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					                                     CTSC eNews

V O L U M E   I I                                                                                           S P R I N G      2 0 1 0

                            From the Director’s Desk:
IN THIS I SSUE 
                                                   WELCOME to the spring 2010 issue of the CTSC eNews! We’ve reached
  ARRA Research
                                                   some important milestones in our research mission to foster multidisciplinary,
  Update                                           multi-institutional collaborative research to yield new, effective patient treat-
  New CTSC Core                                    ments, educate and mentor the translational research scientists of the future,
  Service                                          and enhance health care to the underserved in our surrounding communities.
                                                      Since our spring 2009 issue of this newsletter, the CTSC has continued to
  Obama’s “Call to                                 fund Pilot, Community, Novel and Education mentoring awards. These projects
  Service”                                         represent researchers from Weill Cornell Medical College and investigators from
                                                   CTSC partner institutions.
  Profiled CTSC                                       In this issue, we invite you to read about the research accomplishments of
  Researchers                                      CTSC awardees. I am also delighted to announce that the CTSC received three
                            American Recovery and Reinvestment Act (ARRA) Administrative Supplements. An additional three
  Recent Events
                            ARRA awards were in partnership with several other CTSA’s (Clinical Translational Science Awards).
                            Please read “Translational Research to the Forefront” to find out more about these breakthrough initia-
                            tives.
                              The CTSC continues to reach out into the community with the newly launched Community Education
  CTSC Web site             Interactive Video Conferencing Program and the “United We Serve” drive.
                              Looking ahead to a new decade, our goal is to continue efforts to deepen and broaden our relation-
                            ships across partner institutions and strengthen community ties to translate science into medical prac-
  Need Help with            tice. We look forward to continuing to foster translational research while serving the needs of our re-
  Developing and            search community.

  Preparing Your
                            Julianne Imperato-McGinley, M.D.
  Clinical Research         Associate Dean, Translational Research and Education
  Study Budget?             Program Director, Clinical and Translational Science Center
  The CTSC is here to       Abby Rockefeller Mauzé Distinguished Professor of Endocrinology in Medicine
  help!                     Chief, Division of Endocrinology

  Click here for details.
                                            Bringing Translational Research to
                                                   the Forefront through ARRA
                            By Geraldine Amera                 The Act allocated $10.4 billion to   Medical College collaborating with
                                                               the National Institutes of Health    its partners, the Hunter College
                            The American Recovery and          (NIH) for the support and ad-        School of Nursing, the Hunter Col-
                            Reinvestment Act (ARRA) was        vancement of biomedical re-          lege Center for Study of Gene
                            signed into law by President       search. The recipients of awards     Structure and Function, and the
                            Obama on February 17, 2009,        resulting from the act are those     Burke Institute.
                            to preserve jobs while creating    with the highest potential for         These projects support the
                            new ones, create economic          creating scientific progress         CTSC’s key mission, to overcome
                            activity and growth, and to        within two years.                    barriers to biomedical innovation
                            invest in scientific advance-        Three Administrative Supple-       by coordinating novel translational
                            ment.                              ments were awarded directly to       research projects across institu-
                                                               the Clinical and Translational       tions and disciplines.
                                                               Science Center at Weill Cornell                (continued on next page)
                                                                                                                  PAGE   2




Continued from page 1

The supplements awarded to            tations is to increase community        tant Professor of Psychology in the
WCMC come under three National        access to high quality health infor-    Department of Psychiatry was the
Center for Research Resources         mation by engaging those in under-      speaker and the topic discussed was
(NCRR) designated award catego-       served communities in discussions       “Fall Prevention.”
ries: Community Engagement,           on a wide range of health topics. The
                                                                              The next event is scheduled to broad-
Workforce Development, and Pilot      investigator team, using equipment
                                                                              cast simultaneously to three churches
Projects. Three additional awards     already in place at the Hunter Gene
                                                                              in Jamaica, Queens and the Bronx in
were given to CTSC investigators      Center, hopes to improve medical
                                                                              March. Future events will be coordi-
who are collaborating with the        information access to the commu-
                                                                              nated on a monthly basis.
following institutions: Albert Ein-   nity.
stein Medical Center, the Univer-
sity of Florida, and Columbia Pres-                                           Hunter College School
byterian Medical Center.
                                                                              of Nursing:

