Disease or Trait Name by z8OBCl

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									     Disease or Trait Name     Student assigned
1    Alcohol Dependence
2    Alzheimer’s Disease
3    Ankylosing spondylitis
4    Celiac Disease
5    Antidepressant Response
6    Heroin Addiction
7    Chron’s Disease
8    Alopecia Areata
9    Statin Response
10   Warfarin Sensitivity
11   Multiple Sclerosis
12   Psoriasis
13   Sudden Cardiac Arrest
14   Schizophrenia
15   Parkinson’s Disease
16   Venous thromboembolism
17   Caffeine metabolism
18   Type I diabetes
19   Malaria Resistance
20   Photic Sneeze Reflex
21   Response to Exercise
22   Norovirus resistance
23   Muscle Performance
24   Resistance to HIV/AIDS
25   Rheumatoid arthritis
26   Scoliosis
27   Hypothyroidism
28   Pancreatic Cancer
29   Lou Gehrig’s Disease
30   Thyroid Cancer
31   Essential Tremor
32   Brain Aneurysm
33   Longevity
Student instructions:

If you have not already discussed single nucleotide polymorphisms (SNPs) in your class,
familiarize yourself with what SNPs are: here is a fun tutorial at 23andme:
https://www.23andme.com/gen101/snps/

After watching, take a moment to define a SNP for yourself:


Companies, such as 23andme, that provide personal direct to consumer (DTC) genome
tests currently do not sequence your entire genome. They look for an association between
single nucleotide changes and particular phenotypes. Thus, the strength of the science is
anchored in the strength of the association in large population studies.
If you want to read more about these associations, you can see a brief (optional) overview
of genome-wide association studies at the NIH:
http://www.genome.gov/20019523

For our class activity, your goal will be to familiarize yourself with the 23andme website
(www.23andme.com). To do this, you will each be assigned a unique disease or trait that
23andme tests for. You will do all of your research at the 23andme website, thus, this
should not take too long to complete. During class, you will have 2 minutes to tell someone
else about your genetic test. You will not be allowed to read from a card, so be sure to know
some basics. You are expected to know the answers to the basic questions below. You
should convey the answers in your short 2-minute speed talk. (You will have these prompts
when speed talking with your classmates.)

1. Briefly describe the trait or disease you were assigned. (See
https://www.23andme.com/health/all/)

2. What is the most significant consequence to having a particular phenotype associated
with this trait or disease (i.e. is it an inability to drink milk or is it cardiac arrest, etc.)

3. Is your trait or disease associated with a single SNP or are there multiple SNPs factoring
in?

4. How transparent is the company being about the strength of the science of this SNP
association?
     Were there multiple studies published on the association with the SNP(s) and your
       gene?
     Was this considered to be an “established” or “preliminary” research report by
       23andme?
     Do the studies published on this apply to those of various ethnicities? African?
       Asian? European?
5. Would you want to be tested for this? Why or why not?

                                 Prompts for Discussion
                 (Each pair of students can have this during discussion)

1. Briefly describe the trait or disease you were assigned.

2. What is the most significant consequence to having a particular phenotype associated
with this trait or disease (i.e. is it an inability to drink milk or is it cardiac arrest, etc.)

3. Is your trait or disease associated with a single SNP or are there multiple SNPs factoring
in?

4. How transparent is the company being about the strength of the science of this SNP
association?
     Were there multiple studies published on the association with the SNP associations
       and your gene?
     Was this considered to be an “established” or “preliminary” research report by
       23andme?
     Do the studies published on this apply to those of various ethnicities? African?
       Asian? European?

5. Would you want to be tested for this? Why or why not?

								
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