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					Chapter 3 herbs that clear heat syndrome     清热药




Introduction
concepts clear heat


    Clear heat                      Clear fire

       Symptoms: fever、Dry mouth sore/dry throat、
       Red face, eyes、constipation、yellow/red urine,
              burning sensation of five centres
             red tough, yellow coating fast pulse
           exterior H:pungent cold exterior herbs
Heat
syndrome
                       False Heat:Clear false Heat
           interior H         Heat in Qi-clear heat/fire
                      true H Heat in Blood -clear heat/cool blood

                             damp Heat―clear heat eliminating dampness
                             toxic heat    -clear fire detox
                                        热毒疮疡
   Pharmacology characters

Clear heat detox:
Heat & toxic syndrome
       1st stage of heat syndrome
     toxic ulcer, carbuncle疮痈肿毒
                                    bacteria/virus
     throat sore swollen
       dysentery痢疾
Clear heat


             anti-bacteria
             anti-infection
             anti-toxin
             anti-peroxide damage
             anti-inflammation
                  factors
tonify normal Qi


     enhance immune function
     protect mitochondria
     keep Ca++ stable
     detox
clear heat downward fire


 “fire heater than Heat”,heat still in
 Qi. symptoms:High fever、 agitated ,  烦躁


 heat syndrome second stage, acute
 stage.
 herbal effects:clear heat,detox+
 sedation 、anti-seizure 。
          镇静             抗惊厥
      clear heat cool blood
Symptoms: heat go into blood。Acute
heat syndrome depletionary phase
  ,CNS symptoms, organs function
衰竭期


failure.
1、anti bacteris/virus、detox;
2、enhance heart functions circulation;
3、relax microvessels,remove microcirculation
     spasm;
4、stop bleed;
5、sedation, clear heat CNS.
 clear damp heat herbs

   treat damp heat: chronic diseases,
hepatitis, urinary tract infection,
dysentery.

1、anti-bactria/virus、anti fugi;
 2、reduce closterol 降脂、pretect
liver保肝利胆;
common pharmacology effects


Anti-pathogen

  *herbs clear heat/detox & clear damp heat
  --can anti bacteria/virus
  Damp heat herbs ---anti fungi better,
anti-infection




       Anti-acute infecton
 Anti-toxin

1、direct effects
  (1)degradation of Endotoxin
   A、damage endotxin stuctures;
   B、preotect lysosome membrane .
 (2)anti-Exotoxin
2、indirect effects―reduce bacteria toxin
  (1) antihyuronidase抗透明质酸酶
  (2) inhibit coagulase
  Relieve fever
       解热




(1)relax vessels,spread heat through skin;
(2)reduce pyrogen ;致热源


(3)prevent heat medium secretion or synthsis
(4)change Na+/Ca2+ratio:,tempteture;
,temp。

             differ with exterior herbs:
              these herrbs清热药退热 no sweating.
 Effects on immunity

     most herbs can enhance immunity
    functions.

 Some herbs also can inhibit abnormal
    immune action
Other effects
Anti-cancer 、sedation、
       anti-hypertension
Protect liver、
benefit gallbladder
                 利胆
      Huanglian(coptis root)黄 连
Function &
                 Clear damp/heat,
 indication
                downward fire/detox
              Hypertension,
              supra-ventricular arrhythmia,
              Dysentery,
              Acute Enteritis,
              cholecystitis,
              respiratory tract infection
              diabetes
components
                  Berberine, coptisine ,
                  worenine, palmatine
Pharmacology effects

1、main effects


  (l)anti-microbes
  Berberine:
  1)broad-spectrum anti-microbwes
  2)concoct/combination-anti-micobes
(2)anti-toxin
Berberine: anti-toxin, enhance body
resistant to toxin.
(3)anti-pyretic
(4)anti-ulcer
Inhibit acid, anti- helicobacterpylori
(5) sedation, mesmerize   镇静催眠   、