Improving                                                                     Encouraging

Community Health                                                              Healthcare Careers
                                                                              Kristine Gebbie, DrPh, RN, Dean of
Education through                                                             the Hunter College School of Nursing,

Interactive Video                                                             City University of New York (HCSON)
                                      Jane Seley, NP and                      has partnered with WCMC CTSC to
Conferencing                          David Brillon, MD, Associate Profes-
                                                                              lead a research project that aims to
                                      sor, Division of Endocrinology
Principal Investigator Julianne Im-                                           boost student interest in nursing and
perato-McGinley, MD, has teamed                                               other allied health professions.
up with Robert Dottin, PhD, and
                                      David Brillon, MD and Jane Seley, NP
Donald Tobias, PhD to pioneer a                                               Through a two-year Community En-
                                      presented the first discussion with
project that explores the use of                                              gagement with Nursing and Science
                                      the video conferencing technology
interactive video conferencing for                                            (CENS) program, students among
                                      which was broadcasted at a church,
community education. The pur-                                                 minority groups that are traditionally
                                      located in Brooklyn on December 8,
pose is to disseminate medical                                                under-represented in health careers
                                      2009. The topic that was covered
information to underserved com-                                               are offered mentorship, after-school
                                      “Diabetes: What It Is and What You
munities on a wide scale. Video-                                              activities, and summer research in-
                                      Can Do About It” engaged thirty-five
conferencing technology facilitates                                           ternships in scientific research. This
                                      community members for the dura-
the improvement of community                                                  pioneering program aspires to create
                                      tion of the discussion.
health education by providing for a                                           new jobs while increasing student
novel interactive exchange of real-                                           exposure to health careers and re-
                                      A second interactive video confer-
time information between experts                                              search as a contribution to the health
                                      encing event occurred on February
located at separate sites and the                                             of the community.
                                      25, 2010 at a community center on
multiple communities involved.
                                      the upper east side of the Manhat-
The primary goal of these presen-
                                      tan. Nimali Jayasinghe, PhD, Assis-
                                                                                                                   PAGE         3




                  WCMC and the                         BDNF has focused on its role in       found only in humans may hold
                                                       neuropsychiatric illnesses, clues     the secret.
                  Burke Institute:                     into its possible role in the func-
                                                                                             In preliminary studies, mice that
                  Focusing on Stroke                   tional recovery from stroke have
                                                       recently begun to surface.            were genetically- engineered to
                  Due in part to the increase of
                                                       In other brain regions such as        express the humanized BDNF
                  the elderly population in Amer-
                                                       the hippocampus, BDNF has             variant displayed significant im-
                  ica, the incidence and preva-
                                                       been shown to protect neurons         pairment in cognitive tasks at six
                  lence of stroke continues to
                                                       from stress and to support the        months post-ischemic brain in-
                  rise. Considerable long-term
Drs. Lee and                                           cellular processes that underlie      jury, when compared to mice
                  health burdens have been as-
Cho have                                               learning and memory. Studies          that express the wild type BDNF.
                  sociated with stroke; it is the
made signifi-                                          have shown that in vivo, BDNF         Continuing to study “knock-in”
                  leading cause of severe, long-
cant headway                                           serves to rescue motorneurons,        mice that express the genetic
towards their     term disability in the U.S. De-
                                                       hippocampal, and substantia           variant of BDNF may bring us
goal to deline-   spite this, few treatment strate-
                                                                                             ever closer to understanding the
                                                       nigral cells from traumatic and
ate the role of   gies exist that address acute
                                                                                             impact of BDNF in the weeks
                                                       toxic brain injury. Yet, little is
BDNF in the       ischemic stroke.
                                                       known about the post-ischemic         following ischemic stroke. Ex-
brain’s recov-
                                                                                             ploring the molecular mecha-
ery from          Increasing evidence suggests
                                                       neuroprotective role of BDNF.
                                                                                             nisms underlying the role of
ischemic          that synaptic plasticity and re-
stroke.                                                Drs. Lee and Cho have made            BDNF in stroke recovery may
                  modeling continues to occur for
                                                       significant headway towards           help to reveal potential targets
                  up to several weeks following
                                                       their goal to delineate the role of   for drugs and other therapeutic
                  the initial tissue injury that
                                                       BDNF in the brain’s recovery          strategies.
                  results from stroke. Francis
                                                       from ischemic stroke. A common
                  Lee, MD, PhD from WCMC part-
                                                       human single nucleotide poly-
                  nered with Sunghee Cho, PhD
                                                       morphism (SNP) of BDNF that is
                  at the Burke Research Insti-
                  tute, located in Westchester, to
                  test the hypothesis that stroke-
                  induced secretion of BDNF
                  plays a critical role in the func-
                  tional recovery from stroke.


