BRIAN HERBERT, Ph.D.
Stockholm, New Jersey 07460 (973) 207-0591 Brian.Herbert1@verizon.net
Scientist with Trial Master File, Clinical Document Organization, and Case Report Form
Scientist with patent law experience
Medicinal Chemist with 8 years experience in a multi-disciplinary drug discovery environment
Originator and coinventor of 3 CNS Clinical Drug Candidates (Phases 1-3 ready)
Successful record of project leadership in the Nicotinic 7 program
Trial Master File
Reviewed and bookmarked Case Report Form (CRF) files.
Familiarity with ICH E6 and FDA guidelines for Clinical and Regulatory documents
utilized for Clinical Studies.
Identified, coded, and filed clinical documents.
Migrated Phase I, II and III trial documents.
Review Regulatory filings of Pre-Clinical documents.
Performed audits of CRO’s trial master file documents to assure orderly documentation.
Prepared documents for inspection during mock FDA audits.
Worked with legal counsel on preparation and filing of fourteen Nicotinic 7 project
patents and six 5-HT6 project patents.
Patent writing services and IP strategy recommendations.
Assisted with office actions/written opinion responses for the Memory Pharmaceuticals
Intellectual Property portfolio.
Coinvented three Clinical Candidates and two Pre-Clinical Development Nominees for the
Nicotinic 7 program (cognition) at Memory Pharmaceuticals. The Nicotinic 7 program
was a highly successful internal program for cognition that was partnered with Roche.
Project co-leader for the Nicotinic 7 back-up program (2004-2008)
Created a portfolio of analogs designed to address various compound profile
Prioritized compounds and analyzed data with internal team representatives.
Collaborated drug discovery efforts with representatives from the Roche team.
Initiated, led, and completed chemistry efforts on the Nicotinic 7 program
Characterized and synthesized metabolites of the Lead Development Candidates on both
the Nicotinic 7 and the Serotonin 5-HT6 projects.
Route selection and method development for the Lead Development Candidate on the
Serotonin 5-HT6 project (cognition and metabolism).
Synthesized novel compounds targeting CNS receptors, analogs of biologically active
compounds, and both natural and unnatural product targets.
Performed milligram and gram scale batches of emerging compounds for advanced
Demonstrated creative problem solving as an active contributor to chemistry efforts, both
internal and external.
ISIS Base, Beilstein, Accelerys and Chem Draw, Symyx, NMR, HPLC, MS, Isco and
Biotage Flash chromatography
Contract Synthesis Group Liaison
Coordinated planning, execution, and delivery of synthetic targets with our contract
Designed stable- and radio-labeled analogs and metabolites of clinical candidates
Brian Herbert, Ph.D. Page 2
Performed scale up of emerging compounds for advanced assays
Led the introduction and implementation of Synthematics/Symyx electronic notebook,
MDL SMART purchasing and inventory system, and Repository database at Memory
Involved in refinement of ISIS database and Pipeline pilot.
Located, digitized, indexed, and cataloged research notebook collections.
Chemical purchasing and inventory system management.
Compound Repository management.
Enumeration for the United States Census Bureau.
PROFESSIONAL and WORK EXPERIENCE
Contractor - Clinical NPS Pharmaceuticals December, 2010-August 31, 2012
Companion Private Elder Care July, 2010-December, 2011
Enumerator US Census Bureau April-August, 2010
Backroom Day Target April, 2010-Present
Consultant Influmedix February, 2010-February, 2011
Consultant - Patent Law Group Hoffman-La Roche Pharmaceuticals August, 2009-February, 2010
Senior Staff Scientist Memory Pharmaceuticals January, 2001-July, 2009: three
Senior Scientist Gliatech February-December 2000
Intramural Research Trainee, National Institutes of Health 1998-2000
mentored by Dr. Kenneth L. Kirk
Post-Doctoral Research University of Illinois 1995-1998
Associate, mentored by
Professor Scott E. Denmark
Graduate Student, mentored by Imperial College, London, England, 1989-1995
Professor Anthony G.M. Barrett Colorado State University,
PRG Winning Patents Workshop July 17‐20, 2012
PRG Patent Bar Review Course November 7-11, 2011
MS Office 2011, Intermediate and Advanced November-December, 2011
Drew Medicinal Chemistry Course September, 2002
Doctor of Philosophy in Chemistry Colorado State University
Masters of Science in Chemistry Northwestern University
Bachelors of Science - Cum Laude (Biology, Math, and Chemistry) St. Andrews Presbyterian College
Fifteen issued patents, ten publications in peer reviewed journals and books, and two poster