Curriculum_Vitae_Andrey_Anisimov by ajizai

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									                                                                                   July, 2009


                                        Curriculum Vitae
                                        Andrey Anisimov

  Date of birth          November 7, 1964
  Nationality            RUSSIAN

  Work address           Molecular/Cancer Biology Laboratory, Biomedicum Helsinki
                         P.O.B. 63, 00014 Helsinki, Finland, Phone: +358-9-1912 5562
  E-mail                 ANDREY.ANISIMOV@HELSINKI.FI



EDUCATION


1995              PHD (ST.-PETERSBURG STATE UNIVERSITY)

1989              M.SC. (PETROZAVODSK STATE UNIVERSITY)




WORK EXPERIENCE
1989-1991 Junior Research Associate, The Institute of Biology, Karelian Research Center, Petrozavodsk,
     Russia
1991-1994 Post-graduate fellowship in biochemistry, Biological Faculty, Petrozavodsk State University,
     Russia
1994-1996 Research associate, Biological faculty, Department of Science, Petrozavodsk State University,
     Russia
1996-2000 Adjunct professor (Docent) and Senior research associate (molecular biology and
     immunology), Biological Faculty, Department of Science, Petrozavodsk State University, Russia
2001-2003 Research scientist, Unicrop LTD., HBSP, Helsinki, Finland
2003-2007 Senior research scientist, Unicrop LTD., HBSP, Helsinki, Finland
2007-present Postdoctoral researcher, Molecular/Cancer Biology Laboratory, Biomedicum Helsinki,
     University of Helsinki
2010-present Staff scientist (AAV Gene Transfer and Cell Therapy Core Facility), Biocenter Finland,
     University of Helsinki



ACADEMIC FELLOWSHIPS; GRANTS AND AWARDS
1996-1997 - Grant 95-0-10.0-187 (RSCI - Center for Basic Research at St.-Petersburg State University)
1996-1998 - Grant 96-04-49873 (RFBR - Russian Fund for Basic Research)
1999-2001 - Grant 99-04-49442 (RFBR - Russian Fund for Basic Research)
2011 (12.9.2011) – Medix prize for the best finnish scientific paper in molecular biology (web:
                   http://biomedicum.com/index.php?page=1501&lang=1 ) - Tvorogov D, Anisimov A,
                   Zheng W et al. Effective Suppression of Vascular Network Formation by


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Andrey Anisimov, Ph.D.                                                        Curriculum Vitae

                 Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor
                 Dimerization. Cancer Cell. 2010 Dec 14;18(6):630-640.