         berberine
2.Other effects
  1. cardiovascular system effects
  (1)reduce ventricular arrhythmia
      & auricular premature beat
  (2)promote cardiac contractility
  (3)reduce heart rate
  (4)low blood pressure
    ( block vessel wall a receptor)
   ( specially for diastolic pressure)
  (5) anti-angina
(6) Prevent platelet adhesion
(7) Anti cancer, low blood sugar,
Reduce chlesterol, anti-brain ischemic
                 Side effects
 Little
 A few suffer from allergic reactions(drug
  rashes)
 Gastrointestinal effects: fullness, nausea,
  vomiting
             Huangqin黄 芩
                      Clear damp/heat
Function &          Downward fire/detox
                       Stop bleeding,
 indication         sophisticated buck安胎
           Damp heat、summer heat,
        Stuffed chest, nausea, dysentery,
           Jaundice, lung heat cough,
           vomit blood, nose bleeding,
            Fetal movement c’s heat,
             toxic ulcer, carbuncle.
components
                 baicalein
 Pharmacology effects


1、main effects
       (1)anti-microbes
       Broad spectrum,G+、G-
       (2) anti-inflammation
       Acute/chronic autoimmune disease
       (3) anti-allergy: type I allergy
(4) protect liver function
      promote bile secreting
(5) anti- atherosclerosis, low cholesterol
(6) anti-oxidants-free oxyradical damage
(7) low BP, anti- myocardial ischemia
    anti-arrthymia.
   2.Other effects

(1)inhibit CNS & relax muscle
(2) Prevent platelet adhesion
(3)relax vessel muscle
(4) anti-cancer
        Jinyinhua金银花
 Function
 indication     Clear heat/fire
                 Exterior heat、
                  ulcer carbuncle
                  furuncle; boil
                             疖肿



components          Dysentery
                 chlorogenic acid
              flavonoid compound
1、main effects



  (1)anti-microbes
  1)Broad spectrum antibiootic
  2)Combine Lianqiao连翘enhance antibiotic effect
  3)Inhibit virus..
(2)anti-entoxin
(3)anti-inflammation abate feve
(4) Enhance immunity
 2.Other effects


 Reduce cholesterol、
benefit bile secretion、
 Protect liver function
    Stop bleeding
    Daqinye &Banlangen
              大青叶                       板蓝根


Function
indication          Clear heat detox
                    cool blood消斑

        Heat/toxin in blood,unconscious        发斑神昏,


        Throat pain swollen, erysipelas        丹毒口疮




components                     indigo
                    couroupitine A, tryptanthrin
1、main effects



 (1)anti-microbes
 1) Daqingye inhibit bacterias
           大青叶


 2) Banlangen anti-virus
(2)both enhance immunity
(3)benefit to live function
2.Other effect


Anti - leukaemia
               Zhimu知 母
Function &
                      Clear heat/ fire,
 indication        produce jing/stop thirsty
                  Heat/ fire hurt liquid in body
              High fever, thirsty, heat in lung-cough
                Heat form bone骨蒸潮热 sonstipation

Components
              steroidal saponin, flavonoid
1、main effects



  (1)anti-microbes:
  against Staphylococcus aureus. A & B-hemolytic
  strepcholerace, Salmonella typhi, E.Coli, Bacillus subtilis.
  (2)anti-pyretic (abate fever) it has a slow onset
  but pronged duration.
3、Anti-diabatic low sugar
(1)it can reabsorb the sugar in faty cells
(2)reduce components liver starch in Liver.
 2.Other effects


(1)enhance memorization of brain
(2)enhance adrenal cortex
(3)anti-cancer
        Qinghao青 蒿
Function&
            清热解暑,除蒸,截疟
 indication
                    Summer heat
                ying weak-fase heat
         Night feel heat, morning feel cool,
                 the heat from bone
                 Malaria, jaundice
Components
                 Artemisine,
                 artemisinin;
                  arteannuin
1、main effects



    (1) Anti-malarial
    1)Found in China
    2)nice effective low toxicity
    3)kill malaria in RBC directly
(2)antibiotic, it can inhibit
stsphylococcus aureus, Neisserria catarrhalis
(3) antihypertensive: it can decrease heart rate,
inhibit contraction of the cardiac muscle.
(4)Antipyretic
(5)Cholagogic: it can increase the production &
 excretion of bile in rates.
(6) Enhance immunity
2.Other effects


(1)benefit to cadiac syetem
(2)Anti-cancer

				
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posted:10/20/2012
language:English
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