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					                   BIOLOGY AND CHEMISTRY OF VISION


                                              JUNE 19 – 24, 2011
                                              CAREFREE, ARIZONA


                                               ORGANIZERS:
                                            Theodore G. Wensel
                                             Vladimir Kefalov




           THE FEDERATION GRATEFULLY ACKNOWLEDGES THE FOLLOWING
                                     EDUCATIONAL GRANTS FOR THE
                          FASEB SUMMER RESEARCH CONFERENCES:


                                         Platinum Level Support:
                                            *National Eye Institute




*The project described was supported by Award Number U13EY021709 from the National Eye Institute. The content is solely
   the responsibility of the authors and does not necessarily represent the official views of the National Eye Institute or the
                                                 National Institutes of Health.
      FINAL CONFERENCE
          PROGRAM




NO PART OF THE CONFERENCE PROCEEDINGS MAY BE REFERENCED. PLEASE
   CONTACT AUTHORS DIRECTLY FOR PERMISSION TO CITE THEIR WORK.
                               Biology and Chemistry of Vision
                                      June 19-24, 2011
                                      Carefree, Arizona


                                                Co-Organizers:
                                              Theodore G. Wensel
                                            Baylor College of Medicine
                                                   Houston, TX

                                                Vladimir Kefalov
                                               Washington University
                                                  St. Louis, MO


Sunday,
June, 19, 2011
4:00PM – 9:00AM                           Conference Registration

6:00PM – 7:00 PM                          FASEB Opening Reception

7:00PM – 8:30 PM                          Dinner

8:45PM – 9:45 PM                          Keynote Speaker
                                          William W. Hauswirth, University of Florida
                                          “Cone-Targeted Gene Therapy”


Monday,
June, 20, 2011
7:30AM – 9:00AM                           Breakfast

Session 1:                                Protein Structure/Function
9:00AM – 12:00PM                          Gebhard Schertler, Paul Scheerer Institute

9:00AM – 9:15AM                           Welcome from FASEB

9:15AM - 9:45AM                           Gebhard Schertler, Paul Scheerer Institute
                                          GPCR Conformational Transitions
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
9:45AM –10:15AM                           Mingjie Zhang, Hong Kong University of Science and Technology
                                          PDZ scaffolds in photoreceptors

10:15AM – 10:30 AM                        Yoshinori Shichida:Kyoto University
                                          Role of UV-sensitive pigment on the molecular evolution of
                                          vertebrate visual pigments

10:30AM – 11:00AM                         Group photo & FASEB Sponsored Coffee Break

11:00AM – 11:30AM                         Heidi Hamm, Vanderbilt University
                                          G protein interaction with activated rhodopsin leads to opening a
                                          cleft between Gα helical and GTPase domains

11:30AM – 12:00PM                         Vsevolod Gurevich, Vanderbilt University
                                          Arrestin shape-shifting: rhodopsin-bound conformation and
                                          monomer-dimer-tetramer equilibrium of free arrestin-1

12:00PM – 12:15PM                         Michael Redmond, National Eye Institute
                                          Aromatic residues govern retinol isomerization by RPE65

12:15PM – 1:15PM                          Lunch

                                          Free Afternoon

4:00 PM- 4:30 PM                          Data Blitz: 5 talks, 5 minutes each

4:30PM – 6:00PM                           Poster Session I (1 hr. Sponsored Bar)

6:00PM – 7:00PM                           Dinner

Session 2:                                New approaches to therapy
7:00PM – 9:45PM                           Jane Sowden, University College, London

7:00PM - 7:30PM                           Jane Sowden, University College London;
                                          Towards retinal stem cell therapy – transplanting photoreceptors

7:30PM – 8:00PM                           Cynthia Montana, Washington University, St. Louis
                                          Progress toward transdifferentiating adult mouse rods into cones in
                                          vivo.


8:00PM – 8:15PM                           Kenton Woodard, University of North Carolina, Chapel Hill
                                           Adeno-associated virus variant trafficking in the retina using Cy5
                                          labeled virus

8:15PM – 8:30PM                           FASEB Sponsored Coffee Break

8:30PM – 9:00PM                           Gustavo D. Aguirre, University of Pennsylvania
                                          Life and death of cones in retinal diseases, and rescue with gene
                                          therapy

9:00PM – 9:15PM                           Gennadiy P. Moiseyev, Univ. of Oklahoma Health Sciences Center
                                          PBN Protects the Retina from Light-induced Degeneration by
                                          Inhibiting RPE65 Isomerohydrolase Activity
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
9:15PM – 9:45PM                           David Gamm, U. of Wisconsin, Madison
                                          Induced pluripotent stem cells

Tuesday,
June, 21, 2011
7:30AM – 9:00AM                           Breakfast

Session 3                                 Synaptic Signaling
9:00AM – 12:00PM                          Catherine Morgans, OHSU

9:00AM - 9:30AM                           Wallace Thoreson
                                          Mechanisms of release at cone ribbon synapses."