                  Brain-derived neurotrophic fac-
                  tor (BDNF), a widely expressed
                  growth factor in mammalian
                  nervous systems, has received
                  considerable attention in recent
                                                                                              Sunghee Cho, PhD,
                  years for its role in stress adap-
                                                                                              Associate Professor of Neu-
                  tation, neurogenesis, synapto-        Francis Lee, MD, PhD,
                                                                                              rology/ Neurosciences,
                                                        Associate Professor,
                  genesis, and angiogenesis.                                                  Burke Medical Research
                                                        Department of Psychiatry
                  Though most of the research on                                              Institute
                                                                                                                            PAGE       4



V O L U M E    I I




   ARRA Grant                       velop a professional social    gress. The project will bring
                                                                                                    Studying Pediatric
                                    network that opens com-        scientists together through
   Collaborations                                                                                   Diseases: Multi
                                    munication between scien-      a comprehensive network
                                                                                                    Institutional
   with CTSA                        tists known as VIVOweb.        by presenting data about
                                                                   them including their re-         Collaborations
   Network                          VIVOweb is based on tech-      search focus, publications,      Working to address one of our

   Nationwide                       nology initially designed at   awards, and partners. The        nation’s most concerning health
                                    Cornell University. Highly     use of existing biological       problems, the increasing preva-
   Combining expertise across
                                    competitive, this $6 million   knowledge is one of the          lence of pediatric hypertension,
   multiple disciplines through
                                    grant was one of two           driving forces behind this       Patricia Giardina, MD, Associate
   the collaboration of es-
                                    awarded nationwide and         ontology-driven data man-        Director of the CTSC Clinical and
   teemed individuals in a
                                    the team is led by Principal   agement network. VI-             Translational Research Unit and
   trans-institutional manner
                                    Investigator Michael           VOweb seeks to extend            Professor of Clinical Pediatrics at
   not only accelerates scien-
                                    Conlon, Director of Bio-       VIVOweb to all CTSC inves-       WCMC, has teamed up with an-
   tific progress but endeavors
                                    medical Informatics at Uni-    tigators.                        other NYC CTSA, Harry Shmoon,
   to advance the overall
                                    versity of Florida Medical                                      MD, Program Director of the In-
   health of our nation’s econ-
                                    Center. Curtis Cole, MD,       A Multi Disciplinary             stitute of Clinical and Transla-
   omy and its people. As
                                    Director of CTSC Informat-                                      tional Research at Albert Einstein
   exampled by WCMC investi-                                       Translational
                                    ics and WCMC Chief Infor-                                       College of Medicine of Yeshiva
   gators being named as                                           Partnership
                                    mation Officer leads the                                        University.
   partners with esteemed                                          Ron Silverman, MD, Profes-
                                    WCMC team.
   awardee institutions such                                       sor of Ophthalmology at
                                                                                                    The direct awardee of the ARRA
   as Albert Einstein Medical                                      WCMC has partnered with
                                                                                                    funding, Dr. Shmoon is working
   Center, University of Flor-                                     YC Chen, PhD, Professor of
                                                                                                    to establish a multidisciplinary
   ida, and Columbia Presby-                                       Physics at Hunter College
                                                                                                    infrastructure within the CTSA
   terian Medical Center for                                       received an administrative
                                                                                                    consortium to closely examine the
   several exciting new pro-                                       supplement to the Hunter
                                                                                                    short-term effects of lifestyle
   jects. Through these part-                                      College Gene Center for
                                                                                                    modification on this growing
   nerships, the WCMC CTSC                                         their revolutionary collabo-
                                                                                                    problem. Children between the
   is an indirect recipient of an                                  rative work on developing
                                                                                                    ages of 7 and 18, and diagnosed
   additional one million dol-                                     higher resolution ultrasound
                                                                                                    with essential hypertension, are
   lars of ARRA funding.                                           images for the clinical exami-
                                                                                                    randomized to either home-based
                                                                   nation of the eye and superfi-
                                                                                                    intensive lifestyle modification or
                                                                   cial tissues. Their supple-
   VIVOweb:                         Curtis L. Cole, MD                                              standard of care intervention
                                    Chief Information              ment was based on a pilot
   Social Networking                                                                                (SCI). Outcomes will be followed
                                    Officer                        project initially funded
                                                                                                    using several measures: 24-hour
   for Researchers                                                 through the CTSC.
                                                                                                    ambulatory blood pressure moni-
   ARRA funds were awarded          By fostering alliances be-                                      toring, echocardiogram, exercise
   to the University of Florida,    tween scientists, VIVOweb                                       testing, biomarkers, quality of
   in a partnership with Cor-       will promote knowledge
   nell University, WCMC            sharing, thereby speeding
   CTSC, and four other aca-        the pace of biomedical pro-
   demic institutions to de-
                                                                                         PAGE        5