MEETING PRESENTATIONS AND ABSTRACTS/POSTERS
  1. Lappalainen JP, Theelen T, Verheyen F, Biessen EA, Aavik E, Anisimov A, Alitalo K, Daemen
      MJ, Sluimer JC, Ylä-Herttuala S. Periadventitial Adenoviral Ang-1/2 Gene Transfer Interferes
      With Atherosclerotic Plaque Progression And Angiogenesis In The Carotid Artery Of LDLr-/-
      ApoB100/100 Mice. Arteriosclerosis, Thrombosis and Vascular Biology 2012, April 18-20, Chicago,
      Illinois. P….
  2. Tvorogov D, Anisimov A, Zheng W, Tammela T, Leppänen V-M, Laurinavicius S, Holnthoner
      W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen N, Alitalo K. Effective
      suppression of vascular network formation by combination of antibodies blocking VEGFR ligand
      binding and receptor dimerization. The 8th International Duodecim Symposium, June 9-11 2011
      Vanajanlinna, Finland Endothelial growth factors in cancer and cardiovascular diseases. P. 95.
  3. Anisimov A, Leppänen V-M, Tvorogov D, Jeltsch M, Korpisalo P, Ylä-Herttuala S, Alitalo K.
      Vascular engineering of muscle by recombinant adeno-associated viruses encoding vascular
      endothelial growth factors. The 8th International Duodecim Symposium, June 9-11 2011
      Vanajanlinna, Finland Endothelial growth factors in cancer and cardiovascular diseases. P. 52.
  4. Yamamoto M, Anisimov A, Holopainen T, Zheng W, Alitalo K. Overexpression of VEGF-C
      sensitizes tumor angiogenesis and growth to Notch pathway inhibition. The 8th International
      Duodecim Symposium, June 9-11 2011 Vanajanlinna, Finland Endothelial growth factors in
      cancer and cardiovascular diseases. P. 98.
  5. Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T,
      Lehti K, Alitalo K. Notch restricts lymphatic vessel sprouting induced by vascular endothelial
      growth factor. The 8th International Duodecim Symposium, June 9-11 2011 Vanajanlinna,
      Finland Endothelial growth factors in cancer and cardiovascular diseases. P. 100.
  6. Jeltsch M, Leppänen V-M, Anisimov A, Tvorogov D, Kalkkinen N, Toivanen P, Ylä-Herttuala S,
      Ballmer-Hofer K, Alitalo K. Structure/function relationships within the VEGF/VEGF receptor
      families. The 8th International Duodecim Symposium, June 9-11 2011 Vanajanlinna, Finland
      Endothelial growth factors in cancer and cardiovascular diseases. P. 67.
  7. Heloterä H, Pulkki K, Leow CC, Ylä-Herttuala S, Koh GY, Alitalo K, Holopainen T, Saharinen P,
      D’Amico G, Anisimov A, Lampinen A, Lohela M. Angiopoietin-2 blocking antibody acts at
      endothelial cell-cell junctions and inhibits lung metastasis. The 8th International Duodecim
      Symposium, June 9-11 2011 Vanajanlinna, Finland Endothelial growth factors in cancer and
      cardiovascular diseases. P. 61.
  8. Anisimov A, Alitalo A, Soronen J, Korpisalo P, Kaijalainen S, Ylä-Herttuala S, Alitalo K.
      Vascular effects of long-term VEGF-C and VEGF-D expression in mouse skeletal muscle. Novo
      Nordisk Foundation Consortium, 8th annual conference on Vascular Biology in Complications of
      Diabetes. Vår Gård, Saltsjöbaden, Sweden, October 30 – November 1, 2008. P.2.
  9. Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-
      Herttuala S, Alitalo K. Activated forms of VEGF-C and VEGF-D provide improved vascular
      function in skeletal muscle. EMBO Workshop, 4-5 June 2009, Biomedicum Helsinki. P.57.
  10. Weltner Jere, Ras Trokovic, Andrey Anisimov, Samer Hussein, Kari Alitalo, Timo Otonkoski.
      AAV vectors for iPS induction. Wednesday 26 - Friday 28 May INTERNATIONAL
      SCIENTIFIC SYMPOSIUM "stem cells in biology and disease" (there is a poster in the folder
      “Presentations”).
  11. Heckman C. A., T. Holopainen, A. Anisimov, L. Andersson, U. Hodgson, V. L. Kinnula, K.
      Alitalo Lymphangiogenic Potential Of Cells Isolated From Chylous Pleural Effusions Of LAM
      Patients A63 THE UNSTOPPABLE PROGRESS IN LYMPHANGIOLEIOMYOMATOSIS
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Andrey Anisimov, Ph.D.                                                         Curriculum Vitae

       RESEARCH / Thematic Poster Session / Sunday, May 16/8:15 AM-4:00 PM / Area B, Hall G
       (First Level), Morial Convention Center. Am J Respir Crit Care Med 181;2010:A2098.
   12. Kuvshinov V., Anissimov A. and Yahya B. Molecular approaches to control transgene escape.
       International Congress of Plant Molecular Biology (ISPMB) Barselona, Spain, June 23-28, 2003.
   13. Kuvshinov V., Anissimov A., Yahya B., Koivu K. and Kanerva A. Molecular means to prevent
       transgene escape from GM plants. The 7th International Symposium onm the Biosafety of
       Genetically Modified Organisms. Beijing, China, October 10-16, 2002.




