SURFACE ADSORBED NANOEMULSION OF OLMESARTAN MEDOXOMIL FOR ORAL DRUG DELIVERY Sumita Singh, Vikas Bali and Kamla Pathak Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura 281001. Email Id: email@example.com Abstract: Capsular dosage form of surface adsorbed nanoemulsion (NE) was developed with the objective to overcome the problem associated with solubility of olmesartan medoxomil, high surfactant concentration and handling problems of liquid dosage form. Various oils, surfactants and cosurfactants mixtures were used to identify the components of NE. NE formulations were optimized on the basis of percentage transmittance, viscosity, refractive index, globule size, zeta potential, and polydispersity index. The composition of optimized formulation was capmul MCM (10 % v/v), tween 80 (11.25 % v/v), PEG 400 (3.75 % v/v) and double distilled water (75 % v/v) as oil, surfactant, cosurfactant and aqueous phase, respectively. The optimized NE formulation (2ml) was adsorbed over 400 mg of colloidal silicon dioxide to produce a free flowing solid granular NE. Conversion of NE to granular NE and its reconstitution to NE did not affect the release profile of drug as observed by similarity factor was 66 and 73 respectively. However, % CDR of drug form NE, granular NE and reconstituted NE was significantly higher (p< 0.05) in comparison to drug suspension (2%w/v). The percentage enhancement in CDR after 12 h, for optimized NE, granular NE and reconstituted NE was found to be 2.041, 2.027 and 2.000, respectively. The present study established granular nanoemulsion as a viable delivery system that can present itself for capsulation.
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