9:30PM –10:00AM                           Catherine Morgans, Oregon Health and Science University
                                          Molecular mechanisms of synaptic signaling

10:00AM – 10:15AM                         Mühlhans, Johanna, University of Erlangen-Nuremberg
                                          Trying to understand complexity: Complexins in the retina

10:15AM – 10:45AM                         Break

10:45AM – 11:15AM                         Richard Kramer University of California, Berkeley
                                          Two types of horizontal cell feedback at the photoreceptor ribbon
                                          synapse

11:15AM – 11:45AM                         Takahisa Furukawa, Osaka Bioscience Institute
                                          Molecular development and function of the photoreceptor synapse

11:45AM – 12:00PM                         Ching-KangJason Chen, Virginia Commonwealth Univ.
                                          Involvement of Gbeta5/R7RGS proteins in mammalian vision Short
                                          Talk Selected From Submitted Abstracts

12:00PM – 1:15PM                          Lunch

                                          Free Afternoon

4:00 PM - 4:30 PM                         Data Blitz: 5 talks, 5 minutes each

4:30PM – 6:00PM                           Poster Session I (continued; cash bar)

6:00PM – 7:00PM                           Dinner

Session 4:                                Photoreceptors
7:00PM – 9:45PM                           Vadim Arshavsky, Duke University

7:00PM - 7:30PM                           Gordon Fain, UCLA
                                          Modulation of response termination in rods

7:30PM – 8:00PM                           Alexander Kolesnikov, Washington University, St. Louis
                                          Regulation of G protein activation by beta & gamma subunits




This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
8:00PM – 8:15PM                           Satoro Kawamura, Osaka University et al:
                                          Lower activation and faster inactivation of transducin in cones than
                                          in rods in the carp retina

8:15PM – 8:30PM                           Break

8:30PM – 8:45PM                           Nikolai Artemyev, University of Iowa
                                          Transgenic mouse model with impaired light-induced translocation
                                          of transducin

8:45PM – 9:00PM                           Rolf Herrmann, Duke University
                                          Photoresponse recovery rate impacts cone- but not rod-dominant
                                          vision

9:00PM - 9:15PM                           Wendy W.S. Yue,, Johns Hopkins University
                                          Activation of Visual Pigments by Light and Heat

9:15PM – 9:45PM                           Barry Willardson, Brigham Young University
                                          Assembly of G Protein Complexes


Wednesday,
June, 22, 2011
7:30AM – 9:00AM                           Breakfast

Session 5                                 Invertebrates
9:00AM – 12:00PM                          Roger Hardie University of Cambridge


9:00AM - 9:30AM                           Roger Hardie, University of Cambridge
                                          TRP channels and phototransduction

9:30PM –10:00AM                           Shawn Xu, University of Michigan
                                          Light detection in C elegans

10:00AM – 10:15AM                         Terakita Akihisa, Osaka City University:
                                          Investigation of visual pigments in the four-layered retina of jumping
                                          spiders

10:15AM – 10:45AM                         FASEB Sponsored Coffee Break

10:45AM – 11:15AM                         Nansi Colley, University of Wisconsin
                                          A new photoreceptor chaperone

11:15AM – 11:45PM                         Baruch Minke, Hebrew University
                                          A PLC-mediated threshold enables single photon detection by
                                          suppressing intrinsic dark noise in Drosophila photoreceptors

11:45AN – 12:00PM                         Vladen Slepak, University of Miami
                                          Rhodopsin-based visual system in coral larvae

12:00PM – 1:15PM                          Lunch

1:15 PM- 2:30 PM                          Meet the Experts Session
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
                                          Free Afternoon

4:00PM – 6:00PM                           Poster Session II (1 hr. sponsored bar)

6:00PM – 7:00PM                           Dinner

Session 6:                                Non-image-forming light detection
7:00PM – 9:45PM                           Steven Hughes, Oxford University

7:00PM - 7:30PM                           Robert Lucas, University of Manchester
                                          Melanopsin contributions to light evoked activity in the mouse brain

7:30PM – 8:00PM                           Samer Hattar, Johns Hopkins University
                                          Photoentrainment and pupillary light reflex are mediated by distinct
                                          populations of M1 ipRGCs

8:00PM – 8:15PM                           Phyllis Robinson, University of MD, Baltimore County
                                          Regulation of melanopsin signaling by PKA

8:15PM – 8:30PM                           Break

8:30PM – 8:45PM                           Takahiro Yamashita, Kyoto University:
                                          Opn5 is a UV-sensitive bistable pigment that couples with Gi
                                          subtype of G protein

8:45PM – 9:15PM                           Steven Hughes, Oxford University
                                          New insights into melanopsin (Opn4) signalling

9:15PM – 9:45PM                           Elena Oancea, Brown University
                                          Rhodopsin mediates UV signal transduction in human skin


Thursday,
June, 23, 2011
7:30AM – 9:00AM                           Breakfast

Session 7                                 Cones
9:00AM – 12:15PM                          Maureen Neitz, University of Washington
9:00AM - 9:30AM                           Maureen Neitz, University of Washington
                                          The role of cone opsin mutations in common vision disorders.

