JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Vol. 41 No. 1 January 2011
2 The Benchmark Analysis of Gastric, Colorectal and Rectal Cancer Pathways: Toward Establishing
Standardized Clinical Pathway in the Cancer Care
Munemasa Ryu, Masaaki Hamano, Akira Nakagawara, Masayuki Shinoda, Hideaki Shimizu, Takeshi Miura,
Isao Yoshida, Atsushi Nemoto and Aki Yoshikawa
We aimed at establishing a standard clinical pathway for cancer treatment in Japan by benchmarking DPC
(diagnosis procedure combination) data of gastric and colorectal cancers from ﬁve Japanese cancer centers.
10 Cancer Trends and Incidence and Mortality Patterns in Turkey
Hakki Hakan Yılmaz, Nuray Yazıhan, Dilara Tunca, Arzu Sevinc, Emire Ozen Olcayto, Nejat Ozgul¨ ¨
and Murat Tuncer
The ﬁve most frequent cancer types in Turkey are lung, prostate, skin, breast and stomach. The expected rise
in cancer incidence and prevalence requires well designed and efﬁcient cancer control programs as
implemented in best practice country cases.
17 Phase III Trial of Everolimus in Metastatic Renal Cell Carcinoma: Subgroup Analysis of Japanese
Patients from RECORD-1
Taiji Tsukamoto, Nobuo Shinohara, Norihiko Tsuchiya, Yasuo Hamamoto, Masayuki Maruoka, Hiroyuki
Fujimoto, Masashi Niwakawa, Hirotsugu Uemura, Michiyuki Usami, Akito Terai, Hiro-omi Kanayama,
Yoshiteru Sumiyoshi, Masatoshi Eto and Hideyuki Akaza
The results of this subgroup analysis suggest that the beneﬁts of everolimus in Japanese patients with
metastatic renal cell carcinoma are similar to those observed in the overall pivotal Phase III trial population.
25 A Phase II Study of Cisplatin and Irinotecan As Induction Chemotherapy Followed by Concomitant
Thoracic Radiotherapy with Weekly Low-dose Irinotecan in Unresectable, Stage III, Non-Small Cell
Lung Cancer: JCOG 9706
Koji Takeda, Shunichi Negoro, Masahiro Tanaka, Haruhiko Fukuda, Kazuhiko Nakagawa, Masaaki
Kawahara, Hiroshi Semba, Shinzoh Kudoh, Toshiyuki Sawa, Nagahiro Saijo and Masahiro Fukuoka
A Phase II study found that cisplatin plus irinotecan followed by concomitant thoracic radiotherapy with
irinotecan was feasible for patients with unresectable Stage III non-small cell lung cancer.
32 Survival and Prognostic Factors in Malignant Pleural Mesothelioma: A Retrospective Study of
314 patients in the West Part of Japan
Shuko Nojiri, Kenichi Gemba, Keisuke Aoe, Katsuya Kato, Takuhiro Yamaguchi, Tsugumichi Sato, Kiyoshi
Kubota and Takumi Kishimoto
Our study indicated that baseline conditions at diagnosis were important prognostic factors for patients with
malignant mesothelioma. A high C-reactive protein level was also identiﬁed as an important prognostic factor.
40 Population-based Survival of Cancer Patients Diagnosed Between 1993 and 1999 in Japan: A
Chronological and International Comparative Study
Tomohiro Matsuda, Wakiko Ajiki, Tomomi Marugame, Akiko Ioka, Hideaki Tsukuma and Tomotaka Sobue,
Research Group of Population-Based Cancer Registries of Japan
Relative 5-year survival (1997–1999) was 54.3% in Japan. Major improvement was observed in several
primary sites. Survival was lower than in the US, but similar to that in European countries.
52 Feasibility and Robustness of Ampliﬁcation Refractory Mutation System (ARMS)-based KRAS Testing
Using Clinically Available Formalin-ﬁxed, Parafﬁn-embedded Samples of Colorectal Cancers
Naomi Ogasawara, Hideaki Bando, Yasuyuki Kawamoto, Takayuki Yoshino, Katsuya Tsuchihara, Atsushi
Ohtsu and Hiroyasu Esumi
The robustness of ARMS/S KRAS mutation testing was evaluated using formalin-ﬁxed, parafﬁn-embedded
samples. ARMS/S testing was reliable, but the success rate was impaired by interfering substrates that had
contaminated the templates.
