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Aspirin_Report_Guidelines

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					Chem 14BL                                                                                    Fall 2002
                                  Report Guideline for Assignment 4
                                      The Synthesis of Aspirin


QUIZ (WEEKS 1 AND 2)
        Only one quiz will be given covering both parts of this assignment. It will be given at the beginning of lab
during the second period of the assignment on 11/21 – 11/27.

                                               WEEK 1 - SYNTHESIS
PRE-LAB WORK (INDIVIDUAL)
Introduction
In preparing for lab set up your notebook with the following information:
• The title of the experiment
• A reference (i.e. complete reference of the experiment including title of the lab manual, author, edition and
    page number of the experiment in the manual etc.) Include any changes to the procedure that you know you
    will make.
• A short introduction (Summarize in a two or three sentences the goals of the experiment. Outline the kinds of
    techniques that you will use in the experiment)
• A brief flow chart summary of the key procedures of the experiment
• MSDS information for Salicylic acid (Reagent Grade), Sulfuric acid (Concentrated), and Acetic anhydride
    (Reagent Grade) Note: Select the site that gives you the MSDS information closest to the
    concentration or grade listed above for each individual chemical.) For each compound give: Product
    Name, Chemical Formula, Formula Weight, Melting Point; Boiling Point and Density, Health Hazard Data
    (summarize in your own words), Spill and Disposal procedures (summarize in your own words)

IN-LAB WORK
Data: (Individual)
• In tabular form note the weights and volumes of the reagents that you use, AND all observations during the
   synthesis..

POST-LAB NOTEBOOK REPORT (DUE NOV 21-27)
Data Analysis
• Calculate the theoretical moles of aspirin (Be sure to identify the limiting reagent in your procedure)
• Calculate the % crude yield
• Calculate of the % corrected yield

Conclusions
• Summarize your results
• Compare the % crude yield and the % corrected yield with 100%. Explain why they are different or slightly
   different.
• What can you conclude about the % crude yield? That is, if your % crude yield or % corrected yield is
   greater than 100%, explain why or if your % crude yield or % corrected yield is less than 50%, explain
   why (be specific).

                              Week 2 - Analyses by Titration and Melting Point
QUIZ
A quiz covering the first two parts of this assignment will be given at the beginning of lab periods on 11/21 –
11/27.

PRE-LAB WORK (INDIVIDUAL)
Introduction
In preparing for lab set up your notebook with the following information:
• Include any changes to the procedure that you know you will make. (Note: you will not be analyzing a
    mass spectrum of the aspirin sample, nor carrying out the Beer’s Law analysis..)
• A short introduction of the two analysis procedures you will be doing.


IN-LAB WORK
Data: (Individual)
Data tables will need to be prepared in class after you determine who will be responsible for collecting the various
data for the assignment. You will need to obtain copies of your partner’s work after the lab period in order for
each person to have a complete set of data

POST-LAB NOTEBOOK REPORT (DUE DEC 3 – 6)
Data (from the lab notebooks of the original experimenters)
• Clear records of whose aspirin product is used for each part of the analyses.
• Melting point data for each of the aspirin products.
• An orderly table for the titrimetric data including the weight of product used for each titration , the initial and
   the final buret readings, and the concentration of the standard NaOH.

Data Analysis and Calculations
Titrations:
• Calculate the actual moles of aspirin and the %purity for each sample.

Error Analysis
Titrations:
Discuss why the purity is less than or greater than 100%. Compare the purity to the inherent error in the titrations
and your relative average deviation for your trials.

Conclusions
• Summarize your results.
• Compare the melting point of aspirin from the literature with the melting point ranges that you observed in the
   lab. Are your products pure based on the melting point ranges that you observed? What can you conclude?

				
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