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					 Study   Compound         Animal                                Observations      Slide   Photo
Number                    Number                                                  Taken   Taken
M193B     Allyl Alcohol    B276    Mild Hepatocyte Lipid Vacuolation
                                   Minimal Hepatocyte Enlargement, Minimal
          Gemfibrozil      B204    Increased Hepatocyte Granular Cytoplasm &
                                   Mild Apoptosis
                                   Mild Hepatocyte Enlargement, Mild
          Gemfibrozil      B228    Increased Hepatocyte Granular Cytoplasm
                                   & Mild Apoptosis
M193C    Cyclosporin A     C046    Moderate Hepatocyte Palor
          Etoposide        C072    Minimal Apoptosis
                                   Mild Apoptosis, Mild Enlarged Hepatocytes,
           Etoposide       C082
                                   Mild Incr. Eosinophilic Granular Cytoplasm
M193D    Chlorpromazine    D228    Minimal Fatty Change
                                   Mild Apoptosis, Minimal Fatty Change,
                                   Mild Leukocytosis, Peritonitis Present,
            Sulindac       D035    Moderate Necrosis, Mild Hepatocellular
                                   Enlargement, Mild Incr. Granular Eosiniphilc
                                   Cytoplasm
           Clotrimazol     D072    Mild Fatty Change, Minimal Leukocytosis
           Clotrimazol     D083    Moderate Fatty Change, Minimal Necrosis
           Miconazole      D166    Mild Fatty Change
                                   Moderate Fatty Change, Mild Necrosis,
                                   Moderate Hepatocellular Enlargement,
           Miconazole      D178
                                   Moderate Incr. Eosinophillic Granular
                                   Cytoplasm
                                   Mild Apoptosis, Moderate Fatty Change,
                                   Moderate Hepatocellular Enlargement,
           Miconazole      D179
                                   Moderate Incr Eosinophilic Granular
                                   Cytoplasm
                                   Mild Hepatocyte Enlargement, Mild Incr
          Valprioc Acid    D264
                                   Granular Eosinophilic Cytoplasm
           Ibuprofen       D047    Minimal Fatty Change
                                   Mild Apoptosis, Minimal Fatty Change,
                                   Peritonitis Present, Moderate Hepatocellular
           Ibuprofen       D058
                                   Enlargement, Moderate Incr Granular
                                   Eosinophilic Cytoplasm
                                  Mild Necrosis, Moderate Hepatocellular
          Ibuprofen        D059   Enlargement, Moderate Incr Granular
                                  Eosinophilic Cytoplasm
        Ketoconazole       D095   Minimal Apoptosis
                                  Mild Apoptosis, Minimal Fatty Change
        Ketoconazole       D106   Mild Hepatocellular Enlargement, Mild
                                  Incr Granular Eosinophilic Cytoplasm
                                  Minimal Hepatocyte Enlargement, Minimal
M193E     Itraconazol      E239
                                  Increased Hepatocyte Granular Cytoplasm
          Celecoxib        E179   Tissues Unavailable for Evaluation
                                  Mild Fatty Change, Mild Hepatocyte
          Celecoxib        E180   Enlargement, Mild Incr Graunular Eosinophilic
                                  Cytoplasm
                                  Minimal Fatty Change, Mild Hepatocyte
          Celecoxib        E190   Enlargement, Mild Incr Granular Eosinophilic
                                  Cytoplasm
           Enoxacin        E060   Mild Fatty Change
                                  Minimal Apoptosis, Minimal Fatty Change,
        Ethinylestradiol   E094   Mild Hepatocytes Enlarged, Mild Incr
                                  Eosinophilic Granular Cytoplasm
        Ethinylestradiol   E096   Tissues Unavailable For Evaluation
                                  Mild Hepatocyte, Mild Incr Granular
         Methotrexate      E166
                                  Eosinophilic Cytoplasm, Moderate Congestion
          Naproxen         E262   Marked Peritonitis
          Naproxen         E263   Tissues Unavailable For Evaluation
                                  Minimal Apoptosis, Minimal Hepatocyte
          Naproxen         E264   Enlargement, Minimal Incr Eosinophil
                                  Granular Cytoplasm
M193F    Atorvastatin      F156   Minimal Necrosis
                                  Minimal Apoptosis, Mild Hepatocyte
         Atorvastatin      F166   Enlargement, Mild Incr Granular Eosinophilic
                                  Cytoplasm
        Norethindrone      F130   Minimal Fatty Change
                                  Minimal Apoptosis, Minimal Fatty Change,
        Norethindrone      F142   Mild Hepatocyte Enlargement, Mild Incr
                                  Eosinophilic Granular Cytoplasm
          Genistein        F59    Mild Fatty Change
                                Minimal Apoptosis, Mild Fatty Change, Mild
         Mifepristone    F094   Hepatocyte Enlargement, Mild Incr Granular
                                Eosinophilic Cytoplasm
        Rosiglitazone    F036   Mild Fatty Change
                                Minimal Apoptosis, Minimal Fatty Changes,
        Rosiglitazone    F047   Mild Hepatocyte Enlargement, Mild Incr
                                Granular Eosinophilic Cytoplasm
                                Minimal Hepatocyte Enlargement, Minimal Incr
         Pravastatin     F204
                                Eosinophilic Cytoplasm
                                Minimal Apoptosis, Mild Hepatocyte
         Pravastatin     F215   Enlargement, Mild Incr Granular Eosinophilic
                                Cytoplasm