life, and nutritional assessment.
                                      A N e w To o l f o r R e s e a r c h e r s
Following a baseline assessment,
                                      By Nelena Jackson
short-terms effects of SCI will be
assessed by the investigators         A new tool for researchers was launched in November 2009.
collecting all of the above data      ResearchMatch is a national volunteer research registry that
at six-month intervals.
                                      brings together researchers and willing volunteers who wish
                                      to get involved in research studies. This national registry
                                      developed by institutions affiliated with the Clinical and
                                      Translational Science Awards (CTSA), provides a secure,
                                      web-based approach to address a key barrier to advancing
                                      research: participant recruitment. The WCMC CTSC is a par-
                                      ticipant of the thirty-nine member ResearchMatch consor-
                                      tium and encourages individuals to join this volunteer regis-
                                      try. This easy-to-use tool is free and confidential and will
                                      increase the availability of research studies to both re-
                                      searchers and research volunteers alike. At this time only
                                      the volunteer recruitment component is active. The investi-
                                      gator search function is expected to be available in the
 Patricia Giardina, MD, Chief         spring.
 of the Division of Pediatric
 Hematology/ Oncology
                                      Please pass this information onto potential volun-
                                      teers. For more information, visit:
Dr. Giardina has also teamed up       www.researchmatch.org?route=weill_cornell.
with Nancy Green, MD, Columbia
University Medical College on
another multicenter study with
several aims, all of which focus
on further delineating the mo-
lecular genetics behind sickle cell
disease. Partners include Albert
Einstein College of Medicine,
Yale University, University of
Rochester and Children’s Hospi-
tal Oakland.
                                                                                                                               PAGE     6




                              CTSC “Call to Service” Drive
 “…I am asking you to make a lasting       collaborative and focused effort to pro-        Over 300 items were collected: canned
commitment to make better the lives        mote service as a way of life for all           and non-perishable food items, binders,
of your fellow Americans - a commit-       Americans.                                      notebooks, pens and pencils. All donated
 ment that must endure beyond one                                                          school supplies were distributed to under-
                                           Answering President Obama’s call to ser-
 day, or even one presidency. At this                                                      privileged children in grades K-12 by The
                                           vice, the WCMC CTSC with its partner,
moment of great challenge and great                                                        River Fund New York, a Queens-based
                                           the Cornell University Cooperative Exten-
change, I am asking you to play your                                                       non-profit organization that is dedicated
                                           sion, New York City (CUCE, NYC), col-
 part; to roll up your sleeves and join                                                    to providing physical, emotional, and
                                           lected canned goods and school supplies
 in the work of remaking this nation.                                                      spiritual support to those in need. Do-
                                           throughout this past summer. This 81-
 And if you do, then I truly believe a                                                     nated food items were sent to The Bow-
                                           day initiative inspired communities to
   new and better day is within our                                                        ery Mission, an organization that has
                                           come together in service and in remem-
                reach.”                                                                    been providing support to New York City’s
                                           brance of those who lost their lives on
   - President-elect Barack Obama,                                                         poor and homeless since 1879.
                                           Sept. 11, 2001.
               1/14/09
                                                                                           In response to the growing percentage of
 Contributed to by Linda Baichoo                                                           New Yorkers in need due to the economy,

