Dwarfism and Gigantism

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					Dwarfism, Gigantism, and
      Acromegaly By: Megan Sanford
                               Dwarfism
                                           • AKA: Growth
                                             Hormone Deficiency
                                             and Hyposecretion of
                                             the GH
                                             – A person of short
                                               stature
                                             – Disproportionate body
                                               parts
                                             – “Pituitary Dwarfism”
                                             – 1 in every 3800 births
    Shortest Man to ever Live: Gul
Mohammed: 22.5 inches tall, lived to age
                 29
                 Dwarfism cont.
• Little Peoples of
  America (LPA)
• Caused by deficiency of
  Pituitary Gland
  – Limited production of GH,
    called somatotrophin
• Growth failure, distorted
  facial appearance,
  delayed bone age and
  many organ problems
                                Shortest Woman to ever Live: Pauline
                                Musters: 23 inches tall, lived to age 19
      Treatments for Dwarfism
• Daily injections of
  Human Growth
  Hormone (HGH)
• Since 1985, new types
  of HGH have been
  developed from a
  genetically-engineered
  bacteria
   – Ex: rhGH
• $10,000-40,000 a year
  depending on severity
                  Gigantism
• "Pituitary gigantism"
  and Hypersecretion of
  the GH
• Bone growth in an
  excess amount
• Can result in
  “hoarseness, sleep
  apnea, joint pain,
  cardiovascular disease,
  hypertension, insulin
  resistance, visual
  impairment and severe
  headaches” (MedNet, 1)
                            Tallest Man to ever Live: Robert Wadlow:
                                     8’11.1”, lived to age 22
                      Gigantism cont.
                                            • Gigantism, when
                                              purely inherited, is
                                              characterized by the
                                              top 1% of the
                                              population
                                            • Treatment is limited to
                                              surgery and certain
                                              growth stunting
                                              medicines

Tallest Woman to ever Live: Zeng Jinlian:
         8’1.75”, lived to age 17
                  Acromegaly
                              • Syndrome where the
                                pituitary gland
                                produces excess
                                HGH after epiphyseal
                                plate closure
                              • Affects adults in mid-
                                life
                              • HGH abuse is linked
                                to several forms of
                                acromegaly

Abnormal growth of mandible
              Acromegaly cont.
• Symptoms: “severe
  disfigurement, soft tissue
  swelling of internal
  organs (heart, kidneys,
  and vocal chords) and of
  hands, feet, nose, lips,
  ears, chin, and skin and
  premature death”
  (eMedicineHealth, 2)
• Treatments: surgery,
  drug: Bromocriptine
  (reduces GH secretion),
  and drug: octreotide
  (stops GH production)
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posted:9/18/2012
language:English
pages:9