                                     List of Publications
Peer-review articles

   1. de Oliveira RL, Deschoemaeker S, Henze A-T, Debackere K, Finisguerra V, Takeda Y, Roncal C,
      Dettori D, Tack E, Jönsson Y, Veschini L, Peeters A, Anisimov A, Hofmann M, Alitalo K, Baes
      M, D'hooge J, Carmeliet P, Mazzone M. Gene-Targeting of Phd2 Improves Tumor Response to
      Chemotherapy and Prevents Side-Toxicity. Cancer Cell. 2012 Aug 13;22(2):263-277.
   2. Weltner J, Anisimov A, Alitalo K, Otonkoski T, Trokovic R. iPSC clones reprogrammed via
      rAAV-mediated transduction contain integrated vector sequences. J Virol. 2012 Apr;86(8):4463-
      4467.
   3. Holopainen T, Saharinen P, D’Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A,
      Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh
      GY and Alitalo K. Effects of Angiopoietin-2-blocking antibody on endothelial cell-cell junctions
      and lung metastasis. J Natl Cancer Inst. 2012 Mar 21;104(6):461-475.
   4. Takeda Y, Costa S, Delamarre E, Roncal C, de Oliveira RL, Squadrito ML, Finisguerra V,
      Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T,
      Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De
      Palma M, Mazzone M. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by
      inducing arteriogenesis. Nature. 2011 Oct 9;479(7371):122-6. doi: 10.1038/nature10507.
   5. Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T,
      Lehti K, Ylä-Herttuala S, Alitalo K. Notch restricts lymphatic vessel sprouting induced by
      vascular endothelial growth factor. Blood. 2011 Jul 28;118(4):1154-62. Epub 2011 May 12.
   6. Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-
      Herttuala S, Ballmer-Hofer K, Alitalo K. Structural determinants of vascular endothelial growth
      factor-D - receptor binding and specificity. Blood. 2011 Feb 3;117(5):1507-15. Epub 2010 Dec 8.
      (Prepublished online as Blood First Edition paper, December 8, 2010; DOI 10.1182/blood-2010-
      08-301549.)
   7. Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W,
      Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Effective
      Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR
      Ligand Binding and Receptor Dimerization. Cancer Cell. 2010 Dec 14;18(6):630-40. Epub 2010
      Dec 2.PMID: 21130043 [PubMed - in process]
   8. Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch
      M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, Mervaala
      E, Andersson LC, Knuuti J, Alitalo K. Vascular Endothelial Growth Factor-B Acts as a Coronary
      Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or
      Inflammation. Circulation. 2010 Oct 26;122(17):1725-33. Epub 2010 Oct 11.
   9. Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I,
      Pytowski B, Baldwin M, Ylä-Herttuala S, Alitalo K, Kreuger J, Claesson-Welsh L. VEGF
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Andrey Anisimov, Ph.D.                                                             Curriculum Vitae

      receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J.
      2010 Mar 11.
  10. Leppänen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H,
      Goldman A, Ballmer-Hofer K, Alitalo K. Structural determinants of growth factor binding and
      specificity by VEGF receptor 2. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30.PMID:
      20145116 [PubMed - in process]
  11. Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-
      Herttuala S, Alitalo K. Activated forms of VEGF-C and VEGF-D provide improved vascular
      function in skeletal muscle. Circ Res. 2009 Jun 5;104(11):1302-12. Epub 2009 May 14.
  12. Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, Nottebaum A,
      Vestweber D, Deutsch U, Koh GY, Olsen BR, Alitalo K. Angiopoietins assemble distinct Tie2
      signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol. 2008
      May;10(5):527-37. Epub 2008 Apr 20.
  13. Anisimov A, Koivu K, Kanerva A, Kaijalainen S, Juntunen K, Kuvshinov V. Cloning of new
      rubisco promoters from Brassica rapa and determination of their activity in stably transformed
      Brassica napus and Nicotiana tabacum plants. Molecular Breeding. 2007; 19(3): 241-253.
  14. Kuvshinov V, Anisimov A., Yahya BM, Kanerva A. Double recoverable block of function – a
      molecular control of transgene flow with enhanced reliability. Environmental Biosafety Research.
      2005; 4(2): 103-112.
  15. Kuvshinov V, Anissimov A, Yahya BM. Barnase gene inserted in the intron of GUS—a model
      for controlling transgene flow in host plants. Plant Science. 2004; 167(1): 173-182.
  16. Anisimov AG, Chekmasova AA, Volkova TO, Nemova NN. Erythroid differentiation of K562
      cells resistant to 2-(4'-dimethylaminostyryl)quinoline 1-oxide or 4-nitroquinoline 1-oxide is
      significantly increased after thymidine treatment. Izv Akad Nauk Ser Biol (Moskow). 2003; (3):
      275-284 (russian). English version: Biology Bulletin 2003; 30(3): 220-227.
  17. Anisimov AG, Volkova TO, Chekmasova AA, Nemova NN. Chemically-induced differentiation
      of the tumor cell lines (review). Ontogenez (Moskow). 2002; 33(5): 325-341 (russian). English
      version: Russian Journal of Developmental Biology 2002; 33(5): 263-278.
  18. Anisimov AG, Volkova TO, Chekmasova AA, Nemova NN. Phorbol-12-myristate-13-acetate
      prevents the inhibitory effect of A23187 on erythroid differentiation of K562 cells induced by
      dimethylsulfoxide. Izv Akad Nauk Ser Biol (Moskow). 2002; (2): 142-148 (russian). English
      version: Biology Bulletin 2002; 29(2): 109-114.
  19. Anisimov AG, Chekmasova AA, Volkova TO, Nemova NN. Combination of thymidine and
      dexamethasone increases the K562 tumor cells sensitivity to human leukocytes cytotoxicity.
      Tsitologiia (Russian). 2001; 43(1): 76-81 (russian).
  20. Anisimov AG, Bolotnikov IA, Chekmasova AA, Volkova TO. Interaction of tumor cell
      differentiation induced in vitro and sensitivity of them to nonspecific lysis by natural killer cells.
      Possible mechanisms (review). Tsitologiia. 2000; 42(10): 923-936 (russian).
  21. Anisimov AG, Bolotnikov IA, Volkova TO. Changes in the K562 cell sensitivity to nonspecific
      lysis by human and rat leukocytes under the influence of sodium butyrate, dimethyl sulfoxide and
      phorbol-12-myristate-13-acetate. Ontogenez (Moskow). 2000; 31(1): 47-52 (russian). English
      version: Russian Journal of Developmental Biology 2000; 31(1): 38-43.
  22. Anisimov AG, Bolotnikov IA, Volkova TO. Effect of thymidine and phorbol-12-myristate-13-
      acetate on the erythroid differentiation of K562 cells and their sensitivity to nonspecific lysis by
      rat splenocytes. Biull Eksp Biol Med (Moskow). 1999; 128(11): 521-524 (russian). English
      version: Bulletin of experimental biology and medicine 1999; 128(11): 1109-1112.
  23. Anisimov AG, Bolotnikov IA. Treatment of synchronized K562 cells by tetrafluoroaluminate
      does not modulate the fluorescence of ethidium bromide and 4'6-diamidine-2-phenylindole in case
      of the binding with nucleoid DNA. Tsitologiia. 1999; 41(8): 680-684 (russian).
  24. Anisimov AG, Bolotnikov IA. Interleukin-2 and staurosporine abolish inhibition of splenocyte
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Andrey Anisimov, Ph.D.                                                            Curriculum Vitae

