PowerPoint Presentation by 93WVi17


									Recent key research accomplishments:

Polysaccharide Immunity Section

• Refined specificity of pneumococcal polysaccharide
  ELISA by use of both C PS and heterologous type
  (type 22F) polysaccharide preadsorption

• Developed a new general purpose high yield
  (> 70 %) conjugation method
Recent key research accomplishment:

Cellular Immunity Section

  Identified a Polysaccharide interaction affecting
   activity of toll like receptors (TLRs)
Recent key research accomplishments:
Pathogenic Neisseria Section

• Showed that O acetyl groups on the meningococcal
  group A polysaccharide are critical for induction
  of bactericidal antibodies

• Developed a sensitive gonococcal genetic porin (Por)
  typing system to investigate Por specific
  immunity to gonorrhea
Recent key research accomplishments:
Lipopolysaccharide Section

• Defined a new gene, lgtH, in the biosynthesis
  of meningococcal lipooligosaccharide

• Found that sialylation of the terminal galactose
  of meningococcal LOS requires at least
  a trisaccharide moiety

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