FORMULATION AND ITS EVALUATION OF TERBUTALINE SULPHATE MUCOADHESIVE MICROBEADS BY IONIC-GELATION METHOD Tintu Sara James, Doney Alex Baby, Sheeba Alex, V. Vani Amrita school of pharmacy, AIMS Health Care Campus, Ponekkara P.O, Kochi-24 Email ID: email@example.com Abstract Sustained release formulations maintain a constant level plasma concentration of drug so that multiple and night dosing can be avoided. These products provide an immediate release of drug that promptly produces the desired therapeutic effect, followed by gradual release of additional amounts of drug to maintain this effect over a predetermined period. Terbutaline sulphate is a β 2 stimulant drug which is having a very short half life of less than 4 hours. It is widely used for the treatment of reversible bronchospasm associated with asthma, bronchitis and emphysema Terbutaline sulphate is available in conventional dosage form in thrice a day formulation which leads to saw tooth kinetic resulting in ineffective therapy, so attempt is made to formulate in sustained release ’once a day’ formulation. The beads of terbutaline sulphate are prepared by ionic-gelation method by cross linking sodium alginate and carbopol with calcium ions. On exposure of microbeads to aqueous fluid, hydrophilic matrices take up water, and polymer starts hydrating to form a gel layer. Drug release occurs by diffusion or surface erosion. Invitro evaluation studies like mucoadhesive and floating property, swelling index, particle size, FTIR studies, stability studies, drug entrapment efficiency and drug release kinetics were done. It showed more mucoadhesion in 0.1N HCL (63%) than in phosphate buffer of pH 6.8(42%) which predicts the invivo behaviour of beads. These beads are formulated into capsule by mixing with suitable diluents and this provides an effective drug release for 18 hours.
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