57 Clinical Efﬁcacy and Safety of Sunitinib After Imatinib Failure in Japanese Patients with
Gastrointestinal Stromal Tumor
Kazuya Matsumoto, Akira Sawaki, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Yasumasa Niwa,
Masahiro Tajika, Hiroki Kawai, Shinya Kondo and Kenji Yamao
Sunitinib may be an effective agent for advanced gastrointestinal stromal tumor after failure of imatinib in
63 A Multicenter Phase-II Study of 5-FU, Leucovorin and Oxaliplatin (FOLFOX6) in Patients with
Pretreated Metastatic Colorectal Cancer
Ken Kato, Yoshitaka Inaba, Yasushi Tsuji, Taito Esaki, Akira Yoshioka, Nobuyuki Mizunuma, Toshiro Mizuno,
Hitoshi Kusaba, Hirohumi Fujii, Kei Muro, Yasuhiro Shimada and Kuniaki Shirao
The FOLFOX6 regimen is an efﬁcient and safe therapy for Japanese patients with pretreated colorectal
Hepato-biliary and Pancreatic Medicine
69 Hepatic Arterial Infusion Therapy with a Fine Powder Formulation of Cisplatin for Advanced
Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis
Masaaki Kondo, Manabu Morimoto, Kazushi Numata, Akito Nozaki and Katsuaki Tanaka
Hepatic arterial infusion therapy with a ﬁne powder formulation of cisplatin might be a viable treatment
option for hepatocellular carcinoma patients with portal vein tumor thrombosis.
76 Outcomes and Tolerability of Systemic Chemotherapy for Pancreatic or Biliary Cancer Patients Aged
75 Years or Older
Seigo Yukisawa, Hiroshi Ishii, Masato Matsuyama, Kensuke Kuraoka, Koichi Takano, Akira Kamei and
Gemcitabine monotherapy appears to be safe and resulted in the same treatment effect even in older patients
with pancreatic or biliary tract cancer.
81 Cancer Care and Residents’ Working Hours in Oncology and Hematology Departments:
An Observational Real-time Study in German Hospitals
Stefanie Mache, Norman Schoffel, Bianca Kusma, Karin Vitzthum, Burghard F. Klapp and David A.
The study results partly conﬁrm physicians’ perceived workﬂow problems concerning the long working hours,
the increase in time for administrative duties and the relatively little amount of time spent on direct patient
87 Pessimism Predicts Anxiety, Depression and Quality of Life in Female Cancer Patients
Markus Zenger, Heide Glaesmer, Michael Hockel and Andreas Hinz
Especially women with a high level of pessimism are at risk for higher levels of anxiety and depression in
addition to lowered quality of life in the course of the disease.
95 Impact of Intracranial Extension on Survival in Stage IV Nasopharyngeal Carcinoma: Identiﬁcation of
a Subset of Patients with Better Prognosis
Yu-Chang Hu, Ching-Hsiung Chang, Chien-Hsun Chen, Luo-Ping Ger, Wen-Shan Liu, Li-Ching Lin,
Chung-Man Leung and Kuo-Chen Chang
In this retrospective study, it was demonstrated that a subdivision of Stage T4 nasopharyngeal carcinoma
based on the extent of intracranial involvement would provide better prognostic information.
103 Radiotherapy for Glottic T1N0 Carcinoma with Slight Hypofractionation and Standard Overall
Treatment Time: Importance of Overall Treatment Time
Rikiya Onimaru, Masakazu Hasegawa, Kouichi Yasuda, Akihiro Homma, Nobuhiko Oridate,
Satoshi Fukuda and Hiroki Shirato
Overall treatment time (OTT) seems to be an important factor for a good local control rate for glottic T1N0
carcinoma even when treated with slight hypofractionated radiotherapy.
