 J9 8 /                                 (¿)
$8 s5 %?* ..! H             ƒG ) ƒS #* F M ƒ &=                             ºL 2 i 9 5 ? $ H O c%                         C * ..h M
.4           'K @? 5 1               &       5 ! # L/              !         &? (L         .8€ SK !=             4              5
P % * ƒhi K 4                   WJ @? 5* :                     L
                                                            5 (»            Hs             SU DU ƒh M h D€ } D S/=                        *
                          . /        1)        •*            & €        @ /        ZK P'K !»& DU ƒP               & 4 # g{ !


                                                                                                                                    ˆˆk KL
T      /' ? Ã "IK                Z! „ C :                          1 L #8            M‹- &)                           b:
ƒ\          *8       * J ) e Z ! . #/ :                                ! w         :       % SK * M/5 ƒ:                   (20) !L
                                                            .: (20) V/5 (L C                   !4       5                  |= B


                                                                       .E    X D : =9 F LH       U) • =>         =4       g=M 2 h4 9      (1)

                                                              133
                                                                                           :G$F         $=         Mk$ ( >F
h &b h5                  T M                  $#          SK } D ;< !L B)" B Z $K                                        2
     b ,'           5 /            #*8 B & …                     &5 ƒ@b        :      ! u " SK P WJ !                             )4
P- ;<- 2 h sM S                 G ) * &= S‹5 } D B U 5 Q - ..                              / Z ^*K 5                               ?*
             .M         C 1 '/=        ! $8 O L2 * = =O - / (                                     1 = ) @b                       : !
(1)
     •º          ƒ /      $#*         H z* 5 @ J .K •                   W¶ * ƒ$K         ! …             :8 ^* "-*
         :         ? VWbU 5 G )                    4 * ƒ 5 $ M / 8 W"- :                            5     :[                 ' 4
     Z       ! /J8 @&              !      4C 1 &») SK                       ' } % .../           y\i d/&                    s
                                                                                                                        FU '½ "
..           !      Z        c% ! J8          /          4C * G M             P&»)           O Q Ç& …                            +)'
     .} D !         Y G/L# ' ' % * ƒ# i Ç - P 5 …                                   1 *%                               M‹5         -*
 i"               Š* [ |OC             Q J R&        *…                       / ;< !L $K                Ç&         C         K
8/ $ M M/ / - M/ / s 5 Z                            T J8           } %- S/= * ! ,                    )
                                                                                                 !L Bº " .% @M
     *       u' BU :          y\Q + O # ! 5 :$                     •          K /,C ½             4M* 4O' 1 \ B U
G )               "Q* :s        * * ./ = #/                  *         , * . =4 •                K BU 1)               BU /
+)' (              #/ [ - K &          ? ƒ f?            k* ;K              :2A* 3               Q* /H             1 Z , #2 *
ƒh -K PC @ - 2 h F2 h'/' * h                       h K                 R&       C * ..! s !             ) 4- $ O- …
                                                                               .. 4 * 4OC                #     L $K
P 5 G/J           Š# , B                *K ;<        !L T J8                   $K       SK :(1) &b9 ÅZ2 *
.             (¿             M &        )          - - >Ë •»                                  )
                                                                                   (! -#9 !L T» "                  S/= $8          -)
         /        4C $        1       - V/O              %        5 4C         - >U SU* ƒ /                  *9 (                 .%
                  . H ' @=,- Ri             S{ B U $             [ c%          ='= @         * . - ;< !L B U !
;< !L !\ -               /       4C       ** ƒ$          [ c% @                    J / c ' ?D .% @                     % *
                                                                                .(          ) &)               -         ! 3 OI*


                                               .[        -• 3‰                        @ˆ z • X     € eW b% €           + w L       (1)

                                                                       .(    7 =A K      C< z ') . gv % 4 ‘ | g gA - #7            (1)

