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					- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Pfizer
MANUFACTURER: PFIZER INC. PHARMACEUTICAL DIVISION 235 EAST 42ND STREET NEW YORK, NY 10017 EMERGENCY PHONE NO.: 212-573-2222 MSDS NO.: 0212 REV.: 001 DATE OF ISSUE: June 17, 1992 ----------------------------------------------------------SECTION I. PRODUCT IDENTIFICATION ----------------------------------------------------------MATERIAL NAME: Penicillin Powder CAS NO.: 113-98-4 CHEMICAL NAME: Penicillin G potassium SYNONYMS: Buffered Pfizerpen (IM/IV) CHEMICAL FAMILY: Penicillin FORMULA: C16-H17-K-N2-O4-S ----------------------------------------------------------SECTION II. HAZARDOUS COMPONENTS ----------------------------------------------------------COMPONENT NAME % ----------------------------------------------------------Drug: Penicillin G potassium NA CAS: 113-98-4 Excipients: Sodium citrate 68-04-4 Formulation is a trade secret. Top 5 NA ingredients that are 1% or more of formula are listed. ----------------------------------------------------------SECTION III. PHYSICAL PROPERTIES ----------------------------------------------------------MELTING POINT: 417-423 deg F 214-217 deg C SPECIFIC GRAVITY: NA SOLUBILITY IN WATER: Very Sol. pH: 3% sol'n 5-7.5 ODOR: odorless VAPOR PRESSURE: NA VAPOR DENSITY: NA PERCENT VOLATILE: NA EVAPORATION RATE: NA MOLECULAR WEIGHT: drug: 372.47 APPEARANCE: Vial containing white powder. ----------------------------------------------------------SECTION IV. FIRE AND EXPLOSION DATA ----------------------------------------------------------FLASH POINT: NA METHOD USED: Not Applicable FLAMMABLE LIMITS: LEL: NA UEL: NA EXTINGUISHING MEDIA: Water, Carbon Dioxide, Dry Chemical SPECIAL FIREFIGHTING PROCEDURES: Do not scatter mat'l with high-pressure stream. Dike fire-control water for disposal. UNUSUAL FIRE AND EXPLOSION HAZARDS: Negligible fire hazard when exposed to heat or flame. ----------------------------------------------------------SECTION V. REACTIVITY DATA ----------------------------------------------------------STABILITY: Stable CONDITIONS TO AVOID: None known. INCOMPATIBILITY---(Materials to Avoid): Acids, alkali hydroxides and oxidizers HAZARDOUS DECOMPOSITION PRODUCTS: Nitrogen oxides, Sulfur oxides. HAZARDOUS POLYMERIZATION: Will not occur. CONDITIONS TO AVOID: NA

----------------------------------------------------------SECTION VI. TOXICITY ----------------------------------------------------------CHRONIC: No information on long-term studies ORAL/PARENTERAL: For drug active. ORAL LD-50 (mg/kg): rat: 6700, mouse: 6257. INTRAVENOUS LD-50 (mg/kg): mouse: 400 DERMAL: No data available. EYE: No data available. INHALATION: No data available. TERATOGENICITY: Pregnancy category B. No teratogenic effects in mice, rats and rabbits. CARCINOGENICITY: NTP: No IARC: No OSHA: No OTHER: Serious anaphylactoid reactions require immediate emergency attention. ----------------------------------------------------------SECTION VII. HEALTH HAZARDS ----------------------------------------------------------EFFECTS OF EXPOSURE: INGESTION: Hypersensitive reactions: skin rashes, urticaria, chills, fever, edema, arthralgia and prostration. Continual intravenous therapy may result in severe or fatal potassium poisoning, characterized by convulsions or coma. EYE CONTACT: Dust may be irritating. Sensitization problems exist. SKIN CONTACT: Dust may be irritating. Sensitization problems exist. INHALATION: Dust may be irritating and cause same reactions as under ingestion. Sensitization problems exist. FIRST AID: INGESTION: Severe anaphylactoid reactions require immediate emergency treatment with epinephrine, oxygen and intravenous steroids. EYE CONTACT: Flush with water for at least 15 minutes and get medical attention. SKIN CONTACT: Wash affected area with soap and water. Launder clothing before reuse. For hypersensitivity, get medical attention. INHALATION: Remove to fresh air. If breathing has stopped, perform artificial respiration. For hypersensitivity, get medical attention. ----------------------------------------------------------SECTION VIII. SPILL OR LEAK PROCEDURES ----------------------------------------------------------SPILL OR LEAK PROCEDURES: Sweep or scoop powder and glass fragments into sealed container. Avoid creating dusty conditions. Ventilate and flush with water to remove final traces. Large quantities: wear dust mask and protective clothing. WASTE DISPOSAL METHOD: Incinerate powder in an approved facility. Small (consumer) amounts may be flushed to a sanitary sewer, where permitted by regulations. ----------------------------------------------------------SECTION IX. PROTECTIVE EQUIPMENT ----------------------------------------------------------RESPIRATORY: Dust conditions: use approved dust mask or more protection as needed. GLOVES: None under normal conditions. EYES: None under normal conditions. VENTILATION: LOCAL: No specific requirements. OTHER: If vials break, ventilation to prevent dust. If dust occurs, contain it. SPECIAL: NA

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- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Pfizer
OTHER PROTECTIVE EQUIPMENT: Gloves, dust-resistant safety glasses and dust mask should be worn when handling this material in bulk or when vials are damaged. ----------------------------------------------------------SECTION X. SPECIAL PRECAUTIONS ----------------------------------------------------------HANDLING AND STORAGE: Store vials undamaged, below 86 deg F (30 deg C) and away from poisons. Material is a drug dosage form intended for human use. OTHER PRECAUTIONS: In event of large scale breakage and dusty conditions, ground equipment and avoid sparks, excessive heat, open flame and strong oxidizers. ----------------------------------------------------------This MSDS is based on a limited review of Pfizer's files and standard toxicology textbooks. The information in this MSDS is furnished without warranty of any kind and should be used only as a supplement to information already in your possession concerning this substance. The determination of whether and under what conditions this substance should be used by your employees is yours to make. ----------------------------------------------------------DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: Although preparer and owner have taken reasonable care in the preparation of this document, we extend no warranties and make no representation as to the accuracy or completeness of the information contained herein, and assume no responsibility regarding the suitability of this information for the user's intended purposes or for the consequences of its use. Each user should make a determination as to the suitability of the information for their particular purpose(s). This MSDS is the most recent received from the product manufacturer or distributor. ----------------------------------------------------------COMPAS Code: 58980190


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