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									      FORMULATION AND ITS EVALUATION OF TERBUTALINE SULPHATE
        MUCOADHESIVE MICROBEADS BY IONIC-GELATION METHOD
                 Tintu Sara James, Doney Alex Baby, Sheeba Alex, V. Vani
      Amrita school of pharmacy, AIMS Health Care Campus, Ponekkara P.O, Kochi-24
                       Email ID: tintus007@gmail.com



Abstract
Sustained release formulations maintain a constant level plasma concentration of drug so that
multiple and night dosing can be avoided. These products provide an immediate release of drug
that promptly produces the desired therapeutic effect, followed by gradual release of additional
amounts of drug to maintain this effect over a predetermined period. Terbutaline sulphate is a β 2
stimulant drug which is having a very short half life of less than 4 hours. It is widely used for the
treatment of reversible bronchospasm associated with asthma, bronchitis and emphysema
Terbutaline sulphate is available in conventional dosage form in thrice a day formulation which
leads to saw tooth kinetic resulting in ineffective therapy, so attempt is made to formulate in
sustained release ’once a day’ formulation. The beads of terbutaline sulphate are prepared by
ionic-gelation method by cross linking sodium alginate and carbopol with calcium ions. On
exposure of microbeads to aqueous fluid, hydrophilic matrices take up water, and polymer starts
hydrating to form a gel layer. Drug release occurs by diffusion or surface erosion. Invitro
evaluation studies like mucoadhesive and floating property, swelling index, particle size, FTIR
studies, stability studies, drug entrapment efficiency and drug release kinetics were done. It
showed more mucoadhesion in 0.1N HCL (63%) than in phosphate buffer of pH 6.8(42%) which
predicts the invivo behaviour of beads. These beads are formulated into capsule by mixing with
suitable diluents and this provides an effective drug release for 18 hours.

								
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