                                Minimal Hepatocyte Enlargement, Minimal
         Raloxifene      F226
                                Incr Granular Eosinophilic Cytoplasm
         Raloxifene      F240   Minimal Fatty Change
M193G     Aspirin        G084   Minimal Fatty Change
                                Mild Fatty Change, Mild Hepatocyte
           Aspirin       G096   Enlargement, Mild Incr Graunular Eosinophilic
                                Cytoplasm
         Cytarabine      G250   Minimal Fatty Change
                                Minimal Hepatocyte Enlargement, Minimal Incr
         Cytarabine      G251
                                Eosinophilic Cytoplasm
         Cytarabine      G262   Minimal Fatty Change
        Phenothiazine    G204   Minimal Apoptosis
        Phenothiazine    G214   Mild Fatty Change
M193H   Beta-Estradiol   H035   Minimal Focal Necrosis
                                Mild Hepatocellular Enlargement, Mild Incr
        Beta-Estradiol   H046
                                Eosinophilic Granular Cytoplasm
        Acetazolamide    H095   Minimal Focal Fatty Change
         Sulfadoxine     H106   Minimal Multifocal Fatty Change
           Atropine      H250   Minimal Focal Fatty Change
           Sulindac      H203   Minimal Focal Necrosis
         Azithromycin    H262   Minimal Focal Fatty Change
                                Minimal Hepatocyte Enlargement, Minimal
M193I     Catechole      I240
                                Incr Eosinophilic Granular Cytoplasm
                                Minimal Hepatocyte Enlargement, Minimal
         Thioguanine     I192
                                Incr Eosinophilic Granular Cytoplasm
                                 Minimal Hepatocyte Enlargement, Minimal
         Promethazine     I250
                                 Incr Eosinophilic Granular Cytoplasm
                                 Mild Multifocal Fatty Change, Mild Hepatocyte
         Promethazine     I262   Enlargement, Mild Incr Eosinophilic Granular
                                 Cytoplasm
                                 Minimal Focal Fatty Change, Minimal
         Promethazine     I264   Hepatocyte Enlargement, Minimal Incr
                                 Eosinophilic Cytoplasm
          Zomepirac       I274   Minimal Multifocal Fatty Change
                                 Minimal Hepatocyte Enlargement, Minimal
          Zomepirac       I276
                                 Incr Eosinophilic Granular Cytoplasm
                                 Mild Apoptosis, Moderate Hepatocytic
         Methotrexate     I166   Enlargement, Moderate Incr Eosinophilic
                                 Granular Cytoplasm
                                 Minimal Hepatoctyic Enlargement, Minimal
          Fluvastatin     I083
                                 Incr Eosinophilic Granular Cytoplasm
                                 Moderate Hepatoctyic Enlargement, Moderate
          Fluvastatin     I094
                                 Incr Eosinophilic Granular Cytoplasm
M193J    Amlodipine       J059   Minimal Focal Fatty Change
         Sparfloxacin     J155   Minimal Focal Fatty Change
         Sparfloxacin     J166   Minimal Focal Fatty Change
                                 Minimal Apoptosis, Mild Hepatocyte
         Azathioprine     J276   Enlargement, Mild Incr Granular Eosinophilic
                                 Cytoplasm
        Clarithromycin    J238   Mild Multifocal Fatty Change
                                 Minimal Hepatoctyic Enlargement, Minimal
          Etoposide       J191
                                 Incr Eosinophilic Granular Cytoplasm
M193K      Digoxin        K060   Minimal Multifocal Fatty Change
                                 Minimal Hepatoctyic Enlargement, Minimal
        Tamoxifen-Base    K142
                                 Incr Eosinophilic Granular Cytoplasm
                                 Minimal Apoptosis, ModerateHepatoctyic
          Meloxicam       K118   Enlargement, Moderate Incr Eosinophilic
                                 Granular Cytoplasm, Minimal Multifocal Necrosis
        Ethylene Glycol   K204   Mild Focal Fatty Change
                                 Mild Multifocal Fatty Change, Minimal
         Procarbazine     K274    Hepatocyte Enlargement, Minimal Incr
                                  Eosinophilic Granular Cytoplasm
          Penicillamine     K250   Mild Multifocal Fatty Change
                                   Minimal Hepatoctyic Enlargement, Minimal
M193L     Mitomycin C       L084
                                   Incr Eosinophilic Granular Cytoplasm
                                   Mild Hepatocyte Enlargement, Mild Incr
          Mitomycin C       L096
                                   Granular Eosinophilic Cytoplasm
                                   Minimal Hepatoctyic Enlargement, Minimal
            Acyclovir       L142
                                   Incr Eosinophilic Granular Cytoplasm
          Famciclovir       L154   Mild Multifocal Fatty Change
                                   Mild Hepatocyte Enlargement, Mild Incr
          Famciclovir       L156
                                   Granular Eosinophilic Cytoplasm
                                   Mild Hepatocyte Enlargement, Mild Incr
           Nevirapine       L262
                                   Granular Eosinophilic Cytoplasm
                                   Minimal Multifocal Fatty Change
            Modafinil       L228   Mild Focal Fresh Hemorrhage,
                                   Mild Focal Congestion
                                   Mild Multifocal Fatty Change
            Sildenafil      L274   Minimal Hepatoctyic Enlargement, Minimal
                                   Incr Eosinophilic Granular Cytoplasm
                                   Minimal Hepatoctyic Enlargement, Minimal
            Sildenafil      L286
                                   Incr Eosinophilic Granular Cytoplasm
           Sildenafil       L288   Minimal Multifocal Fatty Change
        Lead (IV) Acetate   L204   Mild Focal Fatty Change
    10/19/2012


