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Direct Effects and Indirect Action of Ionizing Radiation on Cellular

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									  Direct Effects and Indirect
Action of Ionizing Radiation on
       Cellular Biology
             Direct Effects
 When ionizing radiation directly acts on a
  cell it can strike the DNA, which is a key
  molecule in the cell.
 When DNA sustains a direct hit that hit
  can be fatal or alter the DNA’s behavior by
  causing chromosome breakage.
      Chromosomal Damage
 When the chromosome is damaged, the
  alterations can cause mutations.
 Those mutations can result in cancer
  which could in turn result in the death of
  the individual.
             Indirect action
 Indirect action is the ionizing action that
  interacts with water inside the body.
 Indirect action is particularly damaging
  because it induces radiolysis of water.
         Radiolysis of Water
 During radiolysis of water, free radicals are
  formed.
 Free radicals are electrophilic and skip
  around inside the body causing damage
  as they go.
      Effects on The Population
   Alenka, who was born in Belarus in 1984,
    has sustained many surgeries from the
    effects of ionizing radiation suffered in the
    aftermath of Chernobyl.

								
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