"United We Serve" is a nationwide                                                          WCMC CTSC again teamed up with CUCE
                                                                                           for donations during the 2009 winter holi-
service initiative to help meet growing
                                                                                           day season. Holiday gifts in the form of
social needs resulting from the eco-
                                                                                           toys and canned food items were col-
nomic downturn. This initiative aims
                                                                                           lected during the CTSC Holiday Drive.
to both expand the impact of existing
                                                                                           The proceeds from the CTSC holiday
organizations by engaging new volun-
                                                                                           drive went to the Bowery’s Mission Men’s
teers in their work and to encourage
                                           Ready for school with supplies in tow.
                                                                                           program and the River Fund New York.
volunteers to develop a sustained,         Photo courtesy of The River Fund




                           Laboratory Core Service Unveils

By Geraldine Amera                     The instrument has capacity for      He further explains that, “the
                                       96- and 384-well single-spot         use of multiplex assays saves
In August 2009, the CTSC Core          plates in addition to 96-well        money and time for the inves-
Lab unveiled the new Sector            multi-spot plates. Data is avail-    tigator when compared to
Imager 2400 (SI2400).                  able for researchers to manipu-      conventional ELISA.”
                                       late and customize reports for
Researchers will be able to use        download or print out.               Use of the SI 2400 CTSC is
Multi-Array technology and elec-                                            available to all investigators in
trochemiluminescence detection         Yuan Shan Zhu, MD, PhD, Direc-       the CTSC. To make a reser-
to detect biomarkers in single and     tor of the CTSC Core Lab, be-        vation to use the instrument,
multiple formats. The customized       lieves that the new imager pro-      please click here for the Res-
plates allow multiple analytes to      vides “great advantage for stud-     ervation Calendar. For more
be measured at the same time           ies with limited amounts of sam-     information, email Dr. Zhu at
using small sample volume in                                                                                    Yuan Zhu, MD, PhD
                                       ples such as blood samples from      yuz2002@med.cornell.edu.
addition to developing novel as-                                                                                demonstrating the
                                       pediatric cohorts and small ani-                                         use of the Meso 2400.
say formats.                           mal studies.”                                                            Photo by Rafeya Khan
                                                                                             PAGE        7




       R e s e a r c h i n t h e Ko r e a n C o m m u n i t y
By Louise Holmes                that the incidence of depression    Co-investigators, Ms. So-Young
                                among Korean male immi-             Park and Dr. Jinah Shin, and
Kunsook Bernstein, PhD,         grants is closely matched to        research team members lead by
                                that of Korean female immi-         Dr. Bernstein, gathered data by
Professor of Nursing at
                                grants.                             working with Korean community
(Hunter College School of
                                                                    organizations such as:
Nursing) HCSON received
                                Bernstein’s research has            churches, Buddhist temples,
the 2008 CTSC Community
                                yielded significant results, and    senior centers, health fairs, and
Award, for leading a re-
                                as a result has received a CTSC     local business agencies.
search study that sought to
                                planning award. She has sub-        Using the findings from the
explore both the prevalence
                                mitted two articles for publica-    CTSC Community Award re-
and risk factors of depres-
                                tion.                               search project, Bernstein applied
sion among Korean immi-
                                                                    successfully for a CTSC Planning
grants in New York City.
                                Bernstein, herself a Korean         Grant with Co-Investigator Dr.
                                native, has remained active in      Heejung Bang, Associate Profes-
Her findings demonstrated
                                the NYC Korean community            sor of Public Health at Weill Cor-
that factors such as social
                                since her own immigration to        nell Medical College. They plan
isolation, low socioeconomic
                                the U.S in the 1970’s. To com-      to identify the barriers that pre-
status, language barriers
                                mence her research, she organ-      vent Korean immigrants from
and discrimination all con-
                                ized conferences in the Korean      seeking help –including per-
tribute to the onset of de-
                                Community, the first to an-         ceived discrimination, embar-
pression in Korean immi-
                                nounce her initial project and      rassment over English language
grants. The cohort in Bern-
                                enlist support for participation,   skills, and the stigma of admit-
stein’s study included 304
                                and the second at the comple-       ting they need help. The plan is
males and females; most of
                                tion of the project to publicize    to develop a tool for health care
these subjects immigrated
                                the research outcomes and           professionals to use with their
to the United States within
                                celebrate the shared success of     patients to measure the barriers
the past 10-20 years.
                                the community/academic re-          and then test it within the Ko-
                                search collaboration. Dr. Bern-     rean community.
“The research results show a
                                stein is committed to ensuring
13.2 percent prevalence of
                                that her research makes a dif-
depression among Korean
                                ference for this community.
immigrants, which is ap-
proximately twice the rate of
                                Bernstein launched the study
depression reported in the
                                as a “Mental Health Initiative”
U.S. general population,”
                                of the Korean American Behav-
Bernstein reported, “Yet
                                ioral Health Association
many do not seek treat-
                                (KABHA) of which she is a
ment.” The NYC Korean
                                board member, with additional
community has grown dra-
                                funding from The Beautiful
matically over the last nine
                                Foundation, a Korean commu-
years, due to new immigra-
                                nity foundation led by commu-       Kunsook Berstein, PhD,
tion laws, and many experi-
                                nity members to solve and           Professor of Nursing, Hunter
ence depression because of                                          College
                                manage problems in their own
acculturative stress.                                               Courtesy of Weill Cornell Medicine
                                local community and the Clini-
                                cal and Translational Science
Whereas most studies find a
                                Center.
higher incidence of depres-
sion in women than men,
Bernstein’s study uncovered
                                                                                         PAGE    8