                                                                 134
. (2)«G                G
                       Š       - J H & S cP n h& +1 „G$ H nDI                      I > » :P / -            } D !»- *
                                                                                       :G/ ' 1W            O - L/                ?*
@              i 9 @M               d ,C         ? /             *     T' ? $K              C …                S?     P'U
    B                     t
                   4 @= 5 Ì # G ) (                   2* &= B                  8 MU 2* : #                      U W5 @f K @=,-
^ 'U           5 P '/= @\ 4 5 B &                  K ƒ…              - Š       C                 1 = !                    * .:
( 4* C                     8 / * :/ , ( 4 P'‹5 F                     @=,- &= @                   C * ..$ M / 8 > C
•              2           -* ƒ /           *9 S # M B                 ?           C 5 G* 4 /= !                 Hs Š            *
         (3)
2*         y\i             O     2* y        •       2 /             1 = !                        O J -* ..               (
(                      < L ! K ! 5 ..1 = !                   /       2* G* 4 /= 2* S/                            1 & &Z u
                                                                                                               .} D - .
                                                            ...            !       , (                           'g C*
    &)             5 •              L 1 \          +/         ! <,C Ì Z :dH'8< >'&                                  "%8#
$#€- ! S/=                      * ƒIntima of arteries ' , ./                                 /     J           ' )& * )L/
(G ( 6$& Y G+ZP) ./ 8 @>K 1 D 8 / * $                                          1 # /- = *              C         1 ?          !
Š8                 /                           L
                           >/ % ..:/ 4 = $8 ! (¿ * O „ 4'* (>'- %… ('l ) 4O' : $8 *
                                                                                        .$           *K Atheroma                 =
    k          * &          1 D9 * •# /= !              [     (&4 5 !              ,    4                  $         c%
                                                                           . ./         y\i         5# B U 5 QU 4OC *
! c k* &= @                           f*         , $#*            @iO-* ;<             !L @& :         @=,- $K            5
  &
 &½4               4O' :        $8 * ./          @>9 1 D 8 / * 1 ?                               c% ! u»" ƒ i 9
                                                                                   . ' #* 1 D9 * .                        (




 < => $ Q hf " (3484) +,- (1152/4) 3)) 2                $34 ( $(2859) +,- Q hf " 195/4           " # 2 ()8 2 % % ' (2)
                                                                         .(4400) X’ U %- 2 X >J ( (340/9) :; ()8 2
     M                 0 /# $[          X -74 TCA =) 7 % 9 E 8=     0 3@K .7=HF CH C „= 9 1 F 7J' …v{ S MV- (3)
                                                                                                         .I7 - 1, FV
                                                             135
$s MK #/           *1 = !                     /      ?          S‹5 ;< !L G/ Z* …                    w D          - K
•         9* &         1 D9 •*                           y\i + O # * *                 u'           &= h>/ J* 4
                                                                                                        .(1) /              H /
                                (2)
:         %    SU .K              :{..R •Œ Œ I Ž2? • '• (
                                      JP •       • • Œ                          >Œ W •‘ &
                                                                                • N Œ Œ %Œ ŽFŒ Œ } :B                 G
Y !           Z#* % ƒ•            9 <,C * # i Ç - P 5 $K                          4M 5 c3 -* L 5 :8 (…                          :8)
    - f - PZ b S/= .K ƒ                     , $#*               5 PM " * ( L O : ) 0D9 % V/4 P'K B
P Z S*8 PH - 5 4                       0DK /                     - ^# " :        SK hi K !»&        C !*ƒ
                                                                                                                  .P         ¶L*
‚/ L hDU             (     Bf'9 C $#*                     c%         /       C *…            ! ;< !L                  -*
    5 ?        :      L 5 ! „ C # i * 0D9 08 O                                           * 2K @M            &»                  )
                                                                                                                          . 4M


                                               :(1)f$]K             2(      G$ VP & l       EL$< f$O             EP (


 G 2 3F “>HV (8 / 7F (            $bc># 4-% ‡W =>C<             )C 14 ( Zf FV 1,' `n= ( 1>, b' 9 : 5a Z• j #/@ 1=>< / (           (1)

    )C C– — >8) f F “>HV b > CJ 2 (? = b' 9 E j                   j •      b- 7 X 7<e) {=> 1|”         b' 9 e x /# ..Z> <V b7J
                                                                                                                              . =>C<
                                       .(            !      :                   ) z K +UF (A b7=F T<>V ˜J +Q l X' Z{ ' ™ Z^W
                                                                                      :š}– 1J › œ ‹ 15 7 ( 3) > D +J C XW
                                                                                            .Proliferative phase ) CJ •1
                                                                                             .Secretary Phase € eˆ CJ •2
                                                                                                            .R      CJ •3
3@n# - J I7 ž % ' I%) R    I%         Z % 1 $ZA %        > • 3@W $3@gJ (A c>F 2 | N 3 < p 3 3 M=• %' 2 3 | e X 7<M +J XgY
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-Patrick C. & others Alternative medicine. (1991) First ed – Reader's •
                                                   digest – London.




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