 Study    Compound            Animal                              Observations                                 Slide   Photo
Number                        Number                                                                           Taken   Taken
M193C      Leflunomide         132     Lekocytosis


M193E    Dexamethasone         118     Fatty Change, Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm

M193E      Fluconazole         204     Nulcear/Cytoplasmic Condensation (Apoptosis)

M193E      Thioguanine         130     Necrosis

M193E      Thioguanine         132     Fatty Change

M193E      Thioguanine         143     Nulcear/Cytoplasmic Condensation (Apoptosis)

                                       Hemorrhage, Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm,
M193F      Simivastatin        119
                                       Necrosis
                                       Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm,
M193F    Diethylstilbestrol    190
                                       Nuclear/Cytoplasmic Condensation (Apoptosis)
M193F      Hydroxyurea         287     Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm, Necrosis


M193G     Fluphenazine          36     Normal

M193G    Acetaminophen          60     Normal

M193G       Rofecoxib          167     Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm, Necrosis

M193G      Doxorubican         274     Fatty Change

M193G      Doxorubican         287     Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm, Necrosis




 Study    Compound            Animal                              Observations                                 Slide   Photo
Number                        Number                                                                           Taken   Taken
    10/19/2012



M193H     Torsemide     168   Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm, Necrosis


M193I      Naproxen     178   Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm, Necrosis


M193J                         Hepatocyte Enlargement, Eosinophilic Granular Cytoplasm, Necrosis
          Lomustine     120
M193J    Indomethacin   262   Fatty Change
Study        Compound      Animal     Tissue                                   Observations   Frame
  #                          #                                                                Number
M193M        Paroxetine     191        Brain     Normal                                       M193M191

M193M         Tramadol      311        Brain     Normal                                       M193M311




 M193N        Corn Oil       20        Heart     Normal                                       M193NH20

 M193N        Corn Oil       20     Sm. Intestine Normal                                      M193NI20

 M193N        Corn Oil       20       Kidney     Normal                                       M193NK20

 M193N        Cisapride      72     Sm. Intestine Normal                                      M193N72

 M193N        Disitoxin      96        Heart     Normal                                       M193N96

 M193N                                Kidney     Normal
              Flutamide     119                                                               M193N119

 M193N                                 Heart     Normal
              Lacidipine    144                                                               M193N144

 M193N                                 Heart     Normal
              Valsartan     190                                                               M193N190




                                                 Normal
M193O         Corn Oil       22        Heart                                                  M193OH22

                                                 Normal
M193O         Corn Oil       22      Stomach                                                  M193OS22

                                                 Normal
M193O         Corn Oil       22       Kidney                                                  M193OK22

                                                 Normal
M193O         Carbachol     215        Brain                                                  M193O215

                                       Heart     Normal
M193O          Timolol      360                                                               M193O360

                                                 Pelvis Dilation (taken at 4x objective)
M193O        Aceclofenac     46       Kidney                                                  M193O46




10/19/2012
              Carvedilol     72       Heart    Normal                  M193O72
M193O
                                      Heart    Normal
M193O        Nimodipine      143                                       M193O143

                                      Heart    Normal
M193O        Nitrendipine    168                                       M193O168

                                      Heart    Normal
M193O           Water        188                                       M193O188




                                   Sm Intestine Normal
 M193P          Water        165                                       M193P165

                                      Heart    Normal
 M193P          Water        165                                       M193PH165

                                      Heart    Normal
 M193P        Doxazosin      215                                       M193P215

              Levodopa       263      Brain    Normal                  M193P263
 M193P
              Loratadine     287      Heart    Myofiber Degeneration   M193P287
 M193P
                                      Heart    Normal
 M193P        Sparteine      334                                       M193P334

                                      Brain    Normal
 M193P       Sumatriptan     360                                       M193P360




                                      Heart    Fresh Hemorrhage
M193Q        Amytriptyline   154                                       M193Q154

                                      Heart    Congestion
M193Q        Amytriptyline   167                                       M193Q167

                                               Normal
M193Q          Caffeine      192      Brain                            M193Q192

                                               Congestion
M193Q Deschlorpheneramine    239      Heart                            M193Q239




10/19/2012

				
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