                       Translational Researcher:
                    Manikkam Suthanthiran, MD
By Nelena Jackson                 a synergistic combination of    hope to explore the possi-
                                  both.”   In addition to his     bility of stopping immuno-
In his pursuit to unravel         highly productive labora-       suppressants six to nine

the mysteries behind trans-       tory, Suthanthiran devotes      months after transplanta-

plantation, Manikkam              a significant amount of time    tion.”

Suthanthiran, MD, who is          to clinical transplantation

one of the pioneers of pan-       research, seeking to de-        As an experienced author
                                  velop new treatments right      and co-author of numerous
creatic islet cell transplan-
                                                                  publications, Suthanthiran
tation, continues to explore      at the bedside.
                                                                  also serves as the editor of
new therapeutic and moni-                                         the Journal of Transplanta-
                                  Through patient scheduling,     tion. He presented findings
toring strategies that are at
                                                                  from his research at the
the cutting edge of trans-        pre and post-procedure
                                                                  American Transplant Con-
plantation technology. Dr.        assessments, procedural         gress in Boston from May
                                  assistance and monitoring       30 to June 3, 2009.
Suthanthiran’s current
CTSC project is investigat-       capabilities, the services
                                                                  Dr. Manikkam Suthanthiran
ing early kidney rejection        provided by CTSC’s outpa-       received the prestigious
                                  tient unit have proven piv-     NIH MERIT (Method to Ex-
by looking at biomarkers of
                                                                  tend Research in Time)
urine and blood samples of        otal to Suthanthrian’s clini-
                                                                  award in 2009. Dr. Manik-
transplant patients.              cal studies. “Patients under-   kam Suthanthiran has been
                                  going biopsy are admitted       elected by his peers for
                                                                  inclusion in the
Dr. Suthanthiran draws            to the CTSC; without this
                                                                  Best Doctors in America®
upon his many roles to for-       resource, it would be al-       from 1992 to 2010.
mulate hypothesis for his         most impossible to do the

research studies. He states       kind of testing we have

that,” I think we are fortu-      done over the last decade.”

nate in our lab to combine
basic and clinical science.       On the horizon, Dr. Suthan-

In addition to being a            thiran’s research seeks to

transplant physician, I also      improve the management

spend a lot of time running       of transplant patients over

a research laboratory in          the long term. “Going for-

which we have 15-20 re-           ward we are going to be

searchers; half are basic         involved in creating toler-     Manikkam Suthanthiran,
                                  ance in transplant patients.    MD, Stanton Griffis
scientists and half are clini-
                                  Once patients receive a         Distinguished Professor of
cal so we bridge both basic
                                  transplant, they will need
                                                                  Medicine
science and clinical science;
for us it is not either or, but   immunosuppressants
                                  throughout their lives. We
                                                                                           PAGE          9




