201109150958040A by DVfdoh


                                   ORAL DRUG DELIVERY

                          Sumita Singh, Vikas Bali and Kamla Pathak

Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura 281001.

Email Id: singh.sumita64@gmail.com


Capsular dosage form of surface adsorbed nanoemulsion (NE) was developed with the objective
to overcome the problem associated with solubility of olmesartan medoxomil, high surfactant
concentration and handling problems of liquid dosage form. Various oils, surfactants and
cosurfactants mixtures were used to identify the components of NE. NE formulations were
optimized on the basis of percentage transmittance, viscosity, refractive index, globule size, zeta
potential, and polydispersity index. The composition of optimized formulation was capmul
MCM (10 % v/v), tween 80 (11.25 % v/v), PEG 400 (3.75 % v/v) and double distilled water (75
% v/v) as oil, surfactant, cosurfactant and aqueous phase, respectively. The optimized NE
formulation (2ml) was adsorbed over 400 mg of colloidal silicon dioxide to produce a free
flowing solid granular NE. Conversion of NE to granular NE and its reconstitution to NE did not
affect the release profile of drug as observed by similarity factor was 66 and 73 respectively.
However, % CDR of drug form NE, granular NE and reconstituted NE was significantly higher
(p< 0.05) in comparison to drug suspension (2%w/v). The percentage enhancement in CDR after
12 h, for optimized NE, granular NE and reconstituted NE was found to be 2.041, 2.027 and
2.000, respectively. The present study established granular nanoemulsion as a viable delivery
system that can present itself for capsulation.

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