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                                     Symposium 2009
        “Cytokines in Health and Diseases”
Date:              November 13th, 2009

Location:         New Residence Hall, McGill University, 3625 Avenue du Parc,
                  Montreal, QC

8:30 -Welcome - Dr Alex Prat – Symposium 2009 organizer

8:35-9:15 - Overview of the role of IL-23 and IL-17 in innate and adaptive immunity
Dr. Thomas Korn (Department of Neurology/Technical University of Munich)

9:15-9:45 - The role of IL-2 in driving Foxp3+ Treg cell-mediated control of autoimmunity
Dr Ciro Piccirillo (McGill University)

9:45-10:15 –TBA

10:15-10:30      Refreshment Break

10:30-11:00 - Role of the IL-23-IL-17 axis in autoimmunity
Dr Estelle Bettelli (Benaroya Research Institute, Seattle)

11:00-11:30 -Role of IL-17 and IL- 23 on HIV infectiveness and progression
Dr Petronela Ancuta (CRCHUM -Université de Montréal)

11:30-12:00 - Transcription factors and cytokines: their involvement in autoimmune CNS disease
Dr. Michael Racke (Ohio State University Neuroscience center)

12:00-12:30 - Cytokine-based therapies-future perspectives
Dr. Daniel Cua (DNAX- Sherring-Plough Biopharma, California)

12:30-13:00 - Immunology Montreal Members; Annual General Assembly no 3. meeting
Dr. Marianna Newkirk - Président
- The agenda will be posted on the website prior to the meeting

13:00 Lunch*

(Updated: Oct 7th 2009)

Symposium 2009 Immunology Montreal                                                           1
*To all that have confirmed interest in attending the symposium.
This event is open to all.
Free but reservations are required. Send email to:
Deadline to reserve November 6th, 2009. Complimentary lunch will follow to all persons that
have confirmed interest in attending the symposium.
Co-organized with the EndMS research and training Network (Dr Jack Antel).

                                Made possible by Sponsoring

  Immunology Montreal, CIHR, Novartis, J.L. Freeman s.e.c., Teva Neuroscience,

This symposium will focus on the role of conventional and novel cytokines in immune
system homeostasis, during infections, as well as in the development of autoimmune
inflammation. In the previous symposium, we focused on tumor necrosis factor (TNF)
as a therapeutic target in three different diseases and as well discuss the potential side
effects of such therapy. In the current symposium, we will gather experts in the field of
the IL-17-IL-23 axis, including the important role of IL-1β, IL-6, TGF-β and IL-22 in the
regulation of this axis. Functions of IFNγ and IL-12 will also be addressed, but
This symposium with the focus on cytokines organized by Immunology Montreal will be
held with a target audience Immunologists (Investigators and Trainees) that are Basic.
Scientists or Clinicians from McGill University, University of Montreal, Institut de
Recherche Clinique de Montreal and Institut Armand-Frappier (affiliated with the
University of Quebec at Montreal). The media and the general public will be welcome.

Profiles of confirmed speakers:

Dr Thomas Khorn (Munich) After training in clinical neurology and neuroimmunology,
Dr Khorn spent 3 years as a postdoc in Vijay Kuchroo's lab at Harvard Medical School,
Boston. Currently, he is setting up an independent group in experimental
neuroimmunology at the Department of Neurology at the Technical University in Munich.
The main research focus will be the investigation of the development and regulation of T
cell responses against glial and astrocytic targets using animal models of

Dr Ciaro Piccirilo (McGil University) is associate professor of Microbiology and
Immunology at McGill University. He is an expert on the role of TGF in the development
of autoimmune diseases, including T1 diabetes, MS and IBD.

Dr Estelle Bettelli (Harvard) received her PhD in Hematology/Immunology from the
University Denis Diderot, Paris7, France in 2001. She performed a postdoctoral
fellowship in the Department of Neurology at the Brigham and Women’s Hospital,
Boston, and became an Assistant Professor at Harvard Medical School in 2009. Dr.
Bettelli is now an Assistant Member at the Benaroya Research Institute and an affiliated
Assistant Professor in the Department of Immunology, University of Washington School
of Medicine, Seattle. Research in Dr. Bettelli’s laboratory is focused on understanding
the development, regulation and functions of T helper 17 (Th17) cell responses during
autoimmunity and cancer.

Symposium 2009 Immunology Montreal                                                            2
Dr Petronela Ancuta (Université de Montréal) is a Research Assistant Professor at
the Université de Montréal, Faculty of Medicine, Department of Microbiology and
Immunology and her laboratory is located at the CHUM-Research Center, Saint-Luc
Hospital. She received a PhD in Immunology from the Université de Paris-Sud, Orsay,
France (2000) and underwent post-doctoral studies at Dana-Farber Cancer Institute and
Harvard Medical School, Boston, MA, USA (2001-2006). Dr Ancuta’s current research
program focuses on the characterization of dendritic cell and CD4+ T-cell heterogeneity
in the context of HIV pathogenesis, with the long-term goals to design new potent and
safe dendritic cell-based HIV vaccines and to eradicate viral reservoirs from discrete T-
cell subsets.

Dr Micheal K. Racke (OSU) received his M.D. from the University of Medicine and
Dentistry of New Jersey-New Jersey Medical School. He completed his neurology
training at Emory University in Atlanta and a neuroimmunology fellowship at the National
Institutes of Health. In July, 2006, he assumed the chairmanship of neurology at The
Ohio State University College of Medicine. His research focuses on understanding how
inflammation gets established in the central nervous system and developing novel
therapeutics by studying the animal model experimental autoimmune encephalomyelitis.
His research also centers on the pathogenesis of multiple sclerosis.

Dr Daniel Cua (DNAX) is the leading expert in the field of IL-23 and TH17
biology. As a senior Scientist at DNAX he discovered the existence of these cytokines
and explored the biological role of IL-23 in autoimmune inflammation.


We anticipate ~200 participants. [Room capacity (Ballroom B) is 220 theatre-style].
This will be open to the public, and we will invite journalists. For the latter, since the
venue is located on McGill property, staff from McGill prepares the news release in both.
English and French (with our help). Communication offices of University of Montreal and
the CHUM will also team up with McGill staff to promote a wider diffusion of this event in
both the French and English Scientific community.


 We invite your organization / company to sponsor this symposium. Immunology
Montreal has charitable status, and we will be pleased to provide a receipt for your

This is a great opportunity for your company to increase its visibility. All sponsors will
have their logos displayed on the program, Newsletter and website, with the size of the
logo reflecting the level of support. Contact Micheline Paré: to have your name listed.


Symposium 2009 Immunology Montreal                                                           3
To publicize the symposium, we will send out an email newsletter to all on the
Immunology Montreal mailing list, and as well request that the newsletter is forwarded to
students, trainees, resident and doctors of the CHUM (Université de Montréal) and
MUHC (McGill). We will also have it posted on the Immunology Montreal website (see for past symposia).

Symposium 2009 Immunology Montreal                                                      4
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