Globulins of the human blood
In the human biochemistry study, the blood components are widely divided. Human plasma
being one of the important constituent is majorly responsible for the accurate flow of blood in
the human body. Human plasma is made up of water and proteins and occupies almost 55% of
total blood volume in the human body. However this substance is a regenerating substance in
the body which can be easily formed again by it, so can be donated for medication or research
purposes without causing any deficiency to the body.
In the human plasma there are 3 types of serum proteins present albumin, fibrinogen and
Globulin. When the fibrinogen is separated from the plasma it becomes the serum part.
Fibrinogen is the clotting part of the blood. Albumin is also a globular protein, but not a
globulin. All other serum globular proteins except the albumin are globulins. Some globulins are
produced in the liver, while others are produced by the immune system of the human body.
The serum globulins are categorized into 4 types based on its properties. Protein
electrophoresis is the method which is used to categorize these serum globulins into the
following four categories:
Alpha 1 globulins
Alpha 2 globulins
Alpha globulins are a group of the globular proteins that are very volatile in an electrically
charged solution or the alkaline solutions. These alpha globulins withhold several blood
enzymes in it. There are various types of alpha globulins which are further divided into Alpha 1
and Alpha 2.
Beta globulins are also same like the Alpha globulins but are less volatile when compared to
them. This is a globulin in blood plasma that carries iron and are transport proteins, serving as a
substrates upon which other substances are formed, and perform other diverse functions in the
Gamma globulins are the type of globulins that are identified by their position after the process
electrophoresis is done for the extraction of serum protein. These are the antibodies which are
very crucial in the development of various medications and therapeutic use. Being the heaviest,
they are the slowest to segregate in Electrophoresis. Since they are immunologically active,
they are also called as Immunoglobulin. These are very important part of human blood as their
excess and deficiency both are not good for health and can cause a disease called
"gammopathy". An excess of it is called as “hypergammaglobulinemia” whereas deficiency is
called as “hypogammaglobulinemia”.
Injections are given to the patients to boost immunity in patients who are unable to produce
the required gamma globulins quantity naturally because of an immune deficiency. Such
injections are less common in modern medical practice than they were previously, as they have
been replaced by the use of hepatitis A vaccine. However, being a substance taken from blood,
gamma globulin injections, along with blood transfusions and intravenous drug use, could pass
along Hepatitis C to its recipient, which is the major cause of its replacement in the medical use.
Apart from gamma globulins, there are medications available foe alpha and bets too in the
world which can be taken.
Learn more about such Biological products by visiting at http://www.accessbiologicals.com/