9:30PM –10:00AM                           Maarten Kamermans, Netherlands Institute of Neuroscience
                                          Unconventional inhibition in the outer retina – mechanism and
                                          function.

10:00AM – 10:15AM                         Karl-Wilhelm Koch , Carl von Ossietzky University
                                          Diversity of zebrafish guanylate cyclase-activating proteins
                                          represents a fine-tuned calcium network in cone cells


10:15AM – 10:45AM                         FASEB Sponsored Coffee Break

10:45AM – 11:15AM                         Visvanathan Ramamurthy, West Virginia University
                                          PDE6 in Cones.
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
11:15AM – 11:45AM                         Joseph Carroll, Medical College of Wisconsin
                                          Imaging the Cone Mosaic in Retinal Disease

11:45AM – 12:00PM                         Tatiana I. Rebrik, Duke University
                                          CNG-Modulin: a novel modulator of cone photoreceptor cGMP-
                                          gated channel

12:00PM – 12:30PM                         Business Meeting

12:30PM – 1:30PM                          Lunch

                                          Free Afternoon

1:30PM – 6:00PM                           Optional Organized Group Activity

4:00PM – 6:00PM                           Poster Session II (continued; cash bar)

6:00PM – 7:00PM                           Dinner

Session 8:                                Retinal cell and molecular biology
7:00PM – 9:45PM                           Dusanka Deretic, University of New Mexico

7:00PM - 7:30PM                           Dusanka Deretic, University of New Mexico
                                          Photoreceptor trafficking complexes

7:30PM – 8:00PM                           Hannie Kremer, Radboud University Nijmegen Medical Centre
                                          The Usher protein network in photoreceptor cells: lessons on
                                          structure and function’

8:00PM – 8:15PM                           Muna Naash, University of Oklahoma Health Sciences Center RDS
                                          C-terminus is sufficient to initiate outer segment formation

8:15PM – 8:30PM                           Break

8:30PM – 8:45PM                           Hemant Khanna, University of Michigan
                                          Accumulation of RAF-1 kinase inhibitory protein (RKIP) is
                                          associated with CEP290-mediated photoreceptor degeneration in
                                          ciliopathies

8:45PM – 9:00PM                           Vincent Marion, Faculté de Médecine de Strasbourg, Strasbourg,
                                          France
                                          Bardet Biedl Syndrome chaperonin-like proteins depletion induces
                                          photoreceptor cells death due to Endoplasmic Reticulum Stress


9:00PM - 9:15PM                           Shannath Merbs, Johns Hopkins
                                          Cell-specific DNA methylation patterns in the retina

9:15PM – 9:45PM                           Igor Nasonkin, National Eye Institute
                                          DNA Methyltransferases in retinal development and postmitotic
                                          retina



This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
Friday,
June, 24, 2011
7:30AM – 8:30AM                           Breakfast

Session 9                                 RPE and Visual Cycle
8:30AM – 11:30PM                          Gabriel Travis, UCLA.

8:30AM - 9:00AM                           Marcelo Norciari, Cornell-Weill Medical School.
                                          Intracellular protein trafficking

9:00AM – 9:30AM                           Douglas Vollrath, Stanford University
                                          mTOR-mediated dedifferentiation characterizes an RPE stress
                                          response

9:30AM – 9:45AM                           Yesuke Takahashi, Univ. of Oklahoma Health Sciences Center
                                          An alternative isomerohydrolase in retinal Muller cells in a cone-
                                          dominant species

9:45AM – 10:00AM                          Break

10:00AM – 10:15AM                         Minghao Jin, LSU Health Sciences Center
                                          Identification and characterization of new negative regulators of
                                          RPE65

10:15AM – 10:45AM                         Gabriel Travis, UCLA
                                          Retinoid isomerase-2 in Muller cells

10:45AM – 11:15PM                         Anant Menon, Cornell)
                                          Opsin-mediated phospholipid flip-flop: implications for the visual
                                          cycle

11:15AM – 11:30AM                         Closing Comments

11:30AM                                   Departures
                                          Boxed Lunches Available


                                             END OF CONFERENCE

                                         For additional information contact:

                                     FASEB Summer Research Conferences
                                             9650 Rockville Pike
                                            Bethesda, MD 20814

                                                  arizona@faseb.org

                                                  www.faseb.org/src




This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.

				
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