110 Disease-speciﬁc Survival in Patients with Renal Cell Carcinoma: An Audit of a Large Series from
Ja Hyeon Ku, Kyung Chul Moon, Cheol Kwak and Hyeon Hoe Kim
Although tumors found in young adults show more favorable histological features, young patients do not have
a higher disease-speciﬁc survival rate after adjusting for clinical and pathological variables.
115 Clinical Outcomes of Patients with pT0 Bladder Cancer after Radical Cystectomy: A Single-institute
Fumimasa Fukuta, Naoya Masumori, Ichiya Honma, Masatoshi Muto, Koji Ichihara, Hiroshi Kitamura and
Patients with pT0 specimens after radical cystectomy for bladder cancer showed favorable outcomes.
However, they should be periodically followed up because pT0 does not always mean cure.
121 Early Detection of 5-FU-induced Acute Leukoencephalopathy on Diffusion-Weighted MRI
Reiko Akitake, Shin’ichi Miyamoto, Fumiyasu Nakamura, Takahiro Horimatsu, Yasumasa Ezoe,
Manabu Muto and Tsutomu Chiba
We report a case of acute leukoencephalopathy induced by 5-ﬂuorouracil. Diffusion-weighted magnetic
resonance imaging is a useful modality for the early detection and deﬁnitive diagnosis of this characteristic
125 Sudden-Onset Pancytopenia with Intracranial Hemorrhage after Oxaliplatin Treatment:
A Case Report and Literature Review
Chung-Jen Teng, Yao-Yu Hsieh, Kuo-Wei Chen, Ta-Chung Chao, Cheng-Hwai Tzeng and Wei-Shu Wang
A male patient with metastatic colon cancer experienced acute pancytopenia, profound coagulopathy and
intracranial hemorrhage after his 17th course of oxaliplatin.
130 Multiple Calcifying Fibrous Pseudotumor of the Bilateral Pleura
Ke Jiang, Jun Nie, Jianjun Wang and Jinsong Li
We describe a case of multiple calcifying ﬁbrous pseudotumor disseminated in the bilateral pleura. We
discuss the differential diagnosis with other benign or malignant soft tissue diseases.
Clinical Trial Note
134 Multicentre Phase II Study of XELOX with Bevacizumab in Late-stage Elderly Patients with
Unresectable Advanced/Recurrent Colorectal Cancer: An ASCA Study
Koji Oba, Masaki Matsuoka, Taroh Satoh, Kei Muro, Noboru Oriuchi, Junichi Sakamoto
and Hideyuki Mishima
This paper shows a protocol of an open-label multicentre Phase II study to evaluate the efﬁcacy and
safety of XELOX and bevacizumab in late-stage elderly patients with unresectable advanced/recurrent
139 Cancer Incidence and Incidence Rates in Japan in 2005: Based on Data from 12 Population-based
Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project
Tomohiro Matsuda, Tomomi Marugame, Ken-ichi Kamo, Kota Katanoda, Wakiko Ajiki and Tomotaka Sobue,
The Japan Cancer Surveillance Research Group
The Japan Cancer Surveillance Research Group estimated the cancer incidence on the basis of 12 cancer
registry data. The total number of incidences in 2005 was estimated as 646 802 (C00 –C96).
148 Clinical Implication of the Antidiuretic Hormone (ADH) Receptor Antagonist Mozavaptan
Hydrochloride in Patients with Ectopic ADH Syndrome
Ectopic ADH Syndrome Therapeutic Research Group, Ken Yamaguchi, Noriharu Shijubo, Tetsuro Kodama,
Kiyoshi Mori, Takahiko Sugiura, Takayuki Kuriyama, Masaaki Kawahara, Tetsu Shinkai,
Haruo Iguchi and Masanori Sakurai
Mozavaptan, the vasopressin V2 receptor antagonist, provides a new treatment option in patients with ectopic
antidiuretic hormone (ADH) syndrome, a fatal medical emergency characterized by dilutional hyponatremia.
153 Image of the Month and Cancer Statistics Digest
Instructions to Authors
Contents of the Journal of the National Cancer Institute