             Hunter College Annual Symposium
By Nelena Jackson

On January 15, 2010, five hundred eighty members of the scientific community filled the Sylvia
and Danny Kaye Playhouse at Hunter College for the 23rd Annual International Symposium. This
year’s nationally renowned conference was titled “Autism: Integrating Genes, Brain and Behav-
ior.” Eleven distinguished guest speakers covered topics addressing the latest statistics, trends,
discoveries, and challenges in the Autism Disease Spectrum. The Autism symposium commenced
with a welcome from Hunter College President Jennifer Raab.        Director of the Center for Study of
Gene Structure and Function at Hunter College, Robert P. Dottin, PhD, gave opening remarks and
introduced the Program Director of the Clinical and Translational Science Center, Julianne Im-
perato-McGinley, MD.

Among the nationally recognized speakers were Marshalyn Yeargin-Allsopp, MD from the Centers
for Disease Control and Prevention, whose talk was titled, “The Epidemiology and Changing Para-
digm of Autism Spectrum Disorders,” and Geraldine Dawson, PhD, the afternoon session keynote
speaker who spoke on “New Directions in Early Detection and Intervention in Autism.” Following
the clinical translational pipeline, the morning session covered topics in basic science and technol-
ogy use in autism animal models, transitioning through the day to clinical practice, and finally
into the afternoon session focusing on the psycho-social aspects of the disease. The CTSC in
conjunction with the Gene Center at Hunter College sponsored the all day event.

The videotaped conference will be available soon on the CTSC website.

The CTSC is Supported by the NIH NCRR CTSA UL1-RR024996. The Hunter College
Gene Center receive support from the NIH NCRR RCMI Award G12-RR-003037.




      Jumpstarting Small Business Innovation
   Research with the NYC Economic Development
                    Corporation
  By Geraldine Amera

  The overview of the Small Business Innovation Research (SBIR) & Small Business Technol-
  ogy Transfer (STTR) that was hosted by WCMC CTSC in early 2009 received an overwhelm-
  ingly positive review, with many attendees requesting a follow-up program on proposal writ-
  ing. In response, WCMC CTSC hosted an intensive one-day SBIR Proposal Writing Workshop
  on October 29, 2009. The workshop, held at the Griffis Faculty Club and presented by the
  New York City Economic Development Corporation (NYCEDC), drew an attendance of over
  100 people, representing not only CTSC, but also several of its partner institutions as well as
  the pharmaceutical and biotechnology industries. The workshop was lead by NIH SBIR ex-
  pert, Lisa Kurek, who covered all aspects of SBIR and STTR proposal preparation, giving
  particular interest to the art of crafting fundable proposals.
                                                                             PAGE   10




                   CTSC Fast-Track Services

Externally                             Core Use Only:
Reviewed and Approved                  Fast Track Applications
Studies:                               If your protocol doesn’t need full CTSC
                                       service, there is a fast-tracked applica-
Short Application
                                       tion process to utilize one or more CTSC
If your project has been ap-
                                       core services. If your research needs
proved through an external peer
                                       are limited to one or more of the follow-
review process and you would
                                       ing core services: biostatistics, research
like to utilize the CTSC, then you
                                       data management services (REDCap),
can use the “Externally Reviewed
                                       the CTSC General Core Laboratory, and/
and Approved” short application
                                       or the CTSC Molecular Core, apply now
form. The requirements are lim-
                                       to use the above CTSC services.
ited. Response within 10
                                       Response within five days!!
days! Click here for a full de-
                                       Click here for a full description of the
scription of the externally
                                       short form review process.
reviewed study review
process.




Do you have an announcement or article you would like to see in our
next eNews issue or on the CTSC website? Contact the CTSC at
CTSC@med.cornell.edu.




                               The CTSC e-News is published by the
                               Clinical and Translational Science Center
                               Weill Cornell Medical College
                               1300 York Avenue, Box 149
                               New York, NY 10065
                               Tel: 646.962.8304
                               Online: http://www.med.cornell.edu/ctsc

                               Copy editor Rita Falbel
                               Co-editor Nelena Jackson
                               Co-editor Geraldine Amera
                               Graphic design and layout by Hamzad Persaud

				
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