       nonspecific cytotoxicity caused by high doses of phorbol myristate acetate in rats. Biull Eksp Biol
       Med (Moskow). 1998;125(3): 300-303 (russian). English version: Bulletin of experimental
       biology and medicine 1998; 125(3): 265-268.
   25. Anisimov AG, Bolotnikov IA. Nicotinamide decreases DNA destabilization in K562 cells treated
       with AlF(-4). Tsitologiia. 1997; 39(9): 822-828 (russian).
   26. Anisimov AG, Bolotnikov IA. Modulation with phorbol myristate acetate and staurosporine of
       interleukin 2- induced proliferation and nonspecific cytotoxicity of rat lymphocytes. Biull Eksp
       Biol Med (Moskow). 1996; 122(10): 394-398 (russian). English version: Bulletin of experimental
       biology and medicine 1996; 122(10).
   27. Anisimov AG, Bolotnikov IA. Modulation of non-specific cytotoxicity of rat splenocytes by
       lectins and activators of G-proteins (AlF4-). Immunologija (Moskow). 1995; (6): 26-30 (russian).
   28. Bolotnikov IA., Anisimov AG. Participation of interleukin-2 in T-cell differentiation and
       development of non-specific cytotoxicity (review). Immunologija (Moskow). 1994; (2): 17-23
       (russian).



Patents

   1. Kuvshinov V, Koivu K, Kanerva A, Anissimov A. Use of phytoene synthase for controlling
      transgene escape. US patent 7,790,950 (September 7, 2010).
   2. Koivu K, Kuvshinov V, Kanerva A, Anissimov A, Kaijalainen S. Process for converting storage
      reserves of dicotyledonous seeds into compositions comprising one or more gene products. US
      patent 7,728,192 (June 1, 2010).
   3. Anissimov A, Kaijalainen S, Koivu K, Juntunen K, Kanerva A. Rubisco Promoters and uses
      thereof. US patent 7,115,733 (October 3, 2006).
   4. Kuvshinov V, Koivu K, Kanerva A, Anissimov A. Molecular mechanisms for gene containment
      in plants. US patent 7,238,853 (July 3, 2007).
   5. Anissimov A, Kaijalainen S, Koivu K, Juntunen K, Kanerva A. Rubisco small subunit promotes
      from Brassica rapa and uses thereof. US patent 7,285,657 (October 23, 2007).
   6. Kuvshinov V, Koivu K, Kanerva A, Anissimov A. Double recoverable block of function. US
      patent 7,495,148 (February 24, 2009)




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