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Endocrine__Hirsutism

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					     In Capsule Series
Endocrine


                                            Hirsutism

        Def. : ↑↑ growth of body hair in androgen dependant areas.
        Etiology :
                    a. Ovarian :
                             1. polycystic ovary syndrome > 90% of cases.
                             2. ovarian tumors secreting androgens.
                    b. Adrenal :
                             1. congenital adrenal hyperplasia ( CAH ).
                             2. Cushing's syndrome.
                    c. Drugs :
                             1.   minoxidil.
                             2.   phenytoin.
                             3.   diazoxide.
                             4.   androgens.

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                                    Gynaecomastia

        Def. : enlargement of i male breast, this is due to a decreased
        androgens : estrogen ratio.
             It should be differentiated from fatty breast which lacks i
             glandular element.
        N.B. :
                 It's unrelated to galactorrhea, breast enlargement is not
                 necessary to make milk.

        Etiology :
                    a. Physiological : neonatal, pubertal                          &       old age.
                    b. Pathological :
                            liver cirrhosis.
                             1.
                            acromegally.
                             2.
                            hyperthyroidism.
                             3.
                            hypogonadism.
                             4.
                            estrogen producing tumor ( testis & adrenal ).
                             5.
                            bronchogenic carcinoma.
                             6.
                    c. Drugs :     spironolactone,             digoxin,
                                   estrogen,                   cimetidine,
                                     -methyl-dopa       &      marijuana.

                                                                                                    - 84 -
   In Capsule Series
Endocrine




